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Programming Structural Synthesis System (PROSSS) provides structural synthesis capability by combining SPAR and CONMIN computer programs with set of interface procedures. SPAR is large general-purpose finite-element structural-analysis program, and CONMIN is large general-purpose optimization program. User supplies two small problem-dependent programs to define design variables, constraints, and objective function.
Abstract not provided.
The F100 Multivariable control synthesis (MVCS) program, was aimed at demonstrating the benefits of LGR synthesis theory in the design of a multivariable engine control system for operation throughout the flight envelope. The advantages of such procedures include: (1) enhanced performance from cross-coupled controls, (2) maximum use of engine variable geometry, and (3) a systematic design procedure that can be applied efficiently to new engine systems. The control system designed, under the MVCS program, for the Pratt & Whitney F100 turbofan engine is described. Basic components of the control include: (1) a reference value generator for deriving a desired equilibrium state and an approximate control vector, (2) a transition model to produce compatible reference point trajectories during gross transients, (3) gain schedules for producing feedback terms appropriate to the flight condition, and (4) integral switching logic to produce acceptable steady-state performance without engine operating limit exceedance.
Programming System for Structural Synthesis, EAL/PROSSS, provides structural-synthesis capability by combining EAL and CONMIN computer programs with set of interface procedures. EAL is general-purpose finiteelement structural-analysis program; CONMIN is general-purpose optimization program. User supplies two smaller problem-dependent programs to define design variables, constraints, and objective function.
An interactive digital computer program for modal analysis and gain estimation for eigensystem synthesis was written. Both mathematical and operation considerations are described; however, the mathematical presentation is limited to those concepts essential to the operational capability of the program. The program is capable of both modal and spectral synthesis of multi-input control systems. It is user friendly, has scratchpad capability and dynamic memory, and can be used to design either state or output feedback systems.
A computer program for spectral synthesis has been developed, based on a list of data for atomic lines described by Kurucz, Peytremann, and Avrett (1973). To demonstrate the usefulness of this program, we present a sample calculation of the region around the C IV resonance doublet at 155 nm, which is a feature in rocket and satellite spectra of B stars. The calculation indicates that the observed feature is a blend of many lines in addition to C IV, so that detailed calculations are necessary for the correct interpretation of the observational data.
A computer code for Preliminary Aircraft Structural Synthesis provides rapid and accurate analysis for aircraft structures that can be adequately modeled by beam finite elements. The philosophy used in developing the program was to provide a basic framework that can be used for structural synthesis. It is anticipated that a user will need to add detail to this framework in order to perform his specific task. With this philosophy in mind, the program was written so that it is easily divided into segments, thereby making it readily adaptable. The theoretical portion of this manual describes the basic structure of the program and details the development of the unique beam element that is used. The present capability of the algorithm is stated and suggestions are made regarding enhancements to this capability. User information is also given that provides an overview of the program's construction, identifies the required inputs, describes the program output, provides some comments on the program use, and exhibits results for a simple example.
Integrated approach to structural synthesis of three-dimensional truss with arbitrary number of nodes, members and topology, noting two programs of synthesis
Integrated approach to structural synthesis of three-dimensional truss with arbitrary number of nodes, members and topology, noting two programs of synthesis
Computer programs for the synthesis of shells of various configurations were developed. The conditions considered are: (1) uniform shells (mainly cones) using a membrane buckling analysis, (2) completely uniform shells (cones, spheres, toroidal segments) using linear bending prebuckling analysis, and (3) revision of second design process to reduce the number of design variables to about 30 by considering piecewise uniform designs. A perturbation formula was derived and this allows exact derivatives of the general buckling load to be computed with little additional computer time.
Automated Design Synthesis (ADS) program is general-purpose numerical optimization program containing wide variety of algorithms. Assumed user prepares analysis problem capable of computing objective function and constraints. Program able to accept as part of input design variable quantities. Optimization process carried out by ADS coupled with user's program. ADS used for constrained and unconstrained function minimization. Solution of general problem separated into three basic levels: Strategy, Optimizer, and One-Dimensional Search. Already significant applications in area of structural synthesis (minimum-weight design).
This paper describes our research in automating the reuse process through the use of application domain models. Application domain models are explicit formal representations of the application knowledge necessary to understand, specify, and generate application programs. Furthermore, they provide a unified repository for the operational structure, rules, policies, and constraints of a specific application area. In our approach, domain models are expressed in terms of a transaction-based meta-modeling language. This paper has described in detail the creation and maintenance of hierarchical structures. These structures are created through a process that includes reverse engineering of data models with supplementary enhancement from application experts. Source code is also reverse engineered but is not a major source of domain model instantiation at this time. In the second phase of the software synthesis process, program specifications are interactively synthesized from an instantiated domain model. These specifications are currently integrated into a manual programming process but will eventually be used to derive executable code with mechanically assisted transformations. This research is performed within the context of programming-in-the-large types of systems. Although our goals are ambitious, we are implementing the synthesis system in an incremental manner through which we can realize tangible results. The client/server architecture is capable of supporting 16 simultaneous X/Motif users and tens of thousands of attributes and classes. Domain models have been partially synthesized from five different application areas. As additional domain models are synthesized and additional knowledge is gathered, we will inevitably add to and modify our representation. However, our current experience indicates that it will scale and expand to meet our modeling needs.
Computer program listings as well as graphical and tabulated data needed by the analyst to perform a BRAVO analysis were examined. Graphical aid which can be used to determine the earth coverage of satellites in synchronous equatorial orbits was described. A listing for satellite synthesis computer program as well as a sample printout for the DSCS-11 satellite program and a listing of the symbols used in the program were included. The APL language listing for the payload program cost estimating computer program was given. This language is compatible with many of the time sharing remote terminals computers used in the United States. Data on the intelsat communications network was studied. Costs for telecommunications systems leasing, line of sight microwave relay communications systems, submarine telephone cables, and terrestrial power generation systems were also described.
Abstract Linear actuators are ubiquitous components at all scales of engineering. DNA nanotechnology offers a unique opportunity for bottom‐up assembly at the molecular scale, providing nanoscale precision with multiple methods for constructing and operating devices. In this paper, DNA origami linear actuators with up to 200 nm travel, based on a rail threading a topologically locked slider, are demonstrated. Two strategies, one‐ and two‐pot assembly, are demonstrated whereby the two components are folded from one or two DNA scaffold strands, respectively. In order to control the position of the slider on the rail, the rail and the inside of the slider are decorated with single‐stranded oligonucleotides with distinct sequences. Two positioning strategies, based on diffusion and capture of signaling strands, are used to link the slider reversibly to determined positions on the rail with high yield and precision. These machine components provide a basis for applications in molecular machinery and nanoscale manufacture including programmed chemical synthesis.
Gas fermentation by autotrophic bacteria, such as clostridia, offers a sustainable path to numerous bioproducts from a range of local, highly abundant, waste and low-cost feedstocks, such as industrial flue gases or syngas generated from biomass or municipal waste. Unfortunately, designing and engineering clostridia remains laborious and slow. The ability to prototype individual genetic part function, gene expression patterns, and biosynthetic pathway performance in vitro before implementing designs in cells could help address these bottlenecks by speeding up design. Unfortunately, a high-yielding cell-free gene expression (CFE) system from clostridia has yet to be developed. Here in this paper, we report the development and optimization of a high-yielding (236 ± 24 μg/mL) batch CFE platform from the industrially relevant anaerobe, Clostridium autoethanogenum. A key feature of the platform is that both circular and linear DNA templates can be applied directly to the CFE reaction to program protein synthesis. We demonstrate the ability to prototype gene expression, and quantitatively map aerobic cell-free metabolism in lysates from this system. We anticipate that the C. autoethanogenum CFE platform will not only expand the protein synthesis toolkit for synthetic biology, but also serve as a platform in expediting the screening and prototyping of gene regulatory elements in non-model, industrially relevant microbes.
Scientific user facilities, such as synchrotron beamlines, are equipped with a wide array of hardware and software tools that require a codebase for human-computer-interaction. This often necessitates developers to be involved to establish connection between users/researchers and the complex instrumentation. The advent of generative AI presents an opportunity to bridge this knowledge gap, enabling seamless communication and efficient experimental workflows. Here we present a modular architecture for the Virtual Scientific Companion by assembling multiple AI-enabled cognitive blocks that each scaffolds large language models (LLMs) for a specialized task. With VISION, we performed LLM-based operation on the beamline workstation with low latency and demonstrated the first voice-controlled experiment at an x-ray scattering beamline. The modular and scalable architecture allows for easy adaptation to new instruments and capabilities. Development on natural language-based scientific experimentation is a building block for an impending future where a science exocortex—a synthetic extension to the cognition of scientists—may radically transform scientific practice and discovery.
This project was funded by the Bioenergy Engineering for Product Synthesis (BEEPS) program under the Funding Opportunity Announcement (FOA) DE-FOA-0001916 Topic Area 5 “Rewiring Carbon Utilization”. This FOA sought projects that would electrocatalytically reduce CO 2 to a carbon intermediate and then upconvert to a multi-carbon product or fuel via non-photosynthetic biological system engineering. The project sought to combine the expertise of OCO Chem, whose chief scientist had previously developed an efficient electrocatalytic reactor for conversion of CO 2 to formate with potential to scale, Montana State University investigators who had recently patented a method for laterally grading membranes with the potential of improving reactant distribution and more uniform efficiency across membrane-based reactors, and University of South Florida which had recently discovered a novel C-C bond forming reaction not known to naturally occur in biological systems and which uses C1 substrates and circumvents the central microbial metabolism.
Neutron-capture elements, those with Z > 35, are the least well understood in terms of nucleosynthesis and formation environments. The rapid neutron-capture, or r -process, elements are formed in the environments and/or remnants of massive stars, while the slow neutron-capture, or s -process, elements are primarily formed in low-mass AGB stars. These elements can provide much information about Galactic star formation and enrichment, but observational data are limited. We have assembled a sample of 68 stars in 23 open clusters that we use to probe abundance trends for six neutron-capture elements (Eu, Gd, Dy, Mo, Pr, and Nd) with cluster age and location in the disk of the Galaxy. In order to keep our analysis as homogeneous as possible, we use an automated synthesis fitting program, which also enables us to measure multiple (3–10) lines for each element. We find that the pure r -process elements (Eu, Gd, and Dy) have positive trends with increasing cluster age, while the mixed r - and s -process elements (Mo, Pr, and Nd) have insignificant trends consistent with zero. Pr, Nd, Eu, Gd, and Dy have similar, slight (although mostly statistically significant) gradients of ∼0.04 dex kpc{sup −1}. The mixed elements also appear to have nonlinear relationships with R {sub GC}.