ACTVD Primer “Arms Control 101”
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To address the challenges of the emerging security environment and its impact on extended deterrence and assurance, there has been an effort in the United States to ensure it maintains capabilities for extended deterrence, to enhance assurances and to continue to pursue with allies non- and counter-proliferation and counterterrorism - including defenses and consequence management-as priorities. These and other activities are important to the US and its allies, and are essential to maintaining and strengthening the Nonproliferation Treaty (NPT) bargain. As the developments leading to the ban treaty suggest, the political requirement for dealing with calls for disarmament in the NPT context is indisputable. This may not have been the understanding of the negotiators of the treaty, but it is today's reality.
The ability to track nuclear material is a challenge for resiliency of complex systems, e.g., harsh environments. RF tags, frequently used in national security applications, cannot be used for technological, operational, or safety reasons. Magnetic Smart Tags (MaST) is a novel tag technology based on magnetoelastic sensing that circumvents these issues. This technology is enabled by a new, cost-effective, batch manufacturing electrochemical deposition (ECD) process. This new advancement in fabrication enables multi-frequency tags capable of providing millions of possible codes for tag identification unlike existing theft deterrent tags that can convey only a single bit of information. Magnetostrictive 70% Co: 30% Fe was developed as the base alloy comprising the magnetoelastic resonator transduction element. Saturation magnetostriction, λ S , has been externally measured by the Naval Research Laboratory to be as high as 78 ppm. Description of a novel MEMS variable capacitive test structure is described for future measurements of this parameter.
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The main accomplishments achieved under this project were: (1) assessing the utility of high spectral resolution lidar (HSRL) measurements from Barrow to determine vertical profiles of aerosols in the Arctic, (2) identifying ways to improve simulations of the vertical profile of black carbon in the Community Atmosphere Model (CAM) via alteration of various microphysical parameters, and (3) assessing the sensitivity of meltwater runoff from the Greenland Ice Sheet to varying amounts, timing, and hygroscopicity of deposited black carbon aerosols.
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Three AMF Sites are needed: Main Site for the AMF1 Observatory, an 'ancillary site' to the SW of the city for measurement of air before crossing Houston. A radar site for the CSAPR between the main and ancillary sites, ideally no more than 50km from either site. We are making preliminary evaluations of sites for tethered balloon system (TBS) activities.
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As the current global pandemic makes abundantly clear, we need a better understanding of infectious disease to safeguard human health, the economy and global security. Modern omics techniques hold the promise of providing a comprehensive understanding of the molecular mechanisms of life, including causes of pathogenesis from infectious disease at the molecular level, but we there is a serious gap in annotation of gene function. For as much as half of the genes and gene products encoded in genomes the molecular and/or cellular function is unknown or only partially understood. Recent innovations in fluorescence microscopy for live cell imaging and genetic engineering make it possible to determine the temporal correlation between molecular events, such as a gene being expressed due to host-pathogen interaction, and cellular events, such as bacterial invasion of immune cells. This is turn allows us to gain new insight as to the molecular and cellular role of individual genes and will enable the discovery and validation of new molecular mechanisms essential for infectious disease. Knowing the molecular mechanisms of disease processes will provide new therapeutic targets or novel countermeasure strategies. We aimed to develop a lattice light sheet fluorescence microscope as a unique resource at LLNL for long time course live cell imaging experiments; to develop the reagents and cell lines needed to monitor molecular events during the course pathogenic bacteria infecting mammalian immune cells; and to demonstrate that we could capture molecular events during an infection. We fully commissioned the LLNL lattice light sheet microscope and conducted initial proof of principle imaging experiments on mammalian immune cells and pathogenic bacteria. It is clear from the experience gained that long time course live cell imaging has tremendous potential to help elucidate molecular mechanisms of host-pathogen interactions and to help annotate gene function, which would establish a basis for new countermeasures. It is also clear that if live cell imaging is to realize its full potential new data processing and analysis tools will need to be developed to facilitate analysis of molecular events within cells; new sample chambers and stages could facilitate studies with a wider range of cell and tissue types; and alternative molecular tagging methods need to be explored to enable more facile engineering of cells labeled with molecular specificity.
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During the Cold-Air Outbreaks in the Marine Boundary Layer Experiment (COMBLE), a project with the overarching goal to shed light on the dynamics and microphysical properties of clouds and precipitation in the high-latitude marine boundary layer during cold-air outbreaks (CAOs), we were tasked with providing and assisting the collection of aerosol filter samples for measuring ice nucleating particle (INP) concentrations. Little is known about the properties of CAO cloud systems, how they vary with surface, environmental, and aerosol conditions, the role of cold-air outbreaks in the global atmospheric and ocean circulation, and the accuracy of the treatment of this atmospheric regime in climate models. Uncertainties in climate projections for the arctic and sub-arctic region are large, in part due to the lack of observational guidance to constrain the treatment of aerosol-cloud-precipitation linkages in climate models.
GRUAN, the Global Climate Observing System (GCOS) Reference Upper Air Network, is an international reference observing network of sites measuring essential climate variables above Earth's surface, designed to fill an important gap in the current global observing system. GRUAN’s objectives are to (1) provide long-term, high-quality climate records, (2) constrain and calibrate data from more spatially comprehensive global observing systems (including satellites and current radiosonde networks) and (3) fully characterize the properties of the atmospheric column.
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Explore the source record for details and available documents.
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