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Luna, Bernadette

Publications and source records attributed to Luna, Bernadette.

36 records · Page 2

Applying Technology Ranking and Systems Engineering in Advanced Life Support

According to the Advanced Life Support (ALS) Program Plan, the Systems Modeling and Analysis Project (SMAP) has two important tasks: 1) prioritizing investments in ALS Research and Technology Development (R&TD), and 2) guiding the evolution of ALS systems. Investments could be prioritized simply by independently ranking different technologies, but we should also consider a technology's impact on system design. Guiding future ALS systems will require SMAP to consider many aspects of systems engineering. R&TD investments can be prioritized using familiar methods for ranking technology. The first step is gathering data on technology performance, safety, readiness level, and cost. Then the technologies are ranked using metrics or by decision analysis using net present economic value. The R&TD portfolio can be optimized to provide the maximum expected payoff in the face of uncertain future events. But more is needed. The optimum ALS system can not be designed simply by selecting the best technology for each predefined subsystem. Incorporating a new technology, such as food plants, can change the specifications of other subsystems, such as air regeneration. Systems must be designed top-down starting from system objectives, not bottom-up from selected technologies. The familiar top-down systems engineering process includes defining mission objectives, mission design, system specification, technology analysis, preliminary design, and detail design. Technology selection is only one part of systems analysis and engineering, and it is strongly related to the subsystem definitions. ALS systems should be designed using top-down systems engineering. R&TD technology selection should consider how the technology affects ALS system design. Technology ranking is useful but it is only a small part of systems engineering.

Jones, Harry

A Multi-Center Controlled Study of the Acute and Chronic Effects of Cooling Therapy for MS

To determine the acute and chronic effects of cooling therapy on patients with MS using objective functional performance measures and self-assessed measures of fatigue. Cooling demyelinated nerves can reduce conduction block, potentially improving symptoms of MS. Significant acute and chronic effects of cooling have not been demonstrated in a multi-center, controlled, blinded study using objective measures of neurologic function. Patients (N=84) with definite MS, mild to moderate disability (EDSS less than 6.0), and self-reported heat sensitivity were enrolled at 5 study sites. Acute effects of cooling were assessed by randomly assigning subjects to high-dose or low-dose cooling for one hour using an active cooling vest and cap (Life Enhancement Technologies, Santa Clara, CA). Settings were individualized to maintain the cooling garments at 55 F for the high-dose treatment and 70 F for the low-dose treatment. Both patients and examining investigators were blinded to treatment assignments. The MSFC and visual acuity/contrast sensitivity were assessed before and 30 minutes after treatment. The following week, subjects had an identical visit with the alternate cooling treatment. Chronic effects of cooling were assessed by randomly assigning the same subjects to unblinded daily home cooling or observation for 4 weeks. All subjects completed the Rochester Fatigue Diary (RFD) twice weekly and subjective measures of strength, cognition, and energy level daily. At the end of the period, subjects completed the Modified Fatigue Impact Scale (MFIS) and underwent another high-dose cooling session with assessment of the MSFC and vision. After a one-week washout period, subjects crossed over to the alternate 4-week treatment. Oral temperatures were reduced with both acute treatments (0.8 +/- .06 F, high and 0.5 +/- .06 F, low). While mean MSFC did not change significantly during individual cooling sessions, post hoc analysis pooling the 3 high-dose cooling sessions revealed an improvement in MSFC scores (acute phase 0.064 +/- 0.020, p = 0.0013; chronic phase 0.044 +/- 0.021, p = 0.0368) from before to after cooling. The change in MSFC scores during the acute cooling sessions was not related to the extent of change in oral temperatures. Both the RFD score and the MFIS indicate a significantly lower fatigue level during the cooling month compared to observation (RFD, 2.53 +/- 0.83,p = 0.0033; MFIS 7.63 +/- 1.56, p = 0.0001).

Luna, Bernadette

Food System Trade Study for a Near-Term Mars Mission

This paper evaluates several food system options for a near-term Mars mission, based on plans for the 120-day BIO-Plex test. Food systems considered in the study are based on the International Space Station (ISS) Assembly Phase and Assembly Complete food systems. The four systems considered are: 1) ISS assembly phase food system (US portion) with individual packaging without salad production; 2) ISS assembly phase food system (US portion) with individual packaging, with salad production; 3) ISS assembly phase food system (US portion) with bulk packaging, with salad production; 4) ISS assembly complete food system (US portion) with bulk packaging with salad and refrigeration/freezing. The food system options are assessed using equivalent system mass (ESM), which evaluates each option based upon the mass, volume, power, cooling and crewtime requirements that are associated with each food system option. However, since ESM is unable to elucidate the differences in psychological benefits between the food systems, a qualitative evaluation of each option is also presented.

Levri, Julie

Practical Considerations of Waste Heat Reuse for a Mars Mission Advanced Life Support System

Energy conservation is a key issue in design optimization of Advanced Life Support Systems (ALSS) for long-term space missions. By considering designs for conservation at the system level, energy saving opportunities arise that would otherwise go unnoticed. This paper builds on a steady-state investigation of system-level waste heat reuse in an ALSS with a low degree of crop growth for a Mars mission. In past studies, such a system has been defined in terms of technology types, hot and cold stream identification and stream energy content. The maximum steady-state potential for power and cooling savings within the system was computed via the Pinch Method. In this paper, several practical issues are considered for achieving a pragmatic estimate of total system savings in terms of equivalent system mass (ESM), rather than savings solely in terms of power and cooling. In this paper, more realistic ESM savings are computed by considering heat transfer inefficiencies during material transfer. An estimate of the steady-state mass, volume and crewtime requirements associated with heat exchange equipment is made by considering heat exchange equipment material type and configuration, stream flow characteristics and associated energy losses during the heat exchange process. Also, previously estimated power and cooling savings are adjusted to reflect the impact of such energy losses. This paper goes one step further than the traditional Pinch Method of considering waste heat reuse in heat exchangers to include ESM savings that occur with direct reuse of a stream. For example, rather than exchanging heat between crop growth lamp cooling air and air going to a clothes dryer, air used to cool crop lamps might be reused directly for clothes drying purposes. When thermodynamically feasible, such an approach may increase ESM savings by minimizing the mass, volume and crewtime requirements associated with stream routing equipment.

Levri, Julie

Modeling of Solid Waste Processing Options in BIO-Plex

BIO-Plex is a ground-based test bed currently under development by NASA for testing technologies and practices that may be utilized in future long-term life support missions. All aspects of such an Advanced Life Support (ALS) System must be considered to confidently construct a reliable system, which will not only allow the crew to survive in harsh environments, but allow the crew time to perform meaningful research. Effective handling of solid wastes is a critical aspect of the system, especially when recovery of resources contained in the waste is required. This is particularly important for ALS Systems configurations that include a Biomass Production Chamber. In these cases, significant amounts of inedible biomass waste may be produced, which can ultimately serve as a repository of necessary resources for sustaining life, notably carbon, water, and plant nutrients. Numerous biological and physicochemical solid waste processing options have been considered. Biological options include composting, aerobic digestion, and anaerobic digestion. Physicochemical options include pyrolysis, SCWO (supercritical water oxidation), various incineration configurations, microwave incineration, magnetically assisted gasification, and low temperature plasma reaction. Modeling of these options is a necessary step to assist in the design process. A previously developed top-level model of BIO-Plex implemented in MATLAB Simulink (r) for the use of systems analysis and design has been adopted for this analysis. Presently, this model only considered incineration for solid waste processing. Present work, reported here, includes the expansion of this model to include a wider array of solid waste processing options selected from the above options, bearing in mind potential, near term solid waste treatment systems. Furthermore, a trade study has also been performed among these solid waste processing technologies in an effort to determine the ideal technology for long-term life support missions.

Rodriguez, Luis F.

Separation and Conditioning of Mars Atmospheric Gases via TSA

Space and planetary exploration almost always presents interesting and unusual engineering challenges. Separations engineering for chemical processes that are critical to humans working in space is no exception. The challenges are becoming clearer as we make the transition from concepts and planning to hardware development, and as we understand better the constraints and environments in which the processes must perform. The coming decade will see a robotic Mars exploration program that has recovered from recent setbacks and is building a knowledge and technology base for human exploration. One of the missions will carry a small chemical pilot plant for demonstrating the manufacture of rocket propellants and life support consumables from the low-pressure (0.01 atm) Martian atmosphere. By manufacturing and storing the fuel and consumables needed for human-return missions in situ, launch mass and landed mass are reduced by tons and missions become far less expensive. The front-end to the pilot plant is a solid-state atmosphere acquisition and separation unit based on temperature-swing adsorption (TSA). The unit produces purified and pressurized (to 1.0 atm) carbon dioxide to downstream reactors that will make methane and oxygen. The unit also produces a nitrogen-argon mixture as a valuable by-product for life support, inflatable structures, and propellant pressurization. With nighttime temperatures falling to -100 degrees C, power availability restricted to a few watts, and flawless operation critical to success, the dusty Martian surface is a difficult place to operate a remote plant. This talk will focus on how this TSA separation process is designed and implemented for this application, and how it might be used in the more distant future for human exploration.

Finn, John E.

Numerical Simulation of a Chemically Reacting Sorbent Bed for LSS Applications

A detailed numerical model of a chemisorption bed has been developed. The model is based on the constant pressure mass transport equation for gaseous flow through a packed bed, and the equation for diffusion and reaction within a spherical particle. Because there is a wealth of data from the NASA and the Navy bodies of literature, the LiOH-H2O-CO2 system is chosen for application of the model and interpretation of results. Prior models of this system from the life support literature are limited. The current model incorporates many of the features of elaborate models developed for investigation of industrial systems or energy applications (e.g., coal, desulphurization): it distinguishes bulk convection and bed dispersion; mass transport to the particle surface, transport within the particle, and reaction. It uses the nonsteady (not pseudo-steady state) form of the equations. The chemistry is modeled as a multi-step, reversible reaction with evolving solid structure. The resulting system of equations is large. The ODEPACK family of solvers is used to integrate the system. Reaction coefficients are determined by experiment. Typical results of the model are illustrated with mission input parameters. Using the model, an explanation is offered for 1) the varied performance results found after pre-breathing (or after simulated pre-breathe conditions), 2) interrupted use and 3) low temperature use. In addition, options for a reusable canister are explored. The computational resource implications of adding energy equations are discussed briefly, as are applicability to other relevant space and undersea systems.

Luna, Bernadette

Physiologic Responses Produced by Active and Passive Personal Cooling Vests

Personal thermoregulatory systems which provide chest cooling are used in the industrial and aerospace environments to alleviate thermal stress. However, little information is available regarding the physiologic and circulatory changes produced by routine operation of these systems. The objectives of this study were to document and compare the subjects' response to three cooling vests in their recommended configurations. The Life Enhancement Tech (LET) lightweight active cooling vest with cap, the MicroClimate Systems Change of Phase garment (MCS), and the Steele Vest were each used to cool the chest regions of 12 male and 8 female Healthy subjects (21 to 69 yr.) in this study. The subjects, seated in an upright position at normal room temperature (approx. 22 C), were tested for 60 min. with one of the cooling garments. The LET active garment had an initial coolant fluid inlet temperature of 60 F, and was ramped down to 50 F. Oral, right and left ear canal temperatures were logged manually every 5 min. Arm, leg, chest and rectal temperatures; heart rate; and respiration were recorded continuously on a U.F.I., Inc. Biolog ambulatory monitor. For men, all three vests had similar, significant cooling effects. Decreases in the average rectal temperature, oral temperature, and ear canal temperatures were approximately 0.2 C, 0.2 C and 0.1 C, respectively. In contrast to the men, the female subjects wearing the MCS and Steel vests had similar cooling responses in which the core temperature remained elevated and oral and ear canal temperatures did not drop. The LET active garment cooled most of the female subjects in this study; rectal, oral and ear temperature decreased about 0.2 C, 0.3 C and 0.3 C, respectively. These results show that the garment configurations tested do not elicit a similar thermal response in all subjects. A gender difference is evident. The LET active garment configuration was most effective in decreasing temperatures of the female subjects; the MCS vest was least effective. For male subjects, the three vests appear to be more nearly equivalent. The active garment system under study included a cooling cap, which may account for some of the difference in response.

Ku, Yu-Tsuan E.

Electroencephalographic Monitoring of Cognitive Fatigue

Mental exhaustion often poses a serious risk, even when performance is not apparently degraded. When such fatigue is associated with sustained performance of a single type of cognitive task it may be related to the metabolic energy required for sustained activation of cortical fields specialized for that task. The objective of this study was to adapt EEG to monitor cortical energy dissipation at a functionally specialized site over a long period of repetitive performance of a cognitive task.

Montgomery, Leslie D.

Physiologic and Functional Responses of MS Patients to Body Cooling Using Commercially Available Cooling Garments

Personal cooling systems are widely used in industrial and aerospace environments to alleviate thermal stress. Increasingly they are also used by heat sensitive multiple sclerosis (HSMS) patients to relieve symptoms and improve quality of life. There are a variety of cooling systems commercially available to the MS community. However, little information is available regarding the comparative physiological changes produced by routine operation of these various systems. The objective of this study was to document and compare the patient response to two passive cooling vests and one active cooling garment. The Life Enhancement Technology, Inc. (LET) lightweight active cooling vest with cap, the MicroClimate Systems (MCS) Change of Phase garment, and the Steele Vest were each used to cool 13 male and 13 female MS subjects (31 to 67 yr.) in this study. The subjects, seated in an upright position at normal room temperature (approximately 22 C), were tested with one of the cooling garments. Oral, fight and left ear temperatures were logged manually every 5 min. An-n, leg, chest and rectal temperatures; heart rate; and respiration were recorded continuously on a U.F.I., Inc. Biolog ambulatory monitor. Each subject was given a series of subjective and objective evaluation tests before and after cooling. The LET and Steele vests test groups had similar, significant (P less than 0.01) cooling effects on oral and ear canal temperature, which decreased approximately 0.4 C, and 0.3 C, respectively. Core temperature increased (N.S.) with all three vests during cooling. The LET vest produced the coldest (P less than 0.01) skin temperature. Overall, the LET vest provided the most improvement on subjective and objective performance measures. These results show that the garment configurations tested do not elicit a similar thermal response in all MS patients. Cooling with the LET active garment configuration resulted in the lowest body temperatures for the MS subjects; cooling with the MCS vest was least effective. For functional responses, the LET test group performed better than the other two vests.

Ku, Yu-Tsuan E.

EEG Analysis of the Effects of Therapeutic Cooling on the Cognitive Performance of Multiple Sclerosis Patients

The objective of this project was to determine whether a controlled period of head and torso cooling would enhance the cognitive performance of multiple sclerosis patients. Nineteen MS patients (11 men and 8 women) participated in the study. Control data were taken from nineteen healthy volunteers (12 men and 7 women). All but six of nineteen MS patients tested improved their cognitive performance, as measured by their scores on the Rao test battery. A second objective was to gain insight into the neurological effects of cooling. Visual evoked potentials (VEPs) stimulated by a reversing checkerboard pattern were recorded before and after cooling. We found that cooling selectively benefited the cognitive performance of those MS patients whose pre-cooling VEPs were abnormally shaped (which is an indication of visual pathway impairment due to demyelinization). Moreover, for female MS patients, the degree of cognitive performance improvement following cooling was correlated with a change in the shape of their VEPs toward a more normal shape following cooling.

Montgomery, Leslie D.

Women Working in Engineering and Science

The presentation will focus on topics of interest to young women pursuing an engineering or scientific career, such as intrinsic personality traits of most engineers, average salaries for the various types of engineers, appropriate preparation classes at the high school and undergraduate levels, gaining experience through internships, summer jobs and graduate school, skills necessary but not always included in engineering curricula (i.e., multimedia, computer skills, communication skills), the work environment, balancing family and career, and sexual harassment. Specific examples from the speaker's own experience in NASA's Space Life Sciences Program will be used to illustrate the above topics. In particular, projects from Extravehicular Activity and Protective Systems research and Regenerative Life Support research will be used as examples of real world problem-solving to enable human exploration of the solar system.

Luna, Bernadette

A Thermal Physiological Comparison of Two HazMat Protective Ensembles With and Without Active Convective Cooling

Wearing impermeable garments for hazardous materials clean up can often present a health and safety problem for the wearer. Even short duration clean up activities can produce heat stress injuries in hazardous materials workers. It was hypothesized that an internal cooling system might increase worker productivity and decrease likelihood of heat stress injuries in typical HazMat operations. Two HazMat protective ensembles were compared during treadmill exercise. The different ensembles were created using two different suits: a Trelleborg VPS suit representative of current HazMat suits and a prototype suit developed by NASA engineers. The two life support systems used were a current technology Interspiro Spirolite breathing apparatus and a liquid air breathing system that also provided convective cooling. Twelve local members of a HazMat team served as test subjects. They were fully instrumented to allow a complete physiological comparison of their thermal responses to the different ensembles. Results showed that cooling from the liquid air system significantly decreased thermal stress. The results of the subjective evaluations of new design features in the prototype suit were also highly favorable. Incorporation of these new design features could lead to significant operational advantages in the future.

Williamson, Rebecca

Enhancement of Cognitive Processing by Multiple Sclerosis Patients Using Liquid Cooling Technology: A Case Study

Cognitive dysfunction is a common symptom in patients with multiple sclerosis (MS). This can have a significant impact on the quality of life of both the patient and of their primary care giver. This case study explores the possibility that liquid cooling therapy may be used to enhance the cognitive processing of MS patients in the same way that it provides temporary relief of some physical impairment. Two MS patients were presented a series of pattern discrimination tasks before and after being cooled with a liquid cooling garment for a one hour period. The subject whose ear temperature was reduced during cooling showed greater electroencephalographic (EEG) activity and scored much better on the task after cooling. The patient whose ear temperature was unaffected by cooling showed less EEG activity and degraded performance after the one hour cooling period.

Montgomery, Leslie D.

Assessment of Cognitive Processing by Multiple Sclerosis Patients Using Electroencephalographic Energy Density Analysis

Recent neuropsychological studies demonstrate that cognitive dysfunction is a common symptom in patients with multiple sclerosis. In many cases the presence of cognitive impairment affects the patient's daily activities to a greater extent than would be found due to their physical disability alone. Cognitive dysfunction can have a significant impact on the quality of life of both the patient and that of their primary caregiver. Two cognitively impaired male MS patients were given a visual discrimination task before and after a one hour cooling period. The subjects were presented a series of either red or blue circles or triangles. One of these combinations, or one fourth of the stimuli, was designated as the "target" presentation. EEG was recorded from 20 scalp electrodes using a Tracor Northern 7500 EEG/ERP system. Oral and ear temperatures were obtained and recorded manually every five minutes during the one hour cooling period. The EEG ERP signatures from each series of stimuli were analyzed in the energy density domain to determine the locus of neural activity at each EEG sampling time. The first subject's ear temperature did not decrease during the cooling period. It was actually elevated approximately 0.05C by the end of the cooling period compared to his mean of control period value. In turn, Subject One's discrimination performance and cortical energy remained essentially the same after body cooling. In contrast, Subject Two's ear temperature decreased approx. 0.8C during his cooling period. Subject Two's ERROR score decreased from 12 during the precooling control period to 2 after cooling. His ENERGY value increased approximately 300%, from a precooling value of approximately 200 to a postcooling value of nearly 600.

Montgomery, Leslie D.

Physiological and Thermal Responses of MS Patients to Head and Vest Cooling: A Case Study

Personal cooling systems are used to alleviate symptoms of multiple sclerosis (MS) and to prevent increased core temperature during daily activities. The objective of this study was to determine the operating characteristics and the physiologic changes produced by short term application of the stationary thermal control system used by most clinical institutions. The Life Enhancement Tech (LET) Mark VII portable cooling system and a lightweight Head-vest active cooling garment were used to cool the head and chest regions of 4 male and 3 female MS patients (30 to 66 yrs. old) in this study. The subjects, seated in an upright position at normal room temperature (approx. 24 C), were tested for 60 min. with the liquid cooling garment (LCG) operated at 50 F. Oral, right and left ear temperatures and cooling system parameters were logged manually every 5 min. Arm, leg, chest and rectal temperatures, heart rate, respiration, and an activity index were recorded continuously on a U.F.I., Inc., Biolog ambulatory monitor. All temperature responses showed extreme variation among subjects. The cold-sensitive subject's rectal temperature increased initially in response to cooling; the heat sensitive subject's rectal temperature decreased. After 40 min. of cooling and during recovery, all subjects'rectal temperatures decreased. Oral temperatures began to decrease after 30 min. of cooling. After 60 min. of cooling, temperature drops ranged from approx. 0.3 - 0.8 C. Oral temperatures continued to decrease during recovery (approx. 0.2 C). The car temperature of the heat sensitive subject was increased after cooling, other subjects exhibited an ear temperature decrease (0.0 - 0.5 C). These data indicate that head and vest cooling may be used to reduce the oral temperatures of MS patients by the approximate amount needed for symptomatic relief as shown by other researchers. The combination of a small subject population and a large subject variance does not permit us to draw statistical conclusions about the temperature response of MS patients. An individual's heat or cold sensitivity may influence their thermal response to cooling. This factor should be considered in the prescribed use of liquid cooling garments in the therapeutic management of MS.

Luna, Bernadette

Operational Characteristics of Two Commercially Available Personal Cooling Vests

Personal thermoregulatory systems which provide chest cooling are used in the industrial and aerospace environments to alleviate thermal stress. However, little information is available regarding the physiologic and circulatory changes produced by routine operation of these systems. The objectives of this study were to compare the effectiveness of two passive cooling vests, and to measure the body temperature and circulatory changes produced by each cooling vest configuration. A Life Enhancement Technologies, (LET) ice vest garment and a Steele, Inc. vest were used to cool the chest region of 11 male subjects (25 to 55 yr) in this study. Calf, forearm and finger blood flows were measured using a tetrapolar impedance rheograph. The subjects, seated in an upright position at normal room temperature (approximately 21 C) were tested for 60 min. with the cooling system operating at its maximum cooling capacity. Blood flows were recorded continuously using a computer data acquisition system with a sampling frequency of 250 Hz. Oral, right and left ear temperatures and cooling system parameters were logged manually every 5 min. Arm, leg, chest and rectal temperatures; heart rate; respiration; and an activity index were recorded continuously on a U.F.I., Inc. Biolog ambulatory monitor. No significant differences were found in either the oral or ear temperature responses to the two vests. However, the rectal and mean skin temperatures at the end of the cooling period were both significantly lower (P less than 0.05), approximately 0.2 and 1.9 C, respectively for the LET vest than for the Steele garment. These data show that different vest configurations may produce different thermal responses in healthy male subjects which should be considered in the use of these cooling garments.

Ku, Yu-Tsuan E.

Space simulation in the Neutral Buoyancy Test Facility

Various methods have been to simulate reduced gravity environments for space systems research and development. Neutral buoyancy has been the most universally used simulation of zero-g. This paper describes the facilities, personnel and experimental work that are associated with the Neutral Buoyancy Test Facility (NBTF) at NASA Ames Research Center (ARC). This facility provides a unique underwater environment for the researcher to simulate reduced gravity activities and evaluate the performances of space-related equipment. The NBTF's small size gives it several advantages over larger water facilities. Second, the facility is used for research purposes only, eliminating any scheduling conflicts with astronaut training. Lastly, the small volume of water allows the researcher to more easily vary the water temperature. This feature is ideal for investigations of astronaut thermal comfort and regulation. Recent investigations have used the NBTF for reduced gravity simulation of locomotion and load-carrying, among other interesting research endeavors.

Luna, Bernadette