Mellado, Bruce | Engineering Papers

DOE OSTI2022

Knowing the unknown: The underestimation of monkeypox cases. Insights and implications from an integrative review of the literature

Monkeypox is an emerging zoonotic disease caused by the monkeypox virus, which is an infectious agent belonging to the genus Orthopoxvirus. Currently, commencing from the end of April 2022, an outbreak of monkeypox is ongoing, with more than 43,000 cases reported as of 23 August 2022, involving 99 countries and territories across all the six World Health Organization (WHO) regions. On 23 July 2022, the Director-General of the WHO declared monkeypox a global public health emergency of international concern (PHEIC), since the outbreak represents an extraordinary, unusual, and unexpected event that poses a significant risk for international spread, requiring an immediate, coordinated international response. However, the real magnitude of the burden of disease could be masked by failures in ascertainment and under-detection. As such, underestimation affects the efficiency and reliability of surveillance and notification systems and compromises the possibility of making informed and evidence-based policy decisions in terms of the adoption and implementation of ad hoc adequate preventive measures. In this review, synthesizing 53 papers, we summarize the determinants of the underestimation of sexually transmitted diseases, in general, and, in particular, monkeypox, in terms of all their various components and dimensions (under-ascertainment, underreporting, under-detection, under-diagnosis, misdiagnosis/misclassification, and under-notification).

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2022

Unveiling hidden physics at the LHC

The field of particle physics is at the crossroads. The discovery of a Higgs-like boson completed the Standard Model (SM), but the lacking observation of convincing resonances Beyond the SM (BSM) offers no guidance for the future of particle physics. On the other hand, the motivation for New Physics has not diminished and is, in fact, reinforced by several striking anomalous results in many experiments. Here we summarise the status of the most significant anomalies, including the most recent results for the flavour anomalies, the multi-lepton anomalies at the LHC, the Higgs-like excess at around 96 GeV, and anomalies in neutrino physics, astrophysics, cosmology, and cosmic rays. While the LHC promises up to 4 ab –1 of integrated luminosity and far-reaching physics programmes to unveil BSM physics, we consider the possibility that the latter could be tested with present data, but that systemic shortcomings of the experiments and their search strategies may preclude their discovery for several reasons, including: final states consisting in soft particles only, associated production processes, QCD-like final states, close-by SM resonances, and SUSY scenarios where no missing energy is produced. New search strategies could help to unveil the hidden BSM signatures, devised by making use of the CERN open data as a new testing ground. We discuss the CERN open data with its policies, challenges, and potential usefulness for the community. We showcase the example of the CMS collaboration, which is the only collaboration regularly releasing some of its data. We find it important to stress that individuals using public data for their own research does not imply competition with experimental efforts, but rather provides unique opportunities to give guidance for further BSM searches by the collaborations. Wide access to open data is paramount to fully exploit the LHCs potential.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗