Evaluation of targeting αVβ3 in breast cancers using RGD peptide-based agents
Not provided.
Radiology, Nuclear Medicine & Medical Imaging↗
Engineering topics
Hobbs, Robert
Publications and source records attributed to Hobbs, Robert.
Toward Individualized Voxel-Level Dosimetry for Radiopharmaceutical Therapy
No abstract prepared.
62 RADIOLOGY AND NUCLEAR MEDICINE↗
Methods for determining absorbed dose information
The disclosure discusses methods for determining absorbed dose information. A tomography imaging device generates an anatomy image relating to anatomy of a particular patient. A tomography imaging device also generates multiple radioactivity images regarding radioactivity distribution of an internally administered pharmaceutical over time in the particular patient. The radioactivity images related to the radioactivity distribution over time are registered. Each radioactivity image is combined with each anatomy image to create activity images. A Monte Carlo simulation for each activity image is run to obtain absorbed dose-rate images of the pharmaceutical at multiple times. The absorbed dose-rate images are integrated over time to obtain a total absorbed dose image. The absorbed dose-rate images and the total absorbed dose image are used to obtain a biologically effective dose (BED) image. The BED image is used to obtain an equivalent uniform does (EUD) of BED values for a chosen anatomical region.
62 RADIOLOGY AND NUCLEAR MEDICINE↗
Method and system for administering internal radionuclide therapy (IRT) and external radiation therapy (XRT)
A computerized method and system for determining an optimum amount of Internal Radionuclide Therapy (IRT) and External Radiation Therapy (XRT) to administer, comprising: obtaining activity image information for an imaged object from a detector; running a Monte Carlo simulation for the activity image information to obtain absorbed dose-rate image information at multiple times; adding the absorbed dose-rate image information from each time to obtain IRT total absorbed dose image information; and utilizing the IRT total dose image information to obtain total dose image information that is equivalent to XRT dose image information in terms of dose-rate, wherein the IRT dose information is converted to equivalent XRT dose information without having to generate BED dose maps.
Sgouros, George↗