Data for EMSL Project 48680 from February 2023
Explore the source record for details and available documents.
Lipton, Mary↗
Engineering topics
Zhang, Ximo
Publications and source records attributed to Zhang, Ximo.
Cryo-EM reveals the molecular basis of laminin polymerization and LN-lamininopathies
Laminin polymerization is the major step in basement membranes assembly. Its failures cause laminin N-terminal domain lamininopathies including Pierson syndrome. We have employed cryo-electron microscopy to determine a 3.7 Å structure of the trimeric laminin polymer node containing α1, β1 and γ1 subunits. The structure reveals the molecular basis of calcium-dependent formation of laminin lattice, and provides insights into polymerization defects manifesting in human disease.
59 BASIC BIOLOGICAL SCIENCES↗