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NASA NTRSDate not supplied

NASA GeneLab: Open Science for Life in Space

The NASA GeneLab project (genelab.nasa.gov) seeks to get the most from space-relevant biology experiments by providing and maintaining a public database consisting of DNA, RNA, protein, and metabolite data from spaceflight experiments. Since these types of data, referred to as omics data, are difficult to understand for non-bioinformaticians, the GeneLab data processing team works with the scientific community to develop methods to process these data. The processed data found on GeneLab reveals information about which genes are turned on and turned off in the space environment, which helps us understand how space changes our biology and how we can best mitigate these effects to travel deeper into space.

Jonathan Oribello↗
DOE OSTI2022

Anomalous structural recovery in the near glass transition range in a polymer glass: Data revisited in light of temperature variability in vacuum oven‐based experiments*

Abstract There is considerable interest in data reported by Cangialosi et al. [Cangialosi, D., Boucher, V. M., Alegría, A., & Colmenero, J. (2013). Physical Review Letters , 111 (9), 095701] that purportedly showed unusual irregular responses in the isothermal structural recovery behavior of glasses because the observation challenges the general view of the dynamics being smooth functions of time as observed in extensive dilatometric experiments by Kovacs [Kovacs, A. J. (1964). In Fortschritte der Hochpolymeren‐Forschung , 3 , 394–507. Springer, Berlin, Heidelberg.] in the 1960s. The reported data show an apparent two mechanism structural (enthalpy) recovery at aging temperatures ranging from 6 to 17 K below which is also controversial as it could not be reproduced in work from Koh and Simon [Koh, Y. P., & Simon, S. L. (2013). Macromolecules , 46(14), 5815–5821.] where a second plateau observed in the enthalpy loss curve was not reproduced in nearly 1‐year‐long experiments at 15 K below . Therefore, it is important to determine what might be possible reasons for the apparent non‐smooth relaxations. Here, we examine the possibility that the poor temperature control of a typical vacuum oven could explain the anomalous results. We used the Tool–Narayanaswamy–Moynihan (TNM) model of structural recovery to calculate the effect of typical vacuum oven temperature variation on the structural recovery of polystyrene and find that we can reproduce the reported experimental results. The issue of temperature control using a vacuum oven is discussed, and data from thermocouple measurements of temperature at various locations inside a vacuum oven are shown.

36 MATERIALS SCIENCE↗
NASA NTRS1973

Apollo lunar sounder experiment

The four basic data products from the ALSE are sounding, profiling, imaging, and noise measurements. Attention was concentrated on the first three products, and both theory and preliminary results are presented. Background information is presented on the experiment and on the data products. Preliminary examples of the types of analyses that can be performed and the conclusions to which they can lead are included. Preliminary analysis of the data for subsurface features was successful in indicating with a high probability the capability of the ALSE to achieve its fundamental goal of substrate sounding. The imagery and profiling data are useful immediately for geologic interpretation, as demonstrated.

Phillips, R. J.↗
NASA NTRS1977

Comparison of ozone measurement techniques using aircraft, balloon, and ground-based measurements

In order to verify the ultraviolet absorption technique used in the Global Atmospheric Sampling Program, two flight experiments were conducted employing several techniques, both in situ and remote, for measuring atmospheric ozone. The first experiment used the NASA CV-990 equipped with an ultraviolet absorption ozone monitor and an ultraviolet spectrophotometer, a balloon ozonesonde, and a Dobson station for determining and comparing the ozone concentration data. A second experiment compared ozone data from an automated sampling system aboard a B-747 with data from a manned system installed on the NASA CV-990 during a cross-country flight with both aircraft following the same flight path separated by 32 kilometers.

Briehl, D.↗
NASA NTRS1993

MIRAGE: The data acquisition, analysis, and display system

Developed for the NASA Johnson Space Center and Life Sciences Directorate by GE Government Services, the Microcomputer Integrated Real-time Acquisition Ground Equipment (MIRAGE) system is a portable ground support system for Spacelab life sciences experiments. The MIRAGE system can acquire digital or analog data. Digital data may be NRZ-formatted telemetry packets of packets from a network interface. Analog signal are digitized and stored in experimental packet format. Data packets from any acquisition source are archived to a disk as they are received. Meta-parameters are generated from the data packet parameters by applying mathematical and logical operators. Parameters are displayed in text and graphical form or output to analog devices. Experiment data packets may be retransmitted through the network interface. Data stream definition, experiment parameter format, parameter displays, and other variables are configured using spreadsheet database. A database can be developed to support virtually any data packet format. The user interface provides menu- and icon-driven program control. The MIRAGE system can be integrated with other workstations to perform a variety of functions. The generic capabilities, adaptability and ease of use make the MIRAGE a cost-effective solution to many experimental data processing requirements.

Rosser, Robert S.↗
DOE OSTI2024

A Comprehensive Investigation of Active Learning Strategies for Conducting Anti-Cancer Drug Screening

It is well-known that cancers of the same histology type can respond differently to a treatment. Thus, computational drug response prediction is of paramount importance for both preclinical drug screening studies and clinical treatment design. To build drug response prediction models, treatment response data need to be generated through screening experiments and used as input to train the prediction models. In this study, we investigate various active learning strategies of selecting experiments to generate response data for the purposes of (1) improving the performance of drug response prediction models built on the data and (2) identifying effective treatments. Here, we focus on constructing drug-specific response prediction models for cancer cell lines. Various approaches have been designed and applied to select cell lines for screening, including a random, greedy, uncertainty, diversity, combination of greedy and uncertainty, sampling-based hybrid, and iteration-based hybrid approach. All of these approaches are evaluated and compared using two criteria: (1) the number of identified hits that are selected experiments validated to be responsive, and (2) the performance of the response prediction model trained on the data of selected experiments. The analysis was conducted for 57 drugs and the results show a significant improvement on identifying hits using active learning approaches compared with the random and greedy sampling method. Active learning approaches also show an improvement on response prediction performance for some of the drugs and analysis runs compared with the greedy sampling method.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1997

Autonomous Navigation with Ground-to-Space Doppler Measurements Referenced to a Temperature-Compensated Crystal Oscillator

The National Aeronautics and Space Administration (NASA) Goddard Space Flight Center (GSFC) has spent several years developing operational Onboard Navigation Systems (ONS's) to provide real-time autonomous, high-accuracy navigation products for spacecraft using NASA's space and ground communication systems. The highly successful Tracking and Data Relay Satellite System (TDRSS) ONS (TONS) experiment on the Explorer Platform/Extreme Ultraviolet Explorer (EP/EUVE) spacecraft, launched June 7, 1992, flight-demonstrated the ONS for high-accuracy navigation using TDRSS forward- link communications services, In late 1994, the ground station ONS (GONS) experiment, using the same EP/EUVE flight hardware, flight-demonstrated the feasibility of high-accuracy autonomous navigation using ground station forward-link communication services, with an ultrastable oscillator (USO) as the frequency reference (1 part in 10(exp 10) over 24 hours). This paper provides a follow-on analysis of GONS performance to assess the navigation accuracy achievable if GONS uses the significantly less stable (5 parts in 10(exp 8) over 24 hours, compared with a specification of 1 part in 10(exp 6)) Temperature-Compensated Crystal Oscillator (TCXO), which is integral to the transponder, as a frequency reference rather than an external USO. The GONS TCXO experiment results from a 20-day period are used to project the expected performance of an operational system. The GONS processes Doppler data derived from nominally scheduled ground station forward-link communication services using a sequential estimation algorithm enhanced by a sophisticated process noise model to provide onboard orbit and frequency determination. To evaluate the navigation accuracies achievable if a TCXO were used, actual experiment data (which used the USO as the frequency reference) were corrupted with errors from real TDRSS one-way return tracking measurements taken from EP/EUVE's TCXO. Analysis of the GONS TCXO experiment performance indicates that real-time onboard position accuracies of better than 300 meters (1 sigma) are achievable with as few as two tracking contacts per day for the EP/EUVE 525-kilometer altitude, 28.5-degree inclination orbit, provided the TCXO is as stable as that in EP/EUVE's TDRSS transponder. GONS using a TCXO frequency reference provides a viable option for many upcoming spacecraft missions with moderate position accuracy requirements and an interest in reducing their operational costs with autonomous navigation.

Radomski, M. S.↗
NASA NTRS1988

Wind, current and swell influences on the ice extent and flux in the Grand Banks-Labrador sea area as observed in the LIMEX '87 experiment

This paper presents data collected by airborne and satellite instruments during the Labrador Ice Margin Experiment, that demonstrate the effects of oceanic and atmospheric processes on the ice conditions in the Grand Banks-Labrador sea area. Special consideration is given to the development of algorithms for extracting information from SAR data. It is shown that SAR data can be used to monitor ice extent, determine ice motion, locate shear zones, monitor the penetration of swell into the ice, estimate floe sizes, and establish the dimensions of the ice velocity zones. It is also shown that the complex interaction of the ice cover with winds, currents, swell, and coastlines is similar to the dynamics established for a number of sites in both polar regions.

Argus, Susan Digby↗
DOE OSTI2022

Combining translational and rotational seismic motions to invert local-scale seismic data for time-variable moment tensors: do rotational motions help for high-frequency seismic data produced by underground explosions?

SUMMARY We present an analysis of combining translational and rotational seismic data in an inversion for the time-variable source time functions corresponding to the components of the seismic moment tensor. We conduct a series of numerical experiments where the data are simulated by a combination of an underground explosion and a co-located double couple shear source and recorded on surface-mounted seismometers within 1–2 km of the source. The experiments are designed to mimic explosion seismology experiments, and thus the data are in the 1–10 Hz frequency range and contain very few surface waves. We use a Monte Carlo method to propagate Earth model uncertainty into the estimates of seismic source parameters. In our experiments, we find that the uncertainty of the estimated seismic source parameters increases when we add rotational seismic motions to the inversion when using a constant number of data channels. In this case, the increased degree of uncertainty in the final results is most likely due to the near-surface Earth model uncertainty that we introduce in our simulations. However, for a fixed number of seismic stations, adding rotational seismic motions to the inversion acts to decrease the uncertainty of the estimated seismic source parameters, most likely due to the increase in the number of data channels used in the inversion.

Poppeliers, Christian (ORCID:0000000159526849)↗
DOE OSTI2025

Charged Lepton Flavor Violating Experiments with Muons

We report on the status of charged lepton flavor violating (CLFV) experiments with muons. We focus on the three "golden channels": $\mu^{+} \rightarrow e^{+} \gamma$, $\mu^{+} \rightarrow e^{+} e^{-} e^{+}$ and $\mu^{-} N \rightarrow e^{-} N$. The collection of upcoming experiments aim for sensitivity improvements up to $10^{4}$ with respect to previous searches. The MEG II experiment, searching for $\mu^{+} \rightarrow e^{+} \gamma$, is currently in its 4th year of physics data-taking with a published result from its first year of data. The Mu3e experiment is an upcoming experiment searching for $\mu^{+} \rightarrow e^{+} e^{-} e^{+}$ with plans of physics data-taking as soon as 2025. The Mu2e and COMET experiments are upcoming searches for $\mu^{-} N \rightarrow e^{-} N$ with the goal of physics data-taking starting in 2027 and 2026 respectively. This proceeding summarizes the signal signature, expected background, resolutions, and timelines for the mentioned searches.

Palo, Dylan [Fermilab]↗
NASA NTRS1992

Post-launch analysis of data from the High Energy Astrophysical Observatory Heavy Nuclei Experiment (HEAO-C3)

The Final Report on the continuing analysis of data from the Heavy Nuclei Experiment (HNE), flown on the HEAO-3 mission, is presented. The HNE was designed to measure the elemental abundances of relativistic cosmic ray nuclei covering the charge range 17 is less than or equal to Z is less than or equal to 130. The result of these measurements is significant to the study of nucleosynthesis, the origin, acceleration, and propagation of cosmic ray nuclei, and the properties of the interstellar medium.

Stone, E. C.↗
NASA NTRS1997

Activation and proliferation of lymphocytes and other mammalian cells in microgravity

The experimental findings reviewed in this chapter support the following conclusions: Proliferation. Human T-lymphocytes, associated with monocytes as accessory cells, show dramatic changes in the centrifuge, in the clinostat and in space. In free-floating cells the mitogenic response is depressed by 90% in microgravity, whereas in cells attached to a substratum activation is enhanced by 100% compared to 1-G ground and inflight controls. The duration of phase G1 of the mitotic cycle of HeLa cells is reduced in hypergravity, resulting in an increased proliferation rate. Other systems like Friend cells and WI38 human embryonic lung cells do not show significant changes. Genetic expression and signal transduction. T-lymphocytes and monocytes show important changes in the expression of cytokines like interleukin-1, interleukin-2, interferon-gamma and tumor necrosis factor. The data from space experiments in Spacelab, Space Shuttle mid-deck, and Biokosmos have helped to clarify certain aspects of the mechanism of T-cell activation. Epidermoid A431 cells show changes in the genetic expression of the proto-oncogenes c-fos and c-jun in the clinostat and in sounding rockets. Membrane function, in particular the binding of ligates as first messengers of a signal, is not changed in most of the cell systems in microgravity. Morphology and Mortility. Free cells, lymphocytes in particular, are able to move and form aggregates in microgravity, indicating that cell-cell contacts and cell communications do take place in microgravity. Dramatic morphological and ultrastructural changes are not detected in cells cultured in microgravity. Important experiments with single mammalian cells, including immune cells, were carried out recently in three Spacelab flights, (SL-J, D-2, and IML-2 in 1992, 1993, and 1994, respectively). The results of the D-2 mission have been published in ref. 75; those of the IML-2 mission in ref. 76. Finally, many cell biology experiments in space have suffered in the past from a lack of adequate controls (like 1-G centrifuges) and of proper experimental conditions (like well-controlled temperature). In this respect the availability of Biorack, outfitted with proper incubators with 1-G control centrifuge as well as a glovebox with a microscope, is a great advantage. It is also desirable that cell biology experiments in space are accompanied or even preceded by a program of ground-based investigations in the fast rotating clinostat and in the centrifuge, and that preparatory experiments be done in parabolic flights and sounding rockets, whenever possible. Proper publication of the results of space experiments is another important need. A great number of data have been published in proceedings and reports that are not available to the broad scientific community. To guarantee the credibility and the international recognition of space biology it is important that the results be published in international, peer reviewed journals.

manned↗
NASA NTRS1986

Millstone Hill measurements and TGCM simulation for the 30 May 1984 annular solar eclipse

On 30 May 1984, the Millstone Hill incoherent scatter radar was operated to gather data on the effects of the annular solar eclipse on the structure and dynamics of the ionosphere and thermosphere. The eclipse path was about 3 deg. south of Millstone which experienced a maximum obscuration of 86% at about 1705 UT. Both the zenith steerable antennas at Millstone were used in the experiment to collect data on the temporal evolution of the eclipse effects. This experiment represented the first opportunity at Millstone to collect data during an eclipse in the absence of a major magnetospheric disturbance which had previously made the unravelling of eclipse effects difficult. In addition, the configuration of the experiment and analysis of the data included a detailed examination of the effects on the neutral atmosphere. A major catalyst for this study was the opportunity to compare the results with the predictions made from the Thermospheric General Circulation Model (TGCM) at NCAR, as a calibration point for the model. The Arecibo and Sondrestrom radars also participated as part of a radar chain experiment. The analysis of the data from these stations is in progress; the initial results from Millstone Hill are presented.

Salah, J. E.↗
NASA NTRS1989

The MSAT-X MARECS B2 satellite experiment - Ground segment results

The results of a recently completed satellite experiment employing the JPL MSAT-X developed land-mobile satellite communication terminal are described. In this experiment, a full duplex 4800-b/s digital data and voice communication link was established through the INMARSAT Marecs B2 satellite between Atlantic City, New Jersey, and Southbury, Connecticut. A series of experiments was performed to characterize the terminal performance over this link. The basic experimental setup and the preliminary results of the speech and data experiments are presented. The satellite environment proved to be near to what was expected, and as a result the experimental results were very close to theory/simulation/laboratory experiments. It was found that the ground-to-ground communication links were more benign links than the ground-to-air and air-to-ground links, and this is reflected in the improved margins for the ground-to-ground links (approximately 5 dB versus 3.2 dB for the aeronautical links).

Jedrey, Thomas C.↗
NASA NTRS1985

Solar neutrinos, solar flares, solar activity cycle and the proton decay

It is shown that there may be a correlation between the galactic cosmic rays and the solar neutrino data, but it appears that the neutrino flux which may be generated during the large solar cosmic ray events cannot in any way effect the solar neutrino data in Davis experiment. Only initial stage of mixing between the solar core and solar outer layers after the sunspot maximum in the solar activity cycle can explain the higher (run number 27 and 71) of solar neutrino data in Davis experiment. But solar flare induced atmospheric neutrino flux may have effect in the nucleon decay detector on the underground. The neutrino flux from solar cosmic rays may be a useful guide to understand the background of nucleon decay, magnetic monopole search, and the detection of neutrino flux in sea water experiment.

Raychaudhuri, P.↗
DOE OSTI2024

A machine-learning-aided data recovery approach for predicting multi-material thermal behaviors in advanced test reactor capsules

Instrumented experiments conducted at test reactors are essential to the deployment of new advanced reactor systems. Designing new experiments and generating data on specific reactor conditions require significant investments in terms of both time and cost. Finite element analysis software can be used to create high-fidelity models of experiment environments in order to support the actual experiments, but computation time remains a concern in terms of applying outcomes to real-time usage of data (e.g., a digital twin [DT]). Here, the present research proposes a machine-learning (ML) aided approach to making temperature and displacement predictions based on the thickness of the outer gas gap on the experimental capsule used for in-pile demonstration of a novel new thermal conductivity probe in the Advanced Test Reactor (ATR). This capsule consisted of U10Zr fuel, a rodlet, sodium, and inner and outer capsules. Gas gaps existed between the fuel and the rodlet, and between the inner and the outer capsule. The learning data pertained to an experimental capsule's radial distributions of temperature and displacement, as obtained based on Abaqus and the physical features. For the first step of ML sequence, the temperature was predicted using three positional parameters. Next, the displacement was predicted using seven additional parameters. Each physical feature was normalized in order to be both nondimensional and standardized. The temperature and displacement predictions showed good agreement with the simulation results in all cases involving interpolation and extrapolation. Furthermore, data similarity enhancement increased the similarity between the training and the target data, thereby increasing the predictive accuracy of the ML models. In certain extrapolation cases involving limited original ML model accuracy, data similarity enhancement and data recovery was able to somewhat improve this accuracy.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2021

SURFplus model calibration for PBX 9012

PBX 9012 is a plastic bonded explosive composed of 90.2 wt % HMX (cyclo-tetramethylene-tetranitramine) and 9.8 % Viton A (vinylidene-hexafluoropropylene copolymer). It has nearly the same composition as LX-07 (90% HMX and 10% Viton A) but with a slightly lower density. Hence it has a higher porosity and is slightly more shock sensitive. Here we describe the SURFplus model calibration for PBX 9012 using data from five shock-to-detonation transition (SDT) gas gun experiments by Burns and Chiquete, detonation front shape data from rate stick experiments and cylinder test experiment reported in Anderson et al., Jackson et al. The SDT experiments provide Pop plot data points (run distance-to-detonation) which characterize shock initiation, Lagrangian velocity time histories from embedded magnetic velocity gauges which give information on the reaction behind the lead shock, and Hugoniot data points for the reactants EOS. The rate stick experiments provide data on the curvature effect which characterize propagating detonation waves. The cylinder test experiments provide data on the detonation release isentrope used to calibrate the products EOS. The HE model uses a Davis reactants EOS with parameters that Burns and Chiquete [2020] fit to Hugoniot data, and Davis products EOS with parameters that Anderson et al. [2020] fit to cylinder test data.

45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEF↗
DOE OSTI2022

Tools Assessing Performance (FY2022 Quarter 4 Report)

We were finally successful in acquiring TTU’s 200-meter tower data for the duration of the Isolated Building Wake Experiment (IBWE). This data will provide an independent measurement of the undisturbed wind profile including heights far above those that are typical of meteorological sensor networks. These measurements will characterize the mean and turbulence throughout the atmospheric surface layer, which will be particularly useful for validation of highfidelity computational fluid dynamics models. This dataset can be shared freely among the TAP team but not outside of it as TTU sells this data to the wind power industry. The journal article overview has been submitted to LANL’s publication review and will be submitted to the Journal of Wind Engineering and Industrial Aerodynamics once the review is complete. We are nearing completion on another two articles. The first discusses analyses of the evolution of the measurements of mean wind speed along the centerline of the building as a function of atmospheric stability. Rather than using individual time steps, all of the wind speed measurements are normalized using the upwind measurement at 2 building heights (H) and filtered by wind direction and atmospheric stability. The second discusses the development of the diffusive wake model and uses the averaged profiles from the first article to validate the behavior of the model. The portion of the section below on the diffusive wake model discussing comparisons with the averaged profiles, will be included in the validation section of this paper.

17 WIND ENERGY↗

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