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NASA NTRS · 20050000662

Proteolysis, proteasomes and antigen presentation

Goldberg, A. L.·Rock, K. L.
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Abstract

Proteins presented to the immune system must first be cleaved to small peptides by intracellular proteinases. Proteasomes are proteolytic complexes that degrade cytosolic and nuclear proteins. These particles have been implicated in ATP-ubiquitin-dependent proteolysis and in the processing of intracellular antigens for cytolytic immune responses.

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Non-NASA CenterReview, TutorialReviewNASA Discipline MusculoskeletalAntigens/immunology/metabolismProteins/metabolismAntigen-Presenting Cells/immunologyEndopeptidases/metabolismAdenosine Triphosphate/metabolism/pharmacologyT-Lymphocytes/immunologySupport, U.S. Gov't, Non-P.H.SSupport, U.S. Gov't, P.H.SSupport, Non-U.S. Gov'tUbiquitins/pharmacology

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Goldberg, A. L., Rock, K. L.. 1992-06-04. Proteolysis, proteasomes and antigen presentation. https://ntrs.nasa.gov/citations/20050000662

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