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Wilbur, Scott

Publications and source records attributed to Wilbur, Scott.

3 records
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DOE OSTI2024

Production of High Specific Activity 155 Tb, 161 Tb and 203 Pb for Research and Clinical Applications: Effective Target Design, Target Material Recycling and Radioisotope Separation (Final Technical Report)

The overall objectives of this project were (1) to develop methods for the production and separation of a diagnostic and therapeutic or “theranostic” pair of radioisotopes, terbium-155 ( 155 Tb) and terbium-161 ( 161 Tb) and (2) to train graduate students and postdoctoral fellows in technologies and methods used in radionuclide production. Radionuclides can be incorporated into drugs called radiopharmaceuticals that target a specific disease (e.g., cancer). The need for theranostic radionuclides is escalating with the clinical translation of radiopharmaceuticals due to their implementation in personalized medicine, which has demonstrated enhanced patient treatments. High purity and high specific activity radionuclides are critical for theranostic agent development, for example to maintain diagnostic image quality, to minimize radiation dose to the patient, and to increase uptake in the targeted tissue (e.g., tumor), especially in the case of receptor- and antigen-targeted agents. The 155 Tb (diagnostic) and 161 Tb (therapeutic) radioisotopes that were generated through this project are a theranostic pair with demonstrated potential for the development and translation into individualized, targeted, and dosimetry-driven radiotherapies. However, the development of such radiotherapies has been hindered by the lack of a routine and reliable supply of these isotopes in the United States. Methods for the production, separation, and supply of 155 Tb and 161 Tb were investigated and developed in this project. Further, the strong emphasis throughout the project on the training of graduate students and postdoctoral fellows has helped to ensure and enhance the nuclear science workforce through the training of the next generation of highly qualified scientists in nuclear and radiochemistry. This grant also continued a collaboration between scientists at the University of Washington (UW), the University of Missouri (MU) and Brookhaven National Laboratory (BNL). All three institutions were involved in the project, but to different degrees on the various tasks through which the overall objectives were met.

07 ISOTOPE AND RADIATION SOURCES↗
DOE OSTI2018

UW Translational Imaging Biomarker and Therapeutic Development

The development and validation of radiotracers is a critical step in the clinical translation of molecular imaging and theranostics to support personalized medicine. The proposed program is to support such efforts by an interdisciplinary team of investigators at the University of Washington (UW) and Fred Hutchinson Cancer Research Center (FHCRC) and to provide opportunities for trainees to learn the spectrum of translational research in imaging biomarkers and therapeutic development. The proposed translational research projects include "Preclinical Evaluation of PET Imaging for Use in the Translation of Targeted Alpha Therapy of Blood-Related Cancers to Clinical Studies" (Project 1-Wilbur, leader); "Hypoxia Imaging: Radiopharmaceuticals, Preclinical Studies, Mechanisms and Clinical trials" (Project 2-Krohn, leader); and "Diagnostic Applications of Radiolabeled Biologics in Solid Tumors" (Project 3-Minoshima, leader). These projects use radiotracers with long half-lives, such as F-18, Zr-89, I-124, and At-211, that can potentially be handled commercially if translation research is successful. The proposed research method is to use an interdisciplinary 'team' of expert investigators and trainees working on a specific project for 1 or 2 years along the timeline and milestones set by the Program Directors. Each team includes 1) a clinician expert; 2) a radiochemistry expert; 3) an imaging or radiation therapy expert; 4) a physicist; 5) trainees; and 6) a UW technology transfer officer. Two groups of trainees will be involved: clinical and basic science (radiochemistry) trainees. Clinical trainees will be recruited from 3 training programs: Nuclear Medicine Resident Program; Radiology Residency Program; and Residency Program in Radiation Oncology. Basic science trainees will be graduate students from degree-awarding departments (chemistry, material sciences, bioengineering) or post-doctoral students (radiology, radiation oncology, or collaborating departments). A goal of training is to develop future investigators who will be able to conduct independent translational research with knowledge and expertise earned in this interdisciplinary team environment. To address clinically relevant questions, the program will organize regular brainstorming meetings participated by clinicians from various medical disciplines; program investigators; trainees; technology transfer officers to discuss medical questions, relevant targets, and technical feasibility. UW provides outstanding research and clinical facilities and resources that can be accessed by investigators. The Departments of Radiology and Radiation Oncology at UW have been at the forefront of translational imaging and therapeutics research efforts in cancer, neurological disorders, and cardiovascular diseases. This funding opportunity will solidify ongoing efforts of interdisciplinary collaborations at UW into a cohesive program that will train a new generation of investigators. This will, in turn, accelerate the translational potential of new radiotracers by rapid developments of proof-of-concept and first-in-man studies along with in vivo validations in a clinically relevant context.

62 RADIOLOGY AND NUCLEAR MEDICINE↗