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At least 181 records · Page 10

Effect of hindlimb suspension and clenbuterol treatment on polyamine levels in skeletal muscle

Polyamines are unbiquitous, naturally occurring small aliphatic, polycationic, endogenous compounds. They are involved in many cellular processes and may serve as secondary or tertiary messengers to hormonal regulation. The relationship of polyamines and skeletal muscle mass of adductor longus, extensor digitorum longus, and gastrocnemius under unloading (hindlimb suspension) conditions was investigated. Unloading significantly affected skeletal muscle polyamine levels in a fiber-type-specific fashion. Under loading conditions, clenbuterol treatment increased all polyamine levels, whereas under unloading conditions, only the spermidine levels were consistently increased. Unloading attenuated the anabolic effects of clenbuterol in predominately slow-twitch muscles (adductor longus), but had little impact on clenbuterol's action as a countermeasure in fast- twitch muscles such as the extensor digitorum longus. Spermidine appeared to be the primary polyamine involved in skeletal muscle atrophy/hypertrophy. Copyright 2002 S. Karger AG, Basel.

NASA Discipline Musculoskeletal↗

Global Mapping of Underwater UV Irradiances and DNA-Weighted Exposures using TOMS and SeaWiFS Data Products

The global stratospheric ozone-layer depletion results In an increase in biologically harmful ultraviolet (UV) radiation reaching the surface and penetrating to ecologically significant depths in natural waters. Such an increase can be estimated on a global scale by combining satellite estimates of UV irradiance at the ocean surface from the Total Ozone Mapping Spectrometer (TOMS) satellite instrument with the SeaWIFS satellite ocean-color measurements in the visible spectral region. In this paper we propose a model of seawater optical properties in the UV spectral region based on the Case I water model in the visible range. The inputs to the model are standard monthly SeaWiFS products: chlorophyll concentration and the diffuse attenuation coefficient at 490nm. Penetration of solar UV radiation to different depths in open ocean waters is calculated using the RT (radiative transfer) quasi-single scattering approximation (QSSA). The accuracy of the QSSA approximation in the water is tested using more accurate codes. The sensitivity study of the underwater UV irradiance to atmospheric and oceanic optical properties have shown that the main environmental parameters controlling the absolute levels of the UVB (280-320nm) and DNA-weighted irradiance underwater are: solar-zenith angle, cloud transmittance, water optical properties, and total ozone. Weekly maps of underwater UV irradiance and DNA-weighted exposure are calculated using monthly-mean SeaWiFS chlorophyll and diffuse attenuation coefficient products, daily SeaWiFS cloud fraction data, and the TOMS-derived surface UV irradiance daily maps. The final products include global maps of weekly-average UVB irradiance and DNA-weighted daily exposures at 3m and 10m, and depths where the UVB irradiance and DNA-weighted dose rate at local noon are equal to 10% of their surface values.

Vasilkov, Alexander↗

Remote Raman Sensor System for Testing of Rocks and Minerals

Recent and future explorations of Mars and lunar surfaces through rovers and landers have spawned great interest in developing an instrument that can perform in-situ analysis of minerals on planetary surfaces. Several research groups have anticipated that for such analysis, Raman spectroscopy is the best suited technique because it can unambiguously provide the composition and structure of a material. A remote pulsed Raman spectroscopy system for analyzing minerals was demonstrated at NASA Langley Research Center in collaboration with the University of Hawaii. This system utilizes a 532 nm pulsed laser as an excitation wavelength, and a telescope with a 4-inch aperture for collecting backscattered radiation. A spectrograph equipped with a super notch filter for attenuating Rayleigh scattering is used to analyze the scattered signal. To form the Raman spectrum, the spectrograph utilizes a holographic transmission grating that simultaneously disperses two spectral tracks on the detector for increased spectral range. The spectrum is recorded on an intensified charge-coupled device (ICCD) camera system, which provides high gain to allow detection of inherently weak Stokes lines. To evaluate the performance of the system, Raman standards such as calcite and naphthalene are analyzed. Several sets of rock and gemstone samples obtained from Ward s Natural Science are tested using the Raman spectroscopy system. In addition, Raman spectra of combustible substances such acetone and isopropanol are also obtained. Results obtained from those samples and combustible substances are presented.

Garcia, Christopher S.↗

Estimating Expressed Temperature and Fractional Area of Hot Lava at the Kilauea Vent with AVIRIS Spectral Measurements

Imaging spectroscopy offers a framework based in physics and chemistry for scientific investigation of a wide range of phenomena of interest in the Earth environment. In the scientific discipline of volcanology knowledge of lava temperature and distribution at the surface provides insight into the volcano status and subsurface processes. A remote sensing strategy to measure surface lava temperatures and distribution would support volcanology research. Hot targets such as molten lava emit spectral radiance as a function of temperature. A figure shows a series of Planck functions calculated radiance spectra for hot targets at different temperatures. A maximum Lambertian solar reflected radiance spectrum is shown as well. While similar in form, each hot target spectrum has a unique spectral shape and is distinct from the solar reflected radiance spectrum. Based on this temperature-dependent signature, imaging spectroscopy provides an innovative approach for the remote-sensing-based measurement of lava temperature. A natural site for investigation of the measurement of lava temperature is the Big Island of Hawaii where molten lava from the Kilauea vent is present at the surface. In the past, Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) data sets have been used for the analysis of hot volcanic targets and hot burning fires. The research presented here builds upon and extends this earlier work. The year 2000 Hawaii AVIRIS data set has been analyzed to derive lava temperatures taking into account factors of fractional fill, solar reflected radiance, and atmospheric attenuation of the surface emitted radiance. The measurements, analyses, and current results for this research are presented here.

Green, Robert O.↗

Predicting SLS Launch Environment using a Novel Multiphase Formulation

Powerful acoustic waves generated during ignition of launch vehicles may be dangerous to the vehicle, its payload, or the surrounding structures. The water-based Ignition Overpressure and Sound Suppression (IOP/SS) system at Kennedy Space Center’s (KSC) Launch Complex 39B (LC-39B) will be used to protect the Space Launch System (SLS) from the acoustic vibrations generated during launch. The IOP/SS system uses enormous amounts of water to dampen and attenuate these sound waves. To better understand the launch environment risks and to study the effectiveness of the IOP/SS system it is desirable to have time-accurate unsteady simulations of the vehicle ignition with water-based sound suppression. This paper presents results obtained with a novel, high-order accurate, and robust numerical method designed for simulating compressible multiphase flows. A positivity-preserving finite difference scheme is utilized which is formally high-order accurate and also provably robust. Robustness is critical due to the extreme nature of the flow which exhibits highly nonlinear shock and rarefaction waves interacting with liquid-gas interfaces with density ratios of the order of 1000:1. Furthermore, the high-order accuracy (and the high resolution property) is desirable for predicting wave phenomena like IOP waves since the signal can be resolved accurately and propagated long distances with fewer grid points. This finite-difference method was developed using NASA’s Launch, Ascent, and Vehicle Aerodynamics (LAVA) Cartesian immersed boundary framework. We present a validation case by applying our solver to the SLS Scale Model Acoustic Test (SMAT). The SLS SMAT is a well-instrumented 5% scale model test meant to represent the SLS at NASA KSC’s LC-39B pad. Scale IOP tests were performed with and without the sound suppression water and included many sensors which recorded the pressure waves produced during ignition. For this validation case we conduct two simulations, likewise with and without sound suppression water, and compare the SLS SMAT pressure sensor signals with our numerical signals at identical locations. Following this validation case we present a study of the SLS launch environment to examine engineering safety concerns about the mobile launch pad. Engineers at KSC redesigned the main flame deflector at LC-39B anticipating the increased loads from the SLS and to repair damage from prior Shuttle missions. This deflector redesign made use of surface pressure and temperature data from LAVA full-scale SLS simulations without the sound suppression system. The engineers were questioning the possibility of increased pressure loads on the underside of the mobile launcher due to the water in the flame trench. Based on the results established in our simulations of the SLS SMAT, we performed updated calculations for SLS at LC-39B with and without water systems active to assess the readiness of the launch pad for Artemis I launch. Our results show that the IOP/SS system is effective at reducing the overpressure signal and overall sound pressure levels felt by the vehicle and additionally that the pressure loads experienced by the mobile launcher (ML) during engine startup is not increased by the presence of water.

EGS↗

Second Symposium on Protection Against Radiations in Space

All space vehicles will be exposed to natural charged particle radiation fields. The effects and possible problems imposed by such radiations are of great concern to those actively engaged in the exploration of space. Materials and components, which may be damaged by the radiation, frequently can be replaced by more radiation resistant items; however, replacement systems are not always possible or practical and, hence, protective measures in the form of shielding must be employed. (One of the more radiation-sensitive systems to be flown in space is man himself.) Many groups are engaged in research on the attenuation and penetration of high-energy space radiation and on the development of methods for the design of shielding which affords protection against the radiation. The purpose of the Second Symposium on Protection Against Radiations in Space, like that of the First, was to bring these groups together to exchange information and share ideas. These proceedings are the written record of the Second Symposium. Invited papers covering the space radiation environment, radiobiological effects, and radiation effects on materials and components comprised the first three sessions. By defining the radiation problems in space and providing for the proper assessment of the radiation effects and shielding requirements, these papers helped to establish the necessary background for the shielding papers which followed in the fourth session.

radiation protection↗

Lidar probing of the atmosphere: Some quantitative aspects

Lidar uses laser energy in radar fashion to observe atmospheric backscattering as a function of range. Because of the short optical and near-optical wavelengths used, very small particles and even the gaseous molecules cause significant scattering. This can complicate the evaluation of the observations by introducing attenuation along the path as a second unknown into the lidar equation. In many cases, however, the observations may be interpreted directly on a qualitative basis and show the distribution of particulate matter in clear air or enable the dimensions of visible cloud to be measured accurately. In other cases, particularly where additional data are available, quantitative solutions can provide useful information on remote targets such as tenuous smoke clouds or haze layers. Examples of such observations are given, illustrating the computational approach to the evaluation of the volume concentration of natural dust and haze layers in the lower atmosphere and the mass concentration of a smoke plume. In both cases lidar data are related to independently obtained data on the particulate concentrations involved.

Collis, R. T. H.↗

Naturally induced secondary radiation in interplanetary space: Preliminary analyses for gamma radiation and radioisotope production from thermal neutron activation

Thermal neutron activation analyses were carried out for various space systems components to determine gamma radiation dose rates and food radiation contamination levels. The space systems components selected were those for which previous radiation studies existed. These include manned space vehicle radiation shielding, liquid hydrogen propellant tanks for a Mars mission, and a food supply used as space vehicle radiation shielding. The computational method used is based on the fast neutron distribution generated by the BRYNTRN and HZETRN transport codes for Galactic Cosmic Rays (GCR) at solar minimum conditions and intense solar flares in space systems components. The gamma dose rates for soft tissue are calculated for water and aluminum space vehicle slab shields considering volumetric source self-attenuation and exponential buildup factors. In the case of the lunar habitat with regolith shielding, a completely exposed spherical habitat was assumed for mathematical convenience and conservative calculations. Activation analysis of the food supply used as radiation shielding is presented for four selected nutrients: potassium, calcium, sodium, and phosphorus. Radioactive isotopes that could represent a health hazard if ingested are identified and their concentrations are identified. For nutrients soluble in water, it was found that all induced radioactivity was below the accepted maximum permissible concentrations.

Plaza-Rosado, Heriberto↗

Waveguide Calibrator for Multi-Element Probe Calibration

A calibrator, referred to as the spider design, can be used to calibrate probes incorporating multiple acoustic sensing elements. The application is an acoustic energy density probe, although the calibrator can be used for other types of acoustic probes. The calibrator relies on the use of acoustic waveguide technology to produce the same acoustic field at each of the sensing elements. As a result, the sensing elements can be separated from each other, but still calibrated through use of the acoustic waveguides. Standard calibration techniques involve placement of an individual microphone into a small cavity with a known, uniform pressure to perform the calibration. If a cavity is manufactured with sufficient size to insert the energy density probe, it has been found that a uniform pressure field can only be created at very low frequencies, due to the size of the probe. The size of the energy density probe prevents one from having the same pressure at each microphone in a cavity, due to the wave effects. The "spider" design probe is effective in calibrating multiple microphones separated from each other. The spider design ensures that the same wave effects exist for each microphone, each with an indivdual sound path. The calibrator s speaker is mounted at one end of a 14-cm-long and 4.1-cm diameter small plane-wave tube. This length was chosen so that the first evanescent cross mode of the plane-wave tube would be attenuated by about 90 dB, thus leaving just the plane wave at the termination plane of the tube. The tube terminates with a small, acrylic plate with five holes placed symmetrically about the axis of the speaker. Four ports are included for the four microphones on the probe. The fifth port is included for the pre-calibrated reference microphone. The ports in the acrylic plate are in turn connected to the probe sensing elements via flexible PVC tubes. These five tubes are the same length, so the acoustic wave effects are the same in each tube. The flexible nature of the tubes allows them to be positioned so that each tube terminates at one of the microphones of the energy density probe, which is mounted in the acrylic structure, or the calibrated reference microphone. Tests performed verify that the pressure did not vary due to bends in the tubes. The results of these tests indicate that the average sound pressure level in the tubes varied by only 0.03 dB as the tubes were bent to various angles. The current calibrator design is effective up to a frequency of approximately 4.5 kHz. This upper design frequency is largely due to the diameter of the plane-wave tubes.

Sommerfeldt, Scott D.↗

'Spherical' disks: Moving toward a unified source model for L1551

To predict the effects of a disk on the spectral energy distribution of a deeply embedded protostar, we construct disk models with power-law temperature distributions T is proportional to r(exp -q). We then use the spherically averaged disk emission as the central source for a spherical envelope, hence the term, 'spherical' disk. We then calculate the predicted spectral energy distribution of the disk and envelope, using a spherically symmetric radiative transport code. Applying this procedure to L1551 IRS 5, we find that the predicted far-infrared flux is not very sensitive to the nature of the central source. The best source model is consistent with the far-infrared emission arising from the infalling region in an 'inside-out' collapse model, independent of the nature of the central source. Disk models are superior to the star-only model when we try to match millimeter interferometer data. While disks with various q can reproduce the observed 2.7 mm interferometer flux, only an active disk (q = 0.5) can produce enough emission in a region small enough to match the observed 2.7 mm visibilities. However, if the disk is backwarmed by the envelope, even purely reprocessing disks can meet this constraint. All types of backwarmed disks are virtually in distinguishable in their millimeter properties. We find that all reasonable envelope models are sufficiently opaque in the mid-infrared to attenuate any disk model to a level well below the observations, unless the ratio of the mid-infrared to far-infrared dust opacities is similar to that of the dust opacities advocated by Mathis, Mezger, & Panagia (1983).

Butner, Harold M.↗

Effects of source vs. interactive actuator assumptions on modelling of a smart structure

Embedded or internal actuators in a structure are being utilized to perform vibration attenuation, pointing maneuvers, damage control, and other adaptive tasks. The controls-structures-interaction (CSI) design process depends strongly on the coupled dynamic response of the structure and the actuators. A bond graph approach is used to guide this analytical study to uncover the effects of certain generic actuator types on the closed-loop, initial condition control of a single-mode structural model and an eighteen-state model of an active truss. So-called 'flow' and 'effort' source actuator types were studied and were shown to have significant differences in closed-loop response for ranges of initial conditions and system open-loop natural frequencies.

Robertshaw, Harry H.↗

The Toba Supervolcano Eruption Caused Severe Tropical Stratospheric Ozone Depletion

Supervolcano eruptions have occurred throughout Earth’s history and have major environmental impacts. These impacts are mostly associated with the attenuation of visible sunlight by stratospheric sulfate aerosols, which causes cooling and deceleration of the water cycle. Supereruptions have been assumed to cause so-called volcanic winters that act as primary evolutionary factors through ecosystem disruption and famine, however, winter conditions alone may not be sufficient to cause such disruption. Here we use Earth system model simulations to show that stratospheric sulfur emissions from the Toba supereruption 74,000 years ago caused severe stratospheric ozone loss through a radiation attenuation mechanism that only moderately depends on the emission magnitude. The Toba plume strongly inhibited oxygen photolysis, suppressing ozone formation in the tropics, where exceptionally depleted ozone conditions persisted for over a year. This effect, when combined with volcanic winter in the extra-tropics, can account for the impacts of supereruptions on ecosystems and humanity.

Atmospheric chemistry↗

Depth-Penetrating Temperature Measurements of Thermal Barrier Coatings Incorporating Thermographic Phosphors

Thermographic phosphors have been previously demonstrated to provide effective non-contact, emissivity-independent surface temperature measurements. Because of the translucent nature of thermal barrier coatings (TBCs), thermographic phosphor-based temperature measurements can be extended beyond the surface to provide depth-selective temperature measurements by incorporating the thermographic phosphor layer at the depth where the temperature measurement is desired. In this paper, thermographic phosphor (Y2O3:Eu) fluorescence decay time measurements are demonstrated to provide through-the-coating thickness temperature readings up to 1100 C with the phosphor layer residing beneath a 100 micron thick TBC (plasma-sprayed 8wt% yttria-stabilized zirconia). With an appropriately chosen excitation wavelength and detection configuration, it is shown that sufficient phosphor emission is generated to provide effective temperature measurements, despite the attenuation of both the excitation and emission intensities by the overlying TBC. This depth-penetrating temperature measurement capability should prove particularly useful for TBC diagnostics where a large thermal gradient is typically present across the TBC thickness. The fluorescence decay from the Y2O3:Eu layer exhibited both an initial short-term exponential rise and a longer-term exponential decay. The rise time constant was demonstrated to provide better temperature indication below 500 C while the decay time constant was a better indicator at higher temperatures.

Eldridge, Jeffrey I.↗

The neurochemical basis of photic entrainment of the circadian pacemaker

Circadian rhythmicity in mammals is controlled by the action of a light-entrainable hypothalamus, in association with two cell clusters known as the supra chiasmatic nuclei (SCN). In the absence of temporal environmental clues, this pacemaker continues to measure time by an endogenous mechanism (clock), driving biochemical, physiological, and behavioral rhythms that reflect the natural period of the pacemaker oscillation. This endogenous period usually differs slightly from 24 hours (i.e., circadian). When mammals are maintained under a 24 hour light-dark (LD) cycle, the pacemaker becomes entrained such that the period of the pacemaker oscillation matches that of the LD cycle. Potentially entraining photic information is conveyed to the SCN via a direct retinal projection, the retinohypothalamic tract (RHT). RHT neurotransmission is thought to be mediated by the release of excitatory amino acids (EAA) in the SCN. In support of this hypothesis, recent experiments using nocturnal rodents have shown that EAA antagonists block the effects of light on pacemaker-driven behavioral rhythms, and attenuate light induced gene expression in SCN cells. An understanding of the neurochemical basis of the photic entrainment process would facilitate the development of pharmacological strategies for maintaining synchrony among shift workers in environments, such as the Space Station, which provide unreliable or conflicting temporal photic clues.

Rea, Michael A.↗

Towards Simulating a Realistic Planetary Seismic Wavefield: The Contribution of the Megaregolith and Low-Velocity Waveguides

Lunar seismograms are distinctly different from their terrestrial counterparts. The Apollo lunar seismometers recorded moonquakes without distinct P- or S-wave arrivals; instead waves arrive as a diffuse coda that decays over several hours making the identification of body waves difficult. The unusual character of the lunar seismic wavefield is generally tied to properties of the megaregolith: it consists of highly fractured and broken crustal rock, the result of extensive bombardment of the Moon. The megaregolith extends several kilometers into the lunar crust, possibly into the mantle in some regions, and is covered by a thin coating of fine-scale dust. These materials possess very low seismic velocities that strongly scatter the seismic wavefield at high frequencies. Directly modeling the effects of the megaregolith to simulate an accurate lunar seismic wavefield is a challenging computational problem, owing to the inherent 3-D nature of the problem and the high frequencies (greater than 1 Hz) required. Here we focus on modeling the long duration code, studying the effects of the low velocities found in the megaregolith. We produce synthetic seismograms using 1-D slowness integration methodologies, GEMINI and reflectivity, and a 3-D Cartesian finite difference code, Wave Propagation Program, to study the effect of thin layers of low velocity on the surface of a planet. These codes allow us generate seismograms with dominant frequencies of approximately 1 Hz. For background lunar seismic structure we explore several models, including the recent model of Weber et al., Science, 2011. We also investigate variations in megaregolithic thickness, velocity, attenuation, and seismogram frequency content. Our results are compared to the Apollo seismic dataset, using both a cross correlation technique and integrated envelope approach to investigate coda decay. We find our new high frequency results strongly support the hypothesis that the long duration of the lunar seismic codes is generated by the presence of the low velocity megaregolith, and that the diffuse arrivals are a combination of scattered energy and multiple reverberations within this layer. The 3-D modeling indicates the extreme surface topography of the Moon adds only a small contribution to scattering effects, though local geology may play a larger role. We also study the effects of the megaregolith on core reflected and converted phases and other body waves. Our analysis indicates detection of core interacting arrivals with a polarization filter technique is robust and lends the possibility of detecting other body waves from the Moon.

Schmerr, Nicholas C.↗

Depth-Selective Diagnostics of Thermal Barrier Coatings Incorporating Thermographic Phosphors

Thermographic phosphors have been previously demonstrated to provide effective non-contact, emissivity-independent surface temperature measurements. Because of the translucent nature of thermal barrier coatings (TBCs), thermographic-phosphor-based temperature measurements can be extended beyond the surface to provide depth-selective temperature measurements by incorporating the thermographic phosphor layer at the depth where the temperature measurement is desired. In this paper, thermographic phosphor (Y2O3:Eu) fluorescence decay time measurements are demonstrated for the first time to provide through-the-coating-thickness temperature readings up to 1000 C with the phosphor layer residing beneath a 100-Fm-thick TBC (plasma-sprayed 8wt% yttria-stabilized zirconia). With an appropriately chosen excitation wavelength and detection configuration, it is shown that sufficient phosphor emission is generated to provide effective temperature measurements, despite the attenuation of both the excitation and emission intensities by the overlying TBC. This depth-selective temperature measurement capability should prove particularly useful for TBC diagnostics, where a large thermal gradient is typically present across the TBC thickness.

Eldridge, Jeffrey I.↗

Depth-Selective Diagnostics of Thermal Barrier Coatings Incorporating Thermographic Phosphors

Thermographic phosphors have been previously demonstrated to provide effective non- contact, emissivity-independent surface temperature measurements. Because of the translucent nature of thermal barrier coatings (TBCs), thermographic-phosphor-based temperature measurements can be extended beyond the surface to provide depth-selective temperature measurements by incorporating the thermographic phosphor layer at the depth where the temperature measurement is desired. In this paper, the use of thermographic phosphor (Y2O3:Eu) luminescence decay time measurements is demonstrated for the first time for through-the-thickness temperature readings up to 1000 C with the phosphor placed beneath a 100-micron-thick TBC (plasma-sprayed 8wt% yttria-stabilized zirconia). With an appropriately chosen excitation wavelength and detection configuration, it is shown that sufficient phosphor emission is generated to provide effective temperature measurements, despite the attenuation of both the excitation and emission intensities by the overlying TBC. This depth-selective temperature measurement capability should prove particularly useful for TBC diagnostics, where a large thermal gradient is typically present across the TBC thickness.

Eldridge, J. I.↗

The Impact of Electromagnetic Cascades of Very-high Energy Gamma Rays on the Extragalactic Gamma-ray Background

As very high energy (VHE) photons propagate through the extragalactic background light (EBL), they interact with the soft photons of the EBL and initiate electromagnetic cascades of photons and electrons. The collective intensity of a cosmological population emitting at VHEs (such as blazars) will be attenuated at the highest energies through interactions with the EBL and enhanced at lower energies by the resulting cascade. As such, depending on the space density and spectra of the sources and the model of the EBL, cascade radiation can provide a significant contribution to the extragalactic gamma-ray background (EGB). Through deflections of the charged particles of the cascade, an intergalactic magnetic field (IGMF) may leave an imprint on the anisotropy properties of the EGB. The impact of a strong IGMF is to isotropize lower energy cascade photons, inducing a modulation in the anisotropy energy spectrum of the EGB. We discuss the implications of cascade radiation for the origins of the EGB and the nature of the IGMF, as well as insight that will be provided by data from the Fermi Large Area Telescope in the upcoming years.

Venters, Tonia↗