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NASA NTRS · 20040090244

Collagen in organ development

Hardman, P.·Spooner, B. S.
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Abstract

It is important to know whether microgravity will adversely affect developmental processes. Collagens are macromolecular structural components of the extracellular matrix (ECM) which may be altered by perturbations in gravity. Interstitial collagens have been shown to be necessary for normal growth and morphogenesis in some embryonic organs, and in the mouse salivary gland, the biosynthetic pattern of these molecules changes during development. Determination of the effects of microgravity on epithelial organ development must be preceded by crucial ground-based studies. These will define control of normal synthesis, secretion, and deposition of ECM macromolecules and the relationship of these processes to morphogenesis.

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NASA Discipline Cell BiologyNASA Discipline Developmental BiologyNASA Program NSCORTNASA Discipline Number 93-10Non-NASA CenterCollagen/blood/physiologySalivary Glands/cytology/embryologyExtracellular Matrix/physiologyGlycine/metabolismSupport, U.S. Gov't, P.H.SSupport, U.S. Gov't, Non-P.H.SIn VitroGravitationAnimalsSupport, Non-U.S. Gov'tCarbon Radioisotopes/metabolismEmbryo and Fetal Development/physiologyMice

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Hardman, P., Spooner, B. S.. 1992-01-01. Collagen in organ development. https://ntrs.nasa.gov/citations/20040090244

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