DOE OSTI · code-167404
Activation Domain Hunter (ADhunter) v2.0
Abstract
ADhunter is a software program that enables accurate identification and quantification of transcriptional activation domains. Unlike previous software, ADhunter uses protein representations from a pre-trained protein language model, model ensembling, and a training dataset from a diverse sampling of protein sequence space for state-of-the-art performance. These advantages enable improved perception of transcriptional activation domains across sequence space that can be used for mapping natural genetic circuits and engineering synthetic genetic circuits. In particular, ADhunter enables fine-tuned control of gene expression through synthetic transcription factors that can be used for complex control of cellular programs.
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Waldburger, Lucas [Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); University of California, Berkeley (UCB); EGSB], Shih, PatrickM. [Joint BioEnergy Institute (JBEI), Emeryville, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); National Technology and Engineering Solutions of Sandia LLC (NTESS) - Sandia National Laboratories (SNL); University of California, Berkeley (UCB); University of California, Davis (UCD)], Staller, Max [University of California, Berkeley (UCB)], Lam, Angelica [University of California, Berkeley (UCB)], Nisonoff, Hunter [University of California, Berkeley (UCB)]. 2025-09-29. Activation Domain Hunter (ADhunter) v2.0. https://doi.org/10.11578/dc.20251017.6
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