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At least 181 records · Page 10

On the Nature of the Arctic’s Positive Lapse Rate Feedback Cause or Symptom of Arctic Amplification

Radiative energy fluxes exiting the atmosphere towards the surface and to space are sensitive to the vertical structure of temperature. Under anthropogenic forcing, this sensitivity gives rise to the lapse-rate feedback. Shown to be negative in the tropics and positive in the Arctic, studies argue that the lapse-rate feedback is the primary cause of Arctic Amplification. While mechanistically the negative tropical lapse-rate feedback is understood, the mechanics of the positive Arctic lapse-rate feedback are less clear. Previous arguments state that the Arctic’s stable stratification is the origin of its positive lapse-rate feedback. We present results using CMIP5 and CMIP6 model output that arguing that the magnitude, spatial variability, seasonality, and inter-model spread in the Arctic lapse-rate feedback is controlled by surface properties and atmosphere-ocean-sea ice energy exchanges, not the degree of stable stratification. We argue that the Arctic’s positive lapse-rate feedback is a seasonal and regional phenomenon that manifests from local surface characteristics and surface albedo, ice insulation, and thermal inertia feedbacks that cause surface warming to outpace atmospheric warming in sea ice-retreat regions. We view the Arctic’s positive lapse-rate feedback as a symptom rather than the primary cause of Arctic Amplification.

Patrick C Taylor↗

Linear Disturbance Amplification Over Blunted Flat Plates in High-Speed Flows

Modal and nonmodal instability characteristics of cylindrically blunted flat plates with varying leading edge radii are described for Mach 4 and Mach 6 freestream conditions. The selection of leading edge radii and freestream parameters is informed by experimental conditions. The investigation of this 2D problem provides a slow entropy layer swallowing which allows for an isolated development of perturbations seeded upstream within different wall-normal regions of the flow. At both Mach numbers, a decrease in modal instability amplification was seen as the leading edge radius was increased. Nonmodal analysis reveals amplifying perturbations in the boundary layer as well as in the entropy layer. The medium bluntness regime exhibits the strongest amplification of nonmodal disturbances that is nonmonotonic in character. Small amplitude boundary forcing at the plate surface or volumetric forcing at various wall-normal heights was used to account for receptivity effects. While wall forcing effectively induced modal instabilities, only an actuation above the boundary layer captured disturbances that amplify within the entropy layer. The optimal nonmodal theory’s entropy-layer disturbance evolution exhibited outstanding agreement with controlled forcing, including receptivity effects. The evolution of entropy-layer disturbances from the optimal nonmodal theory showed excellent agreement with the results of receptivity to controlled forcing. Therefore, the nonmodal optimal growth analysis may provide a useful as well as efficient technique to identify the complete disturbance spectrum in blunt hypersonic configurations, where both modal and nonmodal disturbances can amplify in the boundary-layer and entropy-layer regions.

Boundary layer transition↗

Linear Disturbance Amplification Over Blunted Flat Plates in High-Speed Flows

Modal and nonmodal instability characteristics of cylindrically blunted flat plates with varying leading edge radii are described for Mach 4 and Mach 6 freestream conditions. The selection of leading edge radii and freestream parameters is informed by experimental conditions. The investigation of this 2D problem provides a slow entropy layer swallowing which allows for an isolated development of perturbations seeded upstream within different wall-normal regions of the flow. At both Mach numbers, a decrease in modal instability amplification was seen as the leading edge radius was increased. Nonmodal analysis reveals amplifying perturbations in the boundary layer as well as in the entropy layer. The medium bluntness regime exhibits the strongest amplification of nonmodal disturbances that is nonmonotonic in character. Small amplitude boundary forcing at the plate surface or volumetric forcing at various wall-normal heights was used to account for receptivity effects. While wall forcing effectively induced modal instabilities, only an actuation above the boundary layer captured disturbances that amplify within the entropy layer. The optimal nonmodal theory’s entropy-layer disturbance evolution exhibited outstanding agreement with controlled forcing, including receptivity effects. The evolution of entropy-layer disturbances from the optimal nonmodal theory showed excellent agreement with the results of receptivity to controlled forcing. Therefore, the nonmodal optimal growth analysis may provide a useful as well as efficient technique to identify the complete disturbance spectrum in blunt hypersonic configurations, where both modal and nonmodal disturbances can amplify in the boundary-layer and entropy-layer regions.

Boundary layer transition↗

Potential Link Between Ice Nucleation and Climate Model Spread in Arctic Amplification

Arctic amplification (AA) is simulated by all global climate models, however the spread in the degree of projected warming is large and the underlying mechanisms driving it are poorly understood. The impact of the temperature dependence of immersion freezing on cloud feedbacks and AA is studied using NASA's GEOS-5 model. Parameterizations that exhibit low ice-nucleating particle (INP) concentrations in the high Arctic during summer are found to weaken the cloud-phase feedback. This allows sunlight to readily melt sea-ice in the summer, which decreases the stability of the lower troposphere, causing a decrease in wintertime cloud fraction over open ocean. Arctic amplification was found to span from ∼1.4 to >2.6, which spans 30% of the spread in AA in the coupled model intercomparison project models, depending on the temperature dependence of immersion freezing. These results suggest that summertime INP concentrations may provide an observational constraint on AA.

Ice Nucleation↗

Summer Atmospheric Circulation Over Greenland in Response to Arctic Amplification and Diminished Spring Snow Cover

The exceptional atmospheric conditions that have accelerated Greenland Ice Sheet mass loss in recent decades have been repeatedly recognized as a possible dynamical response to Arctic amplification. Here, we present evidence of two potentially synergistic mechanisms linking high-latitude warming to the observed increase in Greenland blocking. Consistent with a prominent hypothesis associating Arctic amplification and persistent weather extremes, we show that the summer atmospheric circulation over the North Atlantic has become wavier and link this wavier flow to more prevalent Greenland blocking. While a concomitant decline in terrestrial snow cover has likely contributed to this mechanism by further amplifying warming at high latitudes, we also show that there is a direct stationary Rossby wave response to low spring North American snow cover that enforces an anomalous anticyclone over Greenland, thus helping to anchor the ridge over Greenland in this wavier atmospheric state.

Atmospheric dynamics↗

Micro-fluidic partitioning between polymeric sheets for chemical amplification and processing

A system for fluid partitioning for chemical amplification or other chemical processing or separations of a sample, comprising a first dispenser of a first polymeric sheet, wherein the first polymeric sheet contains chambers; a second dispenser of a second polymeric sheet wherein the first dispenser and the second dispenser are positioned so that the first polymeric sheet and the second polymeric sheet become parallel; a dispenser of the fluid positioned to dispense the fluid between the first polymeric sheet and the second polymeric sheet; and a seal unit that seals the first polymeric sheet and the second polymeric sheet together thereby sealing the sample between the first polymeric sheet and the second polymeric sheet and partitioning the fluid for chemical amplification or other chemical processing or separations.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Method for chemical amplification based on fluid partitioning in an immiscible liquid

A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and detection of a sample comprising partitioning the sample into partitioned sections, performing PCR on the partitioned sections of the sample, and detecting and analyzing the partitioned sections of the sample.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Micro-fluidic partitioning between polymeric sheets for chemical amplification and processing

A system for fluid partitioning for chemical amplification or other chemical processing or separations of a sample, comprising a first dispenser of a first polymeric sheet, wherein the first polymeric sheet contains chambers; a second dispenser of a second polymeric sheet wherein the first dispenser and the second dispenser are positioned so that the first polymeric sheet and the second polymeric sheet become parallel; a dispenser of the fluid positioned to dispense the fluid between the first polymeric sheet and the second polymeric sheet; and a seal unit that seals the first polymeric sheet and the second polymeric sheet together thereby sealing the sample between the first polymeric sheet and the second polymeric sheet and partitioning the fluid for chemical amplification or other chemical processing or separations.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Method for chemical amplification based on fluid partitioning in an immiscible liquid

A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and detection of a sample comprising partitioning the sample into partitioned sections, performing PCR on the partitioned sections of the sample, and detecting and analyzing the partitioned sections of the sample.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Chemical amplification based on fluid partitioning

A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and detection of a sample comprising partitioning the sample into partitioned sections, performing PCR on the partitioned sections of the sample, and detecting and analyzing the partitioned sections of the sample.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Multiscale light amplification structures for surface enhanced Raman spectroscopy

A method, system and article of manufacture for amplification of light for surface enhanced Raman spectroscopy. The method and system include a source of input light, a grating with grooves therein, a nanoparticle array disposed in the grooves with the nanoparticles and grating having a variety of selectable parameters. The combination of the nanoparticles and selected characteristics, including generating hot spots, and the features of the grating enable enhanced amplification of the input light signal to provide an output Raman signal of greatly increased intensity for Raman spectroscopy.

Vlasko-Vlasov, Vitalii↗

Chemical amplification based on fluid partitioning

A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and detection of a sample comprising partitioning the sample into partitioned sections, performing PCR on the partitioned sections of the sample, and detecting and analyzing the partitioned sections of the sample.

Anderson, Brian L.↗

Privacy Amplification for Episodic Training Methods

It has been shown that differential privacy bounds improve when subsampling within a randomized mechanism. Episodic training, utilized in many standard machine learning techniques, uses a multistage subsampling procedure which has not been previously analyzed for privacy bound amplification. In this paper, we focus on improving the calculation of privacy bounds in episodic training by thoroughly analyzing privacy amplification due to subsampling with a multi-stage subsampling procedure. The newly developed bound can be incorporated into existing privacy accounting methods.

Tombs, Vandy↗

Ultra-Long Distance BOTDA Sensor System Employing Hybrid Amplification and Advanced Noise Reduction Techniques

Brillouin Optical Time Domain Analysis (BOTDA) sensor systems play a pivotal role in distributed sensing, which enables precise measurements of strain and temperature across extensive fiber lengths. This research offers a comprehensive strategy to extend the sensing range of BOTDA systems beyond tens of kilometers while maintaining high spatial resolutions. Such enhanced sensing is realized through the integration of distributed Raman amplification, inline amplification using erbium-doped fiber amplifiers (EDFA), and advanced noise reduction techniques. Optimizing Raman pump and probe wave profiles ensures the robustness of Brillouin scattering signals, effectively countering attenuation-induced losses. Additionally, enhancing weak Brillouin signals by strategically placing EDFAs at optimal fiber locations keeps sensor sensitivity high. Leveraging inherent redundancy in measured data as a function of frequency and fiber distance, the non-local means (NLM) filter removes noise while preserving essential physical information. In summary, this research has shown a holistic exploration of extending BOTDA’s distance sensing capabilities up to 150 km with spatial resolutions of 8 meters.

Bhatta, Hari↗

Methods for isothermal molecular amplification with nanoparticle-based reactions

The present method of detection involves increasing an amount of analyte molecules by an isothermal molecular amplification approach. In the present approach a starting molecule of interest may be amplified through a reaction it induces with specifically engineered and functionalized particles, namely protected particles A and storage particles B. This reaction may result in a set of output DNA molecules that is larger in number than the input DNA molecules. Thus the reaction between nanoparticles for amplification of a certain DNA sequence (input DNA molecules) may occur when there is a match with a targeted molecule (stored molecules on storage particles B) and if the DNA sequence of the input DNA molecules does not match (partially or completely) the targeted molecule the reaction may not occur. Without a certain molecular input of the input DNA molecule the reaction may not occur.

Gang, Oleg↗

Linear Light Amplifier and Amplification of N-Photon States

We consider a linear quantum amplifier consisting of NA two-level atoms and study the problem of amplification of N-photon states. The N-photon states are associated with N-quantum states of the harmonic oscillator. We show that the process of interaction of the electromagnetic field with atoms can be associated with some transformation of the phase space and functions defined on this phase space. We consider the Husimi functions QN(q, p) of N-quantum states of the harmonic oscillator, which are defined on the phase space, investigate transformation of these functions, and find an explicit form of the density matrix of the amplified N-photon state. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

60 APPLIED LIFE SCIENCES↗

Cavitation during the protein misfolding cyclic amplification (PMCA) method – The trigger for de novo prion generation?

The protein misfolding cyclic amplification (PMCA) technique has become a widely-adopted method for amplifying minute amounts of the infectious conformer of the prion protein (PrP). PMCA involves repeated cycles of 20 kHz sonication and incubation, during which the infectious conformer seeds the conversion of normally folded protein by a templating interaction. Recently, it has proved possible to create an infectious PrP conformer without the need for an infectious seed, by including RNA and the phospholipid POPG as essential cofactors during PMCA. The mechanism underpinning this de novo prion formation remains unknown. In this study, we first establish by spin trapping methods that cavitation bubbles formed during PMCA provide a radical-rich environment. Using a substrate preparation comparable to that employed in studies of de novo prion formation, we demonstrate by immuno-spin trapping that PrP- and RNA-centered radicals are generated during sonication, in addition to PrP-RNA cross-links. We further show that serial PMCA produces protease-resistant PrP that is oxidatively modified. We suggest a unique confluence of structural (membrane-mimetic hydrophobic/hydrophilic bubble interface) and chemical (ROS) effects underlie the phenomenon of de novo prion formation by PMCA, and that these effects have meaningful biological counterparts of possible relevance to spontaneous prion formation in vivo. - Highlights: • Sonication during PMCA generates free radicals at the surface of cavitation bubbles. • PrP-centered and RNA-centered radicals are formed in addition to PrP-RNA adducts. • De novo prions may result from ROS and structural constraints during cavitation.

60 APPLIED LIFE SCIENCES↗

Oscillating surge wave energy converter using a novel above-water power takeoff with belt-arc speed amplification

We investigate the performance of a novel power takeoff (PTO) featuring belt-arc speed amplification for oscillating surge wave energy converters (OSWECs), aiming to address the challenges of extremely low rotary speed and large torque under the low-frequency ocean wave excitations. The belt-arc design significantly increases the rotary speed of the generator, enabling generator downsizing and decreasing the powertrain friction losses. The design also allows for placing the generator above water, eliminating the need for high Ingress Protection ratings for the generator and powertrain, and potentially leading to substantial reductions in capital and maintenance costs. Using the linear potential wave theory, the dynamics of the integrated system are analyzed, and key parameters are identified. To validate the numerical analysis, a 1:10 scale model is designed, fabricated, and tested in a wave tank. Performance evaluations are conducted under regular and irregular wave conditions, with quantified effects of parameter tuning. The results reveal an optimal wave-to-electric efficiency of 48% under regular wave excitation and 20% under irregular excitation. Furthermore, these findings underscore the effectiveness of the proposed novel PTO design in addressing the challenges of low rotation speed and large torque inherent in OSWECs, demonstrating its ability to efficiently convert wave power into electricity.

16 TIDAL AND WAVE POWER↗