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At least 199 records · Page 11

Development of Solar Flare and Energetic Particle Prediction Portal (SEP 3 )

Solar activity is a primary factor determining the state of the Earth’s space environment, geomagnetic and ionospheric disturbances, and radiation hazards. In the current state of knowledge, machine learning (ML) methods provide essential tools for processing data, investigating relationships among various physical properties and characteristics, uncovering hidden connections, and predicting hazardous solar events. The primary difficulty in developing and applying modern machine-learning tools in heliophysics is that the essential data are scattered among over a hundred data repositories developed by instrument teams of space missions and ground-based observatories. In addition, statistical and ML methods require long time series of homogeneous measurements. To facilitate ML-ready data preparation and access, we have developed an interactive database of solar flares integrating the most essential datasets (https://solarflare.njit.edu/). The database performs an initial data processing and is automatically updated. In addition, we are developing the Solar Energetic Particle Prediction Portal (SEP3, https://sun.njit.edu/SEP3), which hosts web applications that allow users to retrieve the database records. The Portal has a search page for browsing the events from the most widely used catalogs and a dedicated space to share the most recent achievements of the team. The interactive widget can display soft X-ray and proton flux time series from GOES satellites and the flare records. The data portal has been used to evaluate the forecasts of solar proton events and investigate machine-learning approaches to SEP prediction.

SMD↗

Materials for Shielding Astronauts from the Hazards of Space Radiations

One major obstacle to human space exploration is the possible limitations imposed by the adverse effects of long-term exposure to the space environment. Even before human spaceflight began, the potentially brief exposure of astronauts to the very intense random solar energetic particle (SEP) events was of great concern. A new challenge appears in deep space exploration from exposure to the low-intensity heavy-ion flux of the galactic cosmic rays (GCR) since the missions are of long duration and the accumulated exposures can be high. Because cancer induction rates increase behind low to rather large thickness of aluminum shielding according to available biological data on mammalian exposures to GCR like ions, the shield requirements for a Mars mission are prohibitively expensive in terms of mission launch costs. Preliminary studies indicate that materials with high hydrogen content and low atomic number constituents are most efficient in protecting the astronauts. This occurs for two reasons: the hydrogen is efficient in breaking up the heavy GCR ions into smaller less damaging fragments and the light constituents produce few secondary radiations (especially few biologically damaging neutrons). An overview of the materials related issues and their impact on human space exploration will be given.

Wilson, J. W.↗

Hazard calculations of diffuse reflected laser radiation for the SELENE program

The hazards from diffuse laser light reflections off water clouds, ice clouds, and fog and from possible specular reflections off ice clouds were assessed with the American National Standards (ANSI Z136.1-1986) for the free-electron-laser parameters under consideration for the Segmented Efficient Laser Emission for Non-Nuclear Electricity (SELENE) Program. Diffuse laser reflection hazards exist for water cloud surfaces less than 722 m in altitude and ice cloud surfaces less than 850 m in altitude. Specular reflections from ice crystals in cirrus clouds are not probable; however, any specular reflection is a hazard to ground observers. The hazard to the laser operators and any ground observers during heavy fog conditions is of such significant magnitude that the laser should not be operated in fog.

Miner, Gilda A.↗

MULTI-OMICS ANALYSIS OF THE IMPACT OF CHRONIC LOW-DOSE RADIATION AND HINDLIMB SUSPENSION ON MURINE BRAIN AND RETINA

The space environment includes hazards like radiation and microgravity which can adversely affect biological systems. We assessed multi-omics multi-tissue NASA GeneLab datasets where 6-month-old female mice were gamma irradiated (IR) and/or hindlimb unloaded (HLU) for 21 days. Whole transcriptome shotgun sequencing (RNA-Seq) and reduced representation bisulfite sequencing (RRBS) of brain and retina samples collected at 4 months post-exposure was performed to better characterize the retinal and neurological responses to spaceflight. We compared epigenomic and transcriptomic profiles within each exposure group for both tissue types to identify correlation (Pearson’s correlation test; p-value < 0.05) between gene expression and DNA methylation levels that may be related to transcriptional regulation. We then obtained genes with methylation-expression correlation that also showed differences in mean expression or dispersion between exposed and control groups (adjusted p-value < 0.25; relaxed to denote ‘hypothesis’) in the brain (37 genes in HLU, 4 in IR, and 156 in HLU+IR) or retina (92 genes in HLU, 1 in IR, and 55 in HLU+IR). Enriched Gene Ontology (GO) terms for these genes are listed in Table 1 for HLU and HLU+IR for both tissue types. No enriched terms and only a few genes were detected with IR-only exposure in the brain (Chmp1a, Limd1, Rab40b, Ubc) and retina (retinoblastoma binding protein Rbbp7). Cellular components related to synapse were enriched in both tissue types. Previous analysis of differentially expressed genes in the retina after 1 month of HLU+IR showed enrichment in the somatodendritic compartment of the neuron, which was also observed in the brain 4 months post-exposure. Interestingly, genes related to ubiquitination showed correlation between methylation and expression and were differentially expressed or dispersed in different exposure groups indicating that this pathway may play an important role in multi-stressor response (Figure 1). The current multi-omics and multi-tissue analysis interrogates the epigenomic and transcriptomic impacts of radiation and hindlimb unloading, in isolation and in combination, on the retina and the brain. The results provide insight into the adaptive response to individual spaceflight hazard analogs and their interplay, as well as hypotheses to be further tested for understanding spaceflight-induced neurological and vision effects.

Prachi Kothiyal↗

An Approach to Quantitative Risk Assessment for Combined Spaceflight Hazards: Evaluating the Impact of Short Sleep Durations on Space Crew Cardiovascular Health

Astronauts embarking on long-duration missions will be exposed to multiple spaceflight hazards including radiation, isolation and confinement, distance from Earth, hostile closed environments, and altered gravity. These hazards pose health risks to the crew in-mission and postflight, including risks to cardiovascular health. For radiation, quantitative risk models have been developed that are based on large-scale epidemiological evidence from exposed terrestrial populations, which are extrapolated to account for the difference in radiological effectiveness between ground-based and in-flight exposures. •Cardiovascular diseases (CVD) are multifactorial, therefore multiple risk factors can influence disease risk estimates. •Astronauts with spaceflight experience is a very small population. •To overcome limitations of cohort, population data from presumed equivalent stressors on Earth can be used to quantitatively assess possible risks. •Sleep disruption and short sleep duration are known consequences of spaceflight and are also established risk factors for cardiovascular disease on earth (Pateletal.,2020). •Coronary Heart Disease (CHD), Myocardial Infarction (MI), and stroke are negative health effects due to short sleep durations and sleep disruptions (Yinetal.,2017); (Cappuccio et al., 2010). •A combined CVD risk model including spaceflight stressor such as sleep, stress, radiation, etc.) will provide more precise estimate of risks.

Spaceflight Hazards↗

Solar cosmic ray events

Nature of charged particle fluxes in vicinity of earth to estimate hazard to Apollo astronauts due to solar cosmic ray events

RADIATION HAZARD↗