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At least 199 records · Page 11
All sourcesNASA NTRSDOE OSTI
DOE OSTI2019

Prospective assessment of taste impairment and nausea during radiotherapy for head and neck cancer

Dysgeusia and nausea are common side effects observed in head and neck cancer patients treated with either exclusive radiotherapy or combined modality treatment. The aim of the present study was to prospectively evaluate dysgeusia, during treatment and follow-up, using the chemotherapy-induced taste alteration scale (CiTAS), a metrics based on 18-items exploring three dimensions (quantitative and qualitative changes in taste perception, and diet-related issues) identified through a four-factor analysis: decline in basic taste, discomfort, phantogeusia–parageusia, and general taste alterations. Moreover, we scored, according to Common Toxicity Criteria Adverse Events, nausea and other treatment-related toxicities. Since, ginger is traditionally used to prevent and/or treat nausea and vomiting, we prophylactically employed a ginger-based supplement named Naumix/Naugin (Gamfarma, Milan, Italy), to potentially mitigate both nausea and taste impairment. Using the CiTAS scale, we highlighted a progressive increase in all dysgeusia dimensions, peaking at the VII week of treatment and a subsequent partial late recovery. In particular, we observed a recovery for discomfort, phantogeusia–parageusia, and general taste alterations at 6 months. Grade 2 nausea, observed to be as low as 12.9% potentially due to the use of ginger, peaked at the III week of treatment. Finally, for patients experiencing nausea, the dysgeusia dimension of discomfort was also relevant.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2026

Flame Chemistry Workshop: a perspective on challenges and strategic actions in combustion experiments and chemical kinetics modeling

Continued progress in the development of predictive models for combustion chemistry—including ignition and flame behavior, species evolution, and combustion system performance—relies on overcoming enduring and emerging challenges in experimental measurements, theoretical formulations, and chemical kinetics mechanism construction. As combustion science continues to coincide with advances in sustainable fuels development, plasma technologies, and automated modeling capabilities, the need for coordinated, community-driven strategies is essential. The Flame Chemistry Workshop (FCWS), held biennially before the International Symposium on Combustion, serves as a dedicated platform to identify, consolidate, and address these challenges in a structured and collaborative manner. This perspective arises from discussions at the 7th FCWS in Milan, Italy (2024), and presents a collective view of the critical barriers currently limiting progress. Across the five technical domains discussed during the 7th FCWS – sustainable fuels combustion, advanced diagnostics for combustion measurements, experiments and modeling in plasma combustion, artificial intelligence and automated methods for theory and mechanisms generation, and chemical kinetic models—a series of persistent and emerging scientific challenges were identified, highlighting the need for deeper integration between three areas: theory, experiments, and modeling. In conclusion, the present article concisely describes present challenges that were identified in each of the technical domains in an effort to streamline and coordinate solutions to accelerate progress in combustion science.

Chemical kinetics↗
DOE OSTI2011

Surface water vulnerability assessment applying the integrity model as a decision support system for quality improvement

The implementation of the Water Framework Directive (WFD) 2000/60/EC, aimed at achieving a 'Good' Ecological Status of surface water bodies by 2015, indicates the adoption of a River Basin Management approach by using a model which works as a support for decision making. This work has applied the suggestions put forward by the WFD by means of a mathematical model called the Integrity Model. This represents valid support when assessing the efficiency of planned interventions which may directly or indirectly play a role in enhancing the quality of surface waters at the basin scale. Herein the results of a preliminary application limited to just two indexes on the Bacchiglione river basin, located in Northern Italy, are both presented and compared with the results of institutional monitoring activities in compliance with set technical regulations. The proposed model appears to be useful when carrying out Strategic Environmental Assessment (SEA) procedures in accordance with Directive 2001/42/EC concerning water management and protection plans as well as for the Environmental Impact Assessment (EIA) procedure to be carried out on the interventions identified.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2011

Routeing of power lines through least-cost path analysis and multicriteria evaluation to minimise environmental impacts

Least-cost path analysis (LCPA) allows designers to find the 'cheapest' way to connect two locations within a cost surface, which can be computed by combining multiple criteria, and therefore by accounting for different issues (environmental impact, economic investment, etc.). This procedure can be easily implemented with modern Geographic Information System (GIS) technologies, and consequently it has been widely employed to support planning and design of different types of linear infrastructures, ranging from roads to pipelines. This paper presents an approach based on the integration of multicriteria evaluation (MCE) and LCPA to identify the most suitable route for a 132 kV power line. Criteria such as cost, visibility, population density, and ecosystem naturalness were used for the analysis. Firstly, spatial MCE and LCPA were combined to generate cost surfaces, and to identify alternative paths. Subsequently, MCE was used to compare the alternatives, and rank them according to their overall suitability. Finally, a sensitivity analysis allowed the stability of the results to be tested and the most critical factors of the evaluation to be detected. The study found that small changes in the location of the power line start and end points can result in significantly different paths, and consequently impact levels. This suggested that planners should always consider alternative potential locations of terminals in order to identify the best path. Furthermore, it was shown that the use of different weight scenarios may help making the model adaptable to varying environmental and social contexts. The approach was tested on a real-world case study in north-eastern Italy.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2012

UK and Italian EIA systems: A comparative study on management practice and performance in the construction industry

This study evaluates and contrasts the management practice and the performance that characterise Environmental Impact Assessments (EIA) in Italy and in the UK. The methodology relies on the investigation of six carefully selected case studies, critically reviewed by referring to EIA and project design information, as well as collecting the opinion of key project participants. The study focuses on the construction industry and on specific key sectors like infrastructure for transport and renewable energy and commercial and tourism development. A main term of reference for the analyses has been established by critically reviewing international literature so as to outline common good practice, requirements for the enhancement of sustainability principles and typically incurred drawbacks. The proposed approach enhances transfer of knowledge and of experiences between the analyzed contexts and allows the provision of guidelines for practitioners. Distinctive differences between the UK and the Italian EIA systems have been detected for pivotal phases and elements of EIA, like screening, scoping, analysis of alternatives and of potential impacts, definition of mitigation strategies, review, decision making, public participation and follow up. - Highlights: Black-Right-Pointing-Pointer The Italian and the UK Environmental Impact Assessment systems are compared. Black-Right-Pointing-Pointer The research is centred on the construction industry. Black-Right-Pointing-Pointer Issues and shortcomings are analysed by investigating six case studies. Black-Right-Pointing-Pointer Integration of EIA with sustainability principles is appraised. Black-Right-Pointing-Pointer General guidelines are provided to assist practitioners in the two national contexts.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
DOE OSTI2012

A multi-scale qualitative approach to assess the impact of urbanization on natural habitats and their connectivity

Habitat loss and fragmentation are often concurrent to land conversion and urbanization. Simple application of GIS-based landscape pattern indicators may be not sufficient to support meaningful biodiversity impact assessment. A review of the literature reveals that habitat definition and habitat fragmentation are frequently inadequately considered in environmental assessment, notwithstanding the increasing number of tools and approaches reported in the landscape ecology literature. This paper presents an approach for assessing impacts on habitats on a local scale, where availability of species data is often limited, developed for an alpine valley in northern Italy. The perspective of the methodology is multiple scale and species-oriented, and provides both qualitative and quantitative definitions of impact significance. A qualitative decision model is used to assess ecological values in order to support land-use decisions at the local level. Building on recent studies in the same region, the methodology integrates various approaches, such as landscape graphs, object-oriented rule-based habitat assessment and expert knowledge. The results provide insights into future habitat loss and fragmentation caused by land-use changes, and aim at supporting decision-making in planning and suggesting possible ecological compensation. - Highlights: Black-Right-Pointing-Pointer Many environmental assessments inadequately consider habitat loss and fragmentation. Black-Right-Pointing-Pointer Species-perspective for defining habitat quality and connectivity is claimed. Black-Right-Pointing-Pointer Species-based tools are difficult to be applied with limited availability of data. Black-Right-Pointing-Pointer We propose a species-oriented and multiple scale-based qualitative approach. Black-Right-Pointing-Pointer Advantages include being species-oriented and providing value-based information.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2017

Land take and the effectiveness of project screening in Environmental Impact Assessment: Findings from an empirical study

Land take is emerging as a global environmental concern, and is particularly critical in intensively developed and land-scarce regions. This paper seeks to understand the effectiveness of the screening stage of Environmental Impact Assessment (EIA) in addressing land take. Screening is the stage where a decision is made as to whether an EIA is required for a project. In many jurisdictions, screening results in three pathways: full EIA directly, preliminary EIA only, or preliminary EIA followed by full EIA. We compared the land take of 217 projects triggering the different pathways in a study region in Italy over a 15-year time interval. Land take was quantified by overlaying the footprint of the projects with a land cover map. The results show that while more attention was given to projects with larger land take impacts overall, the cumulative land take from smaller projects not triggering full EIA was considerable (40% of overall land take). The case-by-case examination conducted through the preliminary EIA was found to work better for some project types (ski areas and small urban development), than for others (quarries). Our findings lead us to advocate improvements in current screening procedures to ensure that the land take impacts are quantified and made explicit in preliminary EIA reports. Our evidence-based approach to determining land take in EIA provides a compelling basis for understanding ways to improve EIA policies, guidance and practice. - Highlights: •We quantified the land take of 217 projects triggering different EIA screening pathways. •Projects that “fly under the radar” of full EIA caused 40% of the overall land take. •The case-by-case examination works better for some project types than others. •We recommend improvements in screening procedures to ensure that land take impacts are quantified.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2018

Assessing direct and indirect emissions of greenhouse gases in road transportation, taking into account the role of uncertainty in the emissions inventory

Highlights: • The use-chain model implemented in this paper is effective in minimizing uncertainty. • Data integration is important to reduce uncertainty. • An innovative metric, Emission Value at Risk, was used to adjust uncertainty values. • Indirect impacts of economic activities change the estimate of GHG emissions. - Abstract: Greenhouse gas (GHG) concentration in the atmosphere has increased since the beginning of the industrial era, with dramatic effects on climate change. Transportation is one of the main sources of GHGs, with more than two-thirds of transport-related GHG emissions attributable to road vehicles. Any policy that aims to reduce GHG emissions needs robust measuring methods that guarantee the quality and reliability of primary data and estimates. However, these estimates are subject to uncertainty, both at the stage of compiling accounting tables and at the stage of using this information to formulate a specific policy question. This paper considers how to reduce uncertainty in estimating GHG emissions from road transportation, with specific reference to a regional emissions inventory in Italy. We propose the application of a use-chain model that can tackle uncertainty in measuring GHG emissions by enhancing the quality of the emissions data registry in the inventory. This new metric, which we call emission value at risk (VaR), draws from methodologies and concepts employed in the insurance and financial sectors. Moreover, additional assessments are performed, integrating the inventory data with those available in the regional energy balance and disaggregated sectoral economic dataset. The results show that a sound accounting method enables uncertainty in emission data to be taken into account, thus improving the design of appropriate strategies to reduce GHG emissions.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2018

Seven good practices for the environmental licensing of coastal interventions: Lessons from the Italian, Cuban, Spanish and Colombian regulatory frameworks and insights on coastal processes

Highlights: • Environmental licensing procedures (ELP) line up by projects instead of environments. • The ELP of four countries was compared according to the generic EIA stages. • The study relies upon the revision of EIA legislation and technical guidelines. • Seven EIA good practices were extracted from the ELP analysis of the four countries. • A changing approach is proposed for the EPL performance on coastal interventions. - Abstract: Environmental licensing is the regulatory procedure that enforces the environmental impact assessment (EIA) of human activities inside a given country. Despite worldwide acceptance of EIA as a valid tool, its application in coastal environments is still too diverse and limited regarding the specificity of the natural processes influencing the shore. This paper compares the Environmental Licensing Procedure (ELP) of four countries, focusing on the activities that could affect the coastal geomorphology. The acquisition and validation of information were done through interviews with EIA representatives in each country, who signalized the official documents of environmental licensing and coastal management to be considered in the documentary review. The results present those differences and similarities among ELP stages in each country, based on the principles of the International Association of Impact Assessment and the national documents analyzed. In sum, 59 interventions associated with human uses and activities in the coastal zone were compared according to the prescriptive character of the environmental licensing in Italy, Spain, Cuba and Colombia. The natural processes influencing coastal geomorphology were also analyzed within the technical criteria included in the official guidelines for the EIA, finding a generalized weakness in processes associated with geochemical courses on coastal environments. By way of discussion, seven good practices are illustrated, according to their pertinence to the impact assessment of the coastal zone: 1) The integration of screening and scoping; 2) Evaluation focusing on the environment rather than the intervention; 3) Binding the coastal zone delimitation; 4) Institutional articulation; 5) Accreditation of environmental consultancies; 6) Official guidelines by types of environment; 7) The integration of environmental geographic information. Finally, general conclusions to assist EIA practitioners operating in the four countries and recommendations to lead further research are provided, introducing a novel process-oriented approach for ELP.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2018

Ranking the importance of Wildfires' human drivers through a multi-model regression approach

Highlights: • Spatial variability of wildfire regimes is closely related to human activities. • Fire variables have different correlation structures with socioeconomic variables. • Rural poverty, economic disparities and social conflicts are associated to high fire risk. • Landscape structure, land-use and cropping systems influence local-scale fire regimes. • Local unemployment rates discriminate among different wildfire regimes. - Abstract: Wildfires are a major ecological disturbance in Mediterranean environments, and affect together natural resources, ecosystem services and human activities. The impact of socioeconomic forces on wildfire regimes is generally less investigated than the effects of biophysical drivers. Being grounded on a multi-model regression analysis of socioeconomic and territorial indicators, the present study identifies relevant factors influencing local-scale wildfires' regimes in Italy. An economically-disadvantaged context with persistent unemployment, rural poverty, social inequalities and population aging proved to be associated to more frequent fire events. Additionally, our analysis points out that occurrence, average size and density of wildfires reflect different correlation profiles with the local-scale socioeconomic context. Along with the socioeconomic profile of local communities, the empirical outcomes of our study show the importance of landscape structure, land-use and cropping systems in local-scale fire regimes. The empirical results of this study justify a multidimensional analysis of relevant socioeconomic dimensions in fire risk assessment and contribute to an informed approach to wildfire management. Moreover, our study provides basic knowledge advancing research on fire prevention, and informing spatial planning and developmental policies aimed at increasing preparedness to large fires.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2011

A combined approach to investigate the toxicity of an industrial landfill's leachate: Chemical analyses, risk assessment and in vitro assays

Solid wastes constitute an important and emerging problem. Landfills are still one of the most common ways to manage waste disposal. The risk assessment of pollutants from landfills is becoming a major environmental issue in Europe, due to the large number of sites and to the importance of groundwater protection. Furthermore, there is lack of knowledge for the environmental, ecotoxicological and toxicological characteristics of most contaminants contained into landfill leacheates. Understanding leachate composition and creating an integrated strategy for risk assessment are currently needed to correctly face the landfill issues and to make projections on the long-term impacts of a landfill, with particular attention to the estimation of possible adverse effects on human health and ecosystem. In the present study, we propose an integrated strategy to evaluate the toxicity of the leachate using chemical analyses, risk assessment guidelines and in vitro assays using the hepatoma HepG2 cells as a model. The approach was applied on a real case study: an industrial waste landfill in northern Italy for which data on the presence of leachate contaminants are available from the last 11 years. Results from our ecological risk models suggest important toxic effects on freshwater fish and small rodents, mainly due to ammonia and inorganic constituents. Our results from in vitro data show an inhibition of cell proliferation by leachate at low doses and cytotoxic effect at high doses after 48 h of exposure. - Research highlights: {yields} We study the toxicity of leachate from a non-hazardous industrial waste landfill. {yields} We perform chemical analyses, risk assessments and in vitro assays on HepG2 cells. {yields} Risk models suggest toxic effects due to ammonia and inorganic constituents. {yields} In vitro assays show that leachate inhibits cell proliferation at low doses. {yields} Leachate can induce cytotoxic effects on HepG2 cells at high doses.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2018

Neurocognitive and physical functioning in the Seveso Women's Health Study

Highlights: • Little research exists on the neurotoxic effects of dioxins in older women. • TCDD was associated with grip strength but not other measures of physical function. • TCDD exposure was not adversely associated with working memory. • This relationship was not modified by menopause nor timing of TCDD exposure around menarche. • TCDD susceptibility may increase as the women age, warranting further research. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is neurotoxic in animals but few studies have investigated its effects on the human brain. Related dioxin-like compounds have been linked to poorer cognitive and motor function in older adults, with effects more pronounced in women, perhaps due to the loss of neuro-protective estrogen in menopause. On 10 July 1976, a chemical explosion in Seveso, Italy, resulted in one of the highest known residential exposures to TCDD. In 1996, we initiated the Seveso Women's Health Study, a retrospective cohort study of the health of the women who were newborn to 40 years old in 1976. Here, we investigate whether TCDD exposure is associated with physical functioning and working memory more than 20 years later. Individual TCDD concentration (ppt) was measured in archived serum collected soon after the explosion. In 1996 and 2008, we measured physical functioning (n=154) and working memory (n=459), respectively. We examined associations between serum TCDD and motor and cognitive outcomes with multivariate linear regression and semi-parametric estimators. A 10-fold increase in serum TCDD was not associated with walking speed (adjusted β=0.0006 ft/s, 95% Confidence Interval (CI): −0.13, 0.13), upper body mobility (adjusted β=−0.06, 95% CI: −0.36, 0.23), or manual dexterity (adjusted β=0.34, 95% CI: −0.65, 1.33). We observed an inverted U-shaped association in grip strength, with poorer strength in the lowest and highest TCDD exposure levels. There was no association between TCDD and the Wechsler digit and spatial span tests. Neither menopause status at assessment nor developmental timing of exposure modified associations between TCDD and working memory. Our findings, in one of the only studies of TCDD's effects on neuropsychological and physical functioning in women, do not indicate an adverse effect on these domains, with the exception of a U-shaped relationship with grip strength. Given the limited assessment and relative youth of the women at this follow-up, future work examining additional neuropsychological outcomes is warranted.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2018

Modelling soil erosion in a Mediterranean watershed: Comparison between SWAT and AnnAGNPS models

Highlights: • Outputs, input data and time requirements are compared for SWAT and AnnAGNPS. • Models are assessed also in wet and dry seasons. • Most of the basin is under moderate or high risk of erosion. • SWAT and AnnAGNPS are compared with RUSLE2015 and PESERA. In this study, the simulations generated by two of the most widely used hydrological basin-scale models, the Annualized Agricultural Non-Point Source (AnnAGNPS) and the Soil and Water Assessment Tool (SWAT), were compared in a Mediterranean watershed, the Carapelle (Apulia, Southern Italy). Input data requirements, time and efforts needed for input preparation, strength and weakness points of each model, ease of use and limitations were evaluated in order to give information to users. Models were calibrated and validated at monthly time scale for hydrology and sediment load using a four year period of observations (streamflow and suspended sediment concentrations). In the driest year, the specific sediment load measured at the outlet was 0.89 t ha{sup −1} yr{sup −1}, while the simulated values were 0.83 t ha{sup −1} yr{sup −1} and 1.99 t ha{sup −1} yr{sup −1} for SWAT and AnnAGNPS, respectively. In the wettest year, the specific measured sediment load was 7.45 t ha{sup −1} yr{sup −1}, and the simulated values were 8.27 t ha{sup −1} yr{sup −1} and 6.23 t ha{sup −1} yr{sup −1} for SWAT and AnnAGNPS, respectively. Both models showed from fair to a very good correlation between observed and simulated streamflow and satisfactory for sediment load. Results showed that most of the basin is under moderate (1.4–10 t ha{sup −1} yr{sup −1}) and high-risk erosion (> 10 t ha{sup −1} yr{sup −1}). The sediment yield predicted by the SWAT and AnnAGNPS models were compared with estimates of soil erosion simulated by models for Europe (PESERA and RUSLE2015). The average gross erosion estimated by the RUSLE2015 model (12.5 t ha{sup −1} yr{sup −1}) resulted comparable with the average specific sediment yield estimated by SWAT (8.8 t ha{sup −1} yr{sup −1}) and AnnAGNPS (5.6 t ha{sup −1} yr{sup −1}), while it was found that the average soil erosion estimated by PESERA is lower than the other estimates (1.2 t ha{sup −1} yr{sup −1}).

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2018

Effects of rows arrangement, soil management, and rainfall characteristics on water and soil losses in Italian sloping vineyards

Highlights: • GC effectiveness varies according to the type of rainfall event and row orientation. • Rows orientation along contour lines prevents runoff also when CT is adopted. • Highest runoff and soil losses depend on “long-lasting” or “intense” events. • Rainfall depth and rainfall maximum intensity count in predicting erosion rate. Erosional processes are highly affected by seasonal climatic fluctuations and soil management practices. Controlled grass cover is one of the most used soil conservation practices adopted in temperate climates, even if the protective effect of grass cover may decrease according to seasonal pattern. This technique is effective and, thus, widely adopted in the inter-rows of orchards such as olives, citrus or vineyards. This study reports the erosive events recorded in two different rain-fed hillslope vineyards with different rows orientation located in the Monferrato region, NW Italy. The study is addressed at compare the effects of different inter-row managements and rainfall characteristics on runoff and soil loss in hillslope vineyards (average slope from 15% to 35%). Rainfall, runoff and erosion variables were monitored in hydraulically bounded vineyard plots, where the inter-rows were managed with tillage and grass cover. Seventy-two erosive events were recorded in the period 1992–1996 in two vineyard plots with rows along the contour lines while 86 erosive events were recorded in two plots with rows up-and-down the slope from 2000 to 2014 (158 erosive events and four plots in total). Events were classified according to rainfall characteristics as “long-lasting”, “intense” and “normal”. In plots with rows along the contour lines, “intense” events were responsible for the highest mean soil loss in tilled plots (0.7 Mg ha{sup −1}) with very high erosion rates (12.3 Mg ha{sup −1}) observed during a single storm. In plots with rows up-and-down the slope the highest erosion rates, 21.2 and 3.4 Mg ha{sup −1}, were recorded during fall “long-lasting” events in the tilled and grass cover plots respectively. The grass cover proved to be effective in decreasing runoff and soil losses during most of the events (at least 68% and 61% of the occurrences, respectively) reducing soil losses especially during summer storms when most of the “intense” events occured. Furthermore, the results show the fundamental role of contour-slope row orientation in reducing runoff and soil losses, disregarding the inter-rows soil management that is adopted.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2016

Single-Fraction Versus Multifraction (3 × 9 Gy) Stereotactic Radiosurgery for Large (>2 cm) Brain Metastases: A Comparative Analysis of Local Control and Risk of Radiation-Induced Brain Necrosis

Purpose: To investigate the local control and radiation-induced brain necrosis in patients with brain metastases >2 cm in size who received single-fraction or multifraction stereotactic radiosurgery (SRS); factors associated with clinical outcomes and the development of brain radionecrosis were assessed. Methods and Materials: Two hundred eighty-nine consecutive patients with brain metastases >2.0 cm who received SRS as primary treatment at Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy, were analyzed. Cumulative incidence analysis was used to compare local control and radiation-induced brain necrosis between groups from the time of SRS. To achieve a balanced distribution of baseline covariates between treatment groups, a propensity score analysis was used. Results: The 1-year cumulative local control rates were 77% in the single-fraction SRS (SF-SRS) group and 91% in the multifraction SRS (MF-SRS) group (P=.01). Recurrences occurred in 25 and 11 patients who received SF-SRS or MF-SRS (P=.03), respectively. Thirty-one patients (20%) undergoing SF-SRS and 11 (8%) subjected to MF-SRS experienced brain radionecrosis (P=.004); the 1-year cumulative incidence rate of radionecrosis was 18% and 9% (P=.01), respectively. Significant differences between the 2 groups in terms of local control and risk of radionecrosis were maintained after propensity score adjustment. Conclusions: Multifraction SRS at a dose of 27 Gy in 3 daily fractions seems to be an effective treatment modality for large brain metastases, associated with better local control and a reduced risk of radiation-induced radionecrosis as compared with SF-SRS.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2010

Measurement and modeling of solar irradiance components on horizontal and tilted planes

In this work new measurements of global and diffuse solar irradiance on the horizontal plane and global irradiance on planes tilted at 20 and 30 oriented due South and at 45 and 65 oriented due East are used to discuss the modeling of solar radiation. Irradiance data are collected in Padova (45.4 N, 11.9 E, 12 m above sea level), Italy. Some diffuse fraction correlations have been selected to model the hourly diffuse radiation on the horizontal plane. The comparison with the present experimental data shows that their prediction accuracy strongly depends on the sky characteristics. The hourly irradiance measurements taken on the tilted planes are compared with the estimations given by one isotropic and three anisotropic transposition models. The use of an anisotropic model, based on a physical description of the diffuse radiation, provides a much better accuracy, especially when measurements of the diffuse irradiance on the horizontal plane are not available and thus transposition models have to be applied in combination with a diffuse fraction correlation. This is particularly significant for the planes oriented away from South. (author)

14 SOLAR ENERGY↗
DOE OSTI2010

A multi-objective approach to solid waste management

The issue addressed in this paper consists in the localization and dimensioning of transfer stations, which constitute a necessary intermediate level in the logistic chain of the solid waste stream, from municipalities to the incinerator. Contextually, the determination of the number and type of vehicles involved is carried out in an integrated optimization approach. The model considers both initial investment and operative costs related to transportation and transfer stations. Two conflicting objectives are evaluated, the minimization of total cost and the minimization of environmental impact, measured by pollution. The design of the integrated waste management system is hence approached in a multi-objective optimization framework. To determine the best means of compromise, goal programming, weighted sum and fuzzy multi-objective techniques have been employed. The proposed analysis highlights how different attitudes of the decision maker towards the logic and structure of the problem result in the employment of different methodologies and the obtaining of different results. The novel aspect of the paper lies in the proposal of an effective decision support system for operative waste management, rather than a further contribution to the transportation problem. The model was applied to the waste management of optimal territorial ambit (OTA) of Palermo (Italy).

09 BIOMASS FUELS↗
DOE OSTI2011

Indicators of waste management efficiency related to different territorial conditions

The amount of waste produced and the control of separate collection are crucial issues for the planning of a territorial Integrated Waste Management System, enabling the allocation of each sorted waste fraction to the proper treatment and recycling processes. The present study focuses on assessing indicators of different waste management systems in areas characterized by different territorial conditions. The investigated case study concerns the municipalities of Emilia Romagna (northern Italy), which present a rather uniform socioeconomic situation, but a variety of geographic, urban and waste management characteristics. A survey of waste generation and collection rates was carried out, and correlated with the different territorial conditions, classifying the municipalities according to altitude and population density. The best environmental performances, in terms of high separate collection rate, were found on average in rural areas in the plain, while the lowest waste generation was associated with rural hill towns.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗