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Gaiser, Karen K.

Publications and source records attributed to Gaiser, Karen K..

The space life sciences strategy for the 21st century

In the 21st century, NASA's long-term strategy for the exploration of the solar system will combine the assurance of human health and performance for long periods in space with investigations aimed at searching for traces of life on other planets and acquiring fundamental scientific knowledge of life processes. Implementation of this strategy will involve a variety of disciplines including radiation health, life support, human factors, space physiology and countermeasures, medical care, environmental health, and exobiology. It will use both ground-based and flight research opportunities such as those found in current ongoing programs, on Spacelab and unmanned biosatellite flights, and during Space Station Freedom missions.

Nicogossian, Arnauld E.

NASA's manned space flight program

The NASA manned space flight program from Project Mercury onward is reviewed. Particular attention is given to the Gemini missions, Apollo, Skylab, and the Space Shuttle. Aspects of medical care and health maintenance in the U.S. space program are treated in some detail. Consideration is also given to opportunities connected with Space Station Freedom, issues for human exploration of the solar system, and international cooperation in the space life sciences.

Nicogossian, Arnauld E.

Critical issues for space life sciences

Human exploration of space requires the interaction of three general systems: environmental health and life support systems, countermeasure systems, and medical care systems. These systems address atmospheric pressure, uncertainties associated with space radiation, the potential for exposure to toxic materials in the closed environment, spacecraft habitability, human physiology, and microgrvaity. While these interdependent systems serve the same overall goal -- the protection of the human crewmember from the hostile space environment -- each has specific essential roles. Individually and in combination the three systems should be responsive to a strategy of risk reduction, so that the scientific possibilities of exploration missions may be maximized.

Nicogossian, Arnauld E.

Physiological adaptation to space flight

In space, adaptive physiological changes have been observed in virtually all body systems, but how far these changes progress with time is not known. Their time course demonstrates variable patterns; some systems show evidence of gradual and progressive change. Biomedical postflight data have shown that a compensatory period of readaptation to one gravity is required after space flight, with longer intervals required for longer missions. Consistent readaptation trends include orthostatic intolerance and neurovestibular difficulties. For the long-duration missions of the exploration era, it is critical to determine the extent to which deleterious changes (e.g., bone loss and possible immunological changes) can be reversed upon return to earth. Radiation protection is another critical enabling element for missions beyond low earth orbit. Radiation exposure guidelines have not been established for exploration missions. Currently our experience is insufficient to prescribe countermeasures for the stay times associated with a lunar base or a mission to Mars. Artificial gravity may provide a solution, but the level and duration of exposure necessary to prevent deconditioning must be determined. Central issues for medical care in remote settings are preventive, diagnostic, and therapeutic care and the minimization of risk.

Nicogossian, Arnauld E.

Enabling human exploration of space - A life sciences overview

In the transition from the short-duration missions of the Space Shuttle era to long-duration exploration missions, the health and safety of crewmembers must be ensured. The body undergoes many complex physiological changes as a result of its adaptation to a microgravity environment and U.S. and Soviet experiences have shown that time is required for readaptation to gravity. The consequences of these changes for the extended exploration missions envisioned for the future are unknown. A Mars mission may require crewmembers to spend many months in microgravity, and then work effectively in a one-third gravity environment. Other problems may arise when returning crewmembers must readapt to earth's gravity. Life Sciences activities are being planned to systematically address the physiological issues involved with long-term manned exploration missions, through ground-based studies and flight investigations on the Shuttle and Space Station Freedom. The areas of focus are artificial gravity, radiation, health care, and space human factors.

Gaiser, Karen K.