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Armstrong, J. W.

Publications and source records attributed to Armstrong, J. W..

At least 55 records · Page 3
All sourcesNASA NTRSDOE OSTI
NASA NTRS1995

Electron density power spectrum in the local interstellar medium

Interstellar scintillation (ISS), fluctuations in the amplitude and phase of radio waves caused by scattering in the interstellar medium, is important as a diagnostic of interstellar plasma turbulence. ISS is also of interest because it is noise for other radio astronomical observations. The unifying concern is the power spectrum of the interstellar electron density. Here we use ISS observations through the nearby (less than or approximately =1 kpc) (ISM) to estimate the spectrum. From measurements of angular broadening of pulsars and extragalactic sources, decorrelation bandwidth of pulsars, refractive steering of features in pulsar dynamic spectra, dispersion measured fluctuations of pulsars, and refractive scintillation index measurements, we construct a composite structure function that is approximately power law over 2 x 10(exp 6) m less than scale less than 10(exp 13) m. The data are consistent with the structure function having a logarithmic slope versus baseline less than 2; thus there is a meaningful connection between scales in the radiowave fluctuation field and the scales in the electron density field causing the scattering. The data give an upper limit to the inner scale, l(sub o) less than or approximately 10(exp 8) m and are consistent with much smaller values. We construct a composite electron density spectrum that is approximately power law over at least the approximately = 5 decade wavenumber range 10(exp -13)/m less than wavenumber less than 10(exp -8)/m and that may extend to higher wavenumbers. The average spectral index of electron density over this wavenumber range is approximately = 3.7, very close to the value expected for a Kolmogorov process. The outer scale size, L(sub o), must be greater than or approximately = 10(exp 13) m (determined from dispersion measure fluctuations). When the ISS data are combined with measurements of differential Faraday rotation angle, and gradients in the average electron density, constraints can be put on the spectrum at much smaller wave numbers. The composite spectrum is consistent with a Kolmogorov-like power law over a huge range (10 or more decades) of spatial wavenumber with an infrared outer scale L(sub o) greater than or approximately 10(exp 18)m. This power-law subrange-expressed as ratio of outer to inner scales-is comparable to or larger than that of other naturally occurring turbulent fluids, such as the oceans or the solar wind. We outline some of the theories for generating and maintaining such a spectrum over this huge wavenumber range.

Armstrong, J. W.↗
NASA NTRS1995

Variation of fractional electron density fluctuations inside 40 R(sub 0) observed by Ulysses ranging measurements

The first measurements of fractional electron density fluctuations delta-n(sub e)/n(sub e), where delta-n(sub e) is rms electron density fluctuation and n(sub e) is the mean electron density, have been carried out inside 40 R(sub 0) using 1991 Ulysses dual-frequency S- and X-band (13 and 3.6 cm) ranging (time delay) measurements. In the frequency band of approximately 6 x 10(exp -5) - 8 x 10(exp -4) Hz (periods of 20 min to 5 hr), delta-n(sub e)/n(sub e) varies from a high near 20% in the slow wind close to the neutral line to a low of 1% in the fast wind far from the neutral line. For spatial wavenumber K approximately = 1.4 x 10(exp -6)/km (period of 5 hr at 250 km/s), delta-n(sub e)/n(sub e) is essentially independent of heliocentric distance over 0.03-1.0 AU in the slow wind; it is a factor of 30 lower in the fast wind than in the slow wind inside 0.1 AU, but exhibits dramatic growth with heliocentric distance inside 0.3 AU. This latter result reinforces current views of the evolution of MHD turbulence and the association of Alfven waves with high speed streams based on in situ fields and particles measurements beyond 0.3 AU. That regions of enhanced density fluctuations near or above the neutral line coincide with regions of enhanced density confirms previous conclusions that they are the interplanetary manifestation of the heliospheric current sheet and extensions of coronal streamers. While the regions of enhanced density fluctuations lie within those of enhanced density, they have boundaries that are distinctly more abrupt, suggesting the separation of plasma of different nature and origin.

Woo, Richard↗
NASA NTRS1995

The effect of space and parabolic flight on macrophage hematopoiesis and function

We used weak electric fields to monitor macrophage spreading in microgravity. Using this technique, we demonstrated that bone marrow-derived macrophages responded to microgravity within 8 s. We also showed that microgravity differentially altered two processes associated with bone marrow-derived macrophage development. Spaceflight enhanced cellular proliferation and inhibited differentiation. These data indicate that the space/microgravity environment significantly affects macrophages.

NASA Discipline Cell Biology↗
NASA NTRS1994

Binding and activation of major histocompatibility complex class II-deficient macrophages by staphylococcal exotoxins

Macrophages from C2D transgenic mice deficient in the expression of major histocompatibility complex (MHC) class II proteins were used to identify binding sites for superantigens distinct from the MHC class II molecule. Iodinated staphylococcal enterotoxins A and B (SEA and SEB) and exfoliative toxins A and B (ETA and ETB) bound to C2D macrophages in a concentration-dependent and competitive manner. All four toxins increased F-actin concentration within 30 s of their addition to C2D macrophages, indicating that signal transduction occurred in response to toxin in the absence of class II MHC. Furthermore, ETA, ETB, SEA, and, to a lesser extent, SEB induced C2D macrophages to produce interleukin 6. Several molecular species on C2D macrophages with molecular masses of 140, 97, 61, 52, 43, and 37 kDa bound SEA in immunoprecipitation experiments. These data indicate the presence of novel, functionally active toxin binding sites on murine macrophages distinct from MHC class II molecules.

Non-NASA Center↗
NASA NTRS1994

Effects of extracellular matrix proteins on macrophage differentiation, growth, and function: comparison of liquid and agar culture systems

Both spaceflight and skeletal unloading suppress the haematopoietic differentiation of macrophages (Sonnenfeld et al., Aviat. Space Environ. Med., 61:648-653, 1990; Armstrong et al., J. Appl. Physiol., 75:2734-2739, 1993). The mechanism behind this reduction in haematopoiesis has yet to be elucidated. However, changes in bone marrow extracellular matrix (ECM) may be involved. To further understand the role of ECM products in macrophage differentiation, we have performed experiments evaluating the effects of fibronectin, laminin, collagen type I, and collagen type IV on macrophage development and function. Bone marrow-derived macrophages cultured on four different ECM substrates in liquid culture medium showed less growth than those cultured on plastic. Significant morphological differences were seen on each of the substrates used. Phenotypically and functionally, as measured by class II major histocompatibility molecule (MHCII) expression, MAC-2 expression, and the secretion of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), these macrophages were similar. In contrast, bone marrow-derived macrophages cultured in suspension, using agar, showed no difference in growth when exposed to ECM proteins. However, IL-6 and TNF-alpha secretion was affected by fibronectin, laminin, collagen type I, and collagen type IV in a concentration-dependent manner. We conclude that the ECM products fibronectin, laminin, collagen type I, and collagen type IV have profound effects on macrophage development and function. Additionally, we suggest that an ECM-supplemented agar culture system provides an environment more analogous to in vivo bone marrow than does a traditional liquid culture system.

Non-NASA Center↗
NASA NTRS1994

Class I and class II major histocompatibility molecules play a role in bone marrow-derived macrophage development

Class I and class II major histocompatibility complex (MHC) molecules play significant roles in T cell development and immune function. We show that MHCI- and MHCII-deficient mice have low numbers of macrophage precursors and circulating monocytes, as well as abnormal bone marrow cell colony-stimulating factor type 1 secretion and bone composition. We suggest that MHCI and MHCII molecules play a significant role in macrophage development.

Non-NASA Center↗
NASA NTRS1994

Electron Density Power Spectrum in the Local Interstellar Medium

Interstellar scintillation (ISS), fluctuations in the amplitude and phase of radio waves caused by scattering in the interstellar medium, is important as a diagnostic of interstellar plasma turbulence. ISS is also of interest because it is noise for other radio astronomical observations.

interstellar↗
NASA NTRS1993

Staphylococcus-mediated T-cell activation and spontaneous natural killer cell activity in the absence of major histocompatibility complex class II molecules

We used major histocompatibility complex class II antigen-deficient transgenic mice to show that in vitro natural killer cell cytotoxicity and T-cell activation by staphylococcal exotoxins (superantigens) are not dependent upon the presence of major histocompatibility complex class II molecules. T cells can be activated by exotoxins in the presence of exogenously added interleukin 1 or 2 or in the presence of specific antibody without exogenously added cytokines.

Non-NASA Center↗
NASA NTRS1993

Upper limits for gravitational radiation from supermassive coalescing binaries

We report a search for waves from supermassive coalescing binaries using a 10.5 day Pioneer 10 data set taken in 1988. Depending on the time to coalescence, the initial frequency of the wave, and the length of the observing interval, a coalescing binary waveform appears in the tracking record either as a sinusoid, a 'chirp', or as a more complicated signal. We searched our data for coalescing binary waveforms in all three regimes. We successfully detected a (fortuitous) 'chirp' signal caused by the varying spin rate of the spacecraft; this nicely served as a calibration of the data quality and as a test of our analysis procedures on real data. We did not detect any signals of astronomical origin in the millihertz band to an upper limit of about 7 x 10 exp -15 (rms amplitude). This is the first time spacecraft Doppler data have been analyzed for coalescing binary waveforms, and the upper limits reported here are the best to date for any waveform in the millihertz band.

Anderson, J. D.↗
NASA NTRS1992

Gravitation and celestial mechanics investigations with Galileo

The gravitation and celestial mechanics investigations that are to be conducted during the cruise and Orbiter phases of the Galileo Mission cover four investigation categories: (1) the gravity fields of Jupiter and its four major satellites; (2) a search for gravitational radiation; (3) mathematical modeling of general relativistic effects on Doppler ranging data; and (4) improvements of the Jupiter ephemeris via Orbiter ranging. Also noted are two secondary objectives, involving a range fix during Venus flyby and the determination of the earth's mass on the bases of the two earth gravity assists used by the mission.

Anderson, J. D.↗
NASA NTRS1992

Observations of large-scale structure in the inner heliosphere with Doppler scintillation measurements

A study of large-scale structure in the inner heliosphere based on unique and extensive Pioneer Venus Doppler scintillation data has been initiated. Preliminary results include the first observation of corotating stream structure inside 35 solar radii. Results on variations of the Doppler scintillations with solar cycle and heliocentric distance, and their implications in terms of solar wind structure and mass flux density, are discussed.

Woo, R.↗
NASA NTRS1992

Observations of the electron density spectrum near the sun during spectral broadening transients

We present high-time resolution spectral broadening data for several transients caused by propagating interplanetary disturbances observed inside 20 solar radii. The results show that the shape and level of the ambient near-sun electron density spectrum undergoes abrupt and substantial change during passage of the disturbance. The steepening of the spectrum to near the Kolmogorov value suggests fully-developed inertial-range turbulence in the wake of the interplanetary disturbance.

Woo, R.↗
NASA NTRS1991

Coincidence probabilities for spacecraft gravitational wave experiments - Massive coalescing binaries

Massive coalescing binary systems are candidate sources of gravitational radiation in the millihertz frequency band accessible to spacecraft Doppler tracking experiments. This paper discusses signal processing and detection probability for waves from coalescing binaries in the regime where the signal frequency increases linearly with time, i.e., 'chirp' signals. Using known noise statistics, thresholds with given false alarm probabilities are established for one- and two-spacecraft experiments. Given the threshold, the detection probability is calculated as a function of gravitational wave amplitude for both one- and two-spacecraft experiments, assuming random polarization states and under various assumptions about wave directions. This allows quantitative statements about the detection efficiency of these experiments and the utility of coincidence experiments. In particular, coincidence probabilities for two-spacecraft experiments are insensitive to the angle between the directions to the two spacecraft, indicating that near-optical experiments can be done without constraints on spacecraft trajectories.

Tinto, Massimo↗