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Shen, Y.

Publications and source records attributed to Shen, Y..

At least 55 records · Page 3
All sourcesNASA NTRSDOE OSTI
DOE OSTI2011

Ortholog identification in the presence of domain architecture rearrangement

Ortholog identification is used in gene functional annotation, species phylogeny estimation, phylogenetic profile construction and many other analyses. Bioinformatics methods for ortholog identification are commonly based on pairwise protein sequence comparisons between whole genomes. Phylogenetic methods of ortholog identification have also been developed; these methods can be applied to protein data sets sharing a common domain architecture or which share a single functional domain but differ outside this region of homology.While promiscuous domains represent a challenge to all orthology prediction methods, overall structural similarity is highly correlated with proximity in a phylogenetic tree, conferring a degree of robustness to phylogenetic methods. In this article, we review the issues involved in orthology prediction when data sets include sequences with structurally heterogeneous domain architectures, with particular attention to automated methods designed for high-throughput application, and present a case study to illustrate the challenges in this area.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS2000

SRTM flight system design and operations overview

This paper provides an overview of the Shuttle Radar Topography Mission (SRTM), with emphasis on flight system implementation and mission operations from systems engineering perspective.

SRTM interferometery syntheticaperature radar INSA↗
NASA NTRS1999

Achievements in the Development of Space-borne Imaging Radar

This article describes past and current achievements in the development of space-borne imaging radar technology and discusses possibilities for the future. The article focuses on space-borne capabilities for civil and scientific purposes.

space-borne imaging radar interferometry↗
NASA NTRS1999

Bone and hormonal changes induced by skeletal unloading in the mature male rat

To determine whether the rat hindlimb elevation model can be used to study the effects of spaceflight and loss of gravitational loading on bone in the adult animal, and to examine the effects of age on bone responsiveness to mechanical loading, we studied 6-mo-old rats subjected to hindlimb elevation for up to 5 wk. Loss of weight bearing in the adult induced a mild hypercalcemia, diminished serum 1,25-dihydroxyvitamin D, decreased vertebral bone mass, and blunted the otherwise normal increase in femoral mass associated with bone maturation. Unloading decreased osteoblast numbers and reduced periosteal and cancellous bone formation but had no effect on bone resorption. Mineralizing surface, mineral apposition rate, and bone formation rate decreased during unloading. Our results demonstrate the utility of the adult rat hindlimb elevation model as a means of simulating the loss of gravitational loading on the skeleton, and they show that the effects of nonweight bearing are prolonged and have a greater relative effect on bone formation in the adult than in the young growing animal.

NASA Discipline Musculoskeletal↗
NASA NTRS1996

Skeletal response to corticosteroid deficiency and excess in growing male rats

The study was designed to investigate bone histomorphometric changes induced by corticosteroid deficiency and supplementation at different dose levels in the rat skeleton. Male rats were adrenalectomized (ADX) or sham-operated and divided into six groups. At 2 days after surgery, sham-operated control rats (CON + PLA) and one group of ADX rats (ADX + PLA) were implanted subcutaneously (s.c.) with placebo pellets. ADX rats in the remaining four groups (ADX + C25, ADX + C50, ADX + C100, and ADX + C300) were implanted sc with corticosterone pellets designed to release 25, 50, 100, or 300 mg of the hormone over a 60 day period. Each ADX rat was also implanted sc with an aldosterone pellet (2.5 mg) similarly designed to release its contents over the same time period. All rats were killed at 3 weeks after implantation of pellets. Terminal blood samples were collected for serum biochemistry and the proximal tibial metaphyses (PTM), tibial diaphyses, and first lumbar vertebrae (LV) were processed undecalcified for quantitative bone histomorphometry. A dose-dependent increase in serum corticosterone concentration was observed in ADX rats implanted with hormone pellets. In comparison to CON + PLA rats, ADX + PLA rats had lower cancellous bone volume associated with a stimulation in longitudinal bone growth, an increase in mineral apposition rate, and a trend for increased osteoclast and osteoblast surfaces in PTM. In contrast, cancellous bone of ADX + C25 rats was preserved at nearly the CON + PLA level. However, the higher doses of corticosterone increased cancellous bone mass, but decreased longitudinal bone growth and all indices of bone resorption and formation in a dose-dependent manner in PTM. Similar cancellous bone changes were observed in the LV of corticosterone-treated rats, with the exception of a lack of an hormonal effect on cancellous bone mass. In the tibial diaphysis, corticosterone inhibited periosteal bone formation in a dose-dependent manner, but did not affect cortical bone mass. The results indicate that corticosteroid deficiency induces cancellous osteopenia, whereas supplementation with a near physiologic dose of the hormone prevents this bone loss in ADX rats. Furthermore, corticosteroid excess inhibits bone growth and bone turnover in a dose-dependent manner, but does not induce cancellous osteopenia in growing male rats.

Non-NASA Center↗
NASA NTRS1996

The Contradiction Between the Measurement Theory of Quantum Mechanics and the Theory that the Velocity of Any Particle Can Not be Larger than the Velocity of Light

By the measurement theory of quantum mechanics and the method of Fourier transform,we proved that the wave function psi(x,y,z,t)= (8/((2(pi)(2L(exp (1/2)))(exp 3))(Phi(L,t,x)Phi(L,t,y)Phi(L,t,z)). According to the theory that the velocity of any particle can not be larger than the velocity of light and the Born interpretation, when absolute value of delta greater than (ct+ L),Phi(L,t,delta) = 0. But according to the calculation, we proved that for some delta, even if absolute value of delta is greater than (ct+L), Phi(L,t,delta) is not equal to 0.

Shen, Y.↗
NASA NTRS1995

(abstract) SIR-C/X-SAR: A Multifaceted Radar

The Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SAR-C/X-SAR) was a joint US/German/Italian project, with flights aboard the shuttle Endeavor in April and October 1994. SIR-C/X-SAR is the first spaceborne multifrequency, multipolarization radar. The SIR-C and the X-SAR were designed to operate in conjunction with each other, collecting data over common sites. Scientists around the world are using the data in conjunction with ground measurements to conduct experiments relating to Earth's ecology, geology, hydrology, and oceanography. In addition, the data are the most comprehensive set yet available for engineering characterization of spaceborne SAR capabilities relative to various radar phenomenology and methodology. Preliminary results show changes between missions in vegetation, ice, snow, flooding, and volcano activity.

imaging↗
NASA NTRS1994

Spaceborne Imaging Radar-C: An Advanced Imaging Radar Studied the Earth

None given. From Intro: The U.S. launched the most sophisticated imaging radar ever on-board the space shuttle Endeavor twice within a year as part of NASA's Mission to Planet Earth Program. Survey image products were available within three months following each of the missions. Most important aspect of SIR-C products is that the images are calibrated.The interferometry experiment conducted during the second flight clearly demonstrated that global high-resolution topographic maps are within the reach of current SAR technology.

SIR-C imaging radar MAPS synthetic radar SAR SRL S↗
NASA NTRS1992

Thermocapillary convection instability in microgravity crystal growth

Energy and linear stability theories are applied to study the stability properties of thermocapillary convection in a half zone model of the float zone crystal growth process. The analyses yield results which provide sufficient conditions for both stability and instability, respectively, and therefore, lower and upper bounds for the Marangoni numbers at which oscillatory thermocapillary convection will appear. The results of the analyses are compared with available experimental and numerical data.

Neitzel, G. P.↗