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Do We Really Need All That Data: From Data to Agency in Automated Microscopy

Kalinin, Sergei V [Univ. of Tennessee, Knoxville, TN (United States); Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)]·Barakati, Kamyar [Univ. of Tennessee, Knoxville, TN (United States)] (ORCID:0000000334876652)·Slautin, Boris N [Univ. of Tennessee, Knoxville, TN (United States)]·Houston, Austin C [Univ. of Tennessee, Knoxville, TN (United States)] (ORCID:0009000587774686)·Pratiush, Utkarsh [Univ. of Tennessee, Knoxville, TN (United States)]·Duscher, Gerd [Univ. of Tennessee, Knoxville, TN (United States)]·Cao, Charles [Univ. of Tennessee, Knoxville, TN (United States)]·Sgouralis, Ioannis [Univ. of Tennessee, Knoxville, TN (United States)]·Spurgeon, Steven R [National Laboratory of the Rockies (NLR), Golden, CO (United States); Colorado School of Mines, Golden, CO (United States)] (ORCID:000000031218839X)·Yang, Charles [Renaissance Philanthropy, New York, NY (United States)]·Channing, Georgia [Hugging Face (France)]
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Abstract

Microscopy is entering an era of automated laboratories and AI-enabled instruments, often justified by a simple narrative of automating experiments to collect more data and train better models. In this work, we argue that, for microscopy, this framing is incomplete and can be counterproductive.

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97 MATHEMATICS AND COMPUTINGautomationdata analysismachine learningmicroscopy

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Kalinin, Sergei V [Univ. of Tennessee, Knoxville, TN (United States); Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)], Barakati, Kamyar [Univ. of Tennessee, Knoxville, TN (United States)] (ORCID:0000000334876652), Slautin, Boris N [Univ. of Tennessee, Knoxville, TN (United States)], Houston, Austin C [Univ. of Tennessee, Knoxville, TN (United States)] (ORCID:0009000587774686), Pratiush, Utkarsh [Univ. of Tennessee, Knoxville, TN (United States)], Duscher, Gerd [Univ. of Tennessee, Knoxville, TN (United States)], Cao, Charles [Univ. of Tennessee, Knoxville, TN (United States)], Sgouralis, Ioannis [Univ. of Tennessee, Knoxville, TN (United States)], Spurgeon, Steven R [National Laboratory of the Rockies (NLR), Golden, CO (United States); Colorado School of Mines, Golden, CO (United States)] (ORCID:000000031218839X), Yang, Charles [Renaissance Philanthropy, New York, NY (United States)], Channing, Georgia [Hugging Face (France)]. 2026-05-11. Do We Really Need All That Data: From Data to Agency in Automated Microscopy. https://doi.org/10.1093/mictod%2Fqaag035

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