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Williams, David A.

Publications and source records attributed to Williams, David A..

15 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2023

Predicting chronic postsurgical pain: current evidence and a novel program to develop predictive biomarker signatures

Chronic pain affects more than 50 million Americans. Treatments remain inadequate, in large part, because the pathophysiological mechanisms underlying the development of chronic pain remain poorly understood. Pain biomarkers could potentially identify and measure biological pathways and phenotypical expressions that are altered by pain, provide insight into biological treatment targets, and help identify at-risk patients who might benefit from early intervention. Biomarkers are used to diagnose, track, and treat other diseases, but no validated clinical biomarkers exist yet for chronic pain. To address this problem, the National Institutes of Health Common Fund launched the Acute to Chronic Pain Signatures (A2CPS) program to evaluate candidate biomarkers, develop them into biosignatures, and discover novel biomarkers for chronification of pain after surgery. This article discusses candidate biomarkers identified by A2CPS for evaluation, including genomic, proteomic, metabolomic, lipidomic, neuroimaging, psychophysical, psychological, and behavioral measures. Acute to Chronic Pain Signatures will provide the most comprehensive investigation of biomarkers for the transition to chronic postsurgical pain undertaken to date. Data and analytic resources generatedby A2CPS will be shared with the scientific community in hopes that other investigators will extract valuable insights beyond A2CPS’s initial findings. This article will review the identified biomarkers and rationale for including them, the current state of the science on biomarkers of the transition from acute to chronic pain, gaps in the literature, and how A2CPS will address these gaps.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2017

Plateaus and Sinuous Ridges as the Fingerprints of Lava Flow Inflation in the Eastern Tharsis Plains of Mars

The Tharsis Montes rift aprons are composed of outpourings of lava from chaotic terrains to the northeast and southwest flank of each volcano. Sinuous and branching channel networks that are present on the rift aprons suggest the possibility of fluvial processes in their development, or erosion by rapidly emplaced lavas, but the style of lava flow emplacement throughout rift apron development is not clearly understood. To better characterize the style of lava emplacement and role of fluvial processes in rift apron development, we conducted morphological mapping of the Pavonis Mons southwest rift apron and the eastern Tharsis plains using images from the High Resolution Imaging Science Experiment (HiRISE), Mars Orbiter Camera (MOC), Context Camera (CTX), Thermal Emission Imaging System (THEMIS), and High Resolution Stereo Camera (HRSC) along with the Mars Orbiter Laser Altimeter (MOLA) Precision Experiment Data Records (PEDRs) and gridded data. Our approach was to: (1) search for depositional fans at the slope break between the rift apron and adjacent low slope plains; (2) determine if there is evidence that previously formed deposits might have been buried by plains units; (3) characterize the Tharsis plains morphologies east of Pavonis Mons; and (4) assess their relationship to the rift apron units. We have not identified topographically significant depositional fans, nor did we observe evidence to suggest that plains units have buried older rift apron units. Flow features associated with the rift apron are observed to continue across the slope break onto the plains. In this area, the plains are composed of a variety of small fissures and low shield vents around which broad channel-fed and tube-fed flows have been identified. We also find broad, flat-topped plateaus and sinuous ridges mixed among the channels, tubes and vents. Flat-topped plateaus and sinuous ridges are morphologies that are analogous to those observed on the coastal plain of Hawai'i, where lava flows have advanced from the volcano's several degree flank onto the nearly zero degree coastal plain. When local volumetric flow rates are low, flow fronts tend to spread laterally and often thicken via endogenous growth, or inflation, of the sheet-like flow units. If flow advance is restricted by existing topography into narrow pathways, inflation can be focused into sinuous, elongate ridges. The presence of plateaus and ridges-emplaced from the rift zones, across the plains to the east of Pavonis Mons-and a lack of fan-like features, or evidence for their burial, are consistent with rift apron lavas crossing a slope break with low local volumetric flow rates that led to inflation of sheet-like and tube-fed lava flows.

Bleacher, Jacob E.↗
NASA NTRS2014

The Geology of the Marcia Quadrangle of Asteroid Vesta: Assessing the Effects of Large, Young Craters

We used Dawn spacecraft data to identify and delineate geological units and landforms in the Marcia quadrangle of Vesta as a means to assess the role of the large, relatively young impact craters Marcia (approximately 63 kilometers diameter) and Calpurnia (approximately 53 kilometers diameter) and their surrounding ejecta field on the local geology. We also investigated a local topographic high with a dark-rayed crater named Aricia Tholus, and the impact crater Octavia that is surrounded by a distinctive diffuse mantle. Crater counts and stratigraphic relations suggest that Marcia is the youngest large crater on Vesta, in which a putative impact melt on the crater floor ranges in age between approximately 40 and 60 million years (depending upon choice of chronology system), and Marcia's ejecta blanket ranges in age between approximately 120 and 390 million years (depending upon choice of chronology system). We interpret the geologic units in and around Marcia crater to mark a major Vestan time-stratigraphic event, and that the Marcia Formation is one of the geologically youngest formations on Vesta. Marcia crater reveals pristine bright and dark material in its walls and smooth and pitted terrains on its floor. The smooth unit we interpret as evidence of flow of impact melts and (for the pitted terrain) release of volatiles during or after the impact process. The distinctive dark ejecta surrounding craters Marcia and Calpurnia is enriched in OH- or H-bearing phases and has a variable morphology, suggestive of a complex mixture of impact ejecta and impact melts including dark materials possibly derived from carbonaceous chondrite-rich material. Aricia Tholus, which was originally interpreted as a putative Vestan volcanic edifice based on lower resolution observations, appears to be a fragment of an ancient impact basin rim topped by a dark-rayed impact crater. Octavia crater has a cratering model formation age of approximately 280-990 million years based on counts of its ejecta field (depending upon choice of chronology system), and its ejecta field is the second oldest unit in this quadrangle. The relatively young craters and their related ejecta materials in this quadrangle are in stark contrast to the surrounding heavily cratered units that are related to the billion years old or older Rheasilvia and Veneneia impact basins and Vesta's ancient crust preserved on Vestalia Terra.

Asteroid Vesta↗
NASA NTRS2012

The Geology of the Marcia Quadrangle of Asteroid 4Vesta: An Integrated Mapping Study Using Dawn Spacecraft Data

We used geologic mapping applied to Dawn data as a tool to understand the geologic history of the Marcia quadrangle of Vesta. This region hosts a set of relatively fresh craters and surrounding ejecta field, an unusual dark hill named Arisia Tholus, and a orange (false color) diffuse material surrounding the crater Octavia. Stratigraphically, from oldest to youngest, three increasingly larger impact craters named Minucia, Calpurnia, and Marcia make up a snowmanlike feature, which is surrounded by a zone of dark material interpreted to consist of impact ejecta and possibly impact melts. The floor of Marcia contains a pitted terrain thought to be related to release of volatiles (1). The dark ejecta field has an enhanced signature of H, possibly derived from carbonaceous chondritic material that accumulated in Vesta s crust (2,3). The dark ejecta has a spectrally distinctive behavior with shallow pyroxenes band depths. Outside the ejecta field this quadrangle contains various cratered terrains, with increasing crater abundance moving south to north away from the Rheasilvia basin. Arisia Tholus, originally suggested as an ancient volcano, appears to be an impact-sculpted basin rim fragment with a superposed darkrayed impact crater. There remains no unequivocal evidence of volcanic features on Vesta s surface, likely because basaltic material of the HED meteorite suite demonstrates magmatism ended very early on Vesta (4). Ongoing work includes application of crater statistical techniques to obtain model ages of surface units, and more detailed estimates of the compositional variations among the surface units.

Williams, David A.↗
NASA NTRS2010

Volcanism on Io: Results from Global Geologic Mapping

We have completed a new 1:15,000,000 global geologic map of Jupiter's volcanic moon, Io, based on a set of 1 km/pixel combined Galileo- Voyager mosaics produced by the U.S. Geological Survey. The map was produced over the last three years using ArcGIS(TM) software, and has undergone peer-review. Here we report some of the key results from our global mapping efforts, and how these results relate to questions regarding the volcano-tectonic evolution of Io.

Williams, David A.↗
NASA NTRS2009

Spatial and Alignment Analyses for a Field of Small Volcanic Vents South of Pavonis Mons and Implications for the Tharsis Province, Mars

A field of small volcanic vents south of Pavonis Mons was mapped with each vent assigned a two-dimensional data point. Nearest neighbor and two-point azimuth analyses were applied to the resulting location data. Nearest neighbor results show that vents within this field are spatially random in a Poisson sense, suggesting that the vents formed independently of each other without sharing a centralized magma source at shallow depth. Two-point azimuth results show that the vents display north-trending alignment relationships between one another. This trend corresponds to the trends of faults and fractures of the Noachian-aged Claritas Fossae, which might extend into our study area buried beneath more recently emplaced lava flows. However, individual elongate vent summit structures do not consistently display the same trend. The development of the volcanic field appears to display tectonic control from buried Noachian-aged structural patterns on small, ascending magma bodies while the surface orientations of the linear vents might reflect different, younger tectonic patterns. These results suggest a complex interaction between magma ascension through the crust, and multiple, older, buried Tharsis-related tectonic structures.

Bleacher, Jacob E.↗
NASA NTRS2008

Global Geologic Mapping of Io: Preliminary Results

A new global geologic map of Jupiter's volcanic moon, Io is being prepared, with the focus being on completion of a draft map by July 2008. Here initial results of the mapping are reported: a preliminary distribution of material units in terms of areas and a visual representation. Additionally, the mapping hopes to address some of the problems in Io geology. Thus far it has been discovered that Io's surface is dominated by plains material, thought to consist of Io's silicate crust covered by pyroclastic deposits and lava flows of silicate and sulfur-bearing composition. Many plains areas contain flow fields that cannot be mapped separately due to a lack of resolution or modification by alteration processes. Discrete lava flows and flow fields are the next most abundant unit, with bright (sulfur?) flows in greater abundance than dark (silicate?) flows. The source of most of Io's heat flow, the paterae, are the least abundant unit in terms of areal extent.Upon completion of the draft map for peer review, it will be used to investigate several specific questions about the geological evolution of Io that previously could not be well addressed, including: comparison of the areas versus the heights of Ionian mountains to assess their stability and evolution; correlation and comparison of Galileo Near-Infrared Mapping Spectrometer and Photopolarimeter-Radiometer hot spot locations with the mapped location of dark versus bright lava flows and patera floors to assess any variations in the types of sources for Io's active volcanism; and the creation of a global inventory of the areal coverage of dark and bright laval flows to assess the relative importance of sulfur versus silicate volcanism in resurfacing Io, and to assess whether there are regional concentrations of either style of volcanism that may have implications on interior processes.

Williams, David A.↗
NASA NTRS2003

Geologic Mapping of the Chaac-Camaxtli Region of Io from Galileo Imaging Data

We produced a geologic/geomorphologic map of the Chaac-Camaxtli region of Io's leading anti-Jovian hemisphere using regional resolution ( 186 m/pixel) Galileo imaging data collected during orbit I27 (February 2000) integrated with lower resolution (1.4 km/pixel) color data, along with other Galileo imaging and spectral data. This is the first regional map of Io made from Galileo data. Nine color and geomorphologic units have been mapped, and the close proximity of dark and various colored bright materials suggests that there is an intimate interaction between (presumably) silicate magmas and sulfur-bearing volatile materials that produced a variety of explosive and effusive deposits in the recent geologic past. This region of Io is dominated by 11 volcanic centers, most of which are paterae that are analogous in morphology to terrestrial calderas but larger in size. Mapping of structural features indicates that most of the active regions occur in topographic lows, and less active or inactive paterae are associated with topographic highs. This indicates that crustal thickness variations influence magma access to the surface. Surface changes in this region since the Voyager flybys are relatively minor (additional bright and dark flows, color changes), although several active vents have migrated within paterae. This observation, along with the identification of the relatively regular spacing of paterae (approx. 100 - 150 km) along a line, may indicate there are multiple interlacing fractures in the crust that serve as magma conduits from the interior. This connection between volcanism and tectonism may have implications for tidal heating mechanisms and their effect on Io's lithosphere. Some inactive patera floors may be evolving into bright plains material, which, if composed of silicates, might explain the strength of Io's crust to support steep patera walls and tall mountains.

Williams, David A.↗
NASA NTRS2002

Geologic Mapping of the Chaac-Camaxtli Region of Io from Galileo Imaging Data

We produced a geologic/geomorphologic map of the Chaac-Camaxtli region of Io's leading anti-Jovian hemisphere using regional resolution (186 m/pixel) Galileo imaging data collected during orbit I27 (February 2000) integrated with lower resolution (1.4 km/pixel) color data, along with other Galileo imaging and spectral data. This is the first regional map of Io made from Galileo data. Nine color and geomorphologic units have been mapped, and the close proximity of dark and various colored bright materials suggests that there is an intimate interaction between (presumably) silicate magmas and sulfur-bearing volatile materials that produced a variety of explosive and effusive deposits in the recent geologic past. This region of Io is dominated by 11 volcanic centers, most of which are paterae that are analogous in morphology to terrestrial calderas but larger in size. Mapping of structural features indicates that most of the active regions occur in topographic lows, and less active or inactive paterae are associated with topographic highs. This indicates that crustal thickness variations influence magma access to the surface. Surface changes in this region since the Voyager flybys (1979) are relatively minor (additional bright and dark flows, color changes), although several active vents have migrated within paterae. This observation, along with the identification of the relatively regular spacing of paterae (approx. 100- 150 km) along a line, may indicate there are multiple interlacing fractures in the crust that serve as magma conduits from the interior. This connection between volcanism and tectonism may have implications for tidal heating mechanisms and their effect on Io's lithosphere. Some inactive patera floors may be evolving into bright plains material, which, if composed of silicates, might explain the strength of Io's crust to support steep patera walls and tall mountains.

Williams, David A.↗
NASA NTRS2001

Evaluation of Sulfur Flow Emplacement on Io from Galileo Data and Numerical Modeling

Galileo images of bright lava flows surrounding Emakong Patera have been analyzed and numerical modeling has been performed to assess whether these flows could have resulted from the emplacement of sulfur lavas on Io. Images from the solid-state imaging.(SSI) camera show that these bright, white to yellow Emakong flows are up to 370 km long and contain dark, sinuous features that are interpreted to be lava conduits, approx. 300-500 m wide and > 100 km long. Near-Infrared Mapping Spectrometer (NIMS) thermal emission data yield a color temperature estimate of 344 K +/- 60 K (less than or equal to 131 C) within the Emakong caldera. We suggest that these bright flows likely resulted from either sulfur lavas or silicate lavas that have undergone extensive cooling, pyroclastic mantling, and/or alteration with bright sulfurous materials. The Emakong bright flows have estimated volumes of approx. 250-350 cu km, similar to some of the smaller Columbia River Basalt flows. If the Emakong flows did result from effusive sulfur eruptions, then they are orders of magnitude greater in volume than any terrestrial sulfur flows. Our numerical modeling results show that sulfur lavas on Io could have been emplaced as turbulent flows, which were capable of traveling tens to hundreds of kilometers, consistent with the predictions of Sagan [ 19793 and Fink et al. [ 19831. Our modeled flow distances are also consistent with the measured lengths of the Emakong channels and bright flows. Modeled thermal erosion rates are approx. 1-4 m/d for flows erupted at approx. 140-180 C, which are consistent with the melting rates of Kieffer et al. [2000]. The Emakong channels could be thermal erosional in nature; however, the morphologic signatures of thermal erosion channels cannot be discerned from available images. There are planned Galileo flybys of Io in 2001 which provide excellent opportunities to obtain high-resolution morphologic and color data of Emakong Patera. Such observations could, along with further modeling, provide additional information to better constrain whether sulfur lavas produced the Emakong flows.

Williams, David A.↗
NASA NTRS2001

The Summer 1997 Eruption at Pillan Patera on Io: Implications for Ultrabasic Lava Flow Emplacement

Galileo data and numerical modeling were used to investigate the summer 1997 eruption at Pillan Patera on Io. This event, now defined as 'Pillanian' eruption style, included a high-temperature (greater than 1600 C), possibly ultrabasic, 140-km-high plume eruption that deposited dark, orthopyroxene-rich pyroclastic material over greater than 125,000 sq km, followed by emplacement of dark flow-like material over greater than 3100 sq km to the north of the caldera. We estimate that the high-temperature, energetic episode of this eruption had a duration of 52- 167 days between May and September 1997, with peak eruption temperatures around June 28, 1997. Galileo 20 m/pixel images of part of the Pillan flow field show a widespread, rough, pitted surface that is unlike any flow surface we have seen before. We suggest that th.s surface may have resulted from (1) a fractured lava crust formed during rapid, low-viscosity lava surging, perhaps including turbulent flow emplacement; (2) disruption of the lava flow by explosive interaction with a volatile-rich substrate: or (3) a combination of 1 and 2 with or without accumulation of pyroclastic materials on the surface. Well-developed flow lobes are observed, suggesting that this is a relatively distal part of the flow field. Shadow measurements at flow margins indicate a thickness of approx. 8-10 m. We have modeled the emplacement of putative ultrabasic flows from the summer 1997 Pillan eruption using constraints from new Galileo data. Results suggest that either laminar sheet flows or turbulent channelized flows could have traveled 50-150 km on a flat. unobstructed surface, which is consistent with the estimated length of the Pillan flow field (approx. 60 km). Our modeling suggests low thermal erosion rates (less than 0.1 m/d), and that the formation of deep (greater than 20 m) erosion channels was unlikely, especially distal to the source. We calculate a volumetric flow rate of approx. 2-7 x l0(exp 3) cu m/s, which is greater than those for typical Mauna Loa/Kilauea flows but comparable to those for the (1783) Laki eruption and the inferred flow rates of the Roza flows in the Columbia River flood basalts. The differences in ultrabasic eruption styles on Earth and Io appear to be controlled by the different eruption environments: Plumes at sites of ultrabasic eruptions on Io suggest strong magma-volatile: interactions on a low-gravity body lacking an atmosphere, whereas the geology at sites of komatiite eruptions on Earth suggest mostly submarine emplacement of thick flows with a pronounced lack of subaerial explosive activity.

Williams, David A.↗
NASA NTRS2001

The Summer 1997 Eruption at Pillan Patera on Io: Implications for Ultrabasic Lava Flow Emplacement

Galileo data and numerical modeling were used to investigate the summer 1977 eruption at Pillan Patera on Io. This event, now defined as "Pillanian" eruption style, included a high-temperature (greater than 1600 C), possible ultrabasic , 140-km-high plume eruption that deposited dark, orthopyroxene-rich pyroclastic material over greater than 125,000 sq km, followed by emplacement of dark flow-like material over greater than 3100 sq km to the north of the caldera. We estimate that the high-temperature, energetic episode of this eruption had a duration of 52 - 167 days between May and September 1997, with peak eruption temperatures around June 28, 1997. Galileo 20 m/pixel images of part of the Pillan flow field show a wide-spread, rough, pitted surface that is unlike any flow surface we have seen before. We suggest that this surface may have resulted from: 1. A fractured lava crust formed during rapid, low-viscosity lava surging, perhaps including turbulent flow emplacement. 2. Disruption of the lava flow by explosive interaction with a volatile-rich substrate. or 3. A combination of 1 and 2 with or without accumulation of pyroclastic material on the surface. Well-developed flow lobes are observed, suggesting that this is a relatively distant part of the flow field.Shadow measurements at flow margins indicate a thickness of-8 - 10 m. We have modeled the emplacement of putative ultrabasic flow from the summer 1997 Pillan eruption using constraints from new Galileo data. Results suggest that either laminar sheet flows or turbulent channelized flows could have traveled 50 - 150 km on a flat, unobstructed surface, which is consistent with the estimated length of the Pillan flow field (approx. 60 km). Our modeling suggests low thermal erosion rates (less than 4.1 m/d), and that the formation of deep (greater than 20 m) erosion channels was unlikely, especially distal to the source. We calculate a volumetric flow rate of approx. 2 - 7 x 10(exp 3)cu m/s, which is greater than those for typical Mauna Loa/Kilaueaq flows but comparable to those for the (1783) Laki eruption and the inferred flow rates of the Roza flows in the Columbia River flood basalts. The differences in ultrabasic eruption styles on Earth and Io appear to be controlled by the different eruption environments; Plumes at sites of ultrabasic eruptions on Io suggest strong magma-volatile interactions on a low-gravity body lacking an atmosphere, whereas the geology at sites of komatiite eruptions on Earth suggest mostly submarine emplacement of thick flows with a pronounced lack of subaerial explosive activity.

Williams, David A.↗
NASA NTRS2001

Evaluation of Sulfur Flow Emplacement on Io from Galileo Data and Numerical Modeling

Galileo images of bright lava flows surrounding Emakong Patera have bee0 analyzed and numerical modeling has been performed to assess whether these flows could have resulted from the emplacement of sulfur lavas on Io. Images from the solid-state imaging (SSI) camera show that these bright, white to yellow Emakong flows are up to 370 km long and contain dark, sinuous features that are interpreted to be lava conduits, -300-500 m wide and >lo0 km lorig. Neiu-Infrared Mapping S estimate of 344 K f 60 G131'C) within the Bmakong caldera. We suggest that these bright flows likely resulted from either sulfur lavas or silicate lavas that have undergone extensive cooling, pyroclastic mantling, and/or alteration with bright sulfurous materials. The Emakoag bright flows have estimated volume of -250-350 km', similar to some of the smaller Columbia River Basalt flows, If the Emakong flows did result from effusive sulfur eruptions, then they are orders of magnitude reater in volume than any terrestrial sulfur flows. Our numerical modeling capable of traveling tens to hundreds of kilometers, consistent with the predictions of Sagan. Our modeled flow distances are also consistent with the measured lengths of the Emakong channels and bright flows.

Williams, David A.↗
NASA NTRS1994

Assessment of antipodal-impact terrains on Mars

The regions anitpodal to Mars' three largest impact basins, Hellas, Isidis, and Argyre, were assessed for evidence of impact-induced disrupted terrains. Photogeology and computer modeling using the Simplified Arbitrary Lagrangian Eulerian (SALE) finite element code suggest that such terrains could have been found by the Hellas impact. Maximum antipodal pressures are 1100 MPa for Hellas, 520 MPa for Isidis, and 150 MPa for Argyre. The results suggest that if antipodal fracturing were associated with later volcanism, then Alba Patera may be related to the Hellas event, as proposed by Peterson (1978). Alba Patera is a unique volcano in the solar system, being a shield volcano which emitted large volume lava flows. This volcanism could be the result of the focusing of seismic energy which created a fractured region that served as a volcanic conduit for the future release of large volumes of magma. No disrupted terrain features are observed antipodal to the Isidis or Argyre basins, although some of the old fractures in Noctis Labyrinthus could have originated in response to the Isidis impact, and later have been reactivated by the Tharsis tectonics assumed to have produced Noctis. If the lower calculated antipodal pressures for Argyre were capable of producing disrupted terrains, then the terrains have been covered subsequently by volcanic or aeolian material, or modified beyond recognition.

Williams, David A.↗