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DOE OSTI · 1855055

Development of Membrane Platforms to Interrogate Host-Pathogen Interactions

Thatcher, Christine E.·Dupree, Amy K.·Webster, Elizabeth R.
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Abstract

Membrane fusion is a critical step in enveloped virus entry and infection; however, molecular understanding of enveloped virus entry and treatment options remain limited. In recent decades, advances in imaging have facilitated the development of methods to study single virus events and membrane organization providing insight towards entry mechanisms. Through these advances, membrane composition and organization have been shown to play a critical role in the entry process. This LDRD uses model membrane platforms and basic biophysics to investigate entry mechanisms of enveloped viruses and understand membrane-based delivery technologies. This team has established foundations for using membrane-based platforms and biophysical techniques at Sandia to characterize membrane fusion.

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Thatcher, Christine E., Dupree, Amy K., Webster, Elizabeth R.. 2021-12-01. Development of Membrane Platforms to Interrogate Host-Pathogen Interactions. https://doi.org/10.2172/1855055

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