Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex
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Engineering topics
Publications and source records attributed to Wang, M..
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In this study, an eight-channel magnetic probe diagnostic system has been designed and installed adjacent to the 4.6 GHz lower hybrid (LH) grill antenna in the low-field side of the Experimental Advanced Superconducting Tokamak (EAST) in order to study the n ∥ evolution of LH waves in the first pass from the launcher to the core plasma. The magnetic probes are separated by 6.6 mm, which allows measurement of the dominant parallel refractive index n ∥ up to n ∥ = 5 for 4.6 GHz LH waves. The magnetic probes are designed to be sensitive to the magnetic field component perpendicular to the background magnetic field with a slit on the casing that encloses the probe. The intermediate frequency stage, which consists of two mixing stages, down-coverts the frequency of the measured wave signals at 4.6 GHz to 20 MHz. A bench test demonstrates the phase stability of the magnetic probe diagnostic system. By evaluating the phase variation of the measured signals along the background magnetic field, the dominant n ∥ of the LH wave in the scrape-off layer has been deduced during the 2019 experimental campaign. In the low density plasma, the measured dominant n ∥ of the LH waves is about 2.1, corresponding to the main peak 2.04 of the launched n ∥ spectrum. n ∥ deduced by the least-squares linear fit method remains near this value in the low density plasma with a high spatial correlation magnitude of 0.9. With an eight-channel probe system, a wave-number spectrum has also been deduced, which has a peak near to the measured dominant n ∥ .
The frozen-in interplanetary magnetic field (IMF) in the solar wind is one of the most important parameters affecting the Earth’s space weather. In the early studies of the IMF’s influence on space weather, significant effects of the north–south component of the IMF B {sub Z} were emphasized, while the radial component of the IMF B {sub X} was largely ignored. However, the IMF near the Earth is not always dominated by the north–south component of the IMF B {sub Z}, and the radial component of the IMF B {sub X} also plays an important role. However, while the effects of the IMF B {sub X} (cone angle) on the magnetopause have been studied in recent years, there has been much less effort to quantify the B {sub X} (cone angle) effects on the bow shock. In this paper, using the bow shock crossing data from multiple satellites, we investigate the IMF cone angle effect on the dayside and nightside of the bow shock. Our results show that under the radial IMF condition, the dayside of the bow shock is located closer to the Earth than the average. At the same time, on the nightside, the bow shock is farther away from the Earth than the average. The mechanism explaining the bow shock location under the radial IMF is not completely understood. We believe that the magnetosonic Mach number and unusual conditions of the magnetosheath, especially for low dynamic pressure, play an important role. In the future, more work is needed to describe the reactions of the Earth’s magnetosphere to different IMF orientations, especially to the radial IMF.
The PandaX-III experiment plans to search for neutrinoless double beta decay (0ν ββ ) of 136 Xe in the China JinPing underground Laboratory (CJPL). The experiment will use a high pressure gaseous time projection chamber (TPC) to register both the energy and the electron track topology of an event. This article is devoted to demonstrate our particular detector setup capabilities for the identification of 0ν ββ and the consequent background reduction. As software tool we use REST, a framework developed for the reconstruction and simulation of TPC-based detector systems. We study the potential for background reduction by introducing appropriate parameters based on the properties of 0ν ββ events. We exploit for the first time not only the energy density of the electron track-ends, but also the electron scattering angles produced by an electron near the end of its trajectory. To implement this, we have added new algorithms for detector signal and track processing inside REST. Their assessment shows that background can be reduced by about 7 orders of magnitude while keeping 0ν ββ efficiency above 20% for the PandaX-III baseline readout scheme, a two-dimensional 3 mm pitch stripped readout. More generally, we use the potential of REST to handle 2D/3D data to assess the impact on signal-to-background significance at different detector granularities, and to validate the PandaX-III baseline choice. Finally, we demonstrate the additional potential to discriminate surface background events generated at the readout plane in the absence of to, by making use of event parameters related with the diffusion of electrons.
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Neutrinos are particles that interact rarely, so identifying them requires large detectors which produce lots of data. Processing this data with the computing power available is becoming more difficult as the detectors increase in size to reach their physics goals. In liquid argon time projection chambers (TPCs) the charged particles from neutrino interactions produce ionization electrons which drift in an electric field towards a series of collection wires, and the signal on the wires is used to reconstruct the interaction. The MicroBooNE detector currently collecting data at Fermilab has 8000 wires, and planned future experiments like DUNE will have 100 times more, which means that the time required to reconstruct an event will scale accordingly. Modernization of liquid argon TPC reconstruction code, including vectorization, parallelization and code portability to GPUs, will help to mitigate these challenges. The liquid argon TPC hit finding algorithm within the L arSoft framework used across multiple experiments has been vectorized and parallelized. This increases the speed of the algorithm on the order of ten times within a stand alone version on Intel architectures. This new version has been incorporated back into LarSoft so that it can be generally used. These methods will also be applied to other low level reconstruction of the wire signals such as the deconvolution. The applications and performance of this modernized liquid argon TPC wire reconstruction will be presented.
Abstract Indirect drive converts high power laser light into x-rays using small high- Z cavities called hohlraums. X-rays generated at the hohlraum walls drive a capsule filled with deuterium–tritium (DT) fuel to fusion conditions. Recent experiments have produced fusion yields exceeding 50 kJ where alpha heating provides ~3× increase in yield over PdV work. Closing the gaps toward ignition is challenging, requiring optimization of the target/implosions and the laser to extract maximum energy. The US program has a three-pronged approach to maximize target performance, each closing some portion of the gap. The first item is optimizing the hohlraum to couple more energy to the capsule while maintaining symmetry control. Novel hohlraum designs are being pursued that enable a larger capsule to be driven symmetrically to both reduce 3D effects and increase energy coupled to the capsule. The second issue being addressed is capsule stability. Seeding of instabilities by the hardware used to mount the capsule and fill it with DT fuel remains a concern. Work reducing the impact of the DT fill tubes and novel capsule mounts is being pursed to reduce the effect of mix on the capsule implosions. There is also growing evidence native capsule seeds such as a micro-structure may be playing a role on limiting capsule performance and dedicated experiments are being developed to better understand the phenomenon. The last area of emphasis is the laser. As technology progresses and understanding of laser damage/mitigation advances, increasing the laser energy seems possible. This would increase the amount of energy available to couple to the capsule, and allow larger capsules, potentially increasing the hot spot pressure and confinement time. The combination of each of these focus areas has the potential to produce conditions to initiate thermo-nuclear ignition.
Geophysical observations show spatial and temporal variations in fault slip style on shallow subduction thrust faults, but geological signatures and underlying deformation processes remain poorly understood. International Ocean Discovery Program (IODP) Expeditions 372 and 375 investigated New Zealand’s Hikurangi margin in a region that has experienced both tsunami earthquakes and repeated slow-slip events. We report direct observations from cores that sampled the active Papaku splay fault at 304 m below the seafloor. This fault roots into the plate interface and comprises an 18-m-thick main fault underlain by ~30 m of less intensely deformed footwall and an ~10-m-thick subsidiary fault above undeformed footwall. Fault zone structures include breccias, folds, and asymmetric clasts within transposed and/or dismembered, relatively homogeneous, silty hemipelagic sediments. The data demonstrate that the fault has experienced both ductile and brittle deformation. As a result, this structural variation indicates that a range of local slip speeds can occur along shallow faults, and they are controlled by temporal, potentially far-field, changes in strain rate or effective stress.
Additive Manufacturing (AM) can create novel and complex engineered material structures. Features such as controlled porosity, micro-fibers and/or nano-particles, transitions in materials and integral robust coatings can be important in developing solutions for fusion subcomponents. A realistic understanding of this capability would be particularly valuable in identifying development paths. Major concerns for using AM processes with lasers or electron beams that melt powder to make refractory parts are the power required and residual stresses arising in fabrication. A related issue is the required combination of lasers or e-beams to continue heating of deposited material (to reduce stresses) and to deposit new material at a reasonable built rate while providing adequate surface finish and resolution for meso-scale features. Some Direct Write processes that can make suitable preforms and be cured to an acceptable density may offer another approach for PFCs.
Two major goals of superconducting radio frequency cavity research and development are achieving higher accelerating gradient and gaining the highest quality factor, a measure of efficiency. However, the consistent improvement of these performance metrics is restricted by many factors, one of which is microstructural defects, such as dislocation substructures within the material. In this work, dislocation evolution is compared in four samples extracted from a 2.8 mm thick large-grain niobium slice, with tensile axes chosen to generate specific dislocation structures during subsequent deformation. The four samples are (1) as-extracted, (2) extracted and annealed, (3) extracted and then deformed to 40% tensile strain, and (4) extracted, annealed at 800 °C 2 h, and then deformed to 40% strain. Electron channeling contrast imaging was performed on all samples to characterize initial dislocation density and dislocation structure evolution due to annealing and deformation, and related to the mechanical behavior observed in stress-strain curves. A fundamental understanding of dislocation evolution in niobium is necessary to develop computational models to simulate cavity forming, which could enable new processing methods for cavity fabrication to be identified that could lead to improved performance.
Highlights: • <110> texture along layer build direction was generated in as-SLMed Inconel 625. • The stress relief process dominates texture and GBCD evolution. • SLMed IN 625 alloy can be GBEed via suitable post annealing. - Abstract: Select laser melting (SLM) is one of the practical metal additive manufacturing processes to fabricate complex structures. The inhomogeneous microstructure and high residual stress are typically resulted from a non-uniform melting and rapid solidification during a SLM process, which has the significant impact on part dimensional instability, corrosion resistance, and mechanical properties. The bulk of current research is limited to the general characterization of grain size, texture, and mechanical properties. However, grain boundary character distribution (GBCD) and its relationship with texture are yet to be understood. This study has shown that the preferred <110> along building direction and <100> along laser scanning direction were produced. The high density of low angle grain boundary (LAGB) can be an indicator of residual stress levels in the as-SLMed samples. The newly-developed ∑3, ∑9 and ∑27 grain boundaries were heavily populated, and the cluster of grains interfaced by ∑3{sup n} (n = 0, 1, 2…) was introduced at the expense of LAGB only at high recrystallization annealing (1150°C or over). The research results suggest that GBCD optimization be possible in the SLMed Inconel 625 alloy via suitable post annealing, which allows improving intergranular corrosion resistance and enhancing mechanical properties.
We explore the impact of an update to the typical approximation for the shape noise term in the analytic covariance matrix for cosmic shear experiments that assumes the absence of survey boundary and mask effects. We present an exact expression for the number of galaxy pairs in this term based on the survey mask, which leads to more than a factor of three increase in the shape noise on the largest measured scales for the Kilo-Degree Survey (KiDS-450) real-space cosmic shear data. We compare the result of this analytic expression to several alternative methods for measuring the shape noise from the data and find excellent agreement. This update to the covariance resolves any internal model tension evidenced by the previously large cosmological best-fitting χ 2 for the KiDS-450 cosmic shear data. The best-fitting χ 2 is reduced from 161 to 121 for 118 degrees of freedom. We also apply a correction to how the multiplicative shear calibration uncertainty is included in the covariance. This change shifts the inferred amplitude of the correlation function to higher values. In conclusion, we find that this improves agreement of the KiDS-450 cosmic shear results with Dark Energy Survey Year 1 and Planck results.