Engineering topics
Publications and source records attributed to Macelroy, R. D..
Various topics related to closed ecological systems are discussed. Space habitats, vegetative growth, photosynthesis, recycling, culture techniques, waste utilization bioreactors and controlled atmospheres on space stations are among the topics covered.
Life support systems in space travel, in closed ecological systems were studied. Topics discussed include: (1) problems of life support and the fundamental concepts of bioregeneration; (2) technology associated with physical/chemical regenerative life support; (3) projection of the break even points for various life support techniques; (4) problems of controlling a bioregenerative life support system; (5) data on the operation of an experimental algal/mouse life support system; (6) industrial concepts of bioregenerative life support; and (7) Japanese concepts of bioregenerative life support and associated biological experiments to be conducted in the space station.
Bioregenerative life support systems for use in space were studied. Concepts of such systems include the use of higher plants and/or microalgae as sources of food, potable water and oxygen, and as sinks for carbon dioxide and metabolic wastes. Recycling of materials within the system will require processing of food organism and crew wastes using microbiological and/or physical chemical techniques. The dynamics of material flow within the system will require monitoring, control, stabilization and maintenance imposed by computers. Studies included higher plant and algal physiology, environmental responses, and control; flight experiments for testing responses of organisms to weightlessness and increased radiation levels; and development of ground based facilities for the study of recycling within a bioregenerative life support system.
A bioregenerative life support system designed to address the fundamental requirements of a functioning independent lunar base is presented in full. Issues to be discussed are associated with CELSS weight, volume and cost of operation. The fundamental CELSS component is a small, highly automated module containing plants which photosynthesize and provide the crew with food, water and oxygen. Hydrogen, nitrogen and carbon dioxide will be initially brought in from earth, recycled and their waste products conserved. As the insufficiency of buffers necessitates stringent cybernetic control, a stable state will be maintained by computer control. Through genetic engineering and carbon dioxide, temperature, and nutrient manipulation, plant productivity can be increased, while the area necessary for growth and illumination energy decreased. In addition, photosynthetic efficiency can be enhanced through lamp design, fiber optics and the use of appropriate wavelengths. Crop maintenance will be performed by robotics, as a means of preventing plant ailments.
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Various attempts to construct an understanding of the influence of solution environment on biomolecular equilibria at the molecular level using computer simulation are discussed. First, the application of the formal statistical thermodynamic program for investigating biomolecular equilibria in solution is presented, addressing modeling and conceptual simplications such as perturbative methods, long-range interaction approximations, surface thermodynamics, and hydration shell. Then, Monte Carlo calculations on the associations of nucleic acid bases in both polar and nonpolar solvents such as water and carbon tetrachloride are carried out. The solvent contribution to the enthalpy of base association is positive (destabilizing) in both polar and nonpolar solvents while negative enthalpies for stacked complexes are obtained only when the solute-solute in vacuo energy is added to the total energy. The release upon association of solvent molecules from the first hydration layer around a solute to the bulk is accompanied by an increase in solute-solvent energy and decrease in solvent-solvent energy. The techniques presented are expectd to displace less molecular and more heuristic modeling of biomolecular equilibria in solution.
Space-based and space-related research in the life sciences is presented in reviews and reports. Topics examined include the long-term effects of weightlessness, cosmic chemistry and chemical and biological evolution, life-support systems for space travel, planetary protection, and the g-scale factor in gravitational biology. Consideration is given to the role of Ca ions in cytological effects of hypogravity, the organic aerosols of Titan, the role of meteorite impacts in the formation of organic molecules, prebiotic synthesis of purines and pyrimidines, atmosphere behavior of gas-closed mouse-algal systems, air and water regeneration in advanced regenerative environmental-control and life-support systems, and the influence of gravity on the development of animal systems.
The components of a bioregenerative life-support system intended for use in space are described and the requirements for system control are discussed. Concepts of such systems include the use of higher plants and/or micro-algae as sources of oxygen, CO2 absorption, potable water, and food. In order to focus on the specific problem of reservoirs and buffers, bioregenerative life support in space is contrasted to terrestrial ecological concepts. Some of the future directions of the NASA CELSS (controlled ecological life-support system) program are outlined.
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The sequence of local conformations at C-alpha atoms of a protein has been considered as an informational message string. The total self-information contents and self-information per letter have been evaluated for 83 globular proteins whose structures are known from X-ray crystallography. The derived information contents provide a method of quantitating structural specificity of proteins. This method of analysis enables repeating, intricate structural features to be recognized. Among the globular proteins whose structures have been solved, high potential iron protein stands out with the largest three-letter dependence.
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The intent of the National Aeronautics and Space Administration in supporting the Controlled Environment Life Support System (CELSS) program is to establish the technological basis for the development of life support systems that are relatively independent of resupply. Such systems, it is anticipated, will be needed in the future to support manned space flight involving long duration missions and large numbers of people. The establishment of a resupply-independent life support system requires that all or most of the material in such a system be retained and recycled. In fact, leakage of gases into space, or into atmospheres of significantly lower pressure than that found inside of the system, is inevitable. Technical advances in sealing capabilities may reduce losses in the future, but no seals will ever be perfectly impervious to common atmospheric gases. Thus, a CELSS is envisioned to be a recycling system that will need to be resupplied with gases from time to time.
The study of the behavior of conceptualized, closed, regenerative life support systems by computer modelling is proposed.
The general processes and controls associated with two distinct experimental paradigms are examined. Specific areas for research related to biotic production (food production) and biotic decomposition (waste management) are explored. The workshop discussions were directed toward Elemental cycles and the biological factors that affect the transformations of nutrients into food, of food material into waste, and of waste into nutrients were discussed. To focus on biological issues, the discussion assumed that (1) food production would be by biological means (thus excluding chemical synthesis), (2) energy would not be a limiting factor, and (3) engineering capacity for composition and leak rate would be adequate.
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A visualization of molecular models can lead to a clearer understanding of the models. Sophisticated graphics devices supported by minicomputers make it possible for the chemist to interact with the display of a very large model, altering its structure. In addition to user interaction, the need arises also for other ways of displaying information. These include the production of viewgraphs, film presentation, as well as publication quality prints of various models. To satisfy these needs, the display capability of the Ames Interactive Modeling System (AIMS) has been enhanced to provide a wide range of graphics and plotting capabilities. Attention is given to an overview of the AIMS system, graphics hardware used by the AIMS display subsystem, a comparison of graphics hardware, the representation of molecular models, graphics software used by the AIMS display subsystem, the display of a model obtained from data stored in molecule data base, a graphics feature for obtaining single frame permanent copy displays, and a feature for producing multiple frame displays.
NASA has initiated a research program, CELSS, directed at the acquisition of the knowledge and technology required for the development of an autonomous, regenerative life support system. The program is structured to promote effective, cooperative research in fundamental, applied and engineering science. The initial research thrusts involve investigations into problems of food production, waste processing and system control and integration. In the area of food production both conventional, higher plant-based processes as well as chemosynthetic food production technologies are being investigated. Alternative waste processing procedures, both biological and physicochemical, are being examined. Computer based modelling as an aid to design and analysis is an integral part of the approach to system control and management. A mass balance model depicting the flow of elemental mass in a conceptualized closed, regenerative life support system is described.
Autonomous Life Support Systems (ALSS) are envisioned for long range permanence in space. ALSS would require little or no input of matter for extended periods of time. The design of such a system involves an understanding of both ecological principles and control theory of nonlinear, ill-defined systems. A distinction is drawn between ecosystem survival strategies and the aims of control theory. Experimental work is under way to help combine the two approaches.