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At least 1,801 records · Page 100

SU-E-T-751: Three-Component Kinetic Model of Tumor Growth and Radiation Response for Stereotactic Radiosurgery

Purpose: To develop and study a kinetic model of tumor growth and its response to stereotactic radiosurgery (SRS) by assuming that the cells in irradiated tumor volume were made of three types. Methods: A set of ordinary differential equations (ODEs) were derived for three types of cells and a tumor growth rate. It is assumed that the cells were composed of actively proliferating cells, lethally damaged-dividing cells, and non-dividing cells. We modeled the tumor volume growth with a time-dependent growth rate to simulate the saturation of growth. After SRS, the proliferating cells were permanently damaged and converted to the lethally damaged cells. The amount of damaged cells were estimated by the LQ-model. The damaged cells gradually stopped dividing/proliferating and died with a constant rate. The dead cells were cleared from their original location with a constant rate. The total tumor volume was the sum of the three components. The ODEs were numerically solved with appropriate initial conditions for a given dosage. The proposed model was used to model an animal experiment, for which the temporal change of a rhabdomyosarcoma tumor volume grown in a rat was measured with time resolution sufficient to test the model. Results: To fit the model to the experimental data, the following characteristics were needed with the model parameters. The α-value in the LQ-model was smaller than the commonly used value; furthermore, it decreased with increasing dose. At the same time, the tumor growth rate after SRS had to increase. Conclusions: The new 3-component model of tumor could simulate the experimental data very well. The current study suggested that the radiation sensitivity and the growth rate of the proliferating tumor cells may change after irradiation and it depended on the dosage used for SRS. These preliminary observations must be confirmed by future animal experiments.

60 APPLIED LIFE SCIENCES↗

SU-F-J-142: Proposed Method to Broaden Inclusion Potential of Patients Able to Use the Calypso Tracking System in Prostate Radiotherapy

Purpose: To introduce a non-standard method of patient setup, using BellyBoard immobilization, to better utilize the localization and tracking potential of an RF-beacon system with EBRT for prostate cancer. Methods: An RF-beacon phantom was imaged using a wide bore CT scanner, both in a standard level position and with a known rotation (4° pitch and 7.5° yaw). A commercial treatment planning system (TPS) was used to determine positional coordinates of each beacon, and the centroid of the three beacons for both setups. For each setup at the Linac, kV AP and Rt Lateral images were obtained. A full characterization of the RF-beacon system in clinical mode was completed for various beacons’ array-to-centroid distances, which includes vertical, lateral, and longitudinal offset data, as well as pitch and yaw offset measurements for the tilted phantom. For the single patient who has been setup using the proposed BellyBoard method, a supine simulation was first obtained. When abdominal protrusion was found to be exceeding the limits of the RF-Beacon system through distance-based analysis in the TPS, the patient is re-simulated prone with the BellyBoard. Array to centroid distance is measured again in the TPS, and if found to be within the localization or tracking region it is applied. Results: Characterization of limitations for the RF-beacon system in clinical mode showed acceptable consistency of offset determination for phantom setup accuracy. The nonstandard patient setup method reduced the beacons’ centroid-to-array distance by 8.32cm, from 25.13cm to 16.81cm; completely out of tracking range (greater than 20cm) to within setup tracking range (less than 20cm). Conclusion: Using the RF-beacon system in combination with this novel patient setup can allow patients who would otherwise not be candidates for beacon enhanced EBRT to now be able to benefit from the reduced PTV margins of this treatment method.

60 APPLIED LIFE SCIENCES↗

SU-F-T-211: Evaluation of a Dual Focusing Magnet System for the Treatment of Small Proton Targets

Purpose: To investigate magnetic focusing for small volume proton targets using a doublet combination of quadrupole rare earth permanent magnet Halbach cylinder assemblies Methods: Monte Carlo computer simulations were performed using the Geant4 toolkit to compare dose depositions of proton beams transported through two focusing magnets or in their absence. Proton beams with energies of 127 MeV and initial diameters of 5, 8 and 10 mm were delivered through two identical focusing magnets similar to those currently in experimental use at Loma Linda University Medical Center. Analogous experiments used optimized configurations based on the simulation results. Dose was measured by a diode detector and Gafchromic EBT3 film and compared to simulation data. Based on results from the experimental data, an additional set of simulations was performed with an initial beam diameter of 18 mm and a two differing length magnets (40mm & 68mm). Results: Experimental data matched well with Monte Carlo simulations. However, under conditions necessary to produce circular beam spots at target depth, magnetically focused beams using two identical 40 mm length magnets did not meet all of our performance criteria of circular beam spots, improved peak to entrance (P/E) dose ratios and dose delivery efficiencies. The simulations using the longer 68 mm 2nd magnet yielded better results with 34% better P/E dose ratio and 20–50% better dose delivery efficiencies when compared to unfocused 10 mm beams. Conclusion: While magnetic focusing using two magnets with identical focusing power did not yield desired results, ongoing Monte Carlo simulations suggest that increasing the length of the 2nd magnet to 68 mm could improve P/E dose ratios and dose efficiencies. Future work includes additional experimental validation of the longer 2nd magnet setup as well as experiments with triplet magnet systems. This project was sponsored with funding from the Department of Defense (DOD# W81XWH-BAA-10-1).

60 APPLIED LIFE SCIENCES↗

Homogeneous nucleation in liquid nitrogen at negative pressures

The kinetics of spontaneous cavitation in liquid nitrogen at positive and negative pressures has been studied in a tension wave formed by a compression pulse reflected from the liquid–vapor interface on a thin platinum wire heated by a current pulse. The limiting tensile stresses (Δp = p{sub s}–p, where p{sub s} is the saturation pressure), the corresponding bubble nucleation frequencies J (10{sup 20}–10{sup 22} s{sup –1} m{sup –3}), and temperature induced nucleation frequency growth rate G{sub T} = dlnJ/dT have been experimentally determined. At T = 90 K, the limiting tensile stress was Δp = 8.3 MPa, which was 4.9 MPa lower than the value corresponding to the boundary of thermodynamic stability of the liquid phase (spinodal). The measurement results were compared to classical (homogeneous) nucleation theory (CNT) with and without neglect of the dependence of the surface tension of critical bubbles on their dimensions. In the latter case, the properties of new phase nuclei were described in terms of the Van der Waals theory of capillarity. The experimental data agree well with the CNT theory when it takes into account the “size effect.”.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

One-dimensional magnetophotonic crystals with magnetooptical double layers

One-dimensional magnetophotonic microcavity crystals with nongarnet dielectric mirrors are created and investigated. The defect layers in the magnetophotonic crystals are represented by two bismuth-substituted yttrium iron garnet Bi:YIG layers with various bismuth contents in order to achieve a high magnetooptical response of the crystals. The parameters of the magnetophotonic crystal layers are optimized by numerical solution of the Maxwell equations by the transfer matrix method to achieve high values of Faraday rotation angle Θ{sub F} and magnetooptical Q factor. The calculated and experimental data agree well with each other. The maximum values of Θ{sub F} =–20.6°, Q = 8.1° at a gain t = 16 are obtained for magnetophotonic crystals with m = 7 pairs of layers in Bragg mirrors, and the parameters obtained for crystals with m = 4 and t = 8.5 are Θ{sub F} =–12.5° and Q = 14.3°. It is shown that, together with all-garnet and multimicrocavities magnetophotonic crystals, such structures have high magnetooptical characteristics.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

K{sup -} and p-bar spectra for AuAu collisions at {radical}s = 200 GeV from STAR, PHENIX, and BRAHMS in comparison to core-corona model predictions

Based on results obtained with event generators we have launched the core-corona model. It describes in a simplified way but quite successfully the centrality dependence of multiplicity and of identified particles observed in heavy-ion reactions at beam energies between {radical}s = 17 and 200 GeV. Also the centrality dependence of the elliptic flow, {upsilon}{sub 2}, for all charged and identified particles could be explained in this model. Here we extend this analysis and study the centrality dependence of single-particle spectra of K{sup -} and p-bar measured by the PHENIX, STAR, and BRAHMS Collaborations. We find that also for these particles the analysis of the spectra in the core-corona model suffers from differences in the data published by the different experimental groups, notably for the pp collisions. As for protons and K{sup +}, for each experience the data agree well with the prediction of the core-corona model but the values of the two necessary parameters depend on the experiments. We show as well that the average momentum as a function of the centrality depends in a very sensitive way on the particle species and may be quite different for particles which have about the same mass. Therefore the idea to interpret this centrality dependence as a consequence of a collective expansion of the system, as done in blast way fits, may be premature.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Elastic and transition form factors of light pseudoscalar mesons from QCD sum rules

We revisit F{sub {pi}}(Q{sup 2}) and F{sub P{gamma}}(Q{sup 2}), P = {pi}, {eta}, {eta} Prime , making use of the local-duality (LD) version of QCD sum rules. We give arguments that the LD sum rule provides reliable predictions for these form factors at Q{sup 2} {>=} 5-6 GeV{sup 2}, the accuracy of the method increasing with Q{sup 2} in this region. For the pion elastic form factor, the well-measured data at small Q{sup 2} give a hint that the LD limit may be reached already at relatively low values of momentum transfers, Q{sup 2} Almost-Equal-To 4-8 GeV{sup 2}; we therefore conclude that large deviations from LD in the region Q{sup 2} = 20-50 GeV{sup 2} seem very unlikely. The data on the ({eta}, {eta} Prime ) {yields} {gamma}{gamma}* form factors meet the expectations from the LD model. However, the BaBar results for the {pi}{sup 0} {yields} {gamma}{gamma}* form factor imply a violation of LD growing with Q{sup 2} even at Q{sup 2} Almost-Equal-To 40 GeV{sup 2}, at odds with the {eta}, {eta} Prime case and with the general properties expected for the LD sum rule.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Synthesis of zinc ultrafine powders via the Guen–Miller flow-levitation method

Zinc ultrafine powders (UFPs) with the average particle size of 0.175 to 1.24 μm are synthesized via the flow-levitation method. The peculiarities of the formation of zinc UFPs are considered with respect to the carrier gas properties (heat capacity, thermal conductivity, and diffusion coefficient), as well as the gas flow parameters (pressure and flow rate). The obtained zinc particles are studied via scanning electron microscopy and X-ray diffraction. The factors determining the crystal structure of zinc particles and their size distribution are discussed as well. The data on oxidation of zinc stored in unsealed containers under normal conditions are also presented.

36 MATERIALS SCIENCE↗

Two-photon production of leptons at hadron colliders in semielastic and elastic cases

The mechanism of two-photon dilepton production is studied in the equivalent-photon (Weizsäcker–Williams) approximation. This approximation is shown to describe well experimental data from hadron accelerators. The respective total and differential cross sections were obtained for the LHC and for the Tevatron collider at various energies of colliding hadrons. The differential cross sections were studied versus the dilepton invariant mass, transverse momentum, and emission angle in the reference frame comoving with the center of mass of colliding hadrons. The cases of semielastic and inelastic collisions were examined.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Projectile fragmentation of {sup 40,48}Ca and isotopic scaling in a transport approach

We investigate theoretically projectile fragmentation in reactions of {sup 40,48}Ca on {sup 9}Be and {sup 181}Ta targets using a Boltzmann-type transport approach, which is supplemented by a statistical decay code to describe the de-excitation of the hot primary fragments. We determine the thermodynamical properties of the primary fragments and calculate the isotope distributions of the cold final fragments. These describe the data reasonably well. For the pairs of projectiles with different isotopic content we analyze the isotopic scaling (or isoscaling) of the final fragment distributions, which has been used to extract the symmetry energy of the primary source. The calculation exhibits isoscaling behavior for the total yields as do the experiments. We also perform an impact-parameter-dependent isoscaling analysis in view of the fact that the primary systems at different impact parameters have very different properties. Then the isoscaling behavior is less stringent, which we can attribute to specific structure effects of the {sup 40,48}Ca pair. The symmetry energy determined in this way depends on these structure effects.

74 ATOMIC AND MOLECULAR PHYSICS↗

Elastic Deuteron Scattering on the {sup 12}C Nucleus within a Three-Body Model

The formalism developed earlier for elastic pd scattering on the basis of Glauber theory with allowance for a total spin dependence is modified by replacing pN amplitudes by amplitudes for N{sup 12}C scattering and is applied to elastic deuteron scattering on the {sup 12}C nucleus. The amplitudes for elastic N{sup 12}C scattering are obtained within the optical model. Respective numerical calculations performed at the kinetic deuteron-beam energy of 270 MeV lead to results that agree well with data on the differential cross section for d{sup 12}C scattering into the forward hemisphere, but the calculated spin observable A{sub y}{sup d} agrees with experimental data only qualitatively.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Plasma parameters and existence conditions of monolayer dust structures in the electrode sheath of an RF discharge

The plasma parameters in the electrode sheath of an RF discharge were studied experimentally under the conditions of dust monolayer levitation. A new method is proposed for determining the plasma parameters, such as the average electric field, ion density, and ion velocity. The screening parameter and the dust grain charge are estimated. The criteria of stable levitation of a dust monolayer are considered. The obtained results are compared with the available theoretical and numerical data, as well as with the results obtained using other diagnostic methods.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Magnetostriction of Hexagonal HoMnO{sub 3} and YMnO{sub 3} Single Crystals

We report on the magnetostriction of hexagonal HoMnO{sub 3} and YMnO{sub 3} single crystals in a wide range of applied magnetic fields (up to H = 14 T) at all possible combinations of the mutual orientations of magnetic field H and magnetostriction ΔL/L. The measured ΔL/L(H, T) data agree well with the magnetic phase diagram of the HoMnO{sub 3} single crystal reported previously by other authors. It is shown that the nonmonotonic behavior of magnetostriction of the HoMnO{sub 3} crystal is caused by the Ho{sup 3+} ion; the magnetic moment of the Mn{sup 3+} ion parallel to the hexagonal crystal axis. The anomalies established from the magnetostriction measurements of HoMnO{sub 3} are consistent with the phase diagram of these compounds. For the isostructural YMnO{sub 3} single crystal with a nonmagnetic rare-earth ion, the ΔL/L(H, T) dependences are described well by a conventional quadratic law in a wide temperature range (4–100 K). In addition, the magnetostriction effect is qualitatively estimated with regard to the effect of the crystal electric field on the holmium ion.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Insights into the thermo-hydraulic properties of compacted MX80 bentonite during hydration under elevated temperature

In high-level radioactive waste geological repositories, compacted bentonite undergoes coupled thermo-hydraulic processes due to heat released from a central waste canister and groundwater imbibition from the surrounding host rock. An understanding of these processes is essential for long-term simulations of radionuclide migration and canister corrosion, which requires an understanding of temperature effects on the coupled thermo-hydraulic properties governing these processes. In this study, a tank-scale radial infiltration test was used to investigate water imbibition processes in compacted bentonite under a central heater temperature of 200 °C that simulates high thermal gradients in a repository. Interpretation of this test focuses on evaluation of the liquid water wetting front during hydration and the interpretation of the temperature-dependent transient soil water retention curve (SWRC), thermal conductivity function (TCF), and hydraulic conductivity function (HCF). The SWRC during imbibition follows a temperature-dependent wetting path. Temperature effects on the hydraulic conductivity of bentonite in saturated conditions had the greatest effect on the shape of the HCF, with minimal temperature effects at higher suctions. The transient thermal conductivity data matched well with a new TCF linked with the SWRC shape. Although the bentonite layer was restrained, local deformations during hydration may have affected the shapes of the TCF and HCF.

Engineering↗

No-core shell model calculations of the photonuclear cross section of 10B

Results of ab initio no-core, shell model calculations for the photonuclear cross section of 10B are presented using realistic two-nucleon (NN) chiral forces up to next-to-next-to-next-order (N3LO) softened by the similarity renormalization group method (SRG) with λ=2.02 fm -1 . The electric-dipole response function is calculated using the Lanczos method, with the effects of the continuum included via neutron escape widths derived from R-matrix theory and using the Lorentz integral transform method. The calculated cross section agrees well with experimental data in terms of structure as well as in absolute peak height, σ max =4.85 mb at photon energy ω=23.61 MeV, and integrated cross section 85.36 MeV. mb. We also test the Brink hypothesis by calculating the electric-dipole response for the first nine positive-parity states with J≠0 in 10 B and verify that dipole excitations built upon the ground and excited states have similar characteristics.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Lifetime measurement of excited states in 116 Xe

Lifetimes of excited states in 116 Xe were measured using the recoil-distance Doppler-shift technique. Excited 116 Xe nuclei were populated in the fusion-evaporation reaction 102 Pd( 16 O,2n) 116 Xe. Lifetimes of the $2^{+}_{1}$ and $4^{+}_{1}$ states were evaluated using the differential decay-curve method with $\gamma$-$\gamma$-coincidence data as well as lifetimes of the $6^{+}_{1}$ and $7^{-}_{1}$ states using simulations of spectra considering Doppler-shift attenuation effects.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Excitation functions and isomeric cross-section ratios of (d,xn) reactions on 86 Sr

Excitation functions of the 86 Sr(d,n) 87m,87g Y, 86 Sr(d,2n) 86m,86g Y and 86 Sr(d,3n) 85m,85g Y reactions on enriched 86 Sr target were measured by the activation technique up to deuteron energies of 49 MeV. The isomeric cross-section ratios as a function of projectile energy were deduced from the measured data for 87m Y, 87g Y(cum), 86m Y, 86g Y(cum), 85m Y and 85g Y pairs for the same energy range. All measurements are reported for the first time. The experimental data were compared with the data from the TENDL library which is based on TALYS calculation with default parameters. No satisfactory agreement was observed. Nuclear model calculations were then performed using the codes TALYS and EMPIRE with some parameter adjustments, and compared with the experimental data. The quality of the agreement between experimental data and model calculations was numerically quantified. In general, the data as well as the isomeric cross-section ratios are partially reproduced by the model calculations, provided the input model parameters are properly chosen and the level structure of the product nucleus is thoughtfully considered.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Search for new phenomena in events with at least three photons collected in pp collisions at √s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in events with at least three photons are reported. Data from proton–proton collisions at a centre-of-mass energy of 8 TeV, corresponding to an integrated luminosity of 20.3 fb -1 , were collected with the ATLAS detector at the LHC. The observed data are well described by the Standard Model. Limits at the 95 % confidence level on new phenomena are presented based on the rate of events in an inclusive signal region and a restricted signal region targeting the rare decay Z→3γ, as well as di-photon and tri-photon resonance searches. For a Standard Model Higgs boson decaying to four photons via a pair of intermediate pseudoscalar particles (a), limits are found to be σ× BR (h→aa)× BR (a→γγ) 2 <10 -3 σSM for 10 GeV a < 62 GeV. Finally, limits are also presented for Higgs boson-like scalars (H) for m H > 125 GeV, and for a Z' decaying to three photons via Z'→a+γ→3γ. Additionally, the observed limit on the branching ratio of the Z boson decay to three photons is found to be BR(Z→3γ)<2.2×10 -6 , a result five times stronger than the previous result from LEP.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

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