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Li, Xi

Publications and source records attributed to Li, Xi.

6 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2026

Data for Selected Ion Monitoring for Orbitrap-Based Metabolomics

Orbitrap mass spectrometry in full scan mode enables the simultaneous detection of hundreds of metabolites and their isotope-labeled forms. Yet, sensitivity remains limiting for many metabolites, including low-concentration species, poor ionizers, and low-fractional-abundance isotope-labeled forms in isotope-tracing studies. Here, we explore selected ion monitoring (SIM) as a means of sensitivity enhancement. The analytes of interest are enriched in the orbitrap analyzer by using the quadrupole as a mass filter to select particular ions. In tissue extracts, SIM significantly enhances the detection of ions of low intensity, as indicated by improved signal-to-noise (S/N) ratios and measurement precision. In addition, SIM improves the accuracy of isotope-ratio measurements. SIM, however, must be deployed with care, as excessive accumulation in the orbitrap of similar m/z ions can lead, via space-charge effects, to decreased performance (signal loss, mass shift, and ion coalescence). Ion accumulation can be controlled by adjusting settings including injection time and target ion quantity. Overall, we suggest using a full scan to ensure broad metabolic coverage, in tandem with SIM, for the accurate quantitation of targeted low-intensity ions, and provide methods deploying this approach to enhance metabolome coverage.f

Mass Spectrometry↗
DOE OSTI2024

Selected Ion Monitoring for Orbitrap-Based Metabolomics

Orbitrap mass spectrometry in full scan mode enables the simultaneous detection of hundreds of metabolites and their isotope-labeled forms. Yet, sensitivity remains limiting for many metabolites, including low-concentration species, poor ionizers, and low-fractional-abundance isotope-labeled forms in isotope-tracing studies. Here, we explore selected ion monitoring (SIM) as a means of sensitivity enhancement. The analytes of interest are enriched in the orbitrap analyzer by using the quadrupole as a mass filter to select particular ions. In tissue extracts, SIM significantly enhances the detection of ions of low intensity, as indicated by improved signal-to-noise (S/N) ratios and measurement precision. In addition, SIM improves the accuracy of isotope-ratio measurements. SIM, however, must be deployed with care, as excessive accumulation in the orbitrap of similar m/z ions can lead, via space-charge effects, to decreased performance (signal loss, mass shift, and ion coalescence). Ion accumulation can be controlled by adjusting settings including injection time and target ion quantity. Overall, we suggest using a full scan to ensure broad metabolic coverage, in tandem with SIM, for the accurate quantitation of targeted low-intensity ions, and provide methods deploying this approach to enhance metabolome coverage.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2024

Compact Superconducting RF Accelerators for Water Treatment

Jefferson Lab is actively exploring the environmental applications of compact irradiation facilities utilizing Superconducting Radio Frequency (SRF) accelerator technology ? a well-established technology primarily used in large research machines. Recent advancements, such as the application of thin films of superconducting alloys in radio frequency (RF) resonators and the development of high-capacity cryocoolers, have made it feasible to employ this key technology in compact, standalone irradiation facilities. The main advantage over conventional systems based on normal conducting technology is the significantly enhanced efficiency in beam power generation, enabling exposure to substantially higher radiation doses. In the realm of addressing contaminants in wastewater treatment, particularly concerning persistent substances known as "forever chemicals," this technology presents an attractive solution, given the required considerable effort i.e. dose to break them down. Experiment Numbers:

Vennekate, John↗
DOE OSTI2024

Compact Superconducting RF Accelerators for Water Treatment

Jefferson Lab is actively exploring the environmental applications of compact irradiation facilities utilizing Superconducting Radio Frequency (SRF) accelerator technology ? a well-established technology primarily used in large research machines. Recent advancements, such as the application of thin films of superconducting alloys in radio frequency (RF) resonators and the development of high-capacity cryocoolers, have made it feasible to employ this key technology in compact, standalone irradiation facilities. The main advantage over conventional systems based on normal conducting technology is the significantly enhanced efficiency in beam power generation, enabling exposure to substantially higher radiation doses. In the realm of addressing contaminants in wastewater treatment, particularly concerning persistent substances known as "forever chemicals," this technology presents an attractive solution, given the required considerable effort i.e. dose to break them down. Experiment Numbers:

Vennekate, John↗
DOE OSTI2023

Compact, high-power superconducting radio-frequency accelerators for environmental applications

Electron-beam irradiation has been proven to destructively reduce or eliminate a wide variety of organic chemicals, viruses and bacteria from wastewater, as well as reducing sulfur and nitrous oxides emission from coal-fired power plants. It is estimated that there are approximately 30,000 such particle accelerators in use worldwide for industrial processes including surface and bulk processing of material, medical sterilization, and environmental remediation. Maximum beam power from accelerators used in these applications is currently limited to less than 500 kW, and a higher beam power is needed to reduce treatment costs. The market availability of continuous-wave (CW) electron-beam accelerators with power of the order of ~100 kW is also very limited. Superconducting radio-frequency (SRF) linear accelerators (linacs) are commonly used at basic research laboratories throughout the world due to their exceptionally high efficiency as compared to current industrial varieties. Recent advances in cryogenics, SRF thin films and high-power magnetrons allow for the design of increasingly compact and efficient CW SRF electron linacs in the energy range 1-10 MeV, with up to 1 MW of beam power. A new class of compact, high-efficiency electron-beam accelerators may provide cost-effective solutions for a range of industrial and environmental remediation applications, particularly with respect to tackling one such class of contaminants so-called “forever chemicals”, including per- and polyfluoroalkyl substances (PFASs), which are ubiquitous in a wide range of products and for which there is currently no effective destruction technology. We have recently demonstrated the key technologies required for such accelerators by: 1) operating a Nb3Sn SRF accelerating cavity cooled by commercial cryocoolers up to an accelerating gradient of 12.4 MV/m and 2) demonstrating the phase-locking as well as a high-efficiency power combining scheme for industrial magnetron transmitters. In this presentation, we will introduce the principles and benefits of MW-class SRF linacs, based on the conduction-cooled SRF technology that we have demonstrated for environmental remediation. We propose the development of a 4 MeV, 20 kW prototype to be built at Jefferson Lab as a first accelerator demonstrator unit. We will also present the results from samples study on the effect of electron-beam irradiation on so-called “forever chemicals” such as 1,4-dioxane and PFAS, using an existing multi-purpose 10 MeV, low-power, CW SRF linac at Jefferson Lab.

Ciovati, Gianluigi↗