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Stein, M.

Publications and source records attributed to Stein, M..

At least 19 records

The neuropathic postural tachycardia syndrome

BACKGROUND: The postural tachycardia syndrome is a common disorder that is characterized by chronic orthostatic symptoms and a dramatic increase in heart rate on standing, but that does not involve orthostatic hypotension. Several lines of evidence indicate that this disorder may result from sympathetic denervation of the legs. METHODS: We measured norepinephrine spillover (the rate of entry of norepinephrine into the venous circulation) in the arms and legs both before and in response to exposure to three stimuli (the cold pressor test, sodium nitroprusside infusion, and tyramine infusion) in 10 patients with the postural tachycardia syndrome and in 8 age- and sex-matched normal subjects. RESULTS: At base line, the mean (+/-SD) plasma norepinephrine concentration in the femoral vein was lower in the patients with the postural tachycardia syndrome than in the normal subjects (135+/-30 vs. 215+/-55 pg per milliliter [0.80+/-0.18 vs. 1.27+/-0.32 nmol per liter], P=0.001). Norepinephrine spillover in the arms increased to a similar extent in the two groups in response to each of the three stimuli, but the increases in the legs were smaller in the patients with the postural tachycardia syndrome than in the normal subjects (0.001+/-0.09 vs. 0.12+/-0.12 ng per minute per deciliter of tissue [0.006+/-0.53 vs. 0.71+/-0.71 nmol per minute per deciliter] with the cold pressor test, P=0.02; 0.02+/-0.07 vs. 0.23+/-0.17 ng per minute per deciliter [0.12+/-0.41 vs. 1.36+/-1.00 nmol per minute per deciliter] with nitroprusside infusion, P=0.01; and 0.008+/-0.09 vs. 0.19+/-0.25 ng per minute per deciliter [0.05+/-0.53 vs. 1.12+/-1.47 nmol per minute per deciliter] with tyramine infusion, P=0.04). CONCLUSIONS: The neuropathic postural tachycardia syndrome results from partial sympathetic denervation, especially in the legs.

NASA Discipline Regulatory Physiology

Postbuckling analysis of shear deformable composite flat panels taking into account geometrical imperfections

The effects of initial geometrical imperfections on the postbuckling response of flat laminated composite panels to uniaxial and biaxial compressive loading are investigated analytically. The derivation of the mathematical model on the basis of first-order transverse shear deformation theory is outlined, and numerical results for perfect and imperfect, single-layer and three-layer square plates with free-free, clamped-clamped, or free-clamped edges are presented in graphs and briefly characterized. The present approach is shown to be more accurate than analyses based on the classical Kirchhoff plate model.

Librescu, L.

Lithospheric evolution of the Northern Arabian Shield: Chemical and isotopic evidence from basalts, xenoliths and granites

The evolution of the upper-mantle and the lower-crust (the conteinental lithosphere), is the area of Israel and Sinai was studied, using the chemical composition and the Nd-Sr isotopic systematics from mantle and crustal nodules, their host basalts, and granites. The magmatism and the metasomatism making the lithosphere are related to uprise of mantle diapirs in the uppermost mantle of the area. These diapirs heated the base of the lithosphere, eroded, and replaced it with new hot material. It caused a domal uplift of the lithosphere (and the crust). The doming resulted in tensional stresses that in turn might develop transport channels for the basalt.

Stein, M.

A geometrically nonlinear theory of shear deformable laminated composite plates and its use in the postbuckling analysis

This paper is devoted to the formulation of a higher-order, geometrically nonlinear theory of anisotropic symmetrically-laminated composite plates and to the analysis, in this context, of their postbuckling behavior. Special attention is given to the postbuckling analysis of plates made of transversely isotropic layers for which case, the influence played by the degree of transversal-isotropy of the layers as well as by the goemetrical parameters of the panel is investigated. Finally, the results obtained within the present higher-order theory are compared with their first order transverse shear deformation as well as with their classical (Kirchhoff) counterparts and a number of conclusions concerning their range of applicability and the influence of various parameters are presented.

Librescu, L.

Postbuckling behavior of longitudinally compressed orthotropic plates with three-dimensional flexibility

Postbuckling results for the average longitudinal compressive stress vs applied displacement are obtained for aluminum (isotropic), aluminum/epoxy (quasi-isotropic), and 45-deg graphite/epoxy (orthotropic) plates using classical (Kirchhoff) and conventional transverse shearing theories. An analysis of the results obtained shows that, in the postbuckling range, the classical theory cannot provide reasonably accurate results even for thin plates.

Stein, M.

An approximate buckling analysis for rectangular orthotropic plates with centrally located cutouts

An approximate analysis for predicting buckling of rectangular orthotropic composite plates with centrally located cutouts is presented. In this analysis, prebuckling and buckling problems are converted from a two-dimensional to a one-dimensional system of linear differential equations with variable coefficients. The conversion is accomplished by expressing the displacements as series with each element containing a trigonometric function of one coordinate and a coefficient that is an arbitrary function of the other coordinate. Ordinary differential equations are then obtained from a variational principle. Analytical results obtained from the approximate analysis are compared with finite element analyses for isotropic plates and for specially orthotropic plates with central circular cutouts of various sizes. Experimental results for the specially orthotropic plates are also presented. In nearly all cases, the approximate analysis predicts the buckling mode shapes correctly and predicts the buckling loads to within a few percent of the finite element and experimental results.

Nemeth, M. P.

Nonlinear theory for laminated and thick plates and shells including the effects of transverse shearing

Nonlinear strain displacement relations for three-dimensional elasticity are determined in orthogonal curvilinear coordinates. To develop a two-dimensional theory, the displacements are expressed by trigonometric series representation through-the-thickness. The nonlinear strain-displacement relations are expanded into series which contain all first and second degree terms. In the series for the displacements only the first few terms are retained. Insertion of the expansions into the three-dimensional virtual work expression leads to nonlinear equations of equilibrium for laminated and thick plates and shells that include the effects of transverse shearing. Equations of equilibrium and buckling equations are derived for flat plates and cylindrical shells. The shell equations reduce to conventional transverse shearing shell equations when the effects of the trigonometric terms are omitted and to classical shell equations when the trigonometric terms are omitted and the shell is assumed to be thin.

Stein, M.

Effects of transverse shearing on cylindrical bending, vibration, and buckling of laminated plates

The displacements for cylindrical bending and stretching of laminated and thick plates are expressed through-the-thickness by a few algebraic terms and a complete set of trigonometric terms. Only a few terms of this series are needed to get sufficiently accurate results for laminated and thick plates. Equations of equilibrium based on a sufficient number of terms of this series for displacements are determined using variational theorems from three-dimensional elasticity. Several examples are worked out. The displacements and stresses are obtained for simply supported isotropic and layered beams with a rectangular cross section and a sinusoidal lateral load distribution. These results are compared to an exact elasticity solution. Results for several approximations are obtained for a simply supported and a clamped beam with a rectangular cross section loaded at the center and results are compared to experimental results. Results are also obtained for isotropic and layered beams with a rectangular cross section for several approximations for the lowest natural frequency and buckling load.

Stein, M.

Analytical results for post-buckling behaviour of plates in compression and in shear

The postbuckling behavior of long rectangular isotropic and orthotropic plates is determined. By assuming trigonometric functions in one direction, the nonlinear partial differential equations of von Karman large deflection plate theory are converted into nonlinear ordinary differential equations. The ordinary differential equations are solved numerically using an available boundary value problem solver which makes use of Newton's method. Results for longitudinal compression show different postbuckling behavior between isotropic and orthotropic plates. Results for shear show that change in inplane edge constraints can cause large change in postbuckling stiffness.

Stein, M.

Analytical results for postbuckling behavior of plates in compression and shear

The postbuckling behavior of long rectangular isotropic and orthotropic plates is determined. By assuming trigonometric functions in one direction, the nonlinear partial differential equations of von Karman large deflection plate theory are converted into nonlinear ordinary differential equations. The ordinary differential equations are solved numerically using an available boundary value problem solver which makes use of Newton's method. Results for longitudinal compression show different postbuckling behavior between isotropic and orthotropic plates. Results for shear show that change in inplane edge constraints can cause large change in postbuckling stiffness.

Stein, M.

Postbuckling of long orthotropic plates loaded in combined transverse compression and longitudinal compression or shear

The postbuckling behavior of simply supported, rectangular, isotropic and orthotropic composite plates under combined loading is determined analytically. Results are presented for a long plate loaded beyond its buckling load in either a combination of longitudinal and transverse compression or a combination of transverse compression and inplane shear. Results show that orthotropic plates may behave differently than isotropic plates for these loading conditions. Results also show that the postbuckling behavior of plates in shear with constrained edge displacements is markedly different than their behavior with stress free edges.

Stein, M.

Postbuckling of long orthotropic plates in combined shear and compression

The nonlinear large-deflection partial differential equations of von karman for orthotropic plates loaded in combined shear and compression are converted into a set of first-order nonlinear ordinary differential equations by assuming trigonometric functions in one direction. These equations are solved numerically using a two point boundary problem solver which makes use of Newton's method. Results are obtained which determine the postbuckling behavior of rectangular plates with loading up to about three times the buckling load. Both isotropic and orthotropic composite plates are considered. Results show that orthotropic plates may behave quite differently than isotropic plates and that in-plane boundary conditions are important for plates loaded in shear.

Stein, M.

Postbuckling of orthotropic composite plates loaded in compression

The nonlinear large deflection equations of von Karman are written for 'specially' orthotropic plates. The equations are then manipulated to determine the parameters required to establish postbuckling behavior. It is found that only two new parameters are needed beyond those required for buckling. By assuming trigonometric functions in one direction, the plate equations are converted into ordinary nonlinear differential equations which are solved numerically using a two point boundary problem solver that makes use of Newton's method. The postbuckling behavior is obtained for simply supported and clamped, long, rectangular, orthotropic plates covering the complete range of dimensions and material properties.

Stein, M.