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Brown, D. C.

Publications and source records attributed to Brown, D. C..

9 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS1993

Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine

PURPOSE: To investigate the efficacy and safety of midodrine for treatment of patients with orthostatic hypotension due to autonomic failure. PATIENTS: Ninety-seven patients with orthostatic hypotension were randomized in a 4-week, double-blinded, placebo-controlled study with a 1-week placebo run-in period. Patients ranged in age from 22 to 86 years (mean: 61 years). METHODS: After a 1-week run-in phase, either placebo or midodrine at a dose of 2.5 mg, 5 mg, or 10 mg was administered three times a day for 4 weeks. Both the placebo group and the 2.5-mg midodrine group received constant doses throughout the double-blind phase. The patients receiving 5 mg or 10 mg of midodrine were given doses that were increased at weekly intervals by 2.5-mg increments until the designated dose was reached. Efficacy evaluations were based on an improvement at 1-hour postdose in standing systolic blood pressure and in symptoms of orthostatic hypotension (syncope, dizziness/lightheadedness, weakness/fatigue, and low energy level). RESULTS: Midodrine (10 mg) increased standing systolic blood pressure by 22 mm Hg (28%, p < 0.001 versus placebo). Midodrine improved (p < 0.05) the following symptoms of orthostatic hypotension compared to placebo: dizziness/lightheadedness, weakness/fatigue, syncope, low energy level, impaired ability to stand, and feelings of depression. The overall side effects were mainly mild to moderate. One or more side effects were reported by 22% of the placebo group compared with 27% of the midodrine-treated group. Scalp pruritus/tingling, which was reported by 10 of 74 (13.5%) of the midodrine-treated patients, was most frequent. Other reported side effects included supine hypertension (8%) and feelings of urinary urgency (4%). CONCLUSION: We conclude that midodrine is an effective and well-tolerated treatment for moderate-to-severe orthostatic hypotension associated with autonomic failure.

NASA Discipline Number 14-10↗
NASA NTRS1991

Avionic architecture requirements for Space Exploration Initiative systems

The authors discuss NASA's Strategic Avionics Technology Working Group (SATWG) and the results of the first study commissioned by the SATWG, the Space Avionics Requirements Study (SARS). The goal of the SARS task was to show that an open avionics architecture, using modular, standardized components, could be applied across the wide range of systems that comprise the Space Exploration Initiative. The study addressed systems ranging from expendable launch vehicles and the space station to surface systems such as Mars or lunar rovers and habitats. Top-level avionics requirements were derived from characterizations of each of the systems considered. Then a set of avionics subsystems were identified, along with estimates of the numbers and types of modules needed to meet the requirements. Applicability of these results across the infrastructure was then illustrated. In addition to these tasks, critical technologies were identified, characterized, and assessed in terms of their criticality and impact on the program. Design, development, test, and evaluation methods were addressed to identify potential areas of improvement.

Herbella, C. G.↗
NASA NTRS1983

Energetic atomic and molecular ions in Saturn's magnetosphere

Voyager 1 and 2 sensor data are analyzed in order to derive the composition, energy spectra, and spatial distribution of energetic ions in the Saturn magnetosphere. In order of abundance, the major species are H, H2(+), He, H3(+), C, and O. The fluxes of all species decreased inside the orbit of Dione, and nearly vanished in the 'slot' region within the orbit of Tethys. Both satellite absorption and precipitation due to pitch angle scattering may be important loss processes in that region. In the outer magnetosphere, photodissociation rapidly destroys a large fraction of the H2(+) ions, but dissociation by impact with neutral H atoms is faster for H2(+) ions in the lowest vibrational state. The ground state lifetime of about 23 days places a limit of about 10-100 days on the mean overall residence time for energetic ions in Saturn's magnetosphere.

Hamilton, D. C.↗
NASA NTRS1977

National geodetic satellite program, part 1

Equipment and techniques were evaluated operationally, by the Department of Defense, during the National Geodetic Satellite Program (NGSP). The theory, instrumentation, and data reduction methods used are described. Results obtained during the NGSP are given.

Anderle, R.↗
NASA NTRS1971

Inversion of very large matrices encountered in large scale problems of photogrammetry and photographic astrometry

The simultaneous adjustment of very large nets of overlapping plates covering the celestial sphere becomes computationally feasible by virtue of a twofold process that generates a system of normal equations having a bordered-banded coefficient matrix, and solves such a system in a highly efficient manner. Numerical results suggest that when a well constructed spherical net is subjected to a rigorous, simultaneous adjustment, the exercise of independently established control points is neither required for determinancy nor for production of accurate results.

Brown, D. C.↗
NASA NTRS1971

Metric analysis of minitrack optical and interferometer data

The network analysis program (NAP-2), which has the capability of simultaneously solving for orbits and tracking station error model terms, was, after several modifications, used in the calibration of minitrack stations using minitrack satellite measurements (self-calibration). Several support programs were written to aid in this task. A simultaneous four-arc solution was obtained. A comparison with optically determined arcs for the same time spans showed rms position differences of 67m, 86m, 124m and 168m for the 4 arcs considered. An apparatus incorporating a diffraction grating was designed and successfully used to measure the drift rate of the Fort Myers MOTS camera drive.

Brown, D. C.↗