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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 199 records · Page 11
All sourcesNASA NTRSDOE OSTI
DOE OSTI2017

Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics

Cross-linking of immunoglobulin E–bound FcεRI triggers multiple cellular responses, including degranulation and cytokine production. Signaling is dependent on recruitment of Syk via docking of its dual SH2 domains to phosphorylated tyrosines within the FcεRI immunoreceptor tyrosine-based activation motifs. Using single-molecule imaging in live cells, we directly visualized and quantified the binding of individual mNeonGreen-tagged Syk molecules as they associated with the plasma membrane after FcεRI activation. We found that Syk colocalizes transiently to FcεRI and that Syk-FcεRI binding dynamics are independent of receptor aggregate size. Substitution of glutamic acid for tyrosine between the Syk SH2 domains (Syk-Y130E) led to an increased Syk-FcεRI off-rate, loss of site-specific Syk autophosphorylation, and impaired downstream signaling. Genome edited cells expressing only Syk-Y130E were deficient in antigen-stimulated calcium release, degranulation, and production of some cytokines (TNF-a, IL-3) but not others (MCP-1, IL-4). We propose that kinetic discrimination along the FcεRI signaling pathway occurs at the level of Syk-FcεRI interactions, with key outcomes dependent upon sufficiently long-lived Syk binding events.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1978

Evaluation of the propulsion control system of a planetary rover and design of a mast for an elevation scanning laser/multi-detector system

Vertical wheel loads, wheel speeds, and torque relationships are considered in the design of a propulsion system capable of responding to steering, slope climbing, and irregular local terrains. The system developed is applied to the RPI Mars roving vehicle. The mechanical system required to implement the elevation laser scanning/multidetector principle was the design and construction of a mechanical system for implementing the elevation scanning/multidetector principle is also discussed.

Knaub, D.↗
NASA NTRS1984

Deployable beam flight experiment (MAST)

Improvement of technology of space systems control is discussed. Future space systems such as large antennas or a space station may have dimensions on the order of 30 m to 200 m, yet their basic structures may be relatively lightweight and flexible, making ground tests for loads, controls analyses, and design verifications questionable if not impossible. Abandoning the extensive ground test and analysis verification program that led to the success of previous spacecraft is not a sensible option; making it meaningful using current technology will require inefficient, ultraconservative structure and control designs. New test methods are outlined.

Hanks, B. R.↗
NASA NTRS1992

Active structural control for the mini-MAST and ACES structures

Two experiments based on the maximum entropy/optimal projection design approach are discussed which were conducted by Harris Corporation as part of the NASA Controls Structures Interaction Guest Investigator program. The design equations consist of four coupled matrix equations which specialize to the standard linear-quadratic Guassian Riccati equations, when the plant is known perfectly and a full order controller is desired. These experiments demonstrate successful control system design and implementation for flexible structures.

Collins, E. G., Jr.↗
NASA NTRS1999

Wind Tunnel Model Support Cart with Telescoping Mast and Cable Yaw Drive

The 14-by-22 Foot Subsonic Tunnel at NASA Langley Research Center uses model carts to support and position models in the test section. The carts are portable through the use of air bearings and can be moved from the test to the Model Prep Area (MPA) to change models in preparation for a new test. This paper describes the design of a new model cart that is three feet shorter than existing carts. This will eliminate clearance problems when moving the model and cart from the MPA to the test section.

Gregory, Peyton B.↗
NASA NTRS1999

Experimental Analysis of Mast Lifting and Bending Forces on Vibration Patterns Before and After Pinion Reinstallation in an OH-58 Transmission Test Rig

As part of a cooperative research program between NASA Ames Research Center, NASA Glenn Research Center, and the U.S. Army Laboratories, a series of experiments are being performed on the 500 HP OH-58a Transmission Test Rig at NASA Glenn Research Center. The findings reported in this paper were drawn from Phase 1 of a two-phase experiment, and are focused on the vibration response of an undamaged pinion gear and planetary system operating in situ in the transmission test rig. Phase 2 of the experiment, which is reported elsewhere, introduced a seeded fault into the pinion gear and tracked its progress in real-time. Based on methods presented here, further experimental research will be conducted to examine planetary system faults.

Huff, Edward M.↗
NASA NTRS2014

MODIS Collection 6 Clear Sky Restoral (CSR): Filtering Cloud Mast 'Not Clear' Pixels

Correctly identifying cloudy pixels appropriate for the MOD06 cloud optical and microphysical property retrievals is accomplished in large part using results from the MOD35 1km cloud mask tests (note there are also two 250m subpixel cloud mask tests that can convert the 1km cloudy designations to clear sky). However, because MOD35 is by design clear sky conservative (i.e., it identifies "not clear" pixels), certain situations exist in which pixels identified by MOD35 as "cloudy" are nevertheless likely to be poor retrieval candidates. For instance, near the edge of clouds or within broken cloud fields, a given 1km MODIS field of view (FOV) may in fact only be partially cloudy. This can be problematic for the MOD06 retrievals because in these cases the assumptions of a completely overcast homogenous cloudy FOV and 1-dimensional plane-parallel radiative transfer no longer hold, and subsequent retrievals will be of low confidence. Furthermore, some pixels may be identified by MOD35 as "cloudy" for reasons other than the presence of clouds, such as scenes with thick smoke or lofted dust, and should therefore not be retrieved as clouds. With such situations in mind, a Clear Sky Restoral (CSR) algorithm was introduced in C5 that attempts to identify pixels expected to be poor retrieval candidates. Table 1 provides SDS locations for CSR and partly cloudy (PCL) pixels.

cloud mask↗