Modulation of the substrate preference of a MYST acetyltransferase by a scaffold protein
Not provided.
Biochemistry & Molecular Biology↗
Engineering topics
Paul, Thomas
Publications and source records attributed to Paul, Thomas.
Biodigester Feasibility and Design for Space and Earth Project
Biodigesters harness and utilize byproducts, and are a valuable technology for waste conversion and advanced exploration closed loops targets (6.1.a-E), including that of human waste. On Mars and at JSC, this could lead to growing food and to more sustainable uses of waste. It is critical to understand biogas generation rates, odor management of the effluent, and nutrient viability. Improved efficiency and reliance on this renewable energy source can become feasible for deep space missions.
Terrier, Douglas↗
Utilizing a Suited Manikin Test Apparatus and Space Suit Ventilation Loop to Evaluate Carbon Dioxide Washout
NASA is pursuing technology development of an Advanced Extravehicular Mobility Unit (AEMU) which is an integrated assembly made up of primarily a pressure garment system and a portable life support subsystem (PLSS). The PLSS is further composed of an oxygen subsystem, a ventilation subsystem, and a thermal subsystem. One of the key functions of the ventilation system is to remove and control the carbon dioxide (CO2) delivered to the crewmember. Carbon dioxide washout is the mechanism by which CO2 levels are controlled within the space suit helmet to limit the concentration of CO2 inhaled by the crew member. CO2 washout performance is a critical parameter needed to ensure proper and robust designs that are insensitive to human variabilities in a space suit. A suited manikin test apparatus (SMTA) was developed to augment testing of the PLSS ventilation loop in order to provide a lower cost and more controlled alternative to human testing. The CO2 removal function is performed by the regenerative Rapid Cycle Amine (RCA) within the PLSS ventilation loop and its performance is evaluated within the integrated SMTA and Ventilation Loop test system. This paper will provide a detailed description of the schematics, test configurations, and hardware components of this integrated system. Results and analysis of testing performed with this integrated system will be presented within this paper.
Chullen, Cinda↗
Understanding Columbia's Reentry Problems
Soon after the Space Shuttle Columbia accident occurred last year, a group of CFD analysts from NASA centers and private industry was organized to help determine the cause of the accident. This group was under the direction of the Applied Aeroscience and CFD Branch of the Aeroscience and Flight Mechanics Division at the Johnson Space Center. For external flow simulations, noncommercia2 CFD codes that specialize in hypersonic or high Mach number flows were used. These tools were used to determine heating rates, pressures, and temperatures for a large number of vehicle damage scenarios. Lockheed Martin Space Operations was called upon to provide CFD support in the area of internal flows within the shuttle wing cavity, and for these simulations, FLUENT 6.1 was chosen. Two large-scale, simplified models were m to understand the flow patterns once a breach of the internal wing cavity was initiated. The results were primarily used to visualize flow patterns within the wing cavity. The first CFD model included the entire lee wing without the wheel well cavity. The purpose of the first model, which did not include the reinforced carbon-carbon (RCC) cavity along the wing leading edge, was to visualize the flow field within the wing cavity immediately after the leading edge spar breach, This model assumed that the flow coming into the wing cavity was normal to the spar. It included all of the primary vents that allow for flow between the main cavities of the wing. A six-inch diameter hole was modeled in the spar at the approximate location where the spar breach was judged to have occurred, which was between RCC panels 8 and 9. The results of the modeling showed that at this location, the high temperature, high velocity gas stream entering the wing cavity impinged on the outboard wheel well cavity. Instrumentation in the Shuttle wheel well cavity registered abnormal temperatures during reentry, so the FLUENT results helped support the conclusion of the accident investigation team that the spar breach was in the RCC panel 8-9 area, and that the initial spar breach was likely entering the wing cavity normal to the spar. This model also showed that the flow entering the wing cavity tended to swirl within the cavity just outboard of the wheel well, and did not initially penetrate further into the rear cavities of the wing. The second CFD model was a 2-D simulation of the left wing cavity and the RCC cavity. It was used to visualize the flow through the RCC breach, through the wing spar breach, and into the wing cavity directly outboard of the wheel well. The purpose of this model was to verify whether or not it was possible for the flow to come into the wing cavity normal to the leading edge spar. The results from this 2-D model showed that the internal structure behind the RCC panels probably deflected the flow entering the RCC cavity so that it impinged normal to the spar. As in the 3-D model, this deflected flow stream was Found to impinge on the wheel well outer wall. This model again supported the conclusions regarding the location of the spar breach and how the flow behaved inside the wing cavity.
Paul, Thomas↗
Analysis and Design of Crew Sleep Station for ISS
This paper details the analysis and design of the Temporary Sleep Station (TeSS) environmental control system for International Space Station (ISS). The TeSS will provide crewmembers with a private and personal space, to accommodate sleeping, donning and doffing of clothing, personal communication and performance of recreational activities. The need for privacy to accommodate these activities requires adequate ventilation inside the TeSS. This study considers whether temperature, carbon dioxide, and humidity within the TeSS remain within crew comfort and safety levels for various expected operating scenarios. Evaluation of these scenarios required the use and integration of various simulation codes. An approach was adapted for this study, whereby results from a particular code were integrated with other codes when necessary. Computational Fluid Dynamics (CFD) methods were used to evaluate the flow field inside the TeSS, from which local gradients for temperature, velocity, and species concentration such as CO (sub 2) could be determined. A model of the TeSS, containing a human, as well as equipment such as a laptop computer, was developed in FLUENT, a finite-volume code. Other factors, such as detailed analysis of the heat transfer through the structure, radiation, and air circulation from the TeSS to the US Laboratory Aisle, where the TeSS is housed, were considered in the model. A complementary model was developed in G189A, a code which has been used by NASA/JSC for environmental control systems analyses since the Apollo program. Boundary conditions were exchanged between the FLUENT and G189A TeSS models. G189A provides human respiration rates to the FLUENT model, while the FLUENT model provides local convective heat transfer coefficients to G189A model. An additional benefit from using an approach with both a systems simulation and CFD model, is the capability to verify the results of each model by comparison to the results of the other model. The G189A and FLUENT models were used to evaluate various ventilation designs for the TeSS over a range of operating conditions with varying crew metabolic load, equipment operating modes, ventilation flow rates, and with the TeSS doors open and closed. Results from the study were instrumental in the optimization of a design for the TeSS ventilation hardware. A special case was considered where failure of the TeSS ventilation system occurred. In this case, a study was conducted in order to determine the time required for the CO (sub 2) concentration inside the TeSS to increase to ISS limit values under transient conditions. A lumped-capacitance code, SINDA-FLUINT was used in this case to provide accurate predictions of the human reaction to the TeSS cabin conditions including core and skin temperatures and body heat storage. A simple two-dimensional CFD model of a crewmember inside the TeSS was developed in FLUENT in order to determine the volume envelope of the respired air from the human, which maintained a minimum velocity profile. This volume was then used in the SINDA-FLUINT model to facilitate the calculations of CO (sub 2) concentrations, dry bulb temperatures and humidity levels inside the TeSS.
Keener, John F.↗