DOE OSTI · 2862035
Barium ion sensing with IPG K + molecular probes
Abstract
Fluorophores covalently bound to azacrown ether ionophores can be assembled into sensitive turn-on chemosensors. The size specificity and electron-rich nature of the ionophore's binding domain contribute to both selectivity and strong turn-on fluorescence sensing by various mechanisms when properly constructed. Aza-18-crown-6 ethers are quite selective for binding to K + and Ba 2+ , yet the more electron-withdrawing dicationic nature of barium imposes a larger electronic effect on turn-on fluorescent sensors. Barium chemosensors can be important for measuring soluble Ba 2+ in drinking water and have gained recent attention for their potential to enhance the detection of rare events in xenon decay. Here we quantify the capability of three chemosensors, marketed for biologically useful K + sensing, as effective probes for Ba 2+ ions. Here, we present measurements from bulk spectrofluorometry to characterize the system in aqueous solutions and demonstrate the usefulness of these species for low-background single-ion fluorescence microscopy, revealing new candidates for Ba 2+ sensing.
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Miller, R. L. [Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019, USA] (ORCID:0009000848255535), Byrnes, N. [Department of Physics, University of Texas at Arlington, Arlington, TX 76019, USA], Cameron, C. G. [Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019, USA] (ORCID:0000000309780894), Carlson, A. J. [Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019, USA], Dey, E. [Department of Physics, University of Texas at Arlington, Arlington, TX 76019, USA], Madigan, R. [Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019, USA], Medina, J. [Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019, USA], Melancon, S. [Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019, USA], Navarro, K. E. [Department of Physics, University of Texas at Arlington, Arlington, TX 76019, USA] (ORCID:0009000909715559), Foss, F. W. [Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019, USA] (ORCID:0000000319406580), Jones, B. J. P. [Department of Physics, University of Texas at Arlington, Arlington, TX 76019, USA], Adams, C. [Argonne National Laboratory, Argonne, IL 60439, USA], Almazán, H. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain], Alvarez, V. [Instituto de Instrumentación para Imagen Molecular (I3M), Centro Mixto CSIC – Universitat Politècnica de València, Camino de Vera s/n, Valencia, E-46022, Spain], Aranburu, A. I. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain], Arazi, L. [Unit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, P.O.B. 653, Beer-Sheva, 8410501, Israel], Arnquist, I. J. [Pacific Northwest National Laboratory (PNNL), Richland, WA 99352, USA], Auria-Luna, F. [Department of Organic Chemistry I, Universidad del Pais Vasco (UPV/EHU), Centro de Innovación en Química Avanzada (ORFEO-CINQA), San Sebastián/Donostia, E-20018, Spain] (ORCID:0000000237260493), Ayet, S. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, Paterna, E-46980, Spain] (ORCID:0000000200531691), Azevedo, C. D. R. [Institute of Nanostructures, Nanomodelling and Nanofabrication (i3N), Universidade de Aveiro, Campus de Santiago, Aveiro, 3810-193, Portugal], Bailey, K. [Argonne National Laboratory, Argonne, IL 60439, USA], Ballester, F. [Instituto de Instrumentación para Imagen Molecular (I3M), Centro Mixto CSIC – Universitat Politècnica de València, Camino de Vera s/n, Valencia, E-46022, Spain], Barcelon, J. E. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain], del Barrio-Torregrosa, M. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain; Department of Physics, Universidad del Pais Vasco (UPV/EHU), PO Box 644, Bilbao, E-48080, Spain] (ORCID:0009000170366476), Bayo, A. [Laboratorio Subterráneo de Canfranc, Paseo de los Ayerbe s/n, Canfranc Estación, E-22880, Spain], Benlloch-Rodriguez, J. M. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain], Borges, F. I. G. M. [LIP, Department of Physics, University of Coimbra, Coimbra, 3004-516, Portugal], Brodolin, A. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain; Centro de Física de Materiales (CFM), CSIC & Universidad del Pais Vasco (UPV/EHU), Manuel de Lardizabal 5, San Sebastián/Donostia, E-20018, Spain], Castillo, A. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain], Church, E. [Pacific Northwest National Laboratory (PNNL), Richland, WA 99352, USA], Cid, L. [Laboratorio Subterráneo de Canfranc, Paseo de los Ayerbe s/n, Canfranc Estación, E-22880, Spain], Conde, C. A. N. [LIP, Department of Physics, University of Coimbra, Coimbra, 3004-516, Portugal], Cortes-Parra, C. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, Paterna, E-46980, Spain], Cossío, F. P. [Department of Organic Chemistry I, Universidad del Pais Vasco (UPV/EHU), Centro de Innovación en Química Avanzada (ORFEO-CINQA), San Sebastián/Donostia, E-20018, Spain] (ORCID:0000000245262122), Coupe, R. [Department of Physics and Astronomy, Manchester University, Manchester, M13 9PL, UK], Dietz, P. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain] (ORCID:0009000218030892), Echevarria, C. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain], Elorza, M. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain; Department of Physics, Universidad del Pais Vasco (UPV/EHU), PO Box 644, Bilbao, E-48080, Spain], Esteve, R. [Instituto de Instrumentación para Imagen Molecular (I3M), Centro Mixto CSIC – Universitat Politècnica de València, Camino de Vera s/n, Valencia, E-46022, Spain], Felkai, R. [Unit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, P.O.B. 653, Beer-Sheva, 8410501, Israel], Fernandes, L. M. P. [LIBPhys, Physics Department, University of Coimbra, Rua Larga, Coimbra, 3004-516, Portugal] (ORCID:0000000270618768), Ferrario, P. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain; Ikerbasque (Basque Foundation for Science), Bilbao, E-48009, Spain], Freixa, Z. [Department of Applied Chemistry, Universidad del Pais Vasco (UPV/EHU), Manuel de Lardizabal 3, San Sebastián/Donostia, E-20018, Spain; Ikerbasque (Basque Foundation for Science), Bilbao, E-48009, Spain], García-Barrena, J. [Instituto de Instrumentación para Imagen Molecular (I3M), Centro Mixto CSIC – Universitat Politècnica de València, Camino de Vera s/n, Valencia, E-46022, Spain], Gómez-Cadenas, J. J. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain; Ikerbasque (Basque Foundation for Science), Bilbao, E-48009, Spain], Grocott, J. W. R. [Department of Physics and Astronomy, Manchester University, Manchester, M13 9PL, UK], Guenette, R. [Department of Physics and Astronomy, Manchester University, Manchester, M13 9PL, UK], Hauptman, J. [Department of Physics and Astronomy, Iowa State University, Ames, IA 50011-3160, USA], Henriques, C. A. O. [LIBPhys, Physics Department, University of Coimbra, Rua Larga, Coimbra, 3004-516, Portugal], Hernando Morata, J. A. [Instituto Gallego de Física de Altas Energías, Univ. de Santiago de Compostela, Campus sur, Rúa Xosé María Suárez Núñez, s/n, Santiago de Compostela, E-15782, Spain], Herrero-Gómez, P. [Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel] (ORCID:0000000215177779), Herrero, V. [Instituto de Instrumentación para Imagen Molecular (I3M), Centro Mixto CSIC – Universitat Politècnica de València, Camino de Vera s/n, Valencia, E-46022, Spain], Hervés Carrete, C. [Instituto Gallego de Física de Altas Energías, Univ. de Santiago de Compostela, Campus sur, Rúa Xosé María Suárez Núñez, s/n, Santiago de Compostela, E-15782, Spain], Ifergan, Y. [Unit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, P.O.B. 653, Beer-Sheva, 8410501, Israel], Kellerer, F. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, Paterna, E-46980, Spain], Larizgoitia, L. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain; Department of Physics, Universidad del Pais Vasco (UPV/EHU), PO Box 644, Bilbao, E-48080, Spain], Larumbe, A. [Department of Organic Chemistry I, Universidad del Pais Vasco (UPV/EHU), Centro de Innovación en Química Avanzada (ORFEO-CINQA), San Sebastián/Donostia, E-20018, Spain], Lebrun, P. [Fermi National Accelerator Laboratory, Batavia, IL 60510, USA], Lopez, F. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain], López-March, N. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, Paterna, E-46980, Spain], Mano, R. D. P. [LIBPhys, Physics Department, University of Coimbra, Rua Larga, Coimbra, 3004-516, Portugal], Marauri, A. [Department of Organic Chemistry I, Universidad del Pais Vasco (UPV/EHU), Centro de Innovación en Química Avanzada (ORFEO-CINQA), San Sebastián/Donostia, E-20018, Spain], Marques, A. P. [LIP, Department of Physics, University of Coimbra, Coimbra, 3004-516, Portugal], Martín-Albo, J. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, Paterna, E-46980, Spain], Martínez, A. [Instituto de Instrumentación para Imagen Molecular (I3M), Centro Mixto CSIC – Universitat Politècnica de València, Camino de Vera s/n, Valencia, E-46022, Spain], Martínez-Lema, G. [Unit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, P.O.B. 653, Beer-Sheva, 8410501, Israel], Martínez-Vara, M. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, Paterna, E-46980, Spain], Mistry, K. [Department of Physics, University of Texas at Arlington, Arlington, TX 76019, USA], Molina-Canteras, J. [Department of Organic Chemistry I, Universidad del Pais Vasco (UPV/EHU), Centro de Innovación en Química Avanzada (ORFEO-CINQA), San Sebastián/Donostia, E-20018, Spain] (ORCID:0000000199531132), Monrabal, F. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain; Ikerbasque (Basque Foundation for Science), Bilbao, E-48009, Spain] (ORCID:0000000240475620), Monteiro, C. M. B. [LIBPhys, Physics Department, University of Coimbra, Rua Larga, Coimbra, 3004-516, Portugal], Mora, F. J. [Instituto de Instrumentación para Imagen Molecular (I3M), Centro Mixto CSIC – Universitat Politècnica de València, Camino de Vera s/n, Valencia, E-46022, Spain], Novella, P. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, Paterna, E-46980, Spain], Nygren, D. R. [Department of Physics, University of Texas at Arlington, Arlington, TX 76019, USA], Oblak, E. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain], Palacio, J. [Laboratorio Subterráneo de Canfranc, Paseo de los Ayerbe s/n, Canfranc Estación, E-22880, Spain], Palmeiro, B. [Department of Physics and Astronomy, Manchester University, Manchester, M13 9PL, UK], Para, A. [Fermi National Accelerator Laboratory, Batavia, IL 60510, USA], Parmaksiz, I. [Department of Physics, University of Texas at Arlington, Arlington, TX 76019, USA], Pazos, A. [Department of Applied Chemistry, Universidad del Pais Vasco (UPV/EHU), Manuel de Lardizabal 3, San Sebastián/Donostia, E-20018, Spain] (ORCID:0000000260746213), Pelegrin, J. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain], Pérez Maneiro, M. [Instituto Gallego de Física de Altas Energías, Univ. de Santiago de Compostela, Campus sur, Rúa Xosé María Suárez Núñez, s/n, Santiago de Compostela, E-15782, Spain], Querol, M. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, Paterna, E-46980, Spain], Renner, J. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, Paterna, E-46980, Spain], Rivilla, I. [Department of Organic Chemistry I, Universidad del Pais Vasco (UPV/EHU), Centro de Innovación en Química Avanzada (ORFEO-CINQA), San Sebastián/Donostia, E-20018, Spain; Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain] (ORCID:0000000319847183), Rogero, C. [Centro de Física de Materiales (CFM), CSIC & Universidad del Pais Vasco (UPV/EHU), Manuel de Lardizabal 5, San Sebastián/Donostia, E-20018, Spain], Rogers, L. [Argonne National Laboratory, Argonne, IL 60439, USA], Romeo, B. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain], Romo-Luque, C. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, Paterna, E-46980, Spain], Ruiz-Choliz, E. [Laboratorio Subterráneo de Canfranc, Paseo de los Ayerbe s/n, Canfranc Estación, E-22880, Spain] (ORCID:0000000224177121), Saharia, P. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, Paterna, E-46980, Spain], Santos, F. P. [LIP, Department of Physics, University of Coimbra, Coimbra, 3004-516, Portugal], dos Santos, J. M. F. [LIBPhys, Physics Department, University of Coimbra, Rua Larga, Coimbra, 3004-516, Portugal], Seemann, M. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain; Department of Physics, Universidad del Pais Vasco (UPV/EHU), PO Box 644, Bilbao, E-48080, Spain], Shomroni, I. [Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel], Silva, A. L. M. [Institute of Nanostructures, Nanomodelling and Nanofabrication (i3N), Universidade de Aveiro, Campus de Santiago, Aveiro, 3810-193, Portugal], Silva, P. A. O. C. [LIBPhys, Physics Department, University of Coimbra, Rua Larga, Coimbra, 3004-516, Portugal], Simón, A. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, Paterna, E-46980, Spain], Soleti, S. R. [Donostia International Physics Center, BERC Basque Excellence Research Centre, Manuel de Lardizabal 4, San Sebastián/Donostia, E-20018, Spain; Ikerbasque (Basque Foundation for Science), Bilbao, E-48009, Spain], Sorel, M. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, Paterna, E-46980, Spain]. 2025-10-17. Barium ion sensing with IPG K + molecular probes. https://doi.org/10.1039/d5an00577a
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