Spaceflight alters host-gut microbiota interactions
Not provided.
Biotechnology & Applied Microbiology↗
Engineering topics
Singh, N.
Publications and source records attributed to Singh, N..
Measurement of the 13 C(α, n 0 ) 16 O Differential Cross Section from 0.8 to 6.5 MeV
The cross section of the 13 C(α, n 0 ) 16 O reaction is needed for nuclear astrophysics and applications to a precision of 10% or better, yet inconsistencies among 50 years of experimental studies currently lead to an uncertainty of ≈15%. Here, using a state-of-the-art neutron detection array, we have performed a high resolution differential cross section study covering a broad energy range. These measurements result in a dramatic improvement in the extrapolation of the cross section to stellar energies potentially reducing the uncertainty to ≈5% and resolving long standing discrepancies in higher energy data.
6 ≤ A ≤ 19↗
Characterization and description of a spectrum unfolding method for the $\mathrm{CATRiNA}$ neutron detector array
We report the CATRiNA deuterated neutron detector array at Florida State University consists of 16 2" x 2" and 16 $" x 2" EJ-315 detectors with characteristic light output and pulse-shape discrimination capabilities. The unique properties of the detectors, in part due to the anisotropic nature of (d,n) scattering, are used to extract the energy of neutrons via pulse-height spectrum unfolding. The unfolding method uses the light output and response matrix of the detectors to extract neutron energies, independent of the traditional time-of-flight (ToF) technique. Detailed response matrices of the CATRiNA detectors were measured at the Edwards Accelerator Laboratory at Ohio University via the 9 Be(d,n) and 27 Al(d,n) reactions. Full characterization of the detectors using digital electronics, as well as a description of the unfolding method are reported.
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
Neutron-upscattering enhancement of the triple-alpha process
Abstract The neutron inelastic scattering of carbon-12, populating the Hoyle state, is a reaction of interest for the triple-alpha process. The inverse process (neutron upscattering) can enhance the Hoyle state’s decay rate to the bound states of 12 C, effectively increasing the overall triple-alpha reaction rate. The cross section of this reaction is impossible to measure experimentally but has been determined here at astrophysically-relevant energies using detailed balance. Using a highly-collimated monoenergetic beam, here we measure neutrons incident on the Texas Active Target Time Projection Chamber (TexAT TPC) filled with CO 2 gas, we measure the 3 α -particles (arising from the decay of the Hoyle state following inelastic scattering) and a cross section is extracted. Here we show the neutron-upscattering enhancement is observed to be much smaller than previously expected. The importance of the neutron-upscattering enhancement may therefore not be significant aside from in very particular astrophysical sites (e.g. neutron star mergers).
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
Structural Modeling of the Treponema pallidum Outer Membrane Protein Repertoire: a Road Map for Deconvolution of Syphilis Pathogenesis and Development of a Syphilis Vaccine
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99 GENERAL AND MISCELLANEOUS↗
Imaging the short-lived hydroxyl-hydronium pair in ionized liquid water
The radiolysis of water is ubiquitous in nature and plays a critical role in numerous biochemical and technological applications. Although the elementary reaction pathways for the ionized water have been studied, the short-lived intermediate complex and structural dynamic response after the proton transfer reaction remain poorly understood. Here, using liquid-phase ultrafast electron diffraction technique to measure the intermolecular O··O and O··H bonds, we captured the short-lived radical-cation complex OH(H 3 O + ) that was formed within 140 femtoseconds through a direct oxygen-oxygen bond contraction and proton transfer, followed by the radical-cation pair dissociation and the subsequent structural relaxation of water within 250 femtoseconds. These measurements provide direct evidence of capturing this metastable radical-cation complex before separation, thereby improving our fundamental understanding of elementary reaction dynamics in ionized liquid water.
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
Detection of antimicrobial resistance genes associated with the International Space Station environmental surfaces
Antimicrobial resistance (AMR) is a global health issue. In an effort to minimize this threat to astronauts, who may be immunocompromised and thus at a greater risk of infection from antimicrobial resistant pathogens, a comprehensive study of the ISS “resistome’ was conducted. Using whole genome sequencing (WGS) and disc diffusion antibiotic resistance assays, 9 biosafety level 2 organisms isolated from the ISS were assessed for their antibiotic resistance. Molecular analysis of AMR genes from 24 surface samples collected from the ISS during 3 different sampling events over a span of a year were analyzed with Ion AmpliSeq™ and metagenomics. Disc diffusion assays showed that Enterobacter bugandensis strains were resistant to all 9 antibiotics tested and Staphylococcus haemolyticus being resistant to none. Ion AmpliSeq™ revealed that 123 AMR genes were found, with those responsible for beta-lactam and trimethoprim resistance being the most abundant and widespread. Using a variety of methods, the genes involved in antimicrobial resistance have been examined for the first time from the ISS. Lastly, this information could lead to mitigation strategies to maintain astronaut health during long duration space missions when return to Earth for treatment is not possible.
59 BASIC BIOLOGICAL SCIENCES↗
Doppler Lidar Observations over a High Altitude Mountainous Site Manora Peak in the Central Himalayan Region
The RAWEX-GVAX field campaign has been carried out from June 2011 to March 2012 over a high altitude site Manora Peak, Nainital (29.4 degrees N; 79.2 degrees E; 1958 m amsl) in the central Himalayas to assess the impacts of absorbing aerosols on atmospheric thermodynamics and clouds. This paper presents the preliminary results of the observations and data analysis of the Doppler Lidar, installed at Nainital. Strong updrafts with vertical winds in the range of similar to 2-4 ms(-1) occurred during the daytime and throughout the season indicating thermally driven convection. On the other hand during nighttime, weak downdrafts persisted during stable conditions. Plan Position Indicator scan of Doppler Lidar showed north-northwesterly winds in the boundary layer. The mixing layer height, derived from the vertical velocity variance, showed diurnal variations, in the range similar to 0.7-1 km above ground level during daytime and very shallow during nighttime.
Boundary layer↗
On the brittle nature of rare earth pnictides
The high-pressure structural phase transition and pressure as well temperature induced elastic properties in ReY; (Re = La, Sc, Pr; Y = N, P, As, Sb, Bi) pnictides have been performed using effective interionic interaction potential with emphasis on charge transfer interactions and covalent contribution. Estimated values of phase transition pressure and the volume discontinuity in pressure-volume phase diagram indicate the structural phase transition from NaCl to CsCl structure. From the investigations of elastic constants the pressure (temperature) dependent volume collapse/expansion, second order Cauchy discrepancy, anisotropy, hardness and brittle/ductile nature of rare earth pnictides are computed.
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗
Pressure and temperature induced elastic properties of rare earth chalcogenides
The pressure and temperature dependent mechanical properties as Young modulus, Thermal expansion coefficient of rare earth REX (RE = La, Pr, Eu; X = O, S, Se, and Te) chalcogenides are studied. The rare earth chalcogenides showed a structural phase transition (B1–B2). Pressure dependence of Young modulus discerns an increase in pressure inferring the hardening or stiffening of the lattice as a consequence of bond compression and bond strengthening. Suppressed Young modulus as functions of temperature infers the weakening of the lattice results in bond weakening in REX. Thermal expansion coefficient demonstrates that REX (RE = La, Pr, Eu; X = O, S, Se, and Te) chalcogenides is mechanically stiffened, and thermally softened on applied pressure and temperature.
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗
Cross-Scale Coupling in the Inner Magnetosphere
Magnetosphere-ionosphere (MI) coupling has interested scientists for decades and, in spite of experimental and theoretical research efforts, is still one of the least well-known dynamic processes in space plasma. The reason for this is that the numerous physical processes associated with MI coupling occur over multiple spatial lengths and temporal scales. One typical example of MI coupling is small- and large-scale ring current (RC) electrodynamic coupling. In this talk, we will address the two primary issues of RC electrodynamic coupling: (1) RC self-consistent coupling with electromagnetic ion cyclotron (EMIC) waves (small-scale electrodynamic coupling) and (2) RC self-consistent MI coupling that includes calculation of the magnetospheric electric field (large-scale electrodynamic coupling). We also will emphasize the role of the heavy ions in the number of wave-particle interaction magnetospheric processes. In particular, we will discuss some of the experimental and theoretical studies that have investigated the role of the heavy ions (mainly He(+) and O(+)) in generation and propagation of electromagnetic ion cyclotron waves and their contribution to the heating of magnetospheric electrons and ions. The more recent studies have also shown that the heavy ions can greatly contribute to a generation of lower hybrid waves, ring current precipitation phenomena, and the overall energy redistribution in the inner magnetosphere. Using newly developed 2.5-dimensional particle-in-cell simulations, we study the energization and nonlinear coupling of different plasma waves in the presence of the heavy ions. We have shown that the high frequency wave modes critically depend on the heavy ion density and irrespective of the driven wave modes, both the light and heavy ions undergo significant transverse acceleration. But for the large heavy-ion densities, even the electrons are significantly accelerated in the parallel direction by the waves below the LH frequency.
Khazanov, G. V.↗
The Role of the Heavy Ions in the Wave Magnetospheric Phenomena
This talk will emphasize the role of the heavy ions in the number of wave-particle interaction magnetospheric processes. In particular, we will discuss some of the experimental and theoretical studies that have investigated the role of the heavy ions (mainly He(+) and O(+)) in generation and propagation of electromagnetic ion cyclotron waves and their contribution to the heating of magnetospheric electrons and ions. The more recent studies have also shown that the heavy ions can greatly contribute to a generation of lower hybrid waves, ring current precipitation phenomena, and the overall energy redistribution in the inner magnetosphere. Using newly developed 2.5-dimensional particle-in-cell simulations, we study the energization and nonlinear coupling of different plasma waves in the presence of the heavy ions. We have shown that the high frequency wave modes critically depend on the heavy ion density and irrespective of the driven wave modes, both the light and heavy ions undergo significant transverse acceleration. But for the large heavy-ion densities, even the electrons are significantly accelerated in the parallel direction by the waves below the LH frequency.
Khazanov, G. V.↗
Observed Relationship Between Ion Energization and the Broadband ELF Spectrum
Many existing theories linking broadband ELF wave activity (BBELF) to ion energization and outflow are based on the gyro-resonant heating of ions. Recent studies on the properties of these broadband waves show that other mechanisms may be more relevant. Using data from the Polar satellite, we will present an analysis of the observed relationship between the broadband electric field spectrum and ion energization across the cusp, auroral oval, and polar cap.
Coffey, V. N.↗
The Nonlinear Coupling of Alfven and Lower Hybrid Waves in Space Plasma
Space plasmas support a wide variety of waves, and wave-particle interactions as well as wave-wave interactions which are of crucial importance to magnetospheric and ionospheric plasma behavior. The excitation of lower hybrid waves (LHWs), in particular, is a widely discussed mechanism of interaction between plasma species in space and is one of the unresolved questions of magnetospheric multi-ion plasmas. It is demonstrated that large-amplitude Alfven waves may generate LHWs in the auroral zone and ring current region and in some cases (particularly in the inner magnetosphere) this serves as the Alfven wave saturation mechanism. We present several examples of observational data which illustrate that the proposed mechanism is a plausible candidate to explain certain classes of LHW generation events in the ionosphere and magnetosphere and demonstrate electron and ion energization involving these processes. Furthermore, we will present results from particle-in-cell simulations showing the generation of particle drifts in response to an Alfven wave, resulting in excitation of waves and ion heating in a multi- ion plasma.
Khazanov, G. V.↗
Numerical Model of the Plasma Sheath Generated by the Plasma Source Instrument Aboard the Polar Satellite
The plasma sheath generated by the operation of the Plasma Source Instrument (PSI) aboard the Polar satellite is studied by using a three-dimensional particle-in-cell (PIC) code. When the satellite passes through the region of low-density plasma, the satellite charges to positive potentials as high as 40-50 V, owing to the photoelectron emission. In such a case, ambient core ions cannot accurately be measured or detected. The goal of the onboard PSI is to reduce the floating potential of the satellite to a sufficiently low value so that the ions in the polar wind become detectable. When the PSI is operated, ion-rich xenon plasma is ejected from the satellite, such that the floating potential of the satellite is reduced and is maintained at approximately 2 V. Accordingly, in our three-dimensional PIC simulation we considered that the potential of the satellite is 2 V as a fixed bias. Considering the relatively high density of the xenon plasma in the sheath (10-10(exp 3)/cc), the ambient plasma of low density (<1/cc) is neglected. In the simulations the electric fields and plasma dynamics are calculated self-consistently. We found that an 'apple'-shape positive potential sheath forms surrounding the satellite. In the region near the PSI emission a high positive potential hill develops. Near the Thermal Ion Dynamics Experiment detector away from the PSI, the potentials are sufficiently low for the ambient polar wind ions to reach it. In the simulations it takes only about a couple of tens of electron gyroperiods for the sheath to reach a quasi steady state. This time is approximately the time taken by the heavy Xe(+) ions to expand up to about one average Larmor radius of electrons from the satellite surface. After this time the expansion of the sheath in directions transverse to the ambient magnetic field slows down because the electrons are magnetized. Using the quasi steady sheath, we performed trajectory calculations to characterize the detector response to a highly supersonic polar wind flow. The detected ions' velocity distribution shows significant deviations from a shifted Maxwellian in the ambient polar wind population. The deviations are caused by the effects of electric fields on the ions' motion as they traverse the sheath.
Singh, N.↗
Boronate affinity adsorption of RNA: possible role of conformational changes
Batch equilibrium adsorption isotherm determination is used to characterize the adsorption of mixed yeast RNA on agarose-immobilized m-aminophenylboronic acid. It is shown that the affinity-enhancing influence of divalent cations depends strongly on the precise nature of the cation used, with barium being far more effective than the conventionally-used magnesium. This adsorption-promoting influence of barium is suggested to arise primarily from ionic influences on the structure and rigidity of the RNA molecule, as the adsorption of ribose-based small molecules is not similarly affected. The substitution of barium for the standard magnesium counterion does not greatly promote the adsorption of DNA, implying that the effect is specific to RNA and may be useful in boronate-based RNA separations. RNA adsorption isotherms exhibit sharp transitions as functions of temperature, and these transitions occur at different temperatures with Mg2+ and with Ba2+. Adsorption affinity and capacity were found to increase markedly at lower temperatures, suggestive of an enthalpically favored interaction process. The stoichiometric displacement parameter, Z, in Ba2+ buffer is three times the value in Mg2+ buffer, and is close to unity.
NASA Discipline Environmental Health↗
Ionospheric plasma outflow in response to transverse ion heating: Self-consistent macroscopic treatment
We examined the various likely processes for creating the cavities and found that the mirror force acting on the transversely heated ions is the most likely mechanism. The pondermotive force causing the wave collapse was found to be a much weaker force than the mirror force on the transversely heated ions observed inside the cavities along with the lower hybrid waves. Using a hydrodynamic model for the polar wind we modeled the cavity formation and found that for the heating rate obtained from the observed waves, the mirror force does create cavities with depletions as observed. Some initial results from this study were published in a recent Geophysical Research Letters and were reported in the Fall AGU meeting in San Francisco. We have continued this investigation using a large-scale semikinetic model.
Singh, N.↗
Studies on equatorial shock formation during plasmaspheric refilling
Investigations based on small-scale simulations of microprocesses occurring when a magnetic flux tube refills with a cold plasma are summarized. Results of these investigations are reported in the following attached papers: (1) 'Numerical Simulation of Filling a Magnetic Flux Tube with a Cold Plasma: The Role of Ion Beam-Driven Instabilities'; and (2) 'Numerical Simulation of Filling a Magnetic Flux Tube with a Cold Plasma: Effects of Magnetically Trapped Hot Plasma'. Other papers included are: 'Interaction of Field-Aligned Cold Plasma Flows with an Equatorially-Trapped Hot Plasma: Electrostatic Shock Formation'; and 'Comparison of Hydrodynamic and Semikinetic Treatments for a Plasma Flow along Closed Field Lines'. A proposal for further research is included.
Singh, N.↗