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Peterson, L. E.

Publications and source records attributed to Peterson, L. E..

At least 19 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS2004

Uncertainties in estimates of the risks of late effects from space radiation

Methods used to project risks in low-Earth orbit are of questionable merit for exploration missions because of the limited radiobiology data and knowledge of galactic cosmic ray (GCR) heavy ions, which causes estimates of the risk of late effects to be highly uncertain. Risk projections involve a product of many biological and physical factors, each of which has a differential range of uncertainty due to lack of data and knowledge. Using the linear-additivity model for radiation risks, we use Monte-Carlo sampling from subjective uncertainty distributions in each factor to obtain an estimate of the overall uncertainty in risk projections. The resulting methodology is applied to several human space exploration mission scenarios including a deep space outpost and Mars missions of duration of 360, 660, and 1000 days. The major results are the quantification of the uncertainties in current risk estimates, the identification of factors that dominate risk projection uncertainties, and the development of a method to quantify candidate approaches to reduce uncertainties or mitigate risks. The large uncertainties in GCR risk projections lead to probability distributions of risk that mask any potential risk reduction using the "optimization" of shielding materials or configurations. In contrast, the design of shielding optimization approaches for solar particle events and trapped protons can be made at this time and promising technologies can be shown to have merit using our approach. The methods used also make it possible to express risk management objectives in terms of quantitative metrics, e.g., the number of days in space without exceeding a given risk level within well-defined confidence limits. Published by Elsevier Ltd on behalf of COSPAR.

Non-NASA Center↗
NASA NTRS2004

Historical Study of Radiation Exposures and the Incidence of Cataracts in Astronauts

For over 35 years, astronauts in low Earth orbit or on missions to the moon have been exposed to space radiation comprised of high-energy protons, heavy ions, and secondary neutrons. We reviewed the radiation exposures received by astronauts in space and on Earth, and presented results from the first epidemiological study of cataract incidence in the astronauts. Our data suggested an increased risk for cataracts from space radiation exposures. Using parametric survival analysis and the maximum likelihood method, we estimated the dose-response and age distribution for cataract incidence in astronauts by space radiation. Considering the high-LET dose contributions on specific space missions as well as data from animal studies with neutrons and heavy ions, suggested a linear response with no dose-threshold for cataracts. However, there are unanswered questions related to the importance and the definition of clinically significant cataracts commonly used in radiation protection, especially in light of epidemiological data suggesting that the probability that sub-clinical cataracts will progress is highly dependent on the age at which cataracts appear. We briefly describe a new study that will address the measurement of cataract progression-rates in astronauts and a ground-based comparison group.

Cucinotta, F. A.↗
NASA NTRS2004

Historical Study of Radiation Exposures and the Incidence of Cataracts in Astronauts

For over 35 years, astronauts in low Earth orbit or on missions to the moon have been exposed to space radiation comprised of high-energy protons, heavy ions, and secondary neutrons. We reviewed the radiation exposures received by astronauts in space and on Earth, and presented results from the first epidemiological study of cataract incidence in the astronauts. Our data suggested an increased risk for cataracts from space radiation exposures*. Using parametric survival analysis and the maximum likelihood method, we estimated the dose-response and age distribution for cataract incidence in astronauts by space radiation. Considering the high-LET dose contributions on specific space missions as well as data from animal studies with neutrons and heavy ions, suggested a linear response with no dose-threshold for cataracts. However, there are unanswered questions related to the importance and the definition of "clinically significant" cataracts commonly used in radiation protection, especially in light of epidemiological data suggesting that the probability that "sub-clinical" cataracts will progress is highly dependent on the age at which cataracts appear. We briefly describe a new study that will address the measurement of cataract progression-rates in astronauts and a ground-based comparison group.

Cucinotta, F. A.↗
NASA NTRS2002

Uncertainties in Estimates of the Risks of Late Effects from Space Radiation

The health risks faced by astronauts from space radiation include cancer, cataracts, hereditary effects, and non-cancer morbidity and mortality risks related to the diseases of the old age. Methods used to project risks in low-Earth orbit are of questionable merit for exploration missions because of the limited radiobiology data and knowledge of galactic cosmic ray (GCR) heavy ions, which causes estimates of the risk of late effects to be highly uncertain. Risk projections involve a product of many biological and physical factors, each of which has a differential range of uncertainty due to lack of data and knowledge. Within the linear-additivity model, we use Monte-Carlo sampling from subjective uncertainty distributions in each factor to obtain a Maximum Likelihood estimate of the overall uncertainty in risk projections. The resulting methodology is applied to several human space exploration mission scenarios including ISS, lunar station, deep space outpost, and Mar's missions of duration of 360, 660, and 1000 days. The major results are the quantification of the uncertainties in current risk estimates, the identification of factors that dominate risk projection uncertainties, and the development of a method to quantify candidate approaches to reduce uncertainties or mitigate risks. The large uncertainties in GCR risk projections lead to probability distributions of risk that mask any potential risk reduction using the "optimization" of shielding materials or configurations. In contrast, the design of shielding optimization approaches for solar particle events and trapped protons can be made at this time, and promising technologies can be shown to have merit using our approach. The methods used also make it possible to express risk management objectives in terms of quantitative objective's, i.e., the number of days in space without exceeding a given risk level within well defined confidence limits.

Cucinotta, F. A.↗
NASA NTRS2001

Space Radiation Cancer Risks and Uncertainties for Mars Missions

Projecting cancer risks from exposure to space radiation is highly uncertain because of the absence of data for humans and because of the limited radiobiology data available for estimating late effects from the high-energy and charge (HZE) ions present in the galactic cosmic rays (GCR). Cancer risk projections involve many biological and physical factors, each of which has a differential range of uncertainty due to the lack of data and knowledge. We discuss an uncertainty assessment within the linear-additivity model using the approach of Monte Carlo sampling from subjective error distributions that represent the lack of knowledge in each factor to quantify the overall uncertainty in risk projections. Calculations are performed using the space radiation environment and transport codes for several Mars mission scenarios. This approach leads to estimates of the uncertainties in cancer risk projections of 400-600% for a Mars mission. The uncertainties in the quality factors are dominant. Using safety standards developed for low-Earth orbit, long-term space missions (>90 days) outside the Earth's magnetic field are currently unacceptable if the confidence levels in risk projections are considered. Because GCR exposures involve multiple particle or delta-ray tracks per cellular array, our results suggest that the shape of the dose response at low dose rates may be an additional uncertainty for estimating space radiation risks.

NASA Discipline Radiation Health↗
NASA NTRS2001

Extrapolation of the dna fragment-size distribution after high-dose irradiation to predict effects at low doses

The patterns of DSBs induced in the genome are different for sparsely and densely ionizing radiations: In the former case, the patterns are well described by a random-breakage model; in the latter, a more sophisticated tool is needed. We used a Monte Carlo algorithm with a random-walk geometry of chromatin, and a track structure defined by the radial distribution of energy deposition from an incident ion, to fit the PFGE data for fragment-size distribution after high-dose irradiation. These fits determined the unknown parameters of the model, enabling the extrapolation of data for high-dose irradiation to the low doses that are relevant for NASA space radiation research. The randomly-located-clusters formalism was used to speed the simulations. It was shown that only one adjustable parameter, Q, the track efficiency parameter, was necessary to predict DNA fragment sizes for wide ranges of doses. This parameter was determined for a variety of radiations and LETs and was used to predict the DSB patterns at the HPRT locus of the human X chromosome after low-dose irradiation. It was found that high-LET radiation would be more likely than low-LET radiation to induce additional DSBs within the HPRT gene if this gene already contained one DSB.

NASA Discipline Radiation Health↗
NASA NTRS1999

Monte Carlo mixture model of lifetime cancer incidence risk from radiation exposure on shuttle and international space station

Estimating uncertainty in lifetime cancer risk for human exposure to space radiation is a unique challenge. Conventional risk assessment with low-linear-energy-transfer (LET)-based risk from Japanese atomic bomb survivor studies may be inappropriate for relativistic protons and nuclei in space due to track structure effects. This paper develops a Monte Carlo mixture model (MCMM) for transferring additive, National Institutes of Health multiplicative, and multiplicative excess cancer incidence risks based on Japanese atomic bomb survivor data to determine excess incidence risk for various US astronaut exposure profiles. The MCMM serves as an anchor point for future risk projection methods involving biophysical models of DNA damage from space radiation. Lifetime incidence risks of radiation-induced cancer for the MCMM based on low-LET Japanese data for nonleukemia (all cancers except leukemia) were 2.77 (90% confidence limit, 0.75-11.34) for males exposed to 1 Sv at age 45 and 2.20 (90% confidence limit, 0.59-10.12) for males exposed at age 55. For females, mixture model risks for nonleukemia exposed separately to 1 Sv at ages of 45 and 55 were 2.98 (90% confidence limit, 0.90-11.70) and 2.44 (90% confidence limit, 0.70-10.30), respectively. Risks for high-LET 200 MeV protons (LET=0.45 keV/micrometer), 1 MeV alpha-particles (LET=100 keV/micrometer), and 600 MeV iron particles (LET=180 keV/micrometer) were scored on a per particle basis by determining the particle fluence required for an average of one particle per cell nucleus of area 100 micrometer(2). Lifetime risk per proton was 2.68x10(-2)% (90% confidence limit, 0.79x10(-3)%-0. 514x10(-2)%). For alpha-particles, lifetime risk was 14.2% (90% confidence limit, 2.5%-31.2%). Conversely, lifetime risk per iron particle was 23.7% (90% confidence limit, 4.5%-53.0%). Uncertainty in the DDREF for high-LET particles may be less than that for low-LET radiation because typically there is very little dose-rate dependence. Probability density functions for high-LET radiation quality and dose-rate may be preferable to conventional risk assessment approaches. Nuclear reactions and track structure effects in tissue may not be properly estimated by existing data using in vitro models for estimating RBEs. The method used here is being extended to estimate uncertainty in spacecraft shielding effectiveness in various space radiation environments.

NASA Center LaRC↗
NASA NTRS1995

Discovery of a transient MeV range gamma-ray source

The University of California, San Diego (UCSD)/MIT hard X-ray and gamma-ray instrument on the HEAO 1 surveyed the region near the Galactic center 3 times during its lifetime in 1977-1979. During the 1977 September-October scan, a gamma-ray source was detected south of the Galactic center. The source was below the threshold sensitivity in the spring and fall of 1978. The source was detected with the medium energy phoswich scintillation counters which operated over the 80 keV-2 MeV range, had an area of 42 sq cm each, and a 17 deg FWHM aperture. The error box for the source is centered on l = 2.4 deg, b = -12.2 deg, with a 90% confidence error circle of approximately 3.5 deg radius. The flux in the 333-635 keV range was (1.89 +/- 0.29) x 10(exp -5) photons/(sq cm s keV) and was constant within statistics during the 1 month period the source was in the field of view. The spectrum can be characterized as a Gaussian in the range 300 less than or = E less than or = 650 keV, with a FWHM of 249 +/- 51 keV centered on 461 +/- 22 keV. The flux of this broad Gaussian is (6.6 +/- 1.1) x 10(exp -3) photons/(sq cm s). The source is tentatively identified with the 5.57 hr period low-mass X-ray-emitting binary system 1H 1822-371. Assuming this is correct, the ratio of gamma-ray to X-ray luminosity during the outburst was about 5; at a distance of 8 kpc, the gamma ray luminosity is 4 x 10(exp 37) ergs. The emission may be interpreted as a positron-pair plasma ejected from a compact object, possibly a black hole, and annihilating in a thick accretion disk surrounding the object.

Briggs, M. S.↗
NASA NTRS1990

Temporal behavior of Hercules X-1 - The long-term variability of its pulse profile and the 35 day X-ray intensity modulation

Data collected by the low-energy detectors of the Hard X-Ray and Low Energy Gamma-Ray Experiment on HEAO 1 were analyzed to study the variability in the temporal behavior of Hercules X-1. Data obtained during thirteen pointed observations distributed in 35-day phase provided details on the time and the energy dependence of the pulse shape and the spectra. It was found that a structural change at the inner edge of the accretion disk, but not at the large radii, was likely to cause the 35-day as well as the observed short-term rapid variations of the pulse profile, which had a considerably more pronounced time dependence than energy dependence. It is suggested that the variable mass-channeling scheme and an intervening effect at the inner accretion disk are directly responsible for the 35-day X-ray modulation.

Soong, Y.↗
NASA NTRS1990

Spectral behavior of Hercules X-1 - Its long-term variability and pulse phase spectroscopy

Results are presented of the analysis of the broad-energy-band Her X-1 spectra obtained by HEAO 1. Data from 13 pointed observations covered three 35-day cycles in February, August, and September of 1978. The pulse phase-averaged spectrum did not show any apparent variation during the main-on state, except for the overall intensity. The pulse phase-resolved spectrum, on the other hand, showed a moderately strong phase dependence in each of the main-on state pointings. This may imply that the orientation of the emission region is not changing on a monthly time frame, but the geometry of that region may evolve with time.

Soong, Y.↗
NASA NTRS1989

The BATSE experiment on the Gamma Ray Observatory: Solar flare hard x ray and gamma-ray capabilities

The Burst and Transient Source Experiment (BATSE) for the Gamma Ray Observatory (GRO) consists of eight detector modules that provide full-sky coverage for gamma-ray bursts and other transient phenomena such as solar flares. Each detector module has a thin, large-area scintillation detector (2025 sq cm) for high time-resolution studies, and a thicker spectroscopy detector (125 sq cm) to extend the energy range and provide better spectral resolution. The total energy range of the system is 15 keV to 100 MeV. These 16 detectors and the associated onboard data system should provide unprecedented capabilities for observing rapid spectral changes and gamma-ray lines from solar flares. The presence of a solar flare can be detected in real-time by BATSE; a trigger signal is sent to two other experiments on the GRO. The launch of the GRO is scheduled for June 1990, so that BATSE can be an important component of the Max '91 campaign.

Fishman, G. J.↗
NASA NTRS1987

A scanning modulation collimator observation of the high-energy X-ray source in the Crab Nebula

Two-dimensional maps of the 22-64 keV emission from the Crab Nebula with an angular resolution of 15 arcsec has been synthesized. The maps are generated by application of a maximum entropy method operating on a series of one-dimensional scans obtained with a balloon-borne modulation collimator telescope. The two-dimensional size, shape and orientation of the hard X-ray nebula relative to the pulsar have been measured for the first time. The implications of these results for models of electron transport in the Crab are discussed, and the geometry of the observed X-ray nebula is related to other features of the Crab Nebula system.

Pelling, R. M.↗
NASA NTRS1983

2-165 keV observations of active galaxies and the diffuse background

HEAO 1 spectral observations of 12 active galaxies in the 12-165 keV and 2-50 keV ranges are reported. The spectra of these galaxies in the 2-165 keV range are well represented by a single power law model; within experimental uncertainties a narrow dispersion in power law index attributable to the individual galaxies is observed, while the 2-165 keV luminosities of these galaxies ranged from 3 x 10 to the 43rd to 3 x 10 to the 45th ergs/s. An apparent universality of the spectral form is found which can be interpreted as due to a common electron distribution with a temperature of tens of keV in the Compton scattering region or as a common nonthermal power-law distribution generating the observed flux through synchrotron-Compton processes. The data indicate that relativistic particles are likely to be responsible for the X-rays from cores of active galaxies through synchroton-Compton processes. In addition, it is noted that only weak number evolution, if any at all, is present in active galaxies.

Rothschild, R. E.↗
NASA NTRS1983

Observation of an absorption feature in a gamma ray burst spectrum

A gamma ray burst was detected on March 25, 1978 by the High Energy X-ray and Low Energy Gamma Ray Experiment on HEAO-1. The burst spectrum shows an absorption feature at 55 + or - 5 keV with an equivalent width of 13 + or - 3 keV, values commensurate with those of similar features observed by the KONUS experiment. The burst spectrum also is characterized by a hard component extending from about 0.25-6 MeV. This component can be interpreted in terms of a fireball model for gamma ray bursts, which places the distance to the source at 1 kpc. The integrated fluence of the burst between 0.025 and 6 MeV is 1.5 x 10 to the -5th ergs/sq cm. The burst source has been localized to within a degree of RA = 237.5 deg and Dec = 76.2 deg.

Hueter, G. J.↗
NASA NTRS1982

Observations of 12-200 keV X-rays from GX 339-4

X-ray spectra of GX 339-4 measured on three occasions in 1977 and 1978 are presented. These are the first reported measurements above 10 keV. The spectra can be described as the superposition of a soft component, which is dominant below about 20 keV, and a hard component at higher energy. Simultaneous measurements at lower energy show that the soft component vanished during the observation in early 1978. The behavior of these two components is similar to that of the spectrum of Cygnus X-1; this reinforces the previously noted resemblance in rapid X-ray variability.

Nolan, P. L.↗
NASA NTRS1982

X-ray and gamma-ray upper limits for pulsed emission from radio pulsars

Results are given for an HEAO 1 search for pulsed emissions from 11 radio pulsars, in the 15 keV-11 MeV energy range. The upper limits of the Vela pulsar are found to fall below the low-energy extrapolation of the more than 50 MeV pulsed spectrum observed by the COS B satellite, and while consistent with predictions of a polar cap acceleration model, seem barely consistent with a single power-law interpolation between optical intensity and the 50 MeV intensity. High energy X-ray upper limits for seven of the ten other pulsars, which were chosen on the basis of proximity to earth, high rotational energy loss rates and short periods, are found to be only a few percent of their rotational energy losses, assuming a moment of inertia, an emission solid angle, and a pulse duty cycle, that are all similar to the high energy X-ray duty cycle of the Crab pulsar. These upper limits are below the corresponding fraction for the Crab pulsar in the cases of the Vela pulsar, PSR 1929+10 and PSR 1642-03.

Knight, F. K.↗
NASA NTRS1981

Rapid variability of 10-140 keV X-rays from Cygnus X-1

On five occasions in 1977 and 1978, Cygnus X-1 was observed using the low-energy detectors of the UCSD/MIT Hard X-ray and Low-Energy Gamma Ray experiment on the HEAO 1 satellite. Rapid (times between 0.08 and 1000 sec) variability was found in the 10-140 keV band. The power spectrum was white for frequencies between 0.001 and 0.05 Hz and was proportional to the inverse of the frequency for frequencies between 0.05 and 3 Hz, indicating correlations on all time scales less than approximately 20 s. The shape of the energy spectrum was correlated with intensity; it was harder at higher intensity. If the emission is produced by Comptonization of a soft photon flux in a hot cloud, the heating of the cloud cannot be constant; it must vary on time scales up to approximately 20 s. A variable accretion rate could cause the observed effects.

Nolan, P. L.↗