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At least 199 records · Page 11
All sourcesNASA NTRSDOE OSTI
DOE OSTI2020

Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains poorly understood. Here we report the structure of an unliganded human Fzd5 determined by single-particle cryo-EM at 3.7 Å resolution, with the aid of an antibody chaperone acting as a fiducial marker. We also analyzed the topology of low-resolution XWnt8/Fzd5 complex particles, which revealed extreme flexibility between the Wnt/Fzd-CRD and the Fzd-TM regions. Analysis of Wnt/β-catenin signaling in response to Wnt3a versus a ‘surrogate agonist’ that cross-links Fzd to LRP6, revealed identical structure-activity relationships. Thus, canonical Wnt/β-catenin signaling appears to be principally reliant on ligand-induced Fzd/LRP6 heterodimerization, versus the allosteric mechanisms seen in structurally analogous class A G protein-coupled receptors, and Smoothened. These findings deepen our mechanistic understanding of Wnt signal transduction, and have implications for harnessing Wnt agonism in regenerative medicine.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1971

27-day recurrence and long term modulation of cosmic ray intensity.

Previous work by Balasubrahmanyan and Venkatesan (1970) on the general problem of the solar activity relationship with the 27-day recurrence and long term modulation of cosmic ray intensity, and Lockwood's (1971) comments thereon are discussed in the light of some further work. A possible explanation proposed for the absence of any time lag in both short and long term cosmic ray intensity changes views the long term variation as a result of a superposition of a number of short term decreases.

Balasubrahmanyan, V. K.↗
NASA NTRS1977

The moisture budget in relation to convection

An evaluation of the moisture budget in the environment of convective storms is presented by using the unique 3- to 6-h rawinsonde data. Net horizontal and vertical boundary fluxes accounted for most of the large amounts of moisture which were concentrated into convective regions associated with two squall lines that moved through the area during the experiment. The largest values of moisture accumulations were located slightly downwind of the most intense convective activity. Relationships between computed moisture quantities of the moisture budget and radar-observed convection improved when lagging the radar data by 3 h. The residual of moisture which represents all sources and sinks of moisture in the budget equation was largely accounted for by measurements of precipitation.

Scott, R. W.↗
NASA NTRS1977

The MINE project: Minority Involvement in NASA Engineering

The Mine Project developed by Lewis Research Center (LRC) along with Tennessee State University and Tuskegee Institute, is described. The project calls for LRC to assemble on-going NASA university affairs programs aimed at benefiting the school, its faculty, and its student body. The schools receive grants to pursue research and technology projects that are relevant to NASA's missions. Upon request from the universities, LRC furnishes instructors and lecturers. The schools have use of surplus government equipment and access to NASA research facilities for certain projects. Both the faculty and students of the universities are eligible for summer employment at LRC through special programs. The MINE Project is designed to establish a continuing active relationship of 3 to 5 years between NASA and the universities, and will afford LRC with an opportunity to increase its recruitment of minority and women employees.

Allen, H., Jr.↗
NASA NTRS1984

Structure-activity correlations for organophosphorus ester anticholinesterases. Part 2: CNDO/2 calculations applied to ester hydrolysis rates

Quantitative structure-activity relationships are presented for the hydrolysis of organophosphorus esters, RR'P(O)X, where R and R' are alkyl and/or alkoxy groups and X is fluorine, chlorine or a phenoxy group. CNDO/2 calculations provide values for molecular parameters that correlate with alkaline hydrolysis rates. For each subset of esters with the same leaving group, X, the CNDO-derived net atomic charge at the central phosphorus atom correlates well with the alkaline hydrolysis rate constants. For the whole set of esters with different leaving groups, equations are derived that relate charge, orbital energy and bond order to the hydrolysis rate constants.

Johnson, H.↗
NASA NTRS1985

The X-ray spectra and the rotation-activity connection of RS CVN binaries

Results from a survey of RS CVn binaries which were observed with the Imaging Proportional Counter (IPC) on board the Einstein Observatory are presented. Spectral analyses of the IPC pulse height spectra show that the coronae of RS CVn binaries always contain hot gas with temperatures 10 million K, similar to active late-type main sequence stars, and that at least 2 temperature components are necessary to account for the higher quality IPC spectra (when absorption is unimportant). It is argued that these bimodal temperature distributions indicate true distributions of emission measure vs temperature that are continuous (just as is the case for magnetically-confined coronal plasma loops observed on the Sun). It is shown that none of the derivable X-ray characteristics of RS CVn binaries depend on rotation period, implying that claims of period-activity relationships in RS CVn binaries are unfounded.

Majer, P.↗
NASA NTRS1986

X-ray spectra and the rotation-activity connection of RS Canum Venaticorum binaries

Results are presented from a survey of RS CVn binaries which were observed with the imaging proportional counter (IPC) on board the Einstein Observatory. Spectral analyses of the IPC pulse height spectra show that the coronae of RS CVn binaries always contain hot gas with temperatures in excess of 10 to the 7th K, similar to active late-type main-sequence stars, and that at least two temperature components are necessary to account for the higher quality IPC spectra (when absorption is unimportant). It is argued that these bimodal temperature distributions found by the IPC are indicative of true distributions of emission measure versus temperature that are continuous (just as is the case of magnetically confined coronal plasma loops observed on the sun). It is further shown that none of the derivable X-ray characteristics of RS CVn binaries depend on rotation period, implying that previous claims of period-activity relationships in RS CVn binaries were unfounded.

Majer, P.↗
NASA NTRS1985

QSAR for cholinesterase inhibition by organophosphorus esters and CNDO/2 calculations for organophosphorus ester hydrolysis

Quantitative structure-activity relationships were derived for acetyl- and butyrylcholinesterase inhibition by various organophosphorus esters. Bimolecular inhibition rate constants correlate well with hydrophobic substituent constants, and with the presence or absence of catonic groups on the inhibitor, but not with steric substituent constants. CNDO/2 calculations were performed on a separate set of organophosphorus esters, RR'P(O)X, where R and R' are alkyl and/or alkoxy groups and X is fluorine, chlorine or a phenoxy group. For each subset with the same X, the CNDO-derived net atomic charge at the central phosphorus atom in the ester correlates well with the alkaline hydrolysis rate constant. For the whole set of esters with different X, two equations were derived that relate either charge and leaving group steric bulk, or orbital energy and bond order to the hydrogen hydrolysis rate constant.

Johnson, H.↗
NASA NTRS1985

QSAR for cholinesterase inhibition by organophosphorus esters and CNDO/2 calculations for organophosphorus ester hydrolysis

Quantitative structure-activity relationships were derived for acetyl- and butyrylcholinesterase inhibition by various organophosphorus esters. Bimolecular inhibition rate constants correlate well with hydrophobic substituent constants, and with the presence or absence of cationic groups on the inhibitor, but not with steric substituent constants. CNDO/2 calculations were performed on a separate set of organophosphorus esters, RR-primeP(O)X, where R and R-prime are alkyl and/or alkoxy groups and X is fluorine, chlorine or a phenoxy group. For each subset with the same X, the CNDO-derived net atomic charge at the central phosphorus atom in the ester correlates well with the alkaline hydrolysis rate constant. For the whole set of esters with different X, two equations were derived that relate either charge and leaving group steric bulk, or orbital energy and bond order to the hydrolysis rate constant.

Johnson, H.↗
NASA NTRS1987

Statistical properties of magnetic field fluctuations in the distant plasmasheet

Short (less than 1 min) and long time (greater than 5 min) variations of the plasmasheet magnetic field have been examined during all intervals when ISEE-3 was at distances x less than -200 earth radii. It is determined that short period magnetic turbulence increases by a factor of about 3 with increasing geomagnetic activity, as indicated by AE. In contrast, long period field variations with North-then-South signatures at plasmasheet entry occur about 2.5 times more frequently than South-then-North signatures. This result, combined with other previous ISEE-3 results, is in agreement with the interpretation that the North-South plasmasheet features are plasmoids propagating tailward. However, a statistical examination of the geomagnetic activity relationship indicates that there does not appear to be any substorm dependence on these North-South events.

Tsurutani, Bruce T.↗
NASA NTRS1992

Catalytic methods using molecular oxygen for treatment of PMMS and ECLSS waste streams, volume 2

Catalytic oxidation has proven to be an effective addition to the baseline sorption, ion exchange water reclamation technology which will be used on Space Station Freedom (SSF). Low molecular weight, polar organics such as alcohols, aldehydes, ketones, amides, and thiocarbamides which are poorly removed by the baseline multifiltration (MF) technology can be oxidized to carbon dioxide at low temperature (121 C). The catalytic oxidation process by itself can reduce the Total Organic Carbon (TOC) to below 500 ppb for solutions designed to model these waste waters. Individual challenges by selected contaminants have shown only moderate selectivity towards particular organic species. The combined technology is applicable to the more complex waste water generated in the Process Materials Management System (PMMS) and Environmental Control and Life Support System (ECLSS) aboard SSF. During the phase 3 Core Module Integrated Facility (CMIF) water recovery tests at NASA MSFC, real hygiene waste water and humidity condensate were processed to meet potable specifications by the combined technology. A kinetic study of catalytic oxidation demonstrates that the Langmuir-Hinshelwood rate equation for heterogeneous catalysts accurately represent the kinetic behavior. From this relationship, activation energy and rate constants for acetone were determined.

Akse, James R.↗
NASA NTRS1994

Scope and Abstraction: Two Criteria for Localized Planning

Localization is a general-purpose representational technique for partitioning problem requirements into subproblems. Localized search utilizes a partitioning by breaking the overall search space into several smaller search spaces, one for each subproblem. Unlike most methods of partitioning, localization allows for subproblems that overlap -- i.e., multiple search spaces may be involved in constructing shared pieces of the overall plan. In this paper we focus on two criteria for forming localizations: abstraction and scope. Abstraction-based localizations are motivated by activation relationships between problem requirements. In contrast, scope-based localizations are motivated by the relevance of problem requirements to specific portions of the overall plan. This paper also describes a method for automatically generating scope and abstraction-based localizations. Empirical results are provided that contrast their use in an office-building construction planning domain.

Lansky, Amy L.↗
NASA NTRS1990

Effect of voluntary vs. artificial activation on the relationship of muscle torque to speed

The suggestion by Phillips and Petrofsky (1980) and Wickiewicz et al. (1984) that artificial activation of the knee extensor muscles should result in greater relative changes in torque than those evident with maximal voluntary activation is examined by investigating the speed-torque relationship of the right knee extensor muscle group in eight human subjects in whom activation was achieved by 'maximal' voluntary effort or by electrical stimulation. Torque was measured at a specific knee angle during isokinetic concentric or eccentric actions at velocities between 0.17 and 3.66 rad/s and during isometric actions. It is shown that, with artificial activation, the relative changes in both eccentric and concentric torque were greater as the speed increased; the speed-torque relationship was independed of the extent of activation and was similar to that of an isolated muscle. On the other hand, activation by the central nervous system during maximal effort depended on the speed and the type of muscle action performed.

Dudley, Gary A.↗
NASA NTRS1989

Relationship between solar activities and thunderstorm activities in the Beijing area and the northeast region of China

An analysis of the relationship between the IMF section boundary crossing, solar flares, the sunspot 11 year cycle variation and the thunderstorm index is given, using the superposition epoch method, for data from more than 13,000 thunderstorms from 10 meteorological stations in the Beijing area and the Northeast region during 1957 to 1978. The results show that for some years a correlation exists between the thunderstorm index and the positive IMF section boundary crossing. The thunderstorm index increases obviously within three days near the crossing and on the seventh day after the crossing. The influence of the crossing on thunderstorms is stronger in the first half year than the latter half year. For different classes of solar flares, the influences are not equally obvious. The solar flares which appeared on the west side, especially in the western region (from 0 to 30 deg) have the most obvious influence. There is no discernible correlation between the thunderstorm index and the sunspot eleven-year cycle.

Zhuang, Hong C.↗
NASA NTRS1994

Muscular activity and its relationship to biomechanics and human performance

The purpose of this manuscript is to address the issue of muscular activity, human motion, fitness, and exercise. Human activity is reviewed from the historical perspective as well as from the basics of muscular contraction, nervous system controls, mechanics, and biomechanical considerations. In addition, attention has been given to some of the principles involved in developing muscular adaptations through strength development. Brief descriptions and findings from a few studies are included. These experiments were conducted in order to investigate muscular adaptation to various exercise regimens. Different theories of strength development were studied and correlated to daily human movements. All measurement tools used represent state of the art exercise equipment and movement analysis. The information presented here is only a small attempt to understand the effects of exercise and conditioning on Earth with the objective of leading to greater knowledge concerning human responses during spaceflight. What makes life from nonliving objects is movement which is generated and controlled by biochemical substances. In mammals. the controlled activators are skeletal muscles and this muscular action is an integral process composed of mechanical, chemical, and neurological processes resulting in voluntary and involuntary motions. The scope of this discussion is limited to voluntary motion.

Ariel, Gideon↗
NASA NTRS1976

Study of the relationship between solar activity and terrestrial weather

Evidence for some connection between weather and solar related phenomena is presented. Historical data of world wide temperature variations with relationship to change in solar luminosity are examined. Several test methods for estimating the statistical significance of such phenomena are discussed in detail.

Sturrock, P. A.↗
DOE OSTI2021

Progress Report on Performance of A709 and G91 Steels in Sodium

Specimens in six different processing and heat treatment conditions of A709 H58776 were exposed to sodium at 550, 600, and 650°C, respectively for various exposure times. G91 base metal was tested in sodium at 550, 600, and 650°C, and G91 weldment at 550 and 600°C, respectively. Parallel thermal aging experiments were conducted on G91 and A709 to obtain thermal aging data for comparison with sodium exposure results to separate the thermal and sodium effects. The corrosion data obtained on A709 steel continue to show low corrosion rates, which indicate good compatibility of A709 with sodium when oxygen content is controlled. G91 has also shown acceptable corrosion rates over the temperature range of 550-650°C in sodium. Thermal aging or sodium exposures reduced the tensile strength, uniform elongation, and total elongation for A709 ESR, AOD specimens. These specimens consistently showed higher yield stress and tensile strength and lower uniform and total elongations after sodium exposure than after thermal aging under comparable testing conditions. It implies that there was an additional effect of sodium exposure that gave rise to an increase in tensile strength of A709. Dynamic strain aginginduced flow serrations were completely removed by either thermal aging or sodium exposure at 650°C, which imply that carbon or nitrogen in solution was removed from the solution and formed precipitates during aging or sodium exposures. The tensile data ruled out the possibility of decarburization under the sodium exposure conditions. The HOMO specimens behaved somewhat differently from the ESR and AOD specimens in sodium. While thermal aging and sodium exposures at 550 and 600°C decreased the yield stress and the ultimate tensile strength of G91, there was virtually no additional effect resulting from sodium exposures at these two temperatures. In contrast, sodium exposures at 650°C had a drastic effect on the yield stress and the ultimate tensile strength of G91. It is suggested that G91 experienced decarburization in the 650°C sodium environments. Carbon concentrations in sodium in the SMT-1 and SMT-2 loops were determined by a foil equilibration method. The estimated carbon concentration was in the range of 0.8-1.2 ppm in the SMT-1 loop and 0.3-0.7 ppm in the SMT-2 loop. The carbon activity in sodium in the SMT-2 loop was estimated to be 0.03-0.08 at 600°C, and 0.08-0.2 at 550°C. The carbon activity in sodium at 650°C in the SMT-1 loop was 0.04-0.07. Equilibrium simulation of the carburization – decarburization processes was conducted for A709 and G91 steels exposed in sodium environments at temperatures of 550-700°C. The carbon activity-concentration relationship for G91 was re-evaluated by considering four phases in G91, i.e. bcc ferrite, M 23 C 6 , NbC and VC carbides. It was found that the carburization-decarburization process in G91 steel was dictated by M 23 C 6 carbides at high carbon activities, while NbC carbides dominated the process at low carbon activities. Formation of NbC increases the decarburization resistance of G91 steel. It remains to be understood whether the decarburization resistance provided by MC carbides in G91 can be maintained during long-term operations of SFRs. The carbon concentration-activity relationship for A709 was calculated based on the equilibrium of fcc-austenite and M 23 C 6 carbide phase. The calculations showed that A709 decarburizes at 650°C in the SMT-1 loop environments, which is different from the experimental findings. The carbon concentration-activity relationship in A709 was further evaluated by considering four phases, including fcc-austenite, M 23 C 6 , NbC, and TiC carbide phases. TiC is the most stable carbides among the three carbide phases. The carburization-decarburization process in A709 is dictated by M 23 C 6 carbides at high carbon activities and by TiC at low carbon activities. Formation of TiC increases the decarburization resistance of A709 steel. Because of the complexity of the precipitation process in A709 during sodium exposures, detailed characterization of precipitates in sodium-exposed specimens and improved thermodynamic models are needed to understand the carburization-decarburization behavior of A709. Kinetic analysis of carbon transfer will be investigated for G91 and A709 in future work.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗