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The Zwicky Transient Facility: Data Processing, Products, and Archive

The Zwicky Transient Facility (ZTF) is a new robotic time-domain survey currently in progress using the Palomar 48-inch Schmidt Telescope. ZTF uses a 47 square degree field with a 600 megapixel camera to scan the entire northern visible sky at rates of ∼3760 square degrees/hour to median depths of g ~ 20.8 and r ~ 20.6 mag (AB, 5σ in 30 sec). We describe the Science Data System that is housed at IPAC, Caltech. This comprises the data-processing pipelines, alert production system, data archive, and user interfaces for accessing and analyzing the products. The real-time pipeline employs a novel image-differencing algorithm, optimized for the detection of point-source transient events. These events are vetted for reliability using a machine-learned classifier and combined with contextual information to generate data-rich alert packets. The packets become available for distribution typically within 13 minutes (95th percentile) of observation. Detected events are also linked to generate candidate moving-object tracks using a novel algorithm. Objects that move fast enough to streak in the individual exposures are also extracted and vetted. We present some preliminary results of the calibration performance delivered by the real-time pipeline. The reconstructed astrometric accuracy per science image with respect to Gaia DR1 is typically 45 to 85 milliarcsec. This is the RMS per-axis on the sky for sources extracted with photometric S/N ≥10 and hence corresponds to the typical astrometric uncertainty down to this limit. The derived photometric precision (repeatability) at bright unsaturated fluxes varies between 8 and 25 millimag. The high end of these ranges corresponds to an airmass approaching ∼2—the limit of the public survey. Photometric calibration accuracy with respect to Pan-STARRS1 is generally better than 2%. The products support a broad range of scientific applications: fast and young supernovae; rare flux transients; variable stars; eclipsing binaries; variability from active galactic nuclei; counterparts to gravitational wave sources; a more complete census of Type Ia supernovae; and solar-system objects.

Frank J. Masci↗

ICE-RASSOR: Intelligent Capabilities Enhanced Regolith Advanced Surface Systems Operations Robot

NASA’s Regolith Advanced Surface Systems Operations Robot (RASSOR) is principally designed to mine and deliver regolith for In-Situ Resource Utilization (ISRU) processing. RASSOR’s design enables it to efficiently collect and deposit regolith, return collected material for processing, and myriad related ISRU activities. To reliably perform these operations on the lunar surface, RASSOR software and sensory systems need to be robust and maximize the information extracted from on-board sensory. Herein, we present preliminary findings from the Intelligent Capabilities Enhanced RASSOR project. We apply supervised learning using real data to estimate the soil mass collected without the need for mass flow rate monitors or other explicate sensing techniques. We also create a reduced-order simulation environment to develop autonomous trenching controllers via reinforcement learning and proto-type state estimation architectures. Our initial results suggest that excavated regolith mass can be inferred within 2.9% RMS error of full scale, and reinforcement learning for autonomous operations has learned viable trenching strategies and helped identify desirable sensing capabilities, arrangements, and considerations. Future work includes regolith mass estimation during dynamic operation, expanding our simulation to more complex environments, and transfer learning from simulation to hardware.

machine learning↗

NASA GPM Status and Future Activities

The joint U.S.-Japan Global Precipitation Measurement (GPM) mission is approaching a decade of operations, and continues to pursue research, dataset production, and outreach related to precipitation. Key activities over the last year were the release of an improved “Version 07” of all GPM precipitation and latent heating products, boosting the orbit of the GPM Core Observatory (GPM CO) to 435 km, and improving quality control on precipitation retrievals from the GPM constellation of passive microwave satellites. This presentation summarizes key improvements to the GPM products and provides some examples of the changes between Versions 06 and 07 in algorithm performance. One important operational change that affected Version 07 is that the scanning strategy for the Ka-band radar channel changed in May 2018; all products that depend on Ka were revised to accommodate this change. For example, in Version 07 the Goddard Profiling (GPROF) algorithm has implemented improvements in regions where orographic enhancement and suppression take place and where the surface is snowy/icy, and again covers radiometers reaching back to 1987. The Combined Radar Radiometer Algorithm (CORRA) now incorporates modified drop-size distribution constraints that substantially reduce bias. Revisions to the Convective-Stratiform Heating (CSH) algorithm employ new radiative transfer retrievals as well as accounting for terrain in the vertical coordinates. Each algorithm was adjusted to ensure continuity for each product across the boundary in 2014 between the predecessor Tropical Rainfall Measuring Mission (TRMM) and the GPM CO. The U.S. Science Team’s Integrated Multi-satellitE Retrievals for GPM (IMERG) was upgraded to account for distortions in the probability density function of regional precipitation rates due to weighted averaging in the Kalman filter used for “morphing” the passive microwave data. Maintaining the GPM CO orbital altitude in the the current very active solar cycle has been forcing the use of more fuel than planned and consequently shortening the forecasted life of the mission from the early 2030's to the late 2020's. It was considered vital to regain some of this lifetime to ensure overlap with the upcoming Atmosphere Observing System mission to provide crosscalibration of instruments. To accomplish this, the orbital altitude was raised from 400 to 435 km on 7-8 November 2023. Thereafter, the primary GPM CO algorithms had to be revised to account for the change in observing parameters. By meeting time this action should be complete. Recently, a screening algorithm based on auto-encoding was developed that uncovered 162 orbits (out of the many thousands of orbits across all years and all satellites) of passive microwave retrievals that had highly anomalous values. Removing these defective retrievals has improved the integrity of both the GPROF and IMERG records. However, the nature of the IMERG processing interacted sufficiently badly with the now-discovered anomalous orbits that it was necessary to completely reprocess the IMERG Final Run record, now labeled Version 07B. The presentation also considers major issues that require continued attention, including the use of machine learning algorithms and the operational challenge of swarms of “small”, perhaps short-lived satellites.

GPM↗

Spacecraft Material Characterization Using Reflectance Spectra Extracted from RGB/IR Color Images

The space environment is detrimental to the exterior of the spacecraft and imposes stringent requirements on spacecraft materials. Space materials are often expected to perform for 15-20 years in the harsh space environment without significant degradation of their optical, electrical, mechanical and thermal properties. Further, as commercial activities increase in the space domain, development of predictive capability for material evolution is critical for agile adaption of novel materials. Therefore, it is very important to understand the effects of the space environments on the spacecraft materials. The Materials on the International Space Station Experiment Flight Facility (MISSE-FF) has flown numerous material samples to investigate the effect of LEO space weather exposure on the performance and durability of materials and devices. We are manifest on the MISSE-16 mission, scheduled to launch in June 2022, to fly fifteen novel and well-characterized materials in the LEO environment for a duration of six months. Changes in spectral reflectivity will be measured in real time throughout the mission with an RGB/IR camera. These time-resolved data will function as a "space-truth" reference for our team's ongoing laboratory-based space weather-material interaction experiments. Correlation of the MISSE-16 data with extensive ground testing of duplicate samples under simulated space weather conditions will enable development of fundamental chemical models for material degradation. This paper discusses preliminary results from the ground test campaign to collect the RGB/IR images for pristine and damaged materials and the development of machine learning algorithms to extract reflectance spectra from the color images.

Jainisha R. Shah↗

Spacecraft Material Characterization Using Reflectance Spectra Extracted from RGB/IR Color Images

The space environment is detrimental to the exterior of the spacecraft and imposes stringent requirements on spacecraft materials. Space materials are often expected to perform for 15-20 years in the harsh space environment without significant degradation of their optical, electrical, mechanical and thermal properties. Further, as commercial activities increase in the space domain, development of predictive capability for material evolution is critical for agile adaption of novel materials. Therefore, it is very important to understand the effects of the space environments on the spacecraft materials. The Materials on the International Space Station Experiment Flight Facility (MISSE-FF) has flown numerous material samples to investigate the effect of LEO space weather exposure on the performance and durability of materials and devices. We are manifest on the MISSE-16 mission, scheduled to launch in June 2022, to fly fifteen novel and well-characterized materials in the LEO environment for a duration of six months. Changes in spectral reflectivity will be measured in real time throughout the mission with an RGB/IR camera. These time-resolved data will function as a "space-truth" reference for our team's ongoing laboratory-based space weather-material interaction experiments. Correlation of the MISSE-16 data with extensive ground testing of duplicate samples under simulated space weather conditions will enable development of fundamental chemical models for material degradation. This paper discusses preliminary results from the ground test campaign to collect the RGB/IR images for pristine and damaged materials and the development of machine learning algorithms to extract reflectance spectra from the color images.

Jainisha R. Shah↗

Applications of Intelligent Tutoring Systems to Human-Robotic Exploration of Mars

Space missions with small crews extending over several years with time-delay preventing normal conversations with people on earth will raise many challenges for training. Of special interest are possible three-year missions to Mars, requiring refresher instruction and learning new skills based on unexpected problems with machines and environmental conditions. For example, the crew will be required to monitor and repair more complex life support systems for air and water recycling than we even know how to build today. Highly educated astronauts, often with several doctorate degrees, require a very different mode of interaction than we have developed for school children or even typical college students. Explanation methods may need to differ-using analogies and techniques from different domains-depending on whether the astronaut is an astrophysicist, a pilot, or a geologist.Virtual reality (e.g., for Hubble repair missions) and "integrated" simulations (involving role-playing and emphasizing failure scenarios) are the most common advanced forms of instruction used in space flight today. The emphasis is on collaborative, embodied interaction with the same workstations and tools used in practice (e.g., a cockpit simulator). Otherwise, computerized instructional technology used by NASA is not model-based or tutorial in nature. This discussion will review some of the key instructional methods used at NASA over the past two decades and consider why ITS methods have not been exploited. Some of the problems and opportunities for training for Mars missions are examined, including how using robots in exploration activities will help but raise new training problems. These ideas will be illustrated with examples from the BrahmsVE system in which a browser- based virtual reality display with avatars allows interacting with a distributed multiagent system, in which agents can be people, robots, or software programs. Using BrahmsVE may provide a way for astronauts to interact with proxies of people who serve as instructional coaches on Mars.

Clancey, William J.↗

Short Window Intra-Spacecraft RFID Localization

Logistics management has emerged as a key component to activities conducted in space. The RFID Enabled Autonomous Logistics Management (REALM) system has played a key role in providing cargo tracking capabilities in the noisy environment of the ISS. Currently, the inferencing engines used by REALM to predict the location of RFID tagged items operate on an hour of data. Movements aboard space stations occur on the scales of seconds. In this work we propose a new inferencing engine, that produces an embedding space that represents the location of RFID marked cargo on the scale of 30 seconds to 2 minutes of data, allowing for the categorization of movement of cargo, and predictions of a coarse location in less time than existing engines.

RFID↗

Automatic Generation of Algorithms for the Statistical Analysis of Planetary Nebulae Images

Analyzing data sets collected in experiments or by observations is a Core scientific activity. Typically, experimentd and observational data are &aught with uncertainty, and the analysis is based on a statistical model of the conjectured underlying processes, The large data volumes collected by modern instruments make computer support indispensible for this. Consequently, scientists spend significant amounts of their time with the development and refinement of the data analysis programs. AutoBayes [GF+02, FS03] is a fully automatic synthesis system for generating statistical data analysis programs. Externally, it looks like a compiler: it takes an abstract problem specification and translates it into executable code. Its input is a concise description of a data analysis problem in the form of a statistical model as shown in Figure 1; its output is optimized and fully documented C/C++ code which can be linked dynamically into the Matlab and Octave environments. Internally, however, it is quite different: AutoBayes derives a customized algorithm implementing the given model using a schema-based process, and then further refines and optimizes the algorithm into code. A schema is a parameterized code template with associated semantic constraints which define and restrict the template s applicability. The schema parameters are instantiated in a problem-specific way during synthesis as AutoBayes checks the constraints against the original model or, recursively, against emerging sub-problems. AutoBayes schema library contains problem decomposition operators (which are justified by theorems in a formal logic in the domain of Bayesian networks) as well as machine learning algorithms (e.g., EM, k-Means) and nu- meric optimization methods (e.g., Nelder-Mead simplex, conjugate gradient). AutoBayes augments this schema-based approach by symbolic computation to derive closed-form solutions whenever possible. This is a major advantage over other statistical data analysis systems which use numerical approximations even in cases where closed-form solutions exist. AutoBayes is implemented in Prolog and comprises approximately 75.000 lines of code. In this paper, we take one typical scientific data analysis problem-analyzing planetary nebulae images taken by the Hubble Space Telescope-and show how AutoBayes can be used to automate the implementation of the necessary anal- ysis programs. We initially follow the analysis described by Knuth and Hajian [KHO2] and use AutoBayes to derive code for the published models. We show the details of the code derivation process, including the symbolic computations and automatic integration of library procedures, and compare the results of the automatically generated and manually implemented code. We then go beyond the original analysis and use AutoBayes to derive code for a simple image segmentation procedure based on a mixture model which can be used to automate a manual preproceesing step. Finally, we combine the original approach with the simple segmentation which yields a more detailed analysis. This also demonstrates that AutoBayes makes it easy to combine different aspects of data analysis.

Fischer, Bernd↗

NASA GPM Status and Future Activities

The joint U.S.-Japan Global Precipitation Measurement (GPM) mission is approaching a decade of operations, and continues to pursue research, dataset production, and outreach related to precipitation. One key activity over the last year was the release of an improved “Version 07” of all GPM precipitation and latent heating products. This talk summarizes key improvements to the GPM products for which NASA has lead responsibility and provides some examples of the changes between Versions 06 and 07 in algorithm performance. One important operational change that affected Version 07 is that the scanning strategy for the Ka-band radar channel changed in May 2018; all products that depend on Ka were revised to accommodate this change. For example, in Version 07 the Goddard Profiling (GPROF) algorithm has implemented improvements in regions where orographic enhancement and suppression take place and where the surface is snowy/icy, and again covers radiometers reaching back to 1987. The Combined Radar Radiometer Algorithm (CORRA) now incorporates modified drop-size distribution constraints that substantially reduce bias. Revisions to the Convective-Stratiform Heating (CSH) algorithm employ new radiative transfer retrievals as well as accounting for terrain in the vertical coordinates. Each algorithm was adjusted to ensure continuity for each product across the boundary in 2014 between the predecessor Tropical Rainfall Measuring Mission (TRMM) and the GPM Core Observatory. The U.S. Science Team’s Integrated Multi-satellitE Retrievals for GPM (IMERG) was upgraded to account for distortions in the probability density function of regional precipitation rates due to weighted averaging in the Kalman filter used for “morphing” the passive microwave data. The talk will conclude by considering major issues that require continued attention, including the use of machine learning algorithms, the operational challenge of swarms of “small”, perhaps short-lived satellites, and estimates of the remaining lifespan of the Core Observatory.

Global Precipitation Measuremen↗

Developing Methods for Exercise System Kinematics Tracking

BACKGROUND How to quantify the load and forces produced by exercise equipment and their Vibration Isolation and Stabilization (VIS) platforms in-flight is an active area of investigation. Kinematic tracking paired with system modeling can provide insights as well as verification and validation of simulations used for system design and development. Traditional motion capture methods can require significant cost in equipment procurement and crew-time, but newer lessons learned can be leveraged [1]. The VIS systems of current and future exercise hardware on the International Space Station (ISS) such as the Cycle Ergometer with Vibration Isolation System (CEVIS) and the European Enhanced Exploration Exercise Device (E4D) are not currently outfitted with IMUs or similar measurement devices. Video-based methods would enable use of multi-purpose, crew-familiar flight equipment. An initial exploration of video-based solutions was performed utilizing 2-camera video from crew cycling on Teal-CEVIS on the ISS. METHODS AND RESULTS Our group has scoped a variety of video-based object tracking methods. To date, we have primarily investigated computer vision toolkits such as openCV. Techniques explored include key-point detection, background subtraction, region-of interest tracking, color-based tracking, tag masking and tracking, and corner detection. Although object-tracking and 6D pose estimation is a rich field, space applications are a unique problem that are challenging for existing software and toolkits. The majority of the existing object-tracking applications involve vehicles/pedestrians and household objects with simple backgrounds. We have identified the following features which pose particular challenges for on-station exercise equipment tracking: Busy and visually cluttered background Low-textured tracking object with relatively small motions Occlusions and motion by human subject and loose, floating objects Limited number of video cameras with no fixed global references Limited ability to add tags, markers, or visual references to the tracking object Lack of training data for Machine Learning (ML) algorithms CONCLUSION We will summarize the efficacy of techniques tested for a ground mock-trial and the on-station exercise trial. It is likely that human-in-loop feedback or a conglomerate of methods is required. ML-based methods, like those implemented for human body tracking [2], may still be a viable option, but more training data and validation is needed.

L B Nilsson↗

Developing Methods for Exercise System Kinematic Tracking

BACKGROUND How to quantify the load and forces produced by exercise equipment and their Vibration Isolation and Stabilization (VIS) platforms in-flight is an active area of investigation. Kinematic tracking paired with system modeling can provide insights as well as verification and validation of simulations used for system design and development. Traditional motion capture methods can require significant cost in equipment procurement and crew-time, but newer lessons learned can be leveraged [1]. The VIS systems of current and future exercise hardware on the International Space Station (ISS) such as the Cycle Ergometer with Vibration Isolation System (CEVIS) and the European Enhanced Exploration Exercise Device (E4D) are not currently outfitted with IMUs or similar measurement devices. Video-based methods would enable use of multi-purpose, crew-familiar flight equipment. An initial exploration of video-based solutions was performed utilizing 2-camera video from crew cycling on Teal-CEVIS on the ISS. METHODS AND RESULTS Our group has scoped a variety of video-based object tracking methods. To date, we have primarily investigated computer vision toolkits such as open CV. Techniques explored include key-point detection, background subtraction, region-of interest tracking, color-based tracking, tag masking and tracking, and corner detection. Although object-tracking and 6D pose estimation is a rich field, space applications are a unique problem that are challenging for existing software and toolkits. The majority of the existing object-tracking applications involve vehicles/pedestrians and household objects with simple backgrounds. We have identified the following features which pose particular challenges for on-station exercise equipment tracking: 1. Busy and visually cluttered background 2. Low-textured tracking object with relatively small motions 3. Occlusions and motion by human subject and loose, floating objects 4. Limited number of video cameras with no fixed global references 5. Limited ability to add tags, markers, or visual references to the tracking object 6. Lack of training data for Machine Learning (ML) algorithms CONCLUSION We will summarize the efficacy of techniques tested for a ground mock-trial and the on-station exercise trial. It is likely that human-in-loop feedback or a conglomerate of methods is required. ML-based methods, like those implemented for human body tracking [2], may still be a viable option, but more training data and validation is needed.

L Nilsson↗

CyanoSCape: Freshwater Phytoplankton and Floating Aquatic Vegetation Biodiversity

In Southern Africa, the impacts of anthropogenic activities on biodiversity and ecosystem services are exacerbated by the climate crisis. Rapid land use change and the lack of emphasis on environmentally sustainable agricultural practices has hindered hydrological processes and compromised riverine and aquatic ecosystems. This poses obvious risks to natural/indigenous aquatic biodiversity and long-term ecosystem sustainability. Phytoplankton serve as the foundation of the freshwater food web with zooplankton as consumers, which feed fish, invertebrates, and so on up the food chain that comprises the biodiversity of the freshwater system that serves as habitat for biodiversity as well. The diversity of phytoplankton (microscopic organisms) includes photosynthesizing bacteria (cyanobacteria), plant-like diatoms, dinoflagellates, and green algae. Nutrient run-off from agricultural fertilizers and urban overflows, warm temperatures, abundant light availability and compromised hydrological systems provide an ideal environment for cyanobacteria to flourish. Increased prevalence of cyanobacteria, due to both natural and anthropogenic causes, can incur significant effects on the biodiversity of the overall phytoplankton assemblage. These bloom forming algae can significantly outcompete other phytoplankton classes in warmer and eutrophic waters where they are quick to dominate the freshwater system. Eutrophication and toxic cyanobacteria blooms (cyanoHABs) in the inland waters of the Greater Cape Floristic Region (GCFR) incur significant effects on the biodiversity of the overall phytoplankton assemblage and provide a favorable environment forthe overgrowth of floating aquatic vegetation (FAV), which is often invasive and associated with reduced aquatic biodiversity. The algal biodiversity of the GCFR’s freshwater systems is not well characterized. Hyperspectral optical observations are expected to facilitate the improvement of current phytoplankton functional type retrievals significantly, as the sensitivity is sufficient that the distinctive, fine spectral features of different phytoplankton groups can be detected. This will enable testing emerging algorithms and inform the development of new algorithms for use with upcoming hyperspectral satellite missions in this decade. Innovations in optical sensor sensitivity and next generation machine learning capabilities considerably enhance the potential for accurate and rapid detection of phytoplankton, namely the presence, extent, and diversity of cyanobacteria present in cyanoHABs and additionally, invasive FAV. Upcoming hyperspectral satellite missions such as NASA’s Surface Biology and Geology (SBG), Plankton, Aerosol, Cloud, ocean Ecosystem (PACE), and the European Space Agency’s Copernicus Hyperspectral Imaging Mission (CHIME) will provide imagery with unprecedented spectral and spatial resolution which will further enable the discovery of linkages between the seasonality and dynamics of HABs and FAV. The overarching goal of this project is to utilize hyperspectral data, with recently developed and next-generation algorithms, to determine the biodiversity of freshwater systems phytoplankton assemblage with emphasis on genus level distinction, as well as monitor the prevalence and diversity of FAV.

CyanoSCape↗

NASA Pilot-Engaged Expert Response Using IBM Watson Technology: Prototype Evaluation of Knowledge Retrieval System

NASA Langley Research Center and IBM have been investigating the use of IBM Watson technology in aerospace research and development. One application of Watson technology is the Pilot-Engaged Expert Response (PEER) use case. The PEER system is envisioned as an in-cockpit advisor that will act as a source of situationally-relevant information for pilots and other flight crew members to assist in decision making about real-time events and situations that arise in the course of aircraft operations. PEER will make available vast stores of knowledge and information quickly and directly, putting important informational resources where they are needed most. IBM has worked with NASA to develop an architecture and articulate a roadmap for the development of the PEER system. That vision is built around Watson Discovery Advisor (WDA) software solution, derived from IBM's Jeopardy!-winning automatic question answering system. PEER makes use of WDA's sophisticated question-answering capabilities as its core, adding important User Interface components and other customizations for the cockpit environment, including communication with flight systems and other external data sources. The development plan for PEER includes four development stages, with the current project constituting the first phase. In this project, a prototype instance of PEER was successfully adapted to the aviation domain, enabling users to ask questions about aviation topics and receive useful and accurate answers to these questions. Major tasks accomplished include the development of procedures for domain adaptation through automatic lexicon extraction from domain glossaries; generation of question-answer training data which was used to train the system; and assessment of the effectiveness of domain adaptation, which showed a dramatic improvement in the ability of the PEER system to answer domain-relevant questions. In addition, the vision for the PEER system was pushed forward by the articulation of a plan for the automatic enhancement of question-answering with contextual information. This initial phase focused on two main goals: 1) the targeted domain adaptation of the underlying WDA system to the aviation domain; and, 2) the design of the software systems needed to leverage flight-contextual data. Domain adaptation of the WDA system proceeds via three main activities: Domain data ingestion, lexical customization and model training. A textual corpus consisting of 1,147 individual documents with more than 7.5 million words of text was ingested into the system and this served as the basis of all further development. A domain lexicon of over 3,500 aviation-domain terms was semi-automatically generated from domain documents and used to train the system. In addition, a set of over 500 question-answer (QA) pairs relevant to the PEER use case was developed; these were used to train and assess the system. These important first steps established the basis for the PEER system. In addition, steps were taken towards the integration of the PEER system into the cockpit environment with the development of a functional design for the Contextual Data Augmentation (CDA) subsystem. This subsystem brings to bear contextual data to improve system responses. It has three main submodules: the Contextual Data Collection module, the Contextual Data Selection module, and the Contextual QA Augmentation module. These modules form a processing pipeline that addresses the problems associated with automatically integrating information from external resources into the knowledge-retrieval mechanism.

Machine learning↗

Achieving Accuracy Requirements for Forest Biomass Mapping: A Data Fusion Method for Estimating Forest Biomass and LiDAR Sampling Error with Spaceborne Data

The synergistic use of active and passive remote sensing (i.e., data fusion) demonstrates the ability of spaceborne light detection and ranging (LiDAR), synthetic aperture radar (SAR) and multispectral imagery for achieving the accuracy requirements of a global forest biomass mapping mission. This data fusion approach also provides a means to extend 3D information from discrete spaceborne LiDAR measurements of forest structure across scales much larger than that of the LiDAR footprint. For estimating biomass, these measurements mix a number of errors including those associated with LiDAR footprint sampling over regional - global extents. A general framework for mapping above ground live forest biomass (AGB) with a data fusion approach is presented and verified using data from NASA field campaigns near Howland, ME, USA, to assess AGB and LiDAR sampling errors across a regionally representative landscape. We combined SAR and Landsat-derived optical (passive optical) image data to identify forest patches, and used image and simulated spaceborne LiDAR data to compute AGB and estimate LiDAR sampling error for forest patches and 100m, 250m, 500m, and 1km grid cells. Forest patches were delineated with Landsat-derived data and airborne SAR imagery, and simulated spaceborne LiDAR (SSL) data were derived from orbit and cloud cover simulations and airborne data from NASA's Laser Vegetation Imaging Sensor (L VIS). At both the patch and grid scales, we evaluated differences in AGB estimation and sampling error from the combined use of LiDAR with both SAR and passive optical and with either SAR or passive optical alone. This data fusion approach demonstrates that incorporating forest patches into the AGB mapping framework can provide sub-grid forest information for coarser grid-level AGB reporting, and that combining simulated spaceborne LiDAR with SAR and passive optical data are most useful for estimating AGB when measurements from LiDAR are limited because they minimized forest AGB sampling errors by 15 - 38%. Furthermore, spaceborne global scale accuracy requirements were achieved. At least 80% of the grid cells at 100m, 250m, 500m, and 1km grid levels met AGB density accuracy requirements using a combination of passive optical and SAR along with machine learning methods to predict vegetation structure metrics for forested areas without LiDAR samples. Finally, using either passive optical or SAR, accuracy requirements were met at the 500m and 250m grid level, respectively.

Montesano, P. M.↗

Genomics Study of Effect of Redox-Active Metalloporphyrin on Murine Retina During Spaceflight

Astronauts returning from spaceflight have experienced eye problems, which may decrease retinal performance and lead to long-term effects on visual acuity. This study leverages the collected data from spaceflown murine retinas that were treated with redox-active metalloporphyrin (BuOE) to mitigate spaceflight-induced changes. 10-week-old adult C57BL/6 male mice (n=5 in each of BuOE treated and saline control groups) were flown on Space-X 24 to the ISS national lab, kept in low earth orbit for 35 days and returned to Earth alive. Our analysis of RNA-sequencing data generated from subsequent murine retina tissues uncovered genes, pathways, and epigenetic modifications consistent with therapeutic potential of BuOE. For spaceflown murine samples, the treatment group show differentially expressed genes relative to saline controls that reached significance (adjusted p-value < 0.05) and included genes Gpx3 and Crhbp, which are related to protection against cell oxidative damage and cellular response to organonitrogen compounds. Ranked fold-changes from the same contrast were used for gene set enrichment analysis, which showed biological processes reaching significance (adjusted p-value < 0.05) including glutathione metabolic processes and cellular response to xenobiotic stimulus. The findings from this investigation have the potential to provide valuable insights into the molecular mechanisms underlying conditions like spaceflight associated neuro-ocular syndrome and assess the effectiveness of BuOE as a countermeasure for astronauts experiencing neuro-ophthalmic abnormalities, which can lead to long-term effects on visual acuity.

Machine Learning↗

Genomics Study of Effect of Redox-Active Metalloporphyrin on Murine Retina During Spaceflight

Astronauts returning from spaceflight have experienced eye problems, which may decrease retinal performance and lead to long-term effects on visual acuity. This study leverages the collected data from spaceflown murine retinas that were treated with redox-active metalloporphyrin (BuOE) to mitigate spaceflight-induced changes. 10-week-old adult C57BL/6 male mice (n=5 in each of BuOE treated and saline control groups) were flown on Space-X 24 to the ISS national lab, kept in low earth orbit for 35 days and returned to Earth alive. Our analysis of RNA-sequencing data generated from subsequent murine retina tissues uncovered genes, pathways, and epigenetic modifications consistent with therapeutic potential of BuOE. For spaceflown murine samples, the treatment group show differentially expressed genes relative to saline controls that reached significance (adjusted p-value < 0.05) and included genes Gpx3 and Crhbp, which are related to protection against cell oxidative damage and cellular response to organonitrogen compounds. Ranked fold-changes from the same contrast were used for gene set enrichment analysis, which showed biological processes reaching significance (adjusted p-value < 0.05) including glutathione metabolic processes and cellular response to xenobiotic stimulus. The findings from this investigation have the potential to provide valuable insights into the molecular mechanisms underlying conditions like spaceflight associated neuro-ocular syndrome and assess the effectiveness of BuOE as a countermeasure for astronauts experiencing neuro-ophthalmic abnormalities, which can lead to long-term effects on visual acuity.

Machine Learning↗

Ares Launch Vehicles Overview: Space Access Society

America is returning to the Moon in preparation for the first human footprint on Mars, guided by the U.S. Vision for Space Exploration. This presentation will discuss NASA's mission, the reasons for returning to the Moon and going to Mars, and how NASA will accomplish that mission in ways that promote leadership in space and economic expansion on the new frontier. The primary goals of the Vision for Space Exploration are to finish the International Space Station, retire the Space Shuttle, and build the new spacecraft needed to return people to the Moon and go to Mars. The Vision commits NASA and the nation to an agenda of exploration that also includes robotic exploration and technology development, while building on lessons learned over 50 years of hard-won experience. NASA is building on common hardware, shared knowledge, and unique experience derived from the Apollo Saturn, Space Shuttle, and contemporary commercial launch vehicle programs. The journeys to the Moon and Mars will require a variety of vehicles, including the Ares I Crew Launch Vehicle, which transports the Orion Crew Exploration Vehicle, and the Ares V Cargo Launch Vehicle, which transports the Lunar Surface Access Module. The architecture for the lunar missions will use one launch to ferry the crew into orbit, where it will rendezvous with the Lunar Module in the Earth Departure Stage, which will then propel the combination into lunar orbit. The imperative to explore space with the combination of astronauts and robots will be the impetus for inventions such as solar power and water and waste recycling. This next chapter in NASA's history promises to write the next chapter in American history, as well. It will require this nation to provide the talent to develop tools, machines, materials, processes, technologies, and capabilities that can benefit nearly all aspects of life on Earth. Roles and responsibilities are shared between a nationwide Government and industry team. The Exploration Launch Projects Office at the Marshall Space Flight Center manages the design, development, testing, and evaluation of both vehicles and serves as lead systems integrator. A little over a year after it was chartered, the Exploration Launch Projects team is testing engine components, refining vehicle designs, performing wind tunnel tests, and building hardware for the first flight test of Ares I-X, scheduled for spring 2009. The Exploration Launch Projects team conducted the Ares I System Requirements Review (SRR) at the end of 2006. In Ares' first year, extensive trade studies and evaluations were conducted to refine the design initially recommended by the Exploration Systems Architecture Study, conceptual designs were analyzed for fitness, and the contractual framework was assembled to enable a development effort unparalleled in American space flight since the Space Shuttle. Now, the project turns its focus to the Preliminary Design Review (PDR), scheduled for 2008. Taking into consideration the findings of the SRR, the design of the Ares I is being tightened and refined to meet the safety, operability, reliability, and affordability goals outlined by the Constellation Program. The Ares V is in the early design stage, focusing its activities on requirements validation and ways to develop this heavy-lift system so that synergistic hardware commonality between it and the Ares I can reduce the operational footprint and foster sustained exploration across the decades ahead.

Cook, Steve↗

Predictive Modeling for Differential Diagnosis and Mortality Risk Assessment

The prevalence of electronic health record (EHR) systems has brought prodigious biomedical informatics opportunity. Automated machine learning methods can effectively utilize such data and have become common tools for healthcare predictive modeling. Researches in medical informatics have explored the potential of deep learning and classical models in emergent care scenarios. In particular, predicting differential diagnoses for admissions have proven useful in decreasing unnecessary lab tests and improving inpatient triage decision-making. Moreover, identification of high-risk patients for in-hospital mortality is vitally important to maximize allocation of medical resources.The Medical Information Mart for Intensive Care (MIMIC-III) database, containing de-identified critical care inpatient was used in our study. This data set captures hospital patient laboratory measurements, pharmacologic prescriptions, diagnostic data and procedure event recordings. When considering adult patients and discounting admissions with ICU length of stay less than 24 hours, there were 37,787 unique admissions and 30,414 total patients. We examined the top 25 most prevalent ICD-9 group-level disease specificities in MIMIC-III using a multi-label classification model. In-hospital mortality was modeled as binary classification with 4,155 (13%) adult patients that expired, of which 3,138 (75.5%) were in the ICU setting. The metrics AUC, F1 score, sensitivity and specificity values calculated for each disease label measured prediction performance.The usage of ICD-9 group codes reduced feature dimension from 14,567 to 942 and greatly improved distribution of patient diagnostic categories. Disease temporal patterns were captured by considering the most frequently sampled 6 vital signs and 13 laboratory values. Missing data were imputed at each time-stamp. Time-series raw hourly average values were converted into 5 summary features (mean, standard deviation, number of observations, min & max values). Patient demographic variables such as age, gender, marital status and ethnicity were also factored into the modeling. Choi et al showed that contextual embedding of medical data, diagnostic and procedural codes alone can predict future diagnoses with sensitivity as high as 0.79. We utilized an embedding technique called word2vec which allowed sparse representations of medical history to be transformed into dense word vectors. The mappings captured contextual information by treating each admission as a sentence and learning the most likely neighboring words in a sliding window fashion. Binary and multi-label classification was achieved via collapse models, which do not consider temporal information, as well as recurrent neural networks with regularization, Softmax output layer activation together with categorical cross-entropy as the loss function.

US Army collaboration↗