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Leonard, J. I.

Publications and source records attributed to Leonard, J. I..

At least 19 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS1986

Math modelling as a complement to the scientific inquiry of physiological adaptation to space flight: Fluid, endocrine and circulatory regulation

The contribution of mathematical modeling and computer simulation to the understanding of problems arising during weightless space flight is reviewed. Examples from fluid, endocrine, and circulatory regulation are provided to illustrate the utility of modeling as an adjunct to the process of scientific inquiry, especially in the development and theoretical testing of hypotheses. The models were used to examine the acute and chronic phases of space flight. Paradoxial results appear when data obtained during chronic adaptation is interpreted using theories which pertain to acute adjustments. The modeling process provides a means of developing a theoretical basis for interpreting the chronic adaptive phase of flight.

Leonard, J. I.↗
NASA NTRS1986

Understanding metabolic alterations in space flight using quantitative models: fluid and energy balance

This report summarizes many of the results obtained during the Skylab program, on metabolic changes during weightlessness. The examination of the data was conducted following an integrated multi-disciplinary and multi-experimental approach. Emphasis is given on several major aspects of metabolic adaptation to space flight: fluid-electrolyte regulation, mechanisms of hormone disturbances, energy balance and etiology of weight loss. The aim is to obtain a composite picture of the fluid, electrolyte and energy response to weightlessness.

Non-NASA Center↗
NASA NTRS1985

Understanding metabolic alterations in space flight using quantitative models - Fluid and energy balance

The results of an integrated multidisciplinary and multiexperimental investigation, using data from the Skylab program, of metabolic adaptation to space flight are summarized and discussed. The effects of space flight on fluid-electrolyte regulation, mechanisms of hormone disturbances, energy balance, and the etiology of weight loss are emphasized. A composite picture of the fluid, electrolyte, and energy response to weightlessness, based primarily on data gathered from the nine Skylab crewmen, is presented.

Leonard, J. I.↗
NASA NTRS1985

Development of countermeasures for use in space missions

Several measures used to mitigate the inappropriate adaptive responses of space flight are investigated. Weighlessness results in a cephalic fluid shift, which causes a reduction in the circulating blood volume, and removal of weight bearing forces from musculoskeletal systems. The physiological changes that occur from one-g initiated hypovolemia and zero-g initiated fluild shifts are analyzed and compared. The role of barorecptors on the activation of the adrenergic responses that occurs as a result of hypovolemia is studied. The proper selection and administration of in-flight and post flight countermeasures, which include passive and active physical conditioning techniques, drugs, and vitamins are examined.

Nicogossian, A. E. T.↗
NASA NTRS1985

Predictions of cardiovascular responses during STS reentry using mathematical models

The physiological adaptation to weightless exposure includes cardiovascular deconditioning arising in part from a loss of total circulating blood volume and resulting in a reduction of orthostatic tolerance. The crew of the Shuttle orbiter are less tolerant to acceleration forces in the head-to-foot direction during the reentry phase of the flight at a time they must function at a high level of performance. The factors that contribute to orthostatic intolerance during and following reentry and to predict the likelihood of impaired crew performance are evaluated. A computer simulation approach employing a mathematical model of the cardiovascular system is employed. It is shown that depending on the severity of blood volume loss, the reentry acceleration stress may be detrimental to physiologic function and may place the physiologic status of the crew near the borderline of some type of impairment. They are in agreement with conclusions from early ground-based experiments and from observations of early Shuttle flights.

Leonard, J. I.↗
NASA NTRS1985

A systems analysis of the erythropoietic responses to weightlessness. Volume 1: Mathematical model simulations of the erythropoietic responses to weightlessness

Theoretical responses to weightlessness are summarized. The studies include development and validation of a model of erythropoiesis regulation, analysis of the behavior of erythropoiesis under a variety of conditions, simulations of bed rest and space flight, and an evaluation of ground-based animal studies which were conducted as analogs of zero-g. A review of all relevant space flight findings and a set of testable hypotheses which attempt to explain how red cell mass decreases in space flight are presented. An additional document describes details of the mathematical model used in these studies.

Leonard, J. I.↗
NASA NTRS1985

A systems analysis of the erythropoietic responses to weightlessness. Volume 2: Description of the model of erythropoiesis regulation. Part A: Model for regulation of erythropoiesis. Part B: Detailed description of the model for regulation of erythropoiesis

A mathematical model of the erythropoiesis on total red blood cell mass is presented. The loss of red cell mass has been a consistent finding during space flight. Computer simulation of this phenomenon required a model that could account for oxygen transport, red cell production, and red cell destruction. The elements incorporated into the feedback regulation loop of the model are based on the accepted concept that erythrocyte production is governed by the balance between oxygen supply and demand in the body. The mechanisms and pathways of the control circuit include oxygenation of hemoglobin and oxygenation of tissues by blood transport and diffusional processes. Other features of the model include a variable oxygen-hemoglobin affinity, and time delays which represent time for erythropoietin (erythrocyte-stimulating hormone) distribution in plasma, and time for maturation of the erythrocytes in bone marrow.

Leonard, J. I.↗
NASA NTRS1985

Description, validation, and modification of the Guyton model for space-flight applications. Part A. Guyton model of circulatory, fluid and electrolyte control. Part B. Modification of the Guyton model for circulatory, fluid and electrolyte control

The mathematical model that has been a cornerstone for the systems analysis of space-flight physiological studies is the Guyton model describing circulatory, fluid and electrolyte regulation. The model and the modifications that are made to permit simulation and analysis of the stress of weightlessness are described.

Leonard, J. I.↗
NASA NTRS1985

The behavior of renal-regulating hormones during hypogravic stress

The regulation of fluid and electrolyte behavior during space flight is believed to be under control, in large part, of a group of hormones which have their major effects on renal excretion. The hormones studied include renin-angitensin, aldosterone, and antidiuretic hormone (ADH). The regulatory systems of these renal-regulating hormones as they act individually and in concert with each other are analyzed. The analysis is based on simulations of the mathematical model of Guyton. A generalized theory is described which accounts for both short-term and long-term behavior of this set of hormones.

Leonard, J. I.↗
NASA NTRS1985

An Integrated Analysis of the Physiological Effects of Space Flight: Executive Summary

A large array of models were applied in a unified manner to solve problems in space flight physiology. Mathematical simulation was used as an alternative way of looking at physiological systems and maximizing the yield from previous space flight experiments. A medical data analysis system was created which consist of an automated data base, a computerized biostatistical and data analysis system, and a set of simulation models of physiological systems. Five basic models were employed: (1) a pulsatile cardiovascular model; (2) a respiratory model; (3) a thermoregulatory model; (4) a circulatory, fluid, and electrolyte balance model; and (5) an erythropoiesis regulatory model. Algorithms were provided to perform routine statistical tests, multivariate analysis, nonlinear regression analysis, and autocorrelation analysis. Special purpose programs were prepared for rank correlation, factor analysis, and the integration of the metabolic balance data.

Leonard, J. I.↗
NASA NTRS1984

The first dedicated life sciences Spacelab mission

JIt is pointed out that the Shuttle-borne Spacelab provides the capability to fly large numbers of life sciences experiments, to retrieve and rescue experimental equipment, and to undertake multiple-flight studies. A NASA Life Sciences Flight Experiments Program has been organized with the aim to take full advantages of this capability. A description is provided of the scientific aspects of the most ambitious Spacelab mission currently being conducted in connection with this program, taking into account the First Dedicated Life Sciences Spacelab Mission. The payload of this mission will contain the equipment for 24 separate investigations. It is planned to perform the mission on two separate seven-day Spacelab flights, the first of which is currently scheduled for early 1986. Some of the mission objectives are related to the study of human and animal responses which occur promptly upon achieving weightlessness.

Perry, T. W.↗
NASA NTRS1984

Analysis of head-down tilt as an analog of weightlessness using a methematical simulation model

Antiorthostasis or head down tilt of a moderate degree was used as a ground based analog of weightless space flight to study headward fluid shifts, decreased plasma volume, orthostatic intolerance and muscular skeletal degradation. A mathematical model was used to help interpret these observations. The model proved most valuable for these studies was originally developed as a description of the major circulatory, fluid and electrolyte control systems. Two different experimental studies are employed to validate the model. The first is a 24 hour head down tilt study and the second is a 7 day head down bed rest study. The major issues addressed include the reduction in plasma volume, the dynamic changes of venous pressure and cardiac output, the extent of central hypervolemia during long term zero g exposure, the existence of an early diuresis, the mechanisms which alter the renal regulating hormones during the short term and long term periods, the significance of potassium loss on other zero g responses, and the role of transcapillary filtration in adjusting fluid shifts. The use of mathematical models as an interpretive and analysis technique for experimental research for space life science is illustrated.

Leonard, J. I.↗
NASA NTRS1984

Mathematical modeling of fluid-electrolyte alterations during weightlessness

Fluid electrolyte metabolism and renal endocrine control as it pertains to adaptation to weightlessness were studied. The mathematical models that have been particularly useful are discussed. However, the focus of the report is on the physiological meaning of the computer studies. A discussion of the major ground based analogs of weightlessness are included; for example, head down tilt, water immersion, and bed rest, and a comparison of findings. Several important zero g phenomena are described, including acute fluid volume regulation, blood volume regulation, circulatory changes, longer term fluid electrolyte adaptations, hormonal regulation, and body composition changes. Hypotheses are offered to explain the major findings in each area and these are integrated into a larger hypothesis of space flight adaptation. A conceptual foundation for fluid electrolyte metabolism, blood volume regulation, and cardiovascular regulation is reported.

Leonard, J. I.↗
NASA NTRS1983

Quantitation of tissue loss during prolonged space flight

An analysis of data from the three Skylab missions was performed to assess the lean body mass (LBM) and fat components of inflight body weight loss. Six methods for determining LBM were employed based on changes in total body water, total body potassium, nitrogen balance, potassium balance, and stereophotometric-body density. Those based solely on body potassium, and potassium and nitrogen balances (when expressed as shifts from preflight control), consistently overestimated LBM loss unless appropriate corrections were made. The average results from the various methods indicated that of a mean inflight total body weight loss of 2.7 + or - 0.3 kg (SD) for all nine crewmembers, more than half (1.5 + or - 0.3 kg) can be attributed to loss of LBM (including 1.1 kg body water), the remainder (1.2 + or - 0.3 kg) being derived from fat stores. The reduction of LBM appeared to be complete after the first month of flight and thereafter was largely independent of mission duration, diet, and exercise.

Leonard, J. I.↗
NASA NTRS1983

Space Station and the life sciences

Previous fundamental research in space life sciences is examined, and consideration is devoted to studies relevant to Space Station activities. Microgravity causes weight loss, hemoconcentration, and orthostatic intolerance when astronauts returns to earth. Losses in bone density, bone calcium, and muscle nitrogen have also been observed, together with cardiovascular deconditioning, fluid-electrolyte metabolism alteration, and space sickness. Experiments have been performed with plants, bacteria, fungi, protozoa, tissue cultures, invertebrate species, and with nonhuman vertebrates, showing little effect on simple cell functions. The Spacelab first flight will feature seven life science experiments and the second flight, two. Further studies will be performed on later flights. Continued life science studies to optimize human performance in space are necessary for the efficient operation of a Space Station and the assembly of large space structures, particularly in interaction with automated machinery.

White, R. J.↗
NASA NTRS1983

Simulation of cardiovascular response to acceleration stress following weightless exposure

Physiological adjustments taking place during space flight tend to reduce the tolerance of the crew to headward (+Gz) acceleration experienced during the reentry phase of the flight. This reduced tolerance to acceleration stress apparently arises from an adaptation to the microgravity environment of space, including a decrease in the total circulating blood volume. Countermeasures such as anti-g garments have long been known to improve the tolerance to headward g-force, but their effectiveness in space flight has not been fully evaluated. The simulation study presented in this paper is concerned with the response of the cardiovascular system to g-stress following cardiovascular deconditioning, resulting from exposure to weightlessness, or any of its ground-based experimental analogs. The results serve to demonstrate the utility of mathematical modeling and computer simulation for studying the causes of orthostatic intolerance and the remedial measures to lessen it.

Srinivasan, R.↗