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NASA NTRS · 20050000368

Integrating with integrins

Schwartz, M. A.·Ingber, D. E.
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Abstract

Our central claim is that signaling by integrins provides a mechanism by which signals generated in response to adhesion, soluble hormones, and mechanical forces can interact. Such interactions permit cells to integrate these different classes of external stimuli and hence to orchestrate an efficient response. This integrating function of integrins is likely to be essential for much of development and physiology, as well as complex pathologies such as cancer. Understanding in detail how these signals are transduced and processed is likely to be an important area of research in the near future.

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NASA Discipline Cell BiologyNon-NASA CenterReviewReview, TutorialSignal Transduction/physiologyIntegrins/physiologyNeoplasms/metabolism/pathologyExtracellular Matrix/physiologySupport, U.S. Gov't, Non-P.H.SAnimalsHumanSupport, U.S. Gov't, P.H.SSupport, Non-U.S. Gov'tCell Adhesion

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Schwartz, M. A., Ingber, D. E.. 1994-04-01. Integrating with integrins. https://ntrs.nasa.gov/citations/20050000368

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