Engineering topics
Publications and source records attributed to Fritsch, J. M..
A new approach to the study of arterial baroreflexes was developed for use during the National Aeronautics and Space Administration Spacelab Life Sciences-1 Space Shuttle mission. This method holds promise as a means to characterize the vagal limb of human baroreflex responses comprehensively and efficiently.
The hypothesis that endurance exercise training designed to increase aerobic capacity results in reduced orthostatic tolerance due to alterations of blood-pressure controlling mechanisms was reexamined using a specially designed training in which tolerance to orthostasis and the primary mechanisms associated with the blood-pressure control could be measured before and after the increase in aerobic capacity. Results demonstrate that maximal oxygen uptake can be significantly elevated in individuals of average fit without reducing lower body negative pressure tolerance. The exercise training was found to cause a resting bradycardia, which had no effect on the cardiac vagal reflex response.
The mechanism of the carotid-baroreflex response to weightlessness was investigated in human subjects exposed to simulated microgravity (30 days of 6-day head-down bed rest followed by 5 days of recovery). Baroreceptor-cardiac reflex responses were elicited by a complex sequence of pressure changes delivered to a neck chamber device. The shape of the sigmoid baroreceptor-cardiac response curve was examined for alterations and the occurrence of resetting, as well as for a possible association of the impaired baroreflex function with hypotension during the postexposure orthostatic stress. It was found that the exposure to head-down bed rest caused a significant shift on the R-R interval axis, which paralleled reductions and elevations in baseline HR such that the baseline R-R (operational point) remained in the same position on the response curve. This shift in the location of the reflex relation indicates a significant resetting of the carotid baroreceptors, which may represent an appropriate adaptation which contributes to the maintenance of a constant resting arterial blood pressure before, during, and after bed rest, observed in these study.
The objectives are: (1) to demonstrate the sensitivity of a numerical simulation of a mesoscale convective weather system to the initial conditions; and (2) to provide further evidence of the need for a high resolution observing system that is compatible with numerical-model initial data requirements. To this end, a series of nine numerical-model sensitivity experiments were conducted in which one or more variables from one or more observations (soundings) were omitted and/or adjusted in the model initialization. Two types of surroundings were available for manipulation in the sensitivity experiments. Specifically, for the particular event being simulated (the 1977 Johnstown flash flood), an independent mesoanalysis was available from Bosart and Sanders (1981). In his analysis, Bosart produced a fine-resolution three-dimensional array of data from which soundings that helped to define mesoscale features could be extracted. These 'nonconventional' soundings were added to the conventional sounding data routinely available for model initialization.