Engineering topics

Wolf, Jurgen

Publications and source records attributed to Wolf, Jurgen.

3 records

DOE OSTI2018

Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors

Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other lung cancers, but their precise relationship has remained unclear. Here in this paper we perform a comprehensive genomic (n = 60) and transcriptomic (n = 69) analysis of 75 LCNECs and identify two molecular subgroups: “type I LCNECs” with bi-allelic TP53 and STK11/KEAP1 alterations (37%), and “type II LCNECs” enriched for bi-allelic inactivation of TP53 and RB1 (42%). Despite sharing genomic alterations with adenocarcinomas and squamous cell carcinomas, no transcriptional relationship was found; instead LCNECs form distinct transcriptional subgroups with closest similarity to SCLC. While type I LCNECs and SCLCs exhibit a neuroendocrine profile with ASCL1 high /DLL3 high /NOTCH low , type II LCNECs bear TP53 and RB1 alterations and differ from most SCLC tumors with reduced neuroendocrine markers, a pattern of ASCL1 low /DLL3 low /NOTCH high , and an upregulation of immune-related pathways. In conclusion, LCNECs comprise two molecularly defined subgroups, and distinguishing them from SCLC may allow stratified targeted treatment of high-grade neuroendocrine lung tumors.

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS2012

Sofia Observatory Performance and Characterization

The Stratospheric Observatory for Infrared Astronomy (SOFIA) has recently concluded a set of engineering flights for Observatory performance evaluation. These in-flight opportunities have been viewed as a first comprehensive assessment of the Observatory's performance and will be used to address the development activity that is planned for 2012, as well as to identify additional Observatory upgrades. A series of 8 SOFIA Characterization And Integration (SCAI) flights have been conducted from June to December 2011. The HIPO science instrument in conjunction with the DSI Super Fast Diagnostic Camera (SFDC) have been used to evaluate pointing stability, including the image motion due to rigid-body and flexible-body telescope modes as well as possible aero-optical image motion. We report on recent improvements in pointing stability by using an Active Mass Damper system installed on Telescope Assembly. Measurements and characterization of the shear layer and cavity seeing, as well as image quality evaluation as a function of wavelength have been performed using the HIPO+FLITECAM Science Instrument configuration (FLIPO). A number of additional tests and measurements have targeted basic Observatory capabilities and requirements including, but not limited to, pointing accuracy, chopper evaluation and imager sensitivity. SCAI activities included in-flight partial Science Instrument commissioning prior to the use of the instruments as measuring engines. This paper reports on the data collected during the SCAI flights and presents current SOFIA Observatory performance and characterization.

Temi, Pasquale↗

NASA NTRS1991

Far-Infrared Lines from G45.13 + 0.14 and K 3-50 A: Density Fluctuations in Compact H 2 Regions

The far-infrared lines of (O III) 51.8 and 88.4 microns, (N III) 57.3 microns, (S III) 33.5 microns, and (Ne III) 36.0 microns have been measured in the compact H II regions G45.13+0.14 A and K3-50 A. These measurements were made with the facility cooled grating spectrometer on flights of NASA's Kuiper Airborne Observatory. For both sources, the ratio of the two O(++) lines indicates an electron density N(sub e) approx. 10(exp 3)cm(sup -3). For K3-50 A, this is a factor of 10 to a hundred times lower than the density determined from near-infrared and optical line observations of lower excitation species and from radio measurements of the peak continuum emission. A comparison with other far-infrared measurements for both sources shows that the lower excitation, higher critical density S(++) lines originate from higher density material than do the O(++) lines. Detailed, spherically symmetric models for both sources are presented. These models require clumping, different abundances than the Orion Nebula, and an enhancement in the standard Kurucz stellar atmospheres at energies E greater than 41 eV to obtain reasonable agreement with the measurements. The average nitrogen-to-oxygen abundance ratio for these two H II regions is N/O approx. 0.2, in agreement with other far-infrared studies at Galactic radii greater than or equal to 6 kpc.

Colgan, Sean W. J.↗