Cardiopulmonary Inflammatory Responses to Subacute Meteorite Dust Exposures – Implications for Human Space Exploration
No abstract available
Harrington, A. D.↗
Engineering topics
Chen, L. C.
Publications and source records attributed to Chen, L. C..
Pulmonary Inflammatory Responses to Acute Meteorite Dust Exposures - Implications for Human Space Exploration
New initiatives to begin Lunar and Martian human surface operations within the next few decades are illustrative of the resurgence of interest in human space exploration. However, as with all exploration, there are risks. The previous manned missions to the Moon highlight a major hazard for future human exploration of the Moon and beyond: surface dust. Not only did the dust cause mechanical and structural integrity issues with the suits, the dust 'storm' generated upon reentrance into the crew cabin caused "lunar hay fever" and "almost blindness.". It was further reported that the allergic response to the dust worsened with each exposure. Due to the prevalence of these high exposures, the Human Research Roadmap developed by NASA identifies the Risk of Adverse Health and Performance Effects of Celestial Dust Exposure as an area of concern.
Harrington, A. D.↗
Pulmonary Inflammatory Responses to Acute Meteorite Dust Exposures - Implications for Human Space Exploration
New initiatives to send humans to Mars within the next few decades are illustrative of the resurgence of interest in space travel. However, as with all exploration, there are risks. The Human Research Roadmap developed by NASA identifies the Risk of Adverse Health and Performance Effects of Celestial Dust Exposure as an area of concern. Extended human exploration will further increase the probability of inadvertent and repeated exposures to celestial dusts.
Harrington, A. D.↗
Pulmonary Inflammatory Responses to Acute Meteorite Dust Exposures - to Acute Meteorite Dust Exposures - Exploration
New initiatives to begin lunar and martian colonization within the next few decades are illustrative of the resurgence of interest in space travel. One of NASA's major concerns with extended human space exploration is the inadvertent and repeated exposure to unknown dust. This highly interdisciplinary study evaluates both the geochemical reactivity (e.g. iron solubility and acellular reactive oxygen species (ROS) generation) and the relative toxicity (e.g. in vitro and in vivo pulmonary inflammation) of six meteorite samples representing either basalt or regolith breccia on the surface of the Moon, Mars, and Asteroid 4Vesta. Terrestrial mid-ocean ridge basalt (MORB) is also used for comparison. The MORB demonstrated higher geochemical reactivity than most of the meteorite samples but caused the lowest acute pulmonary inflammation (API). Notably, the two martian meteorites generated some of the highest API but only the basaltic sample is significantly reactive geochemically. Furthermore, while there is a correlation between a meteorite's soluble iron content and its ability to generate acellular ROS, there is no direct correlation between a particle's ability to generate ROS acellularly and its ability to generate API. However, assorted in vivo API markers did demonstrate strong positive correlations with increasing bulk Fenton metal content. In summary, this comprehensive dataset allows for not only the toxicological evaluation of astromaterials but also clarifies important correlations between geochemistry and health.
Harrington, A. D.↗
Acute Meteorite Dust Exposure and Pulmonary Inflammation - Implications for Human Space Exploration
The previous manned missions to the Moon represent milestones of human ingenuity, perseverance, and intellectual curiosity. However, one of the major ongoing concerns is the array of hazards associated with lunar surface dust. Not only did the dust cause mechanical and structural integrity issues with the suits, the dust 'storm' generated upon reentrance into the crew cabin caused "lunar hay fever" and "almost blindness [1-3]" (Figure 1). It was further reported that the allergic response to the dust worsened with each exposure [4]. The lack of gravity exacerbated the exposure, requiring the astronauts to wear their helmet within the module in order to avoid breathing the irritating particles [1]. Due to the prevalence of these high exposures, the Human Research Roadmap developed by NASA identifies the Risk of Adverse Health and Performance Effects of Celestial Dust Exposure as an area of concern [5]. Extended human exploration will further increase the probability of inadvertent and repeated exposures to celestial dusts. Going forward, hazard assessments of celestial dusts will be determined through sample return efforts prior to astronaut deployment. Studies on the lunar highland regolith indicate that the dust is not only respirable but also reactive [2, 6-9], and previous studies concluded that it is moderately toxic; generating a greater response than titanium oxide but a lower response than quartz [6]. The presence of reactive oxygen species (ROS) on the surface of the dust has been implicated. However, there is actually little data related to physicochemical characteristics of particulates and pulmonary toxicity, especially as it relates to celestial dust exposure. As a direct response to this deficit, the present study evaluates the role of a particulate's innate geochemical features (e.g., bulk chemistry, internal composition, morphology, size, and reactivity) in generating adverse toxicological responses in vitro and in vivo. This highly interdisciplinary study evaluates the relative toxicity of six meteorite samples representing either basalt or regolith breccia on the surfaces of the Moon, Mars, and Asteroid 4Vesta (Table 1); three potential candidates for future human exploration or colonization. Terrestrial mid-ocean ridge basalt (MORB) is also used for comparison as a control sample.
Harrington, A. D.↗
Pulmonary Inflammatory Responses To Acute Meteorite Dust Exposures - Implications For Human Space Exploration
The previous manned missions to the Moon represent milestones of human ingenuity, perseverance, and intellectual curiosity. However, one of the major ongoing concerns is the array of hazards associated with lunar surface dust. Not only did the dust cause mechanical and structural integrity issues with the suits, the dust 'storm' generated upon reentrance into the crew cabin caused "lunar hay fever" and "almost blindness" (Figure 1). It was further reported that the allergic response to the dust worsened with each exposure. The lack of gravity exacerbated the exposure, requiring the astronauts to wear their helmet within the module in order to avoid breathing the irritating particles. Due to the prevalence of these high exposures, the Human Research Roadmap developed by NASA identifies the Risk of Adverse Health and Performance Effects of Celestial Dust Exposure as an area of concern. Extended human exploration will further increase the probability of inadvertent and repeated exposures to celestial dusts. Going forward, hazard assessments of celestial dusts will be determined through sample return efforts prior to astronaut deployment. Studies on the lunar highland regolith indicate that the dust is not only respirable but also reactive, and previous studies concluded that it is moderately toxic; generating a greater response than titanium oxide but a lower response than quartz. The presence of reactive oxygen species (ROS) on the surface of the dust has been implicated. However, there is actually little data related to physicochemical characteristics of particulates and pulmonary toxicity, especially as it relates to celestial dust exposure. As a direct response to this deficit, the present study evaluates the role of a particulate's innate geochemical features (e.g., bulk chemistry, internal composition, morphology, size, and reactivity) in generating adverse toxicological responses in vitro and in vivo. This highly interdisciplinary study evaluates the relative toxicity of six meteorite samples representing either basalt or regolith breccia on the surfaces of the Moon, Mars, and Asteroid 4Vesta; three potential candidates for future human exploration or colonization. Terrestrial mid-ocean ridge basalt (MORB) is also used for comparison as a control sample.
Harrington, A. D.↗
Static compression of iron to 300 GPa and Fe(0.8)Ni(0.2) alloy to 260 GPa - Implications for composition of the core
Results are reported on a room temperature static compression study of iron and the Fe(0.8)Ni(0.2) alloy to above 260 GPa, which provide direct pressure-volume measurements on geophysically important materials at the conditions close to those at the inner core boundary. The diffraction patterns obtained by XRD indicate that pure iron remains in the hcp structure to 304 GPa and that Fe(0.8)Ni(0.2) is stable to at least 255 GPa. The results of this study, in conjunction with work at higher temperatures, will make it possible to address directly the question of the composition of the inner core with a level of certainty that were previously applicable only to the mantle.
Mao, H. K.↗
High-pressure phase transition and equation of state of CsI
Stuructural properties of CsI at high pressure have been investigated by the use of synchrotron X-ray-diffraction techniques with the diamond-anvil cell at 300 K. The results indicate that the material undergoes a continuous distortion from B2 to an hcp-like phase, which is stable to at least 302 GPa. The intermediate orthorhombic phase is geometrically different from previous assignments and about 10 percent denser. With the new structure, the p-V results of static pressure experiments, shock-wave studies, and theoretical calculations are now in good agreement.
Mao, H. K.↗
New transformations between crystalline and amorphous ice
High-pressure optical and spectroscopic techniques were used to obtain directly the ice I(h) - hda-ice transformation in a diamond-anvil cell, and the stability of the amorphous form is examined as functions of pressure and temperature. It is demonstrated that hda-ice transforms abruptly at 4 GPa and 77 K to a crystalline phase close in structure to orientationally disordered ice-VII and to a more highly ordered, ice-VIII-like structure at higher temperatures. This is the first time that an amorphous solid is observed to convert to a crystalline solid at low temperatures by compression alone. Phase transitions of this type may be relevant on icy planetary satellites, and there may also be implications for the high-pressure behavior of silica.
Hemley, R. J.↗
LANDSAT-4 horizon scanner performance evaluation
Representative data spans covering a little more than a year since the LANDSAT-4 launch were analyzed to evaluate the flight performance of the satellite's horizon scanner. High frequency noise was filtered out by 128-point averaging. The effects of Earth oblateness and spacecraft altitude variations are modeled, and residual systematic errors are analyzed. A model for the predicted radiance effects is compared with the flight data and deficiencies in the radiance effects modeling are noted. Correction coefficients are provided for a finite Fourier series representation of the systematic errors in the data. Analysis of the seasonal dependence of the coefficients indicates the effects of some early mission problems with the reference attitudes which were computed by the onboard computer using star trackers and gyro data. The effects of sun and moon interference, unexplained anomalies in the data, and sensor noise characteristics and their power spectrum are described. The variability of full orbit data averages is shown. Plots of the sensor data for all the available data spans are included.
Bilanow, S.↗
Landsat-4 horizon scanner flight performance
This paper presents an analysis of the flight data from a new design of horizon scanner flown on Landsat-4. The salient features in the data are described and demonstrated by data plots. High frequency noise must be filtered out to achieve good accuracy, but this is effectively done by 128-point averaging. Sun and moon interference effects are identified. The effects of earth oblateness and spacecraft altitude variations are modeled, and the residual systematic errors are analyzed. Most of the residual errors are apparently explained by the effects of earth radiance variation, with the winter polar regions showing the highest variability in the attitude measurements due to winter stratosphere temperature variations. In general, this sensor provides improved accuracy over those flown on previous missions.
Bilanow, S.↗
An interactive system for compositing digital radar and satellite data
This paper describes an approach for compositing digital radar data and GOES satellite data for meteorological analysis. The processing is performed on a user-oriented image processing system, and is designed to be used in the research mode. It has a capability to construct PPIs and three-dimensional CAPPIs using conventional as well as Doppler data, and to composite other types of data. In the remapping of radar data to satellite coordinates, two steps are necessary. First, PPI or CAPPI images are remapped onto a latitude-longitude projection. Then, the radar data are projected into satellite coordinates. The exact spherical trigonometric equations, and the approximations derived for simplifying the computations are given. The use of these approximations appears justified for most meteorological applications. The largest errors in the remapping procedure result from the satellite viewing angle parallax, which varies according to the cloud top height. The horizontal positional error due to this is of the order of the error in the assumed cloud height in mid-latitudes. Examples of PPI and CAPPI data composited with satellite data are given for Hurricane Frederic on 13 September 1979 and for a squall line on 2 May 1979 in Oklahoma.
Heymsfield, G. M.↗
LANDSAT-D conical scanner evaluation plan
The planned activities involved in the inflight sensor calibration and performance evaluation are discussed and the supporting software requirements are specified. The possible sensor error sources and their effects on sensor measurements are summarized. The methods by which the inflight sensor performance will be analyzed and the sensor modeling parameters will be calibrated are presented. In addition, a brief discussion on the data requirement for the study is provided.
Bilanow, S.↗
Spacecraft attitude calibration/verification baseline study
A baseline study for a generalized spacecraft attitude calibration/verification system is presented. It can be used to define software specifications for three major functions required by a mission: the pre-launch parameter observability and data collection strategy study; the in-flight sensor calibration; and the post-calibration attitude accuracy verification. Analytical considerations are given for both single-axis and three-axis spacecrafts. The three-axis attitudes considered include the inertial-pointing attitudes, the reference-pointing attitudes, and attitudes undergoing specific maneuvers. The attitude sensors and hardware considered include the Earth horizon sensors, the plane-field Sun sensors, the coarse and fine two-axis digital Sun sensors, the three-axis magnetometers, the fixed-head star trackers, and the inertial reference gyros.
Chen, L. C.↗
A general interactive system for compositing digital radar and satellite data
Reynolds and Smith (1979) have considered the combined use of digital weather radar and satellite data in interactive systems for case study analysis and forecasting. Satellites view the top of clouds, whereas radar is capable of observing the detailed internal structure of clouds. The considered approach requires the use of a common coordinate system. In the present investigation, it was decided to use the satellite coordinate system as the base system in order to maintain the fullest resolution of the satellite data. The investigation is concerned with the development of a general interactive software system called RADPAK for remapping and analyzing conventional and Doppler radar data. RADPAK is implemented as a part of a minicomputer-based image processing system, called Atmospheric and Oceanographic Image Processing System. Attention is given to a general description of the RADPAK system, remapping methodology, and an example of satellite remapping.
Ghosh, K. K.↗
Spacecraft momentum management procedures
Techniques appropriate for implementation onboard the space telescope and other spacecraft to manage the accumulation of momentum in reaction wheel control systems using magnetic torquing coils are described. Generalized analytical equations are derived for momentum control laws that command the magnetic torquers. These control laws naturally fall into two main categories according to the methods used for updating the magnetic dipole command: closed loop, in which the update is based on current measurements to achieve a desired torque instantaneously, and open-loop, in which the update is based on predicted information to achieve a desired momentum at the end of a period of time. Physical interpretations of control laws in general and of the Space Telescope cross product and minimum energy control laws in particular are presented, and their merits and drawbacks are discussed. A technique for retaining the advantages of both the open-loop and the closed-loop control laws is introduced. Simulation results are presented to compare the performance of these control laws in the Space Telescope environment.
Chen, L. C.↗
Single-axis attitude determination accuracy
This paper extends the analysis of attitude determination accuracy introduced at the 1975 American Astronautical Society/American Institute of Aeronautics and Astronautics (AAS/AIAA) Astrodynamics Conference. It contains more generalized expressions, new geometrical relations, and additional applications. A complete set of attitude accuracy equations for both arc-length (portion of a great circle) and rotation-angle (dihedral angle) measurements are presented. These expressions can then be applied to determine the geometrical conditions under which a specified accuracy can be achieved by using either the attitude or a selected reference-vector direction as the independent variable. Representative applications to attitude determination accuracy studies and launch window analyses are discussed. The clear physical interpretation and straightforward graphical procedures greatly simplify mission analysis, maneuver planning, hardware configuration studies, and interpretation of results.
Chen, L. C.↗
Geometrical procedures for the analysis of spacecraft attitude and bias determinability
Geometrical procedures are presented for predicting the determinability of spacecraft attitude and bias parameters. An analysis is presented on three common attitude measurements: sun angle, nadir angle, and sun-to-earth mid-scan rotation angle. First, the geometry of these measurements is considered for an arbitrary fixed location of the spacecraft; then the effect of orbital motion is analyzed. The results are summarized in a set of simple geometrical rules. The application of these rules to the Synchronous Meteorological Satellite-2 (SMS-2) is discussed. As a result of this geometrical analysis, modifications were made to the SMS-2 bias determination schedule which substantially enhanced the determinability of attitude sensor biases.
Wertz, J. R.↗