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Lacey, J. C., Jr.

Publications and source records attributed to Lacey, J. C., Jr..

23 records · Page 2
All sourcesNASA NTRSDOE OSTI
NASA NTRS1972

Concepts related to the origin of the genetic apparatus.

Since the genetic apparatus is composed of nucleic acid and protein, the origin of the apparatus involves the origin of polyaminoacids and of polynucleotides, separately or together. Laboratory models for the origins of the separate macromolecular types are considered. The origin of their joint synthesis, believed to have been necessary at a later stage, is also discussed. Proteins and nucleic acids appear to have definite relationships with each other in three major contemporary biological systems, including chromatin, ribosomes, and the protein synthesizing system using nucleic acid templates. Stages considered in connection with the flow of information in the early evolution of the apparatus are environment, protoprotein, protein, RNA, and DNA.

Lacey, J. C., Jr.↗
NASA NTRS1972

Experimental models of communication at the molecular and microsystemic levels.

Communication at both the macromolecular and the (supramacromolecular) microsystemic levels has been demonstrated in artificial polymers and artificial systems. These phenomena are models for communication in evolving and contemporary systems. The significance of a combination of communication at the two levels is emphasized.

Fox, S. W.↗
NASA NTRS1971

The primordial sequence, ribosomes, and the genetic code.

Experimental investigation of the key question of the origin of life concerning the chronological order in the primordial sequence of nucleic acid, protein, and cell. It is pointed out that, when viewed against the background of experiments on the selective reaction of basic homopolyamine acids with mononucleotides (Lacey and Pruitt, 1969; Woese, 1968), the experiments made help to establish a basis for understanding how information originally flowed from proteins to nucleic acids.

Fox, S. W.↗