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Hansen, J.

Publications and source records attributed to Hansen, J..

At least 19 records

Computational design of mechanically coupled axle-rotor protein assemblies

Natural molecular machines contain protein components that undergo motion relative to each other. Designing such mechanically constrained nanoscale protein architectures with internal degrees of freedom is an outstanding challenge for computational protein design. Here we explore the de novo construction of protein machinery from designed axle and rotor components with internal cyclic or dihedral symmetry. We find that the axle-rotor systems assemble in vitro and in vivo as designed. Using cryo–electron microscopy, we find that these systems populate conformationally variable relative orientations reflecting the symmetry of the coupled components and the computationally designed interface energy landscape. These mechanical systems with internal degrees of freedom are a step toward the design of genetically encodable nanomachines.

Science & Technology - Other Topics↗

Acceleration of electrons in the plasma wakefield of a proton bunch

High-energy particle accelerators have been crucial in providing a deeper understanding of fundamental particles and the forces that govern their interactions. To increase the energy of the particles or to reduce the size of the accelerator, new acceleration schemes need to be developed. Plasma wakefield acceleration, in which the electrons in a plasma are excited, leading to strong electric fields (so called ‘wakefields’), is one such promising acceleration technique. Experiments have shown that an intense laser pulse or electron bunch traversing a plasma can drive electric fields of tens of gigavolts per metre and above—well beyond those achieved in conventional radio-frequency accelerators (about 0.1 gigavolt per metre). However, the low stored energy of laser pulses and electron bunches means that multiple acceleration stages are needed to reach very high particle energies. The use of proton bunches is compelling because they have the potential to drive wakefields and to accelerate electrons to high energy in a single acceleration stage. Long, thin proton bunches can be used because they undergo a process called self-modulation, a particle–plasma interaction that splits the bunch longitudinally into a series of high-density microbunches, which then act resonantly to create large wakefields. The Advanced Wakefield (AWAKE) experiment at CERN uses high-intensity proton bunches—in which each proton has an energy of 400 gigaelectronvolts, resulting in a total bunch energy of 19 kilojoules—to drive a wakefield in a ten-metre-long plasma. Electron bunches are then injected into this wakefield. Here we present measurements of electrons accelerated up to two gigaelectronvolts at the AWAKE experiment, in a demonstration of proton-driven plasma wakefield acceleration. Measurements were conducted under various plasma conditions and the acceleration was found to be consistent and reliable. The potential for this scheme to produce very high-energy electron bunches in a single accelerating stage means that our results are an important step towards the development of future high-energy particle accelerators.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Path to AWAKE: Evolution of the concept

This paper describes the conceptual steps in reaching the design of the AWAKE experiment currently under construction at CERN. We start with an introduction to plasma wakefield acceleration and the motivation for using proton drivers. We then describe the self-modulation instability – a key to an early realization of the concept. This is then followed by the historical development of the experimental design, where the critical issues that arose and their solutions are described. We conclude with the design of the experiment as it is being realized at CERN and some words on the future outlook. A summary of the AWAKE design and construction status as presented in this conference is given in Gschwendtner et al. [1] .

43 PARTICLE ACCELERATORS↗

Ice Melt, Sea Level Rise and Superstorms: Evidence from Paleoclimate Data, Climate Modeling, and Modern Observations that 2C Global Warming Could Be Dangerous

We use numerical climate simulations, paleoclimate data, and modern observations to study the effect of growing ice melt from Antarctica and Greenland. Meltwater tends to stabilize the ocean column, inducing amplifying feedbacks that increase subsurface ocean warming and ice shelf melting. Cold meltwater and induced dynamical effects cause ocean surface cooling in the Southern Ocean and North Atlantic, thus increasing Earth's energy imbalance and heat flux into most of the global ocean's surface. Southern Ocean surface cooling, while lower latitudes are warming, increases precipitation on the Southern Ocean, increasing ocean stratification, slowing deepwater formation, and increasing ice sheet mass loss. These feedbacks make ice sheets in contact with the ocean vulnerable to accelerating disintegration. We hypothesize that ice mass loss from the most vulnerable ice, sufficient to raise sea level several meters, is better approximated as exponential than by a more linear response. Doubling times of 10, 20 or 40 years yield multi-meter sea level rise in about 50, 100 or 200 years. Recent ice melt doubling times are near the lower end of the 10-40-year range, but the record is too short to confirm the nature of the response. The feedbacks, including subsurface ocean warming, help explain paleoclimate data and point to a dominant Southern Ocean role in controlling atmospheric CO2, which in turn exercised tight control on global temperature and sea level. The millennial (500-2000-year) timescale of deep-ocean ventilation affects the timescale for natural CO2 change and thus the timescale for paleo-global climate, ice sheet, and sea level changes, but this paleo-millennial timescale should not be misinterpreted as the timescale for ice sheet response to a rapid, large, human-made climate forcing. These climate feedbacks aid interpretation of events late in the prior interglacial, when sea level rose to C6-9m with evidence of extreme storms while Earth was less than 1 C warmer than today. Ice melt cooling of the North Atlantic and Southern oceans increases atmospheric temperature gradients, eddy kinetic energy and baroclinicity, thus driving more powerful storms. The modeling, paleoclimate evidence, and ongoing observations together imply that 2 C global warming above the preindustrial level could be dangerous. Continued high fossil fuel emissions this century are predicted to yield (1) cooling of the Southern Ocean, especially in the Western Hemisphere; (2) slowing of the Southern Ocean overturning circulation, warming of the ice shelves, and growing ice sheet mass loss; (3) slowdown and eventual shutdown of the Atlantic overturning circulation with cooling of the North Atlantic region; (4) increasingly powerful storms; and (5) nonlinearly growing sea level rise, reaching several meters over a timescale of 50-150 years. These predictions, especially the cooling in the Southern Ocean and North Atlantic with markedly reduced warming or even cooling in Europe, differ fundamentally from existing climate change assessments. We discuss observations and modeling studies needed to refute or clarify these assertions.

Computer simulation↗

Linac4 H{sup −} ion sources

CERN’s 160 MeV H{sup −} linear accelerator (Linac4) is a key constituent of the injector chain upgrade of the Large Hadron Collider that is being installed and commissioned. A cesiated surface ion source prototype is being tested and has delivered a beam intensity of 45 mA within an emittance of 0.3 π ⋅ mm ⋅ mrad. The optimum ratio of the co-extracted electron- to ion-current is below 1 and the best production efficiency, defined as the ratio of the beam current to the 2 MHz RF-power transmitted to the plasma, reached 1.1 mA/kW. The H{sup −} source prototype and the first tests of the new ion source optics, electron-dump, and front end developed to minimize the beam emittance are presented. A temperature regulated magnetron H{sup −} source developed by the Brookhaven National Laboratory was built at CERN. The first tests of the magnetron operated at 0.8 Hz repetition rate are described.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Economic Evaluation of Promising Options

This report presents the efforts, undertaken in FY15, aimed at enhancing the Fuel Cycle Options (FCO) Campaign’s capability to perform credible fuel cycle cost estimates and evaluation of financial risk. This effort builds on the work performed in FY14 (Ganda 2014), which focused extensively on understanding the principal drivers of Light Water Reactors (LWR) construction costs, based on historical data. That framework has received further confirmation from the work and the extensive data uncovered in FY15.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

CERN’s Linac4 H{sup −} sources: Status and operational results

Two volume sources equipped with DESY and CERN plasma generators and a low voltage electron dump were operated at 45 kV in the Linac4 tunnel and on a dedicated test stand. These volume sources delivered approximately 20 mA and ensured the commissioning of the Radio Frequency Quadrupole accelerator and of the first section of the Drift Tube Linac. CERN’s prototype of a cesiated surface source equipped with this electron dump was operated continuously from November 2013 to April 2014 on the ion source test stand and is being commissioned in the Linac4 tunnel. Before cesiation, the prototype conditioned in volume mode provided up to 30 mA H{sup −} beam. Short cesiations, of the order of 10 mg effectively reduced the intensity of co-extracted electrons down to 2 - 8 times the H{sup −} current; this cesiated surface operation mode delivered up to 60 mA H{sup −} beam. An H{sup −} beam of the order of 40 mA was sustained up to four weeks operation with 500 μs pulses at 1.2s spacing. A new extraction was designed to match these beam properties. A copy of BNL’s magnetron produced at CERN was tested at BNL and delivered at 40 kV H{sup −} beam exceeding Linac4’s nominal intensity of 80 mA. In this contribution, the performances, dynamic response to cesiation, stability and availability of these prototypes are described. The needed optimization of the emittance of H{sup −} beam above 40 mA is presented, which requires an evolution of the front end that encompasses implementation of a large ceramic insulator.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Feedstock and Conversion Supply System Design and Analysis

The success of the earlier logistic pathway designs (Biochemical and Thermochemical) from a feedstock perspective was that it demonstrated that through proper equipment selection and best management practices, conventional supply systems (referred to in this report as “conventional designs,” or specifically the 2012 Conventional Design) can be successfully implemented to address dry matter loss, quality issues, and enable feedstock cost reductions that help to reduce feedstock risk of variable supply and quality and enable industry to commercialize biomass feedstock supply chains. The caveat of this success is that conventional designs depend on high density, low-cost biomass with no disruption from incremental weather. In this respect, the success of conventional designs is tied to specific, highly productive regions such as the southeastern U.S. which has traditionally supported numerous pulp and paper industries or the Midwest U.S for corn stover.

09 BIOMASS FUELS↗

Climate Sensitivity in the Anthropocene

Climate sensitivity in its most basic form is defined as the equilibrium change in global surface temperature that occurs in response to a climate forcing, or externally imposed perturbation of the planetary energy balance. Within this general definition, several specific forms of climate sensitivity exist that differ in terms of the types of climate feedbacks they include. Based on evidence from Earth's history, we suggest here that the relevant form of climate sensitivity in the Anthropocene (e.g. from which to base future greenhouse gas (GHG) stabilization targets) is the Earth system sensitivity including fast feedbacks from changes in water vapour, natural aerosols, clouds and sea ice, slower surface albedo feedbacks from changes in continental ice sheets and vegetation, and climate-GHG feedbacks from changes in natural (land and ocean) carbon sinks. Traditionally, only fast feedbacks have been considered (with the other feedbacks either ignored or treated as forcing), which has led to estimates of the climate sensitivity for doubled CO2 concentrations of about 3 C. The 2×CO2 Earth system sensitivity is higher than this, being approx. 4-6 C if the ice sheet/vegetation albedo feedback is included in addition to the fast feedbacks, and higher still if climate-GHG feedbacks are also included. The inclusion of climate-GHG feedbacks due to changes in the natural carbon sinks has the advantage of more directly linking anthropogenic GHG emissions with the ensuing global temperature increase, thus providing a truer indication of the climate sensitivity to human perturbations. The Earth system climate sensitivity is difficult to quantify due to the lack of palaeo-analogues for the present-day anthropogenic forcing, and the fact that ice sheet and climate-GHG feedbacks have yet to become globally significant in the Anthropocene. Furthermore, current models are unable to adequately simulate the physics of ice sheet decay and certain aspects of the natural carbon and nitrogen cycles. Obtaining quantitative estimates of the Earth system sensitivity is therefore a high priority for future work.

Anthropocene↗

Linac4 low energy beam measurements with negative hydrogen ions

Linac4, a 160 MeV normal-conducting H{sup −} linear accelerator, is the first step in the upgrade of the beam intensity available from the LHC proton injectors at CERN. The Linac4 Low Energy Beam Transport (LEBT) line from the pulsed 2 MHz RF driven ion source, to the 352 MHz RFQ (Radiofrequency Quadrupole) has been built and installed at a test stand, and has been used to transport and match to the RFQ a pulsed 14 mA H{sup −} beam at 45 keV. A temporary slit-and-grid emittance measurement system has been put in place to characterize the beam delivered to the RFQ. In this paper a description of the LEBT and its beam diagnostics is given, and the results of beam emittance measurements and beam transmission measurements through the RFQ are compared with the expectation from simulations.

43 PARTICLE ACCELERATORS↗

Status and operation of the Linac4 ion source prototypes

CERN's Linac4 45 kV H{sup −} ion sources prototypes are installed at a dedicated ion source test stand and in the Linac4 tunnel. The operation of the pulsed hydrogen injection, RF sustained plasma, and pulsed high voltages are described. The first experimental results of two prototypes relying on 2 MHz RF-plasma heating are presented. The plasma is ignited via capacitive coupling, and sustained by inductive coupling. The light emitted from the plasma is collected by viewports pointing to the plasma chamber wall in the middle of the RF solenoid and to the plasma chamber axis. Preliminary measurements of optical emission spectroscopy and photometry of the plasma have been performed. The design of a cesiated ion source is presented. The volume source has produced a 45 keV H{sup −} beam of 16–22 mA which has successfully been used for the commissioning of the Low Energy Beam Transport (LEBT), Radio Frequency Quadrupole (RFQ) accelerator, and chopper of Linac4.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Making Sense of Palaeoclimate Sensitivity

Many palaeoclimate studies have quantified pre-anthropogenic climate change to calculate climate sensitivity (equilibrium temperature change in response to radiative forcing change), but a lack of consistent methodologies produces a wide range of estimates and hinders comparability of results. Here we present a stricter approach, to improve intercomparison of palaeoclimate sensitivity estimates in a manner compatible with equilibrium projections for future climate change. Over the past 65 million years, this reveals a climate sensitivity (in K W−1 m2) of 0.3-1.9 or 0.6-1.3 at 95% or 68% probability, respectively. The latter implies a warming of 2.2-4.8 K per doubling of atmospheric CO2, which agrees with IPCC estimates.

Rohling, E. J.↗

Arterial baroreflex control of sympathetic nerve activity during acute hypotension: effect of fitness

We examined arterial baroreflex control of muscle sympathetic nerve activity (MSNA) during abrupt decreases in mean arterial pressure (MAP) and evaluated whether endurance training alters baroreflex function. Acute hypotension was induced nonpharmacologically in 14 healthy subjects, of which 7 were of high fitness (HF) and 7 were of average fitness (AF), by releasing a unilateral arterial thigh cuff after 9 min of resting ischemia under two conditions: control, which used aortic and carotid baroreflex (ABR and CBR, respectively) deactivation; and suction, which used ABR deactivation alone. The application of neck suction to counteract changes in carotid sinus transmural pressure during cuff release significantly attenuated the MSNA response (which increased 134 +/- 32 U/14 s) compared with control (which increased 195 +/- 43 U/14 s) and caused a greater decrease in MAP (19 +/- 2 vs. 15 +/- 2 mmHg; P < 0.05). Furthermore, during both trials, the HF subjects exhibited a greater decrease in MAP compared with AF subjects despite an augmented baroreflex control of MSNA. These data indicate that the CBR contributes importantly to the MSNA response during acute systemic hypotension. Additionally, we suggest that an impaired control of vascular reactivity hinders blood pressure regulation in HF subjects.

Non-NASA Center↗

GISS Analysis of Surface Temperature Changes

We describe the current GISS analysis of surface temperature change based primarily on meteorological station measurements. The global surface temperature in 1998 was the warmest in the period of instrumental data. The rate of temperature change is higher in the past 25 years than at any previous time in the period of instrumental data. The warmth of 1998 is too large and pervasive to be fully accounted for by the recent El Nino, suggesting that global temperature may have moved to a higher level, analogous to the increase that occurred in the late 1970s. The warming in the United States over the past 50 years is smaller than in most of the world, and over that period there is a slight cooling trend in the Eastern United States and the neighboring Atlantic ocean. The spatial and temporal patterns of the temperature change suggest that more than one mechanism is involved in this regional cooling.

Hansen, J.↗

GISS Analysis of Surface Temperature Change

We describe the current GISS analysis of surface temperature change for the period 1880-1999 based primarily on meteorological station measurements. The global surface temperature in 1998 was the warmest in the period of instrumental data. The rate of temperature change was higher in the past 25 years than at any previous time in the period of instrumental data. The warmth of 1998 was too large and pervasive to be fully accounted for by the recent El Nino. Despite cooling in the first half of 1999, we suggest that the mean global temperature, averaged over 2-3 years, has moved to a higher level, analogous to the increase that occurred in the late 1970s. Warming in the United States over the past 50 years has been smaller than in most of the world, and over that period there was a slight cooling trend in the Eastern United States and the neighboring Atlantic Ocean. The spatial and temporal patterns of the temperature change suggest that more than one mechanism was involved in this regional cooling. The cooling trend in the United States, which began after the 1930s and is associated with ocean temperature change patterns, began to reverse after 1979. We suggest that further warming in the United States to a level rivaling the 1930s is likely in the next decade, but reliable prediction requires better understanding of decadal oscillations of ocean temperature.

Hansen, J.↗