RuO 2 -NiO Nanosheets on Conductive Nickel Foam for Reliable and Regeneratable Seawater Splitting
Not provided.
Materials Science↗
Engineering topics
Wang, Jinlong
Publications and source records attributed to Wang, Jinlong.
Partially reduced Ru/RuO 2 composites as efficient and pH-universal electrocatalysts for hydrogen evolution
Efficient and long-term stable electrocatalysts for the hydrogen evolution reaction (HER) via water splitting are urgently desired to ease the energy crisis and develop the sustainability of human society. However, the HER performance of state-of-the-art Pt in non-acidic solutions is unsatisfactory due to the severely sluggish kinetics. In this work, DFT theoretical calculations reveal that the Ru/RuO 2 composites enable high HER activity to be pursued under non-acidic conditions because of the distinctive Ru and RuO 2 interface, which possess not only a strong capability to adsorb and dissociate water but also appropriate binding energies of H and OH. Therefore, we employ a simple strategy, including heating under an oxygen-poor environment and/or in situ electrochemical reduction, to partially reduce RuO 2 . The formed Ru/RuO 2 interfaces demonstrate superior HER activities (e.g. η 10 = 17 mV, 35 mV dec –1 in 1 M KOH) than Pt/C (e.g. η 10 = 27 mV, 58 mV dec –1 in 1 M KOH) at both small (10–100 mA cm –2 ) and large (1 A cm –2 ) current densities in alkaline solution and even real seawater. Comprehensive experiments were conducted to investigate the structure-HER performance relationships. Moreover, benefiting from the bifunctional character of RuO2, a two-electrode system based on Ru/RuO 2 composites and RuO 2 exhibits the lowest cell voltage for water splitting in both 1 M KOH and 0.5 M H 2 SO 4 , respectively. A 300 h-stability test at 10 mA cm –2 without an obvious decay demonstrates the industrial prospects of the Ru/RuO 2 composites to generate green energy.
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
Improving operational flexibility of integrated energy system with uncertain renewable generations considering thermal inertia of buildings
Insufficient flexibility in system operation caused by traditional "heat-set" operating modes of combined heat and power (CHP) units in winter heating periods is a key issue that limits renewable energy consumption. In order to reduce the curtailment of renewable energy resources through improving the operational flexibility, a novel optimal scheduling model based on chance-constrained programming (CCP), aiming at minimizing the lowest generation cost, is proposed for a small-scale integrated energy system (IES) with CHP units, thermal power units, renewable generations and representative auxiliary equipments. In this model, due to the uncertainties of renewable generations including wind turbines and photovoltaic units, the probabilistic spinning reserves are supplied in the form of chance-constrained; from the perspective of user experience, a heating load model is built with consideration of heat comfort and inertia in buildings. To solve the model, a solution approach based on sequence operation theory (SOT) is developed, where the original CCP-based scheduling model is tackled into a solvable mixed-integer linear programming (MILP) formulation by converting a chance constraint into its deterministic equivalence class, and thereby is solved via the CPLEX solver. We report the simulation results on the modified IEEE 30-bus system demonstrate that the presented method manages to improve operational flexibility of the IES with uncertain renewable generations by comprehensively leveraging thermal inertia of buildings and different kinds of auxiliary equipments, which provides a fundamental way for promoting renewable energy consumption.
30 DIRECT ENERGY CONVERSION↗
A two-stage approach for combined heat and power economic emission dispatch: Combining multi-objective optimization with integrated decision making
Not Available
Li, Yang (ORCID:0000000265154567)↗
circRNA{sub 0}084043 promote malignant melanoma progression via miR-153-3p/Snail axis
Highlights: • circRNA{sub 0}084043 was significantly up-regulated in melanoma tissue. • circRNA{sub 0}084043 promotes melanoma cell proliferation, invasion and migration. • circRNA{sub 0}084043 directly binds to miR-153-3p, and Snail is directly targeted by miR-153-3p. • circRNA{sub 0}084043 act as the sponge of miR-153-3p to up-regulate Snail expression, and consequently function as an oncogene in melanoma. Circular RNAs (circRNAs) has been found to play an important role in the regulation of multiple diseases, and participate in cancer development. However, the role of circRNA in malignant melanoma has not been reported. In this study, human circRNA microarray was used to screen the dysregulated circRNA in melanoma. We found that circRNA{sub 0}084043 was significantly up-regulated in melanoma tissue, and the result was replicated in a larger sample size. High circRNA{sub 0}084043 expression was an independent risk factor of overall survival in melanoma patients. circRNA{sub 0}084043 promotes melanoma cell proliferation, invasion and migration. Bioinformatics and luciferase reporter assays confirmed that circRNA{sub 0}084043 directly binds to miR-153-3p, and Snail is directly targeted by miR-153-3p. We also demonstrated that circRNA{sub 0}084043 may act as the sponge of miR-153-3p to up-regulate Snail expression, and consequently function as an oncogene in melanoma. Overall, this result elucidates a new mechanism for circRNA{sub 0}084043 in melanoma development and provides a potential therapeutic target for melanoma patients.
60 APPLIED LIFE SCIENCES↗
Time-Resolved Electron-Bunch Diagnostics Using Transverse Wakefields
The development of future free electron lasers (FELs) requires reliable time-resolved measurement of variable ultra-short electron-bunchs characteristics. A possible technique is to streak the bunch in the transverse direction by means of time-dependent external fields. In this paper we explore the possible use of self-generated electromagnetic fields *. A passive deflector, consisting of a dielectric-lined waveguide, is used to produce wakefields that impart a time-dependent transverse kick to the relativistic electron bunch passing off-axis. We investigate the technique and its performances and explore its possible application at the Fermilab Accelerator Science & Technology (FAST) facility.
43 PARTICLE ACCELERATORS↗
miR-137 inhibits glutamine catabolism and growth of malignant melanoma by targeting glutaminase
Glutamine catabolism is considered to be an important metabolic pathway for cancer cells. Glutaminase (GLS) is the important rate-limiting enzyme of glutamine catabolism. miR-137 functions as a tumor suppressor in many human malignant tumors. However, the role and molecular mechanism of miR-137 and GLS in malignant melanoma has not been reported. In this study, we showed that miR-137 was decreased in melanoma tissue, and the low miR-137 level and high GLS expression are independent risk factor in melanoma. miR-137 suppressed the proliferation and glutamine catabolism of melanoma cells. GLS is crucial for glutamine catabolism and growth of malignant melanoma. We also demonstrated that miR-137 acts as a tumor suppressor in melanoma by targeting GLS. This result elucidates a new mechanism for miR-137 in melanoma development and provides a survival indicator and potential therapeutic target for melanoma patients.
60 APPLIED LIFE SCIENCES↗
MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARγ expression: A rat fibrosis model study
Hepatic stellate cells (HSCs) are the primary sources of extracellular matrix (ECM) in normal and fibrotic liver. Peroxisome proliferator-activated receptor gamma (PPARγ) maintains HSCs in a quiescent state, and its downregulation induces HSC activation. MicroRNAs (miRNAs) can induce PPARγ mRNA degradation, but the mechanism by which miRNAs regulate PPARγ in rat HSCs is unclear. This study aimed to investigate some miRNAs which putatively bind to the 3′-untranslated region (3′-UTR) of PPARγ mRNA, and increase expression of ECM genes in rat HSCs. In carbon tetrachloride injection (CCl{sub 4}) and common bile duct ligation (CBDL) liver fibrosis models, miRNAs miR-130a, miR-130b, miR-301a, miR-27b and miR-340 levels were found to be increased and PPARγ expression decreased. Overexpression of miR-130a and miR-130b enhanced cell proliferation by involving Runx3. MiR-130a and miR-130b decreased PPARγ expression by targeting the 3′-UTR of PPARγ mRNA in rat HSC-T6 cells. Transforming growth factor-β1 (TGF-β1) may mediate miR-130a and miR-130b overexpression, PPARγ downregulation, and ECM genes overexpression in cell culture. These findings suggest that miR-130a and miR-130b are involved in downregulation of PPARγ in liver fibrosis. - Highlights: • MiR-130a and miR-130b are increased and PPARγ is decreased in liver fibrosis models. • MiR-130a and miR-130b decreased PPARγ by targeting the 3′-UTR of PPARγ mRNA. • MiR-130a and miR-130b enhanced HSC cell proliferation by involving Runx3. • TGF-β1 may mediate miR-130a and miR-130b overexpression.
60 APPLIED LIFE SCIENCES↗
Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design
Abstract not provided
Butler, Christopher R.↗